{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T11:27:20Z","timestamp":1793618840890,"version":"4.5.0"},"reference-count":63,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T00:00:00Z","timestamp":1789862400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005407","name":"Hong Kong Health Bureau","doi-asserted-by":"publisher","award":["05162876"],"award-info":[{"award-number":["05162876"]}],"id":[{"id":"10.13039\/501100005407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005407","name":"Hong Kong Health Bureau","doi-asserted-by":"publisher","award":["10210686"],"award-info":[{"award-number":["10210686"]}],"id":[{"id":"10.13039\/501100005407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005847","name":"Health and Medical Research Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005847","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002920","name":"University Grants Committee Research Grants Council","doi-asserted-by":"publisher","award":["C4044-21G"],"award-info":[{"award-number":["C4044-21G"]}],"id":[{"id":"10.13039\/501100002920","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["eBioMedicine"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.ebiom.2026.106503","type":"journal-article","created":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T09:28:06Z","timestamp":1791451686000},"page":"106503","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Deciphering the heterogeneity of prodromal \u03b1-synucleinopathy: linking brain biotyping and gut dysbiosis in isolated REM sleep behaviour disorder"],"prefix":"10.1016","volume":"133","author":[{"given":"Shi","family":"Tang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhua","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanlin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyi","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ningning","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhixuan","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianzhang","family":"Ni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaping","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2692-2666","authenticated-orcid":false,"given":"Joey Wing Yan","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Winnie Chiu Wing","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent Chung Tong","family":"Mok","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zigui","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0277-4523","authenticated-orcid":false,"given":"Bei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun Kwok","family":"Wing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ebiom.2026.106503_bib1","series-title":"International Classification of Sleep Disorders, Third Edition, Text Revision (ICSD-3-TR)","year":"2023"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106503_bib2","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/s41572-018-0016-5","article-title":"REM sleep behaviour disorder","volume":"4","author":"Dauvilliers","year":"2018","journal-title":"Nat Rev Dis Primers"},{"issue":"8","key":"10.1016\/j.ebiom.2026.106503_bib3","doi-asserted-by":"crossref","first-page":"2086","DOI":"10.1002\/mds.70346","article-title":"Progression of motor and cognitive functions in isolated REM sleep behavior disorder: a 7-Year prospective matched cohort study","volume":"41","author":"Zhou","year":"2026","journal-title":"Mov Disord"},{"issue":"3","key":"10.1016\/j.ebiom.2026.106503_bib4","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1111\/ejn.14094","article-title":"The clinical heterogeneity of Parkinson's disease and its therapeutic implications","volume":"49","author":"Greenland","year":"2019","journal-title":"Eur J Neurosci"},{"issue":"2","key":"10.1016\/j.ebiom.2026.106503_bib5","doi-asserted-by":"crossref","first-page":"e155","DOI":"10.1212\/WNL.0000000000009763","article-title":"Subtypes of dementia with lewy bodies are associated with \u03b1-synuclein and tau distribution","volume":"95","author":"Ferman","year":"2020","journal-title":"Neurology"},{"key":"10.1016\/j.ebiom.2026.106503_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2025.105753","article-title":"Distinct brain atrophy progression subtypes underlie phenoconversion in isolated REM sleep behaviour disorder","volume":"117","author":"Joza","year":"2025","journal-title":"EBioMedicine"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106503_bib7","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1038\/s41531-025-01012-0","article-title":"Brain-clinical biotyping in patients with idiopathic REM sleep behavior disorder","volume":"11","author":"Tang","year":"2025","journal-title":"NPJ Parkinsons Dis"},{"issue":"8","key":"10.1016\/j.ebiom.2026.106503_bib8","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1038\/s41582-022-00681-2","article-title":"The microbiome-gut-brain axis in Parkinson disease - from basic research to the clinic","volume":"18","author":"Tan","year":"2022","journal-title":"Nat Rev Neurol"},{"key":"10.1016\/j.ebiom.2026.106503_bib9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.parkreldis.2021.11.017","article-title":"Gut microbiome in Parkinson's disease: new insights from meta-analysis","volume":"94","author":"Toh","year":"2022","journal-title":"Parkinsonism Relat Disord"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106503_bib10","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/s41531-021-00156-z","article-title":"Meta-analysis of the Parkinson's disease gut microbiome suggests alterations linked to intestinal inflammation","volume":"7","author":"Romano","year":"2021","journal-title":"NPJ Parkinsons Dis"},{"key":"10.1016\/j.ebiom.2026.106503_bib11","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.ebiom.2019.05.064","article-title":"Gut microbiota in Parkinson's disease: temporal stability and relations to disease progression","volume":"44","author":"Aho","year":"2019","journal-title":"EBioMedicine"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106503_bib12","doi-asserted-by":"crossref","first-page":"2501","DOI":"10.1038\/s41467-023-38248-4","article-title":"Gut microbiome dysbiosis across early Parkinson's disease, REM sleep behavior disorder and their first-degree relatives","volume":"14","author":"Huang","year":"2023","journal-title":"Nat Commun"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106503_bib13","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1002\/mds.27105","article-title":"The nasal and gut microbiome in Parkinson's disease and idiopathic rapid eye movement sleep behavior disorder","volume":"33","author":"Heintz-Buschart","year":"2018","journal-title":"Mov Disord"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106503_bib14","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1186\/s40168-025-02227-2","article-title":"Integrated multi-omics highlights alterations of gut microbiome functions in prodromal and idiopathic Parkinson's disease","volume":"13","author":"Villette","year":"2025","journal-title":"Microbiome"},{"issue":"4","key":"10.1016\/j.ebiom.2026.106503_bib15","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1002\/ana.25853","article-title":"Rest-activity pattern alterations in idiopathic REM sleep behavior disorder","volume":"88","author":"Feng","year":"2020","journal-title":"Ann Neurol"},{"issue":"4","key":"10.1016\/j.ebiom.2026.106503_bib16","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1002\/ana.25435","article-title":"A case-control-family study of idiopathic rapid eye movement sleep behavior disorder","volume":"85","author":"Liu","year":"2019","journal-title":"Ann Neurol"},{"issue":"4","key":"10.1016\/j.ebiom.2026.106503_bib17","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1038\/s43587-024-00590-7","article-title":"Integration of polygenic and gut metagenomic risk prediction for common diseases","volume":"4","author":"Liu","year":"2024","journal-title":"Nat Aging"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106503_bib18","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.sleep.2009.06.008","article-title":"Validation of a new REM sleep behavior disorder questionnaire (RBDQ-HK)","volume":"11","author":"Li","year":"2010","journal-title":"Sleep Med"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106503_bib19","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1159\/000232589","article-title":"The validity, reliability and clinical utility of the Hong Kong Montreal Cognitive Assessment (HK-MoCA) in patients with cerebral small vessel disease","volume":"28","author":"Wong","year":"2009","journal-title":"Dement Geriatr Cogn Disord"},{"issue":"11","key":"10.1016\/j.ebiom.2026.106503_bib20","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1002\/mds.20153","article-title":"Assessment of autonomic dysfunction in Parkinson's disease: the SCOPA-AUT","volume":"19","author":"Visser","year":"2004","journal-title":"Mov Disord"},{"issue":"2","key":"10.1016\/j.ebiom.2026.106503_bib21","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1076\/jcen.24.2.251.992","article-title":"Utility of olfactory identification test for diagnosing Chinese patients with Alzheimer's disease","volume":"24","author":"Chan","year":"2002","journal-title":"J Clin Exp Neuropsychol"},{"issue":"7","key":"10.1016\/j.ebiom.2026.106503_bib22","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1002\/mds.10473","article-title":"The Unified Parkinson's Disease Rating Scale (UPDRS): status and recommendations","volume":"18","year":"2003","journal-title":"Mov Disord"},{"issue":"10","key":"10.1016\/j.ebiom.2026.106503_bib23","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1002\/mds.27802","article-title":"Update of the MDS research criteria for prodromal Parkinson's disease","volume":"34","author":"Heinzel","year":"2019","journal-title":"Mov Disord"},{"issue":"12","key":"10.1016\/j.ebiom.2026.106503_bib24","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1111\/pcn.12931","article-title":"Clinical validity and intrarater and test-retest reliability of the Structured Clinical Interview for DSM-5 - Clinician Version (SCID-5-CV)","volume":"73","author":"Osorio","year":"2019","journal-title":"Psychiatry Clin Neurosci"},{"key":"10.1016\/j.ebiom.2026.106503_bib25","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.sleep.2024.11.032","article-title":"Sleep related injury and its correlates in isolated rapid eye movement sleep behavior disorder","volume":"126","author":"Yang","year":"2025","journal-title":"Sleep Med"},{"issue":"12","key":"10.1016\/j.ebiom.2026.106503_bib26","doi-asserted-by":"crossref","first-page":"2668","DOI":"10.3390\/nu15122668","article-title":"Relative validity of a short food frequency questionnaire for disadvantaged families in Hong Kong","volume":"15","author":"Chan","year":"2023","journal-title":"Nutrients"},{"issue":"8","key":"10.1016\/j.ebiom.2026.106503_bib27","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.3390\/nu16081132","article-title":"Reproducibility and relative validity of a short food frequency questionnaire for Chinese older adults in Hong Kong","volume":"16","author":"Chan","year":"2024","journal-title":"Nutrients"},{"issue":"6","key":"10.1016\/j.ebiom.2026.106503_bib28","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1002039","article-title":"Plant-based dietary patterns and incidence of type 2 diabetes in US men and women: results from three prospective cohort studies","volume":"13","author":"Satija","year":"2016","journal-title":"PLoS Med"},{"issue":"4","key":"10.1016\/j.ebiom.2026.106503_bib29","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.jacc.2017.05.047","article-title":"Healthful and unhealthful plant-based diets and the risk of coronary heart disease in U.S. adults","volume":"70","author":"Satija","year":"2017","journal-title":"J Am Coll Cardiol"},{"issue":"3","key":"10.1016\/j.ebiom.2026.106503_bib30","doi-asserted-by":"crossref","first-page":"e234714","DOI":"10.1001\/jamanetworkopen.2023.4714","article-title":"Association of healthful plant-based diet adherence with risk of mortality and major chronic diseases among adults in the UK","volume":"6","author":"Thompson","year":"2023","journal-title":"JAMA Netw Open"},{"issue":"7","key":"10.1016\/j.ebiom.2026.106503_bib31","doi-asserted-by":"crossref","first-page":"4694","DOI":"10.1016\/j.clnu.2021.06.018","article-title":"Healthful plant-based dietary patterns, genetic risk of obesity, and cardiovascular risk in the UK biobank study","volume":"40","author":"Heianza","year":"2021","journal-title":"Clin Nutr"},{"issue":"11","key":"10.1016\/j.ebiom.2026.106503_bib32","doi-asserted-by":"crossref","first-page":"1994","DOI":"10.1002\/mds.29580","article-title":"Plant-based dietary patterns and Parkinson's disease: a prospective analysis of the UK biobank","volume":"38","author":"Tresserra-Rimbau","year":"2023","journal-title":"Mov Disord"},{"issue":"4","key":"10.1016\/j.ebiom.2026.106503_bib33","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1001\/jamainternmed.2013.13563","article-title":"Added sugar intake and cardiovascular diseases mortality among US adults","volume":"174","author":"Yang","year":"2014","journal-title":"JAMA Intern Med"},{"issue":"3","key":"10.1016\/j.ebiom.2026.106503_bib34","doi-asserted-by":"crossref","first-page":"376","DOI":"10.2337\/dc15-0547","article-title":"Potato consumption and risk of type 2 diabetes: results from three prospective cohort studies","volume":"39","author":"Muraki","year":"2016","journal-title":"Diabetes care"},{"issue":"15","key":"10.1016\/j.ebiom.2026.106503_bib35","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1093\/bioinformatics\/btu170","article-title":"Trimmomatic: a flexible trimmer for Illumina sequence data","volume":"30","author":"Bolger","year":"2014","journal-title":"Bioinformatics"},{"issue":"11","key":"10.1016\/j.ebiom.2026.106503_bib36","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1038\/s41587-023-01688-w","article-title":"Extending and improving metagenomic taxonomic profiling with uncharacterized species using MetaPhlAn 4","volume":"41","author":"Blanco-Miguez","year":"2023","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.ebiom.2026.106503_bib37","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.65088","article-title":"Integrating taxonomic, functional, and strain-level profiling of diverse microbial communities with bioBakery 3","volume":"10","author":"Beghini","year":"2021","journal-title":"Elife"},{"issue":"D1","key":"10.1016\/j.ebiom.2026.106503_bib38","doi-asserted-by":"crossref","first-page":"D445","DOI":"10.1093\/nar\/gkz862","article-title":"The MetaCyc database of metabolic pathways and enzymes - a 2019 update","volume":"48","author":"Caspi","year":"2020","journal-title":"Nucleic Acids Res"},{"issue":"11","key":"10.1016\/j.ebiom.2026.106503_bib39","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1009442","article-title":"Multivariable association discovery in population-scale meta-omics studies","volume":"17","author":"Mallick","year":"2021","journal-title":"PLoS Comput Biol"},{"issue":"6","key":"10.1016\/j.ebiom.2026.106503_bib40","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1016\/j.chom.2026.05.001","article-title":"Long-lasting gut microbiome and fecal metabolome alterations after colorectal adenoma removal and their relationship to colorectal cancer","volume":"34","author":"Nogal","year":"2026","journal-title":"Cell Host Microbe"},{"issue":"11","key":"10.1016\/j.ebiom.2026.106503_bib41","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1005752","article-title":"mixOmics: an R package for 'omics feature selection and multiple data integration","volume":"13","author":"Rohart","year":"2017","journal-title":"PLoS Comput Biol"},{"key":"10.1016\/j.ebiom.2026.106503_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemolab.2023.104986","article-title":"Extension and significance testing of variable importance in projection (VIP) indices in partial least squares regression and principal components analysis","volume":"242","author":"Mahieu","year":"2023","journal-title":"Chemometr Intell Lab Syst"},{"issue":"11","key":"10.1016\/j.ebiom.2026.106503_bib43","doi-asserted-by":"crossref","first-page":"2583","DOI":"10.1002\/mds.28706","article-title":"International multicenter analysis of brain structure across clinical stages of Parkinson's disease","volume":"36","author":"Laansma","year":"2021","journal-title":"Mov Disord"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106503_bib44","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1136\/jnnp-2024-333865","article-title":"Visuospatial dysfunction predicts dementia-first phenoconversion in isolated REM sleep behaviour disorder","volume":"96","author":"Wang","year":"2024","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106503_bib45","doi-asserted-by":"crossref","first-page":"4227","DOI":"10.1038\/s41467-025-56829-3","article-title":"Machine learning-based meta-analysis reveals gut microbiome alterations associated with Parkinson's disease","volume":"16","author":"Romano","year":"2025","journal-title":"Nat Commun"},{"issue":"9","key":"10.1016\/j.ebiom.2026.106503_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.108807","article-title":"Systematic analysis of gut microbiome reveals the role of bacterial folate and homocysteine metabolism in Parkinson's disease","volume":"34","author":"Rosario","year":"2021","journal-title":"Cell Rep"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106503_bib47","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/s41531-024-00724-z","article-title":"Meta-analysis of shotgun sequencing of gut microbiota in Parkinson's disease","volume":"10","author":"Nishiwaki","year":"2024","journal-title":"NPJ Parkinsons Dis"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106503_bib48","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2025.2554195","article-title":"Metabolic modeling links gut microbiota to metabolic markers of Parkinson's disease","volume":"17","author":"Hensen","year":"2025","journal-title":"Gut Microbes"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106503_bib49","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/s41392-024-01743-1","article-title":"Microbiota-gut-brain axis and its therapeutic applications in neurodegenerative diseases","volume":"9","author":"Loh","year":"2024","journal-title":"Signal Transduct Target Ther"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106503_bib50","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1038\/s41522-024-00567-9","article-title":"A population-scale analysis of 36 gut microbiome studies reveals universal species signatures for common diseases","volume":"10","author":"Sun","year":"2024","journal-title":"NPJ Biofilms Microbiomes"},{"key":"10.1016\/j.ebiom.2026.106503_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.smrv.2026.102293","article-title":"Gut microbiota alterations in sleep disturbances: a systematic review and meta-analysis","volume":"88","author":"Wang","year":"2026","journal-title":"Sleep Med Rev"},{"issue":"35","key":"10.1016\/j.ebiom.2026.106503_bib52","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adg1129","article-title":"Eggerthella lenta augments preclinical autoantibody production and metabolic shift mimicking senescence in arthritis","volume":"9","author":"Balakrishnan","year":"2023","journal-title":"Sci Adv"},{"issue":"6","key":"10.1016\/j.ebiom.2026.106503_bib53","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1002\/ana.26084","article-title":"Gut microbiome in progressive multiple sclerosis","volume":"89","author":"Cox","year":"2021","journal-title":"Ann Neurol"},{"issue":"4","key":"10.1016\/j.ebiom.2026.106503_bib54","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1152\/physrev.00018.2018","article-title":"The microbiota-gut-brain axis","volume":"99","author":"Cryan","year":"2019","journal-title":"Physiol Rev"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106503_bib55","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/s41531-024-00802-2","article-title":"Microbial biomarker discovery in Parkinson's disease through a network-based approach","volume":"10","author":"Zhao","year":"2024","journal-title":"NPJ Parkinsons Dis"},{"issue":"10","key":"10.1016\/j.ebiom.2026.106503_bib56","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.1002\/mds.29959","article-title":"Metagenomic analysis reveals large-scale disruptions of the gut microbiome in Parkinson's disease","volume":"39","author":"Metcalfe-Roach","year":"2024","journal-title":"Mov Disord"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106503_bib57","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/s41531-022-00428-2","article-title":"Gut microbiota in dementia with lewy bodies","volume":"8","author":"Nishiwaki","year":"2022","journal-title":"NPJ Parkinsons Dis"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106503_bib58","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s13073-016-0299-7","article-title":"An expansion of rare lineage intestinal microbes characterizes rheumatoid arthritis","volume":"8","author":"Chen","year":"2016","journal-title":"Genome Med"},{"issue":"10","key":"10.1016\/j.ebiom.2026.106503_bib59","doi-asserted-by":"crossref","first-page":"3380","DOI":"10.1128\/JCM.01137-15","article-title":"Cloacibacillus sp., a potential human pathogen associated with bacteremia in Quebec and New Brunswick","volume":"53","author":"Domingo","year":"2015","journal-title":"J Clin Microbiol"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106503_bib60","doi-asserted-by":"crossref","first-page":"6958","DOI":"10.1038\/s41467-022-34667-x","article-title":"Metagenomics of Parkinson's disease implicates the gut microbiome in multiple disease mechanisms","volume":"13","author":"Wallen","year":"2022","journal-title":"Nat Commun"},{"issue":"3","key":"10.1016\/j.ebiom.2026.106503_bib61","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1002\/ana.25982","article-title":"Gut microbial ecosystem in parkinson disease: new clinicobiological insights from multi-omics","volume":"89","author":"Tan","year":"2021","journal-title":"Ann Neurol"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106503_bib62","doi-asserted-by":"crossref","DOI":"10.1080\/20002297.2020.1851112","article-title":"Porphyromonas, Treponema, and Mogibacterium promote IL8\/IFN\u03b3\/TNF\u03b1-based pro-inflammation in patients with medication-related osteonecrosis of the jaw","volume":"13","author":"Li","year":"2020","journal-title":"J Oral Microbiol"},{"issue":"4","key":"10.1016\/j.ebiom.2026.106503_bib63","doi-asserted-by":"crossref","DOI":"10.3390\/microorganisms8040573","article-title":"The controversial role of human gut lachnospiraceae","volume":"8","author":"Vacca","year":"2020","journal-title":"Microorganisms"}],"container-title":["eBioMedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396426003877?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396426003877?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T10:49:13Z","timestamp":1793616553000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352396426003877"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":63,"alternative-id":["S2352396426003877"],"URL":"https:\/\/doi.org\/10.1016\/j.ebiom.2026.106503","relation":{},"ISSN":["2352-3964"],"issn-type":[{"value":"2352-3964","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Deciphering the heterogeneity of prodromal \u03b1-synucleinopathy: linking brain biotyping and gut dysbiosis in isolated REM sleep behaviour disorder","name":"articletitle","label":"Article Title"},{"value":"eBioMedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ebiom.2026.106503","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"106503"}}