{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T09:54:08Z","timestamp":1768557248070,"version":"3.49.0"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T00:00:00Z","timestamp":1695772800000},"content-version":"vor","delay-in-days":269,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100020220","name":"College of Science, University of Arizona","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020220","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019317","name":"Utah Valley University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019317","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Epilepsy &amp; Behavior Reports"],"published-print":{"date-parts":[[2023]]},"DOI":"10.1016\/j.ebr.2023.100622","type":"journal-article","created":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T05:21:52Z","timestamp":1695878512000},"page":"100622","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Effects of valproate on seizure-like activity in Drosophila melanogaster with a knockdown of Ube3a in different neuronal populations as a model of Angelman Syndrome"],"prefix":"10.1016","volume":"24","author":[{"given":"Madeline C.","family":"Moore","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danielle T.","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"3-5","key":"10.1016\/j.ebr.2023.100622_b0005","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1159\/000328837","article-title":"Molecular and clinical aspects of angelman syndrome","volume":"2","author":"Dagli","year":"2012","journal-title":"Mol Syndromol"},{"key":"10.1016\/j.ebr.2023.100622_b0010","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1136\/jmg.40.2.87","article-title":"Angelman syndrome: a review of the clinical and genetic aspects","volume":"40","author":"Clayton-Smith","year":"2003","journal-title":"Journal of Medical Genetics"},{"issue":"5","key":"10.1016\/j.ebr.2023.100622_b0015","doi-asserted-by":"crossref","first-page":"e1006062","DOI":"10.1371\/journal.pgen.1006062","article-title":"Angelman syndrome protein Ube3a regulates synaptic growth and endocytosis by inhibiting BMP signaling in drosophila","volume":"12","author":"Li","year":"2016","journal-title":"PLoS Genetics"},{"issue":"34","key":"10.1016\/j.ebr.2023.100622_b0020","doi-asserted-by":"crossref","first-page":"12399","DOI":"10.1073\/pnas.0805291105","article-title":"A Drosophila model for Angelman syndrome","volume":"105","author":"Wu","year":"2008","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"10.1016\/j.ebr.2023.100622_b0025","doi-asserted-by":"crossref","first-page":"2825","DOI":"10.1093\/hmg\/ddl225","article-title":"Expression of the Rho-GEF Pbl\/ECT2 is regulated by the UBE3A E3 ubiquitin ligase","volume":"15","author":"Reiter","year":"2006","journal-title":"Human Molecular Genetics"},{"key":"10.1016\/j.ebr.2023.100622_b0030","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1007\/s13311-021-01115-5","article-title":"Screening platforms for genetic epilepsies\u2014Zebrafish, iPSC-Derived neurons, and organoids","volume":"18","author":"Shcheglovitov","year":"2021","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.ebr.2023.100622_b0035","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1093\/hmg\/ddn373","article-title":"the drosophila homologue of the angelman syndrome ubiquitin ligase regulates the formation of terminal dendritic branches","volume":"18","author":"Lu","year":"2008","journal-title":"Human Molecular Genetics"},{"key":"10.1016\/j.ebr.2023.100622_b0040","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1016\/j.conb.2011.04.009","article-title":"Drosophila modeling of heritable neurodevelopmental disorders","volume":"21","author":"Gatto","year":"2011","journal-title":"Current Opinion in Neurobiology"},{"key":"10.1016\/j.ebr.2023.100622_b0045","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/S0006-8993(02)03431-5","article-title":"Anticonvulsant valproate reduces seizure-susceptibility in mutant drosophila","volume":"958","author":"Kuebler","year":"2002","journal-title":"Brain Research"},{"key":"10.1016\/j.ebr.2023.100622_b0050","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.pneurobio.2007.10.006","article-title":"From bench to drug: Human seizure modeling using drosophila","volume":"84","author":"Song","year":"2008","journal-title":"Progress in Neurobiology"},{"key":"10.1016\/j.ebr.2023.100622_b0055","doi-asserted-by":"crossref","first-page":"143","DOI":"10.3109\/01677063.2013.817574","article-title":"Seizure-Sensitivity in Drosophila Is Ameliorated by Dorsal Vessel Injection of the Antiepileptic Drug Valproate","volume":"27","author":"Howlett","year":"2013","journal-title":"Journal of Neurogenetics"},{"key":"10.1016\/j.ebr.2023.100622_b0060","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/j.neuroscience.2008.07.024","article-title":"DNA topoisomerase I inhibitors ameliorate seizure-like behaviors and paralysis in a drosophila model of epilepsy","volume":"156","author":"Song","year":"2008","journal-title":"Neuroscience"},{"key":"10.1016\/j.ebr.2023.100622_b0065","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/0092-8674(94)90397-2","article-title":"The drosophila easily shocked gene: A mutation in a phospholipid synthetic pathway causes seizure, neuronal failure, and paralysis","volume":"79","author":"Pavlidis","year":"1994","journal-title":"Cell"},{"key":"10.1016\/j.ebr.2023.100622_b0070","doi-asserted-by":"crossref","first-page":"5810","DOI":"10.1523\/JNEUROSCI.15-08-05810.1995","article-title":"Seizures and failures in the giant fiber pathway of drosophila bang- sensitive paralytic mutants","volume":"15","author":"Pavlidis","year":"1995","journal-title":"The Journal of Neuroscience"},{"key":"10.1016\/j.ebr.2023.100622_b0075","doi-asserted-by":"crossref","unstructured":"Mituzaite J, Petersen R, Claridge-Chang A, Baines RA. Characterization of Seizure Induction Methods in Drosophila. Eneuro 2021;8:ENEURO.0079-21.2021. https:\/\/doi.org\/10.1523\/ENEURO.0079-21.2021.","DOI":"10.1523\/ENEURO.0079-21.2021"},{"key":"10.1016\/j.ebr.2023.100622_b0080","doi-asserted-by":"crossref","first-page":"3500","DOI":"10.1002\/cne.23364","article-title":"Rescue of Easily shocked mutant seizure sensitivity in Drosophila adults: Ethanolamine Kinase and Seizure Susceptibility","volume":"521","author":"Kroll","year":"2013","journal-title":"Journal of Comparative Neurology"},{"key":"10.1016\/j.ebr.2023.100622_b0085","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.brainres.2004.05.111","article-title":"Potassium bromide, an anticonvulsant, is effective at alleviating seizures in the drosophila bang-sensitive mutant bang senseless","volume":"1020","author":"Tan","year":"2004","journal-title":"Brain Research"},{"key":"10.1016\/j.ebr.2023.100622_b0090","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.brainres.2012.12.007","article-title":"Genetic and pharmacological manipulations that alter metabolism suppress seizure-like activity in drosophila","volume":"1496","author":"Stone","year":"2013","journal-title":"Brain Research"},{"key":"10.1016\/j.ebr.2023.100622_b0095","first-page":"51460","article-title":"A low-cost method for analyzing seizure-like activity and movement in drosophila","author":"Stone","year":"2014","journal-title":"Journal of Visualized Experiments"},{"key":"10.1016\/j.ebr.2023.100622_b0100","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.nbd.2017.09.003","article-title":"Glial overexpression of Dube3a causes seizures and synaptic impairments in drosophila concomitant with down regulation of the Na+\/K+ pump ATP\u03b1","volume":"108","author":"Hope","year":"2017","journal-title":"Neurobiology of Disease"},{"key":"10.1016\/j.ebr.2023.100622_b0105","doi-asserted-by":"crossref","first-page":"2216","DOI":"10.1038\/sj.npp.1300764","article-title":"Lithium- and Valproate-Induced alterations in circadian locomotor behavior in drosophila","volume":"30","author":"Dokucu","year":"2005","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.ebr.2023.100622_b0110","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.seizure.2014.09.018","article-title":"Epilepsy research methods update: Understanding the causes of epileptic seizures and identifying new treatments using non-mammalian model organisms","volume":"24","author":"Cunliffe","year":"2015","journal-title":"Seizure"},{"key":"10.1016\/j.ebr.2023.100622_b0115","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1093\/genetics\/100.4.597","article-title":"indirect suppression involving behavioral mutants with altered nerve excitability in drosophila melanogaster","volume":"100","author":"Ganetzky","year":"1982","journal-title":"Genetics"},{"key":"10.1016\/j.ebr.2023.100622_b0120","doi-asserted-by":"crossref","unstructured":"Parker L, Howlett IC, Rusan ZM, Tanouye MA. Seizure and Epilepsy: Studies of Seizure Disorders in Drosophila. Int. Rev. Neurobiol., vol. 99, Elsevier; 2011, p. 1\u201321. https:\/\/doi.org\/10.1016\/B978-0-12-387003-2.00001-X.","DOI":"10.1016\/B978-0-12-387003-2.00001-X"},{"key":"10.1016\/j.ebr.2023.100622_b0125","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1152\/jn.2000.83.2.998","article-title":"Modifications of seizure susceptibility in Drosophila","volume":"83","author":"Kuebler","year":"2000","journal-title":"Journal of Neurophysiology"},{"key":"10.1016\/j.ebr.2023.100622_b0130","doi-asserted-by":"crossref","first-page":"6442","DOI":"10.3390\/ijms21176442","article-title":"Investigating developmental and epileptic encephalopathy using drosophila melanogaster","volume":"21","author":"Takai","year":"2020","journal-title":"International Journal of Molecular Sciences"},{"key":"10.1016\/j.ebr.2023.100622_b0135","doi-asserted-by":"crossref","unstructured":"Parker L, Padilla M, Du Y, Dong K, Tanouye MA. Drosophila as a Model for Epilepsy: bss Is a Gain-of-Function Mutation in the Para Sodium Channel Gene That Leads to Seizures. Genetics 2011;187:523\u201334. https:\/\/doi.org\/10.1534\/genetics.110.123299.","DOI":"10.1534\/genetics.110.123299"},{"key":"10.1016\/j.ebr.2023.100622_b0140","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.braindev.2020.08.014","article-title":"Epilepsy in angelman syndrome: A scoping review","volume":"43","author":"Samanta","year":"2021","journal-title":"Brain Dev"},{"key":"10.1016\/j.ebr.2023.100622_b0145","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/j.neuron.2012.03.036","article-title":"Maternal loss of Ube3a produces an excitatory\/Inhibitory imbalance through neuron Type-Specific synaptic defects","volume":"74","author":"Wallace","year":"2012","journal-title":"Neuron"},{"issue":"26","key":"10.1016\/j.ebr.2023.100622_b0150","first-page":"240","article-title":"Temperature-dependent gene silencing by an expressed inverted repeat in drosophila","volume":"2000","author":"Fortier","year":"2000","journal-title":"genes N Y N"},{"issue":"1","key":"10.1016\/j.ebr.2023.100622_b0155","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/nmeth1146","article-title":"Vector and parameters for targeted transgenic RNA interference in drosophila melanogaster","volume":"5","author":"Ni","year":"2008","journal-title":"Nature Methods"},{"key":"10.1016\/j.ebr.2023.100622_b0160","doi-asserted-by":"crossref","unstructured":"Ni J-Q, Liu L-P, Binari R, Hardy R, Shim H-S, Cavallaro A, et al. A Drosophila Resource of Transgenic RNAi Lines for Neurogenetics. Genetics 2009;182:1089\u2013100. https:\/\/doi.org\/10.1534\/genetics.109.103630.","DOI":"10.1534\/genetics.109.103630"},{"key":"10.1016\/j.ebr.2023.100622_b0165","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/978-1-4939-6371-3_6","article-title":"A guide to Genome-Wide in vivo RNAi applications in drosophila","volume":"1478","author":"Kaya-\u00c7opur","year":"2016","journal-title":"Methods Mol Biol Clifton NJ"},{"issue":"18","key":"10.1016\/j.ebr.2023.100622_b0170","doi-asserted-by":"crossref","first-page":"2815","DOI":"10.3390\/cells11182815","article-title":"Generation and characterization of a novel angelman syndrome mouse model with a full deletion of the Ube3a gene","volume":"11","author":"Syding","year":"2022","journal-title":"Cells"}],"container-title":["Epilepsy &amp; Behavior Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589986423000400?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589986423000400?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T00:09:06Z","timestamp":1762906146000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589986423000400"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"references-count":34,"alternative-id":["S2589986423000400"],"URL":"https:\/\/doi.org\/10.1016\/j.ebr.2023.100622","relation":{},"ISSN":["2589-9864"],"issn-type":[{"value":"2589-9864","type":"print"}],"subject":[],"published":{"date-parts":[[2023]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of valproate on seizure-like activity in Drosophila melanogaster with a knockdown of Ube3a in different neuronal populations as a model of Angelman Syndrome","name":"articletitle","label":"Article Title"},{"value":"Epilepsy & Behavior Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ebr.2023.100622","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"100622"}}