{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T08:51:16Z","timestamp":1791967876179,"version":"4.3.4"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:00:00Z","timestamp":1788480000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["eBioMedicine"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.ebiom.2026.106486","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T12:50:10Z","timestamp":1790859010000},"page":"106486","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Genome-wide analysis of genetic modifiers of Crohn\u2019s disease and ulcerative colitis risk in response to tobacco smoking"],"prefix":"10.1016","volume":"132","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7367-241X","authenticated-orcid":false,"given":"Jingjing","family":"Bai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranko","family":"Gacesa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes R.","family":"Bj\u00f6rk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernadien H.","family":"Jansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaas N.","family":"Faber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rinse K.","family":"Weersma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard","family":"Dijkstra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberley W.J.","family":"van der Sloot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3255-6930","authenticated-orcid":false,"given":"Eleonora A.M.","family":"Festen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriaan Anthonie Van","family":"Bodegraven","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea E.","family":"Van der Meulen-de Jong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annemarie C.","family":"De Vries","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bas","family":"Oldenburg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyriel Y.","family":"Ponsioen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiona D.M.","family":"Van Schaik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Hoentjen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herma","family":"Fidder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janneke","family":"Van der Woude","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeroen M.","family":"Jansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjolijn","family":"Duijvestein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"L\u00f6wenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meike M.C.","family":"Hirdes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nanne","family":"De Boer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nofel","family":"Mahmmod","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.ebiom.2026.106486_bib1","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2022-065186","article-title":"Global, regional and national burden of inflammatory bowel disease in 204 countries and territories from 1990 to 2019: a systematic analysis based on the Global Burden of Disease Study 2019","volume":"13","author":"Wang","year":"2023","journal-title":"BMJ Open"},{"issue":"8067","key":"10.1016\/j.ebiom.2026.106486_bib2","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/s41586-025-08940-0","article-title":"Global evolution of inflammatory bowel disease across epidemiologic stages","volume":"642","author":"Hracs","year":"2025","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.ebiom.2026.106486_bib3","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/S2468-1253(23)00003-1","article-title":"The cost of inflammatory bowel disease in high-income settings","volume":"8","author":"Burisch","year":"2023","journal-title":"Lancet Gastroenterol Hepatol"},{"issue":"2","key":"10.1016\/j.ebiom.2026.106486_bib4","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1007\/s10620-014-3350-9","article-title":"Environmental risk factors for inflammatory bowel diseases: a review","volume":"60","author":"Ananthakrishnan","year":"2015","journal-title":"Digest Dis Sci"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106486_bib5","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-76361-2","article-title":"Identifying environmental risk factors for inflammatory bowel diseases: a Mendelian randomization study","volume":"10","author":"Carreras-Torres","year":"2020","journal-title":"Sci Rep"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106486_bib6","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1038\/s41467-024-44841-y","article-title":"Altered DNA methylation within DNMT3A, AHRR, LTA\/TNF loci mediates the effect of smoking on inflammatory bowel disease","volume":"15","author":"Zhang","year":"2024","journal-title":"Nat Commun"},{"issue":"8000","key":"10.1016\/j.ebiom.2026.106486_bib7","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1038\/s41586-023-06968-8","article-title":"Smoking changes adaptive immunity with persistent effects","volume":"626","author":"Saint-Andr\u00e9","year":"2024","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.ebiom.2026.106486_bib8","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1093\/ibd\/izad268","article-title":"Differential impact of smoking on methylome and transcriptome in Crohn's Disease and ulcerative colitis","volume":"30","author":"Yan Ang","year":"2024","journal-title":"Inflamm Bowel Dis"},{"issue":"11","key":"10.1016\/j.ebiom.2026.106486_bib9","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1038\/s41576-024-00731-z","article-title":"Gene\u2013environment interactions in human health","volume":"25","author":"Herrera-Luis","year":"2024","journal-title":"Nat Rev Genet"},{"issue":"6","key":"10.1016\/j.ebiom.2026.106486_bib10","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1006\/pmed.1996.0117","article-title":"Gene-environment interaction: definitions and study designs","volume":"25","author":"Ottman","year":"1996","journal-title":"Prev Med"},{"issue":"6","key":"10.1016\/j.ebiom.2026.106486_bib11","doi-asserted-by":"crossref","DOI":"10.1093\/ecco-jcc\/jjaf061","article-title":"Gene-environment interactions in inflammatory bowel disease: a systematic review of human epidemiologic studies","volume":"19","author":"Bai","year":"2025","journal-title":"J Crohns Colitis"},{"issue":"2","key":"10.1016\/j.ebiom.2026.106486_bib12","article-title":"Genetic factors interact with tobacco smoke to modify risk for inflammatory bowel disease in humans and mice","volume":"153","author":"Pankaj","year":"2017","journal-title":"Gastroenterology"},{"issue":"11","key":"10.1016\/j.ebiom.2026.106486_bib13","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2017-016695","article-title":"Cohort profile: design and first results of the Dutch IBD biobank: a prospective, nationwide biobank of patients with inflammatory bowel disease","volume":"7","author":"Spekhorst","year":"2017","journal-title":"BMJ Open"},{"issue":"6","key":"10.1016\/j.ebiom.2026.106486_bib14","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1093\/ecco-jcc\/jjaa223","article-title":"Genetic risk scores identify genetic aetiology of inflammatory bowel disease phenotypes","volume":"15","author":"Voskuil","year":"2020","journal-title":"J Crohns Colitis"},{"issue":"22","key":"10.1016\/j.ebiom.2026.106486_bib15","doi-asserted-by":"crossref","first-page":"2867","DOI":"10.1093\/bioinformatics\/btq559","article-title":"Robust relationship inference in genome-wide association studies","volume":"26","author":"Manichaikul","year":"2010","journal-title":"Bioinformatics"},{"issue":"18","key":"10.1016\/j.ebiom.2026.106486_bib16","doi-asserted-by":"crossref","first-page":"3426","DOI":"10.1016\/j.cell.2022.08.004","article-title":"High-coverage whole-genome sequencing of the expanded 1000 genomes project cohort including 602 trios","volume":"185","author":"Byrska-Bishop","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.ebiom.2026.106486_bib17","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.52155","article-title":"The single-cell eQTLGen consortium","volume":"9","author":"van der Wijst","year":"2020","journal-title":"eLife"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106486_bib18","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1002\/sim.973","article-title":"Sample size requirements for matched case-control studies of gene\u2013environment interaction","volume":"21","author":"Gauderman","year":"2002","journal-title":"Stat Med"},{"issue":"11","key":"10.1016\/j.ebiom.2026.106486_bib19","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.4065\/81.11.1462","article-title":"Smoking and inflammatory bowel disease: a meta-analysis","volume":"81","author":"Mahid","year":"2006","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.ebiom.2026.106486_bib20","series-title":"Health Survey\/Lifestyle Monitor 2021","year":"2021"},{"issue":"10","key":"10.1016\/j.ebiom.2026.106486_bib21","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1093\/ecco-jcc\/jjx055","article-title":"A 20-Year temporal change analysis in incidence, presenting phenotype and mortality, in the Dutch IBDSL Cohort\u2014can diagnostic factors explain the increase in IBD incidence?","volume":"11","author":"van den Heuvel","year":"2017","journal-title":"J Crohns Colitis"},{"issue":"2","key":"10.1016\/j.ebiom.2026.106486_bib22","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1002\/sim.4780130206","article-title":"Non-hierarchical logistic models and case-only designs for assessing susceptibility in population-based case-control studies","volume":"13","author":"Piegorsch","year":"1994","journal-title":"Stat Med"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106486_bib23","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1186\/s12864-025-11318-1","article-title":"The case-only design is a powerful approach to detect interactions but should be used with caution","volume":"26","author":"Dong","year":"2025","journal-title":"BMC Genom"},{"issue":"4","key":"10.1016\/j.ebiom.2026.106486_bib24","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1056\/NEJM200107263450401","article-title":"Parity, oral contraceptives, and the risk of ovarian cancer among carriers and noncarriers of a BRCA1 or BRCA2 mutation","volume":"345","author":"Modan","year":"2001","journal-title":"N Engl J Med"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106486_bib25","doi-asserted-by":"crossref","DOI":"10.1186\/s13742-015-0047-8","article-title":"Second-generation PLINK: rising to the challenge of larger and richer datasets","volume":"4","author":"Chang","year":"2015","journal-title":"GigaScience"},{"key":"10.1016\/j.ebiom.2026.106486_bib26","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.12688\/f1000research.53962.1","article-title":"Performing post-genome-wide association study analysis: overview, challenges and recommendations","volume":"10","author":"Adam","year":"2021","journal-title":"F1000Res"},{"issue":"4","key":"10.1016\/j.ebiom.2026.106486_bib27","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1093\/ije\/dyu229","article-title":"Cohort profile: Lifelines, a three-generation cohort study and biobank","volume":"44","author":"Scholtens","year":"2015","journal-title":"Int J Epidemiol"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106486_bib28","doi-asserted-by":"crossref","DOI":"10.1155\/2007\/971816","article-title":"Pathology databanking and biobanking in the Netherlands, a central role for PALGA, the nationwide histopathology and cytopathology data network and archive","volume":"29","author":"Casparie","year":"2007","journal-title":"Anal Cell Pathol"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106486_bib29","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.1038\/s41467-017-01261-5","article-title":"Functional mapping and annotation of genetic associations with FUMA","volume":"8","author":"Watanabe","year":"2017","journal-title":"Nat Commun"},{"issue":"W1","key":"10.1016\/j.ebiom.2026.106486_bib30","doi-asserted-by":"crossref","first-page":"W322","DOI":"10.1093\/nar\/gkac393","article-title":"FABIAN-variant: predicting the effects of DNA variants on transcription factor binding","volume":"50","author":"Steinhaus","year":"2022","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106486_bib31","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1038\/s41467-021-21541-5","article-title":"Accurate imputation of human leukocyte antigens with CookHLA","volume":"12","author":"Cook","year":"2021","journal-title":"Nat Commun"},{"issue":"2","key":"10.1016\/j.ebiom.2026.106486_bib32","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1038\/tpj.2013.18","article-title":"HIBAG\u2014HLA genotype imputation with attribute bagging","volume":"14","author":"Zheng","year":"2014","journal-title":"Pharmacogenom J"},{"issue":"3","key":"10.1016\/j.ebiom.2026.106486_bib33","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1093\/bioinformatics\/btaa684","article-title":"HATK: HLA analysis toolkit","volume":"37","author":"Choi","year":"2021","journal-title":"Bioinformatics"},{"issue":"6","key":"10.1016\/j.ebiom.2026.106486_bib34","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0064683","article-title":"Imputing amino acid polymorphisms in human leukocyte antigens","volume":"8","author":"Jia","year":"2013","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.ebiom.2026.106486_bib35","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/nmeth.4197","article-title":"Salmon provides fast and bias-aware quantification of transcript expression","volume":"14","author":"Patro","year":"2017","journal-title":"Nat Methods"},{"issue":"3","key":"10.1016\/j.ebiom.2026.106486_bib36","article-title":"clusterProfiler 4.0: a universal enrichment tool for interpreting omics data","volume":"2","author":"Wu","year":"2021","journal-title":"Innovation"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106486_bib37","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1186\/s13059-019-1836-7","article-title":"Scaling computational genomics to millions of individuals with GPUs","volume":"20","author":"Taylor-Weiner","year":"2019","journal-title":"Genome Biol"},{"issue":"3","key":"10.1016\/j.ebiom.2026.106486_bib38","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0173847","article-title":"Screening for interaction effects in gene expression data","volume":"12","author":"Castaldi","year":"2017","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106486_bib39","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1038\/s41467-021-21458-z","article-title":"Inflammation status modulates the effect of host genetic variation on intestinal gene expression in inflammatory bowel disease","volume":"12","author":"Hu","year":"2021","journal-title":"Nat Commun"},{"issue":"9","key":"10.1016\/j.ebiom.2026.106486_bib40","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1009440","article-title":"A more accurate method for colocalisation analysis allowing for multiple causal variants","volume":"17","author":"Wallace","year":"2021","journal-title":"PLoS Genet"},{"issue":"4","key":"10.1016\/j.ebiom.2026.106486_bib41","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1016\/j.bbadis.2016.01.020","article-title":"HSPA6 is an ulcerative colitis susceptibility factor that is induced by cigarette smoke and protects intestinal epithelial cells by stabilizing anti-apoptotic Bcl-XL","volume":"1862","author":"Regeling","year":"2016","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"10.1016\/j.ebiom.2026.106486_bib42","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.2147\/COPD.S75978","article-title":"Protein networks in induced sputum from smokers and COPD patients","volume":"10","author":"Baraniuk","year":"2015","journal-title":"Int J Chron Obstruct Pulmon Dis"},{"issue":"15","key":"10.1016\/j.ebiom.2026.106486_bib43","doi-asserted-by":"crossref","first-page":"7419","DOI":"10.1073\/pnas.1821778116","article-title":"A specific amino acid motif of HLA-DRB1 mediates risk and interacts with smoking history in Parkinson's disease","volume":"116","author":"Hollenbach","year":"2019","journal-title":"Proc Natl Acad Sci USA"},{"issue":"9","key":"10.1016\/j.ebiom.2026.106486_bib44","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1002\/art.40852","article-title":"Complex relationships of smoking, HLA-DRB1 genes, and serologic profiles in patients with early rheumatoid arthritis: update from a Swedish population-based case-control study","volume":"71","author":"Hedstr\u00f6m","year":"2019","journal-title":"Arthritis Rheumatol"},{"issue":"11","key":"10.1016\/j.ebiom.2026.106486_bib45","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1002\/art.1780301102","article-title":"The shared epitope hypothesis. an approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis","volume":"30","author":"Gregersen","year":"1987","journal-title":"Arthritis Rheumat"},{"issue":"22","key":"10.1016\/j.ebiom.2026.106486_bib46","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1056\/NEJMoa2513654","article-title":"Interleukin-10 autoantibodies and HLA-DRB1\u221701:03 in inflammatory bowel disease","volume":"394","author":"Gharahdaghi","year":"2026","journal-title":"N Engl J Med"},{"issue":"22","key":"10.1016\/j.ebiom.2026.106486_bib47","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1001\/jama.2024.20429","article-title":"HLA-DRB1\u221701:03 and severe ulcerative colitis","volume":"332","author":"Vestergaard","year":"2024","journal-title":"JAMA"},{"issue":"8","key":"10.1016\/j.ebiom.2026.106486_bib48","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/S2468-1253(26)00113-5","article-title":"HLA-DRB1\u221701:03 in patients with inflammatory bowel disease: a genotype-phenotype association study","volume":"11","author":"Zhang","year":"2026","journal-title":"Lancet Gastroenterol Hepatol"},{"issue":"8","key":"10.1016\/j.ebiom.2026.106486_bib49","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1007\/s00251-015-0849-y","article-title":"Zooming into the binding groove of HLA molecules: which positions and which substitutions change peptide binding most?","volume":"67","author":"van Deutekom","year":"2015","journal-title":"Immunogenetics"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106486_bib50","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1038\/s41467-023-36424-0","article-title":"TRIM40 is a pathogenic driver of inflammatory bowel disease subverting intestinal barrier integrity","volume":"14","author":"Kang","year":"2023","journal-title":"Nat Commun"},{"issue":"8","key":"10.1016\/j.ebiom.2026.106486_bib51","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1093\/aje\/154.8.687","article-title":"Limitations of the case-only design for identifying gene-environment interactions","volume":"154","author":"Albert","year":"2001","journal-title":"Am J Epidemiol"},{"issue":"7","key":"10.1016\/j.ebiom.2026.106486_bib52","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1093\/aje\/kwx228","article-title":"Update on the state of the science for analytical methods for gene-environment interactions","volume":"186","author":"Gauderman","year":"2017","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.ebiom.2026.106486_bib53","doi-asserted-by":"crossref","first-page":"104154","DOI":"10.1016\/j.ebiom.2022.104154","article-title":"Appraising the causal role of smoking in multiple diseases: a systematic review and meta-analysis of Mendelian randomization studies","volume":"82","author":"Larsson","year":"2022","journal-title":"eBioMedicine"}],"container-title":["eBioMedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396426003701?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396426003701?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T08:21:44Z","timestamp":1791966104000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352396426003701"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":53,"alternative-id":["S2352396426003701"],"URL":"https:\/\/doi.org\/10.1016\/j.ebiom.2026.106486","relation":{},"ISSN":["2352-3964"],"issn-type":[{"value":"2352-3964","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genome-wide analysis of genetic modifiers of Crohn\u2019s disease and ulcerative colitis risk in response to tobacco smoking","name":"articletitle","label":"Article Title"},{"value":"eBioMedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ebiom.2026.106486","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"106486"}}