{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T15:48:04Z","timestamp":1784648884971,"version":"3.55.0"},"reference-count":94,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,12,26]],"date-time":"2023-12-26T00:00:00Z","timestamp":1703548800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21NS116937"],"award-info":[{"award-number":["R21NS116937"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["P20AG068024"],"award-info":[{"award-number":["P20AG068024"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R25NS089463"],"award-info":[{"award-number":["R25NS089463"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008333","name":"University of Alabama at Birmingham","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008333","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Epilepsy & Behavior Reports"],"published-print":{"date-parts":[[2024]]},"DOI":"10.1016\/j.ebr.2023.100642","type":"journal-article","created":{"date-parts":[[2023,12,28]],"date-time":"2023-12-28T22:04:10Z","timestamp":1703801050000},"page":"100642","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Aerobic exercise alters DNA hydroxymethylation levels in an experimental rodent model of temporal lobe epilepsy"],"prefix":"10.1016","volume":"25","author":[{"given":"Silvienne C.","family":"Sint Jago","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudhab","family":"Bahabry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Maria","family":"Schreiber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Homola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tram","family":"Ngyuen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Meijia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane B.","family":"Allendorfer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farah D.","family":"Lubin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.ebr.2023.100642_b0010","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a022848","article-title":"Epilepsy: A Spectrum Disorder","volume":"5","author":"Sirven","year":"2015","journal-title":"Cold Spring Harb Perspect Med"},{"issue":"6","key":"10.1016\/j.ebr.2023.100642_b0015","doi-asserted-by":"crossref","first-page":"663","DOI":"10.2174\/0929867320666131119152201","article-title":"Pathophysiogenesis of mesial temporal lobe epilepsy: is prevention of damage antiepileptogenic?","volume":"21","author":"Curia","year":"2014","journal-title":"Curr Med Chem"},{"issue":"10","key":"10.1016\/j.ebr.2023.100642_b0020","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1038\/nrd4126","article-title":"New avenues for anti-epileptic drug discovery and development","volume":"12","author":"Loscher","year":"2013","journal-title":"Nat Rev Drug Discov"},{"issue":"1","key":"10.1016\/j.ebr.2023.100642_b0025","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.clinthera.2017.12.004","article-title":"Role of Physical Activity and Exercise in Alleviating Cognitive Impairment in People With Epilepsy","volume":"40","author":"Allendorfer","year":"2018","journal-title":"Clin Ther"},{"issue":"6","key":"10.1016\/j.ebr.2023.100642_b0030","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1503\/cmaj.051351","article-title":"Health benefits of physical activity: the evidence","volume":"174","author":"Warburton","year":"2006","journal-title":"Can Med Assoc J"},{"issue":"21","key":"10.1016\/j.ebr.2023.100642_b0035","doi-asserted-by":"crossref","DOI":"10.1212\/WNL.0000000000009478","article-title":"Aerobic exercise improves cognition and cerebrovascular regulation in older adults","volume":"94","author":"Guadagni","year":"2020","journal-title":"Neurology"},{"key":"10.1016\/j.ebr.2023.100642_b0040","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.yebeh.2019.04.020","article-title":"A pilot study of combined endurance and resistance exercise rehabilitation for verbal memory and functional connectivity improvement in epilepsy","volume":"96","author":"Allendorfer","year":"2019","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.ebr.2023.100642_b0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.yebeh.2023.109170","article-title":"The relationship between physical activity and cognitive function in people with epilepsy: A systematic review","volume":"142","author":"Alexander","year":"2023","journal-title":"Epilepsy Behav"},{"issue":"4","key":"10.1016\/j.ebr.2023.100642_b0050","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1007\/s11064-016-2165-9","article-title":"Resistance Exercise Reduces Seizure Occurrence, Attenuates Memory Deficits and Restores BDNF Signaling in Rats with Chronic Epilepsy","volume":"42","author":"de Almeida","year":"2017","journal-title":"Neurochem Res"},{"key":"10.1016\/j.ebr.2023.100642_b0055","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.neulet.2017.01.012","article-title":"Epigenetics in epilepsy","volume":"667","author":"Kobow","year":"2018","journal-title":"Neurosci Lett"},{"issue":"1","key":"10.1016\/j.ebr.2023.100642_b0060","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1038\/hdy.2010.54","article-title":"Epigenetics and gene expression","volume":"105","author":"Gibney","year":"2010","journal-title":"Heredity (Edinb)"},{"issue":"2","key":"10.1016\/j.ebr.2023.100642_b0065","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1177\/1073858417705840","article-title":"The Epigenetics of Epilepsy and Its Progression","volume":"24","author":"Hauser","year":"2018","journal-title":"Neuroscientist"},{"key":"10.1016\/j.ebr.2023.100642_b0070","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/j.neuroscience.2013.06.029","article-title":"Status epilepticus triggers early and late alterations in brain-derived neurotrophic factor and NMDA glutamate receptor Grin2b DNA methylation levels in the hippocampus","volume":"248","author":"Ryley Parrish","year":"2013","journal-title":"Neuroscience"},{"issue":"4 Pt 2","key":"10.1016\/j.ebr.2023.100642_b0075","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1017\/S0954579413000618","article-title":"Epigenetic mechanisms in the development of behavior: advances, challenges, and future promises of a new field","volume":"25","author":"Roth","year":"2013","journal-title":"Dev Psychopathol"},{"key":"10.1016\/j.ebr.2023.100642_b0080","doi-asserted-by":"crossref","first-page":"100","DOI":"10.3389\/fgene.2017.00100","article-title":"New insights into 5hmC DNA modification: generation, distribution and function","volume":"8","author":"Shi","year":"2017","journal-title":"Front Genet"},{"issue":"7","key":"10.1016\/j.ebr.2023.100642_b0085","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1101\/gad.276568.115","article-title":"Role of TET enzymes in DNA methylation, development, and cancer","volume":"30","author":"Rasmussen","year":"2016","journal-title":"Genes Dev"},{"issue":"5","key":"10.1016\/j.ebr.2023.100642_b0090","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.ygeno.2014.08.021","article-title":"From development to diseases: the role of 5hmC in brain","volume":"104","author":"Sun","year":"2014","journal-title":"Genomics"},{"issue":"4","key":"10.1016\/j.ebr.2023.100642_b0095","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1002\/acn3.183","article-title":"Methionine increases BDNF DNA methylation and improves memory in epilepsy","volume":"2","author":"Parrish","year":"2015","journal-title":"Ann Clin Transl Neurol"},{"key":"10.1016\/j.ebr.2023.100642_b0100","article-title":"Impact of aerobic exercise and fatty acid supplementation on global and gene-specific DNA methylation","author":"Mastana","year":"2019","journal-title":"Epigenetics"},{"key":"10.1016\/j.ebr.2023.100642_b0105","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.15092","article-title":"Exercise promotes the expression of brain derived neurotrophic factor (BDNF) through the action of the ketone body beta-hydroxybutyrate","volume":"5","author":"Sleiman","year":"2016","journal-title":"Elife"},{"issue":"1","key":"10.1016\/j.ebr.2023.100642_b0110","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s12199-017-0643-6","article-title":"The effect of exercise intensity on brain derived neurotrophic factor and memory in adolescents","volume":"22","author":"Jeon","year":"2017","journal-title":"Environ Health Prev Med"},{"issue":"3","key":"10.1016\/j.ebr.2023.100642_b0115","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.seizure.2010.12.005","article-title":"Cytokines and epilepsy","volume":"20","author":"Li","year":"2011","journal-title":"Seizure"},{"key":"10.1016\/j.ebr.2023.100642_b0120","doi-asserted-by":"crossref","first-page":"685","DOI":"10.3389\/fneur.2019.00685","article-title":"Advances in the Potential Biomarkers of Epilepsy","volume":"10","author":"Kobylarek","year":"2019","journal-title":"Front Neurol"},{"key":"10.1016\/j.ebr.2023.100642_b0125","doi-asserted-by":"crossref","unstructured":"Amar D, Gay NR, Jean Beltran PM, Adkins JN, Almagro Armenteros JJ, Ashley E, et al. Temporal dynamics of the multi-omic response to endurance exercise training across tissues. bioRxiv. 2022:2022.09.21.508770.","DOI":"10.1016\/j.mcpro.2022.100313"},{"issue":"3","key":"10.1016\/j.ebr.2023.100642_b0130","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/0013-4694(72)90177-0","article-title":"Modification of seizure activity by electrical stimulation. II Motor seizure","volume":"32","author":"Racine","year":"1972","journal-title":"Electroencephalogr Clin Neurophysiol"},{"key":"10.1016\/j.ebr.2023.100642_b0135","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3389\/fneur.2018.00007","article-title":"Status Epilepticus: Behavioral and Electroencephalography Seizure Correlates in Kainate Experimental Models","volume":"9","author":"Sharma","year":"2018","journal-title":"Front Neurol"},{"issue":"7","key":"10.1016\/j.ebr.2023.100642_b0140","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1177\/0192623308326093","article-title":"Temporal profile of clinical signs and histopathologic changes in an F-344 rat model of kainic acid-induced mesial temporal lobe epilepsy","volume":"36","author":"Sharma","year":"2008","journal-title":"Toxicol Pathol"},{"issue":"6","key":"10.1016\/j.ebr.2023.100642_b0145","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1177\/0192623309344202","article-title":"Kainic acid-induced F-344 rat model of mesial temporal lobe epilepsy: gene expression and canonical pathways","volume":"37","author":"Sharma","year":"2009","journal-title":"Toxicol Pathol"},{"issue":"1","key":"10.1016\/j.ebr.2023.100642_b0150","doi-asserted-by":"crossref","first-page":"7628","DOI":"10.1038\/s41598-020-64365-x","article-title":"Different exercise training modalities produce similar endothelial function improvements in individuals with prehypertension or hypertension: a randomized clinical trial Exercise, endothelium and blood pressure","volume":"10","author":"Pedralli","year":"2020","journal-title":"Sci Rep"},{"issue":"8","key":"10.1016\/j.ebr.2023.100642_b0155","doi-asserted-by":"crossref","first-page":"3884","DOI":"10.1038\/s41380-019-0605-z","article-title":"Epigenome-wide meta-analysis of blood DNA methylation and its association with subcortical volumes: findings from the ENIGMA Epigenetics Working Group","volume":"26","author":"Jia","year":"2021","journal-title":"Mol Psychiatry"},{"issue":"6","key":"10.1016\/j.ebr.2023.100642_b0160","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1111\/pcn.12835","article-title":"Genome-wide DNA methylation investigation of glucocorticoid exposure within buccal samples","volume":"73","author":"Braun","year":"2019","journal-title":"Psychiatry Clin Neurosci"},{"issue":"2","key":"10.1016\/j.ebr.2023.100642_b0165","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1093\/schbul\/sbv074","article-title":"Correspondence of DNA Methylation Between Blood and Brain Tissue and Its Application to Schizophrenia Research","volume":"42","author":"Walton","year":"2016","journal-title":"Schizophr Bull"},{"issue":"1","key":"10.1016\/j.ebr.2023.100642_b0170","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0003-16.2016","article-title":"CA3 Synaptic Silencing Attenuates Kainic Acid-Induced Seizures and Hippocampal Network Oscillations","volume":"3","author":"Yu","year":"2016","journal-title":"eNeuro"},{"issue":"6226","key":"10.1016\/j.ebr.2023.100642_b0175","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1126\/science.aaa1934","article-title":"Brain structure. Cell types in the mouse cortex and hippocampus revealed by single-cell RNA-seq","volume":"347","author":"Zeisel","year":"2015","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.ebr.2023.100642_b0180","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1186\/s40478-022-01453-1","article-title":"High-resolution transcriptomics informs glial pathology in human temporal lobe epilepsy","volume":"10","author":"Pai","year":"2022","journal-title":"Acta Neuropathol Commun"},{"issue":"1","key":"10.1016\/j.ebr.2023.100642_b0185","doi-asserted-by":"crossref","first-page":"5038","DOI":"10.1038\/s41467-020-18752-7","article-title":"Identification of epilepsy-associated neuronal subtypes and gene expression underlying epileptogenesis","volume":"11","author":"Pfisterer","year":"2020","journal-title":"Nat Commun"},{"issue":"5","key":"10.1016\/j.ebr.2023.100642_b0190","doi-asserted-by":"crossref","first-page":"713","DOI":"10.12965\/jer.36394.197","article-title":"Treadmill exercise improves memory function by inhibiting hippocampal apoptosis in pilocarpine-induced epileptic rats","volume":"14","author":"Lee","year":"2018","journal-title":"J Exerc Rehabil"},{"issue":"5","key":"10.1016\/j.ebr.2023.100642_b0195","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1002\/jnr.24196","article-title":"Physical exercise alters the activation of downstream proteins related to BDNF-TrkB signaling in male Wistar rats with epilepsy","volume":"96","author":"de Almeida","year":"2018","journal-title":"J Neurosci Res"},{"issue":"11","key":"10.1016\/j.ebr.2023.100642_b0200","doi-asserted-by":"crossref","first-page":"2590","DOI":"10.1007\/s11064-019-02877-3","article-title":"Forced Physical Training Increases Neuronal Proliferation and Maturation with Their Integration into Normal Circuits in Pilocarpine Induced Status Epilepticus Mice","volume":"44","author":"Iqbal","year":"2019","journal-title":"Neurochem Res"},{"issue":"Pt A","key":"10.1016\/j.ebr.2023.100642_b0205","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.yebeh.2019.07.032","article-title":"Chronic exercise buffers the cognitive dysfunction and decreases the susceptibility to seizures in PTZ-treated rats","volume":"98","author":"Lin","year":"2019","journal-title":"Epilepsy Behav"},{"issue":"8","key":"10.1016\/j.ebr.2023.100642_b0210","doi-asserted-by":"crossref","first-page":"2112","DOI":"10.1007\/s11064-021-03349-3","article-title":"Exercise Improved the Anti-Epileptic Effect of Carbamazepine through GABA Enhancement in Epileptic Rats","volume":"46","author":"Barzroodi Pour","year":"2021","journal-title":"Neurochem Res"},{"key":"10.1016\/j.ebr.2023.100642_b0215","doi-asserted-by":"crossref","DOI":"10.1016\/j.yebeh.2021.107904","article-title":"Effects of an exercise program on health of people with epilepsy: A randomized clinical trial","volume":"117","author":"Hafele","year":"2021","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.ebr.2023.100642_b0220","doi-asserted-by":"crossref","DOI":"10.1016\/j.yebeh.2021.108335","article-title":"Randomized controlled trial of moderate cardiovascular exercise for patients with drug-resistant epilepsy","volume":"124","author":"Akerlund","year":"2021","journal-title":"Epilepsy Behav"},{"issue":"12","key":"10.1016\/j.ebr.2023.100642_b0225","first-page":"1138","article-title":"Research progress on 5hmC and TET dioxygenases in neurodevelopment and neurological diseases","volume":"39","author":"Wang","year":"2017","journal-title":"Yi Chuan"},{"issue":"1","key":"10.1016\/j.ebr.2023.100642_b0230","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1038\/s41392-022-01211-8","article-title":"Epigenetic regulation of aging: implications for interventions of aging and diseases","volume":"7","author":"Wang","year":"2022","journal-title":"Signal Transduct Target Ther"},{"key":"10.1016\/j.ebr.2023.100642_b0235","unstructured":"Molecular Transducers of Physical Activity Consortium. Molecular Transducers of Physical Activity Consortium (MoTrPAC) \u2013 Adult. 2018."},{"issue":"1","key":"10.1016\/j.ebr.2023.100642_b0240","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s13102-022-00397-2","article-title":"The effect of exercise on cytokines: implications for musculoskeletal health: a narrative review","volume":"14","author":"Docherty","year":"2022","journal-title":"BMC Sports Sci Med Rehabil"},{"issue":"1","key":"10.1016\/j.ebr.2023.100642_b0245","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0166-2236(00)01682-9","article-title":"BDNF and epilepsy: too much of a good thing?","volume":"24","author":"Binder","year":"2001","journal-title":"Trends Neurosci"},{"key":"10.1016\/j.ebr.2023.100642_b0250","article-title":"The Role of Brain-Derived Neurotrophic Factor in Epileptogenesis: an Update","volume":"12","author":"Wang","year":"2021","journal-title":"Front Pharmacol"},{"issue":"3","key":"10.1016\/j.ebr.2023.100642_b0255","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1111\/j.1535-7511.2005.05312.x","article-title":"Brain-derived neurotrophic factor and epilepsy\u2013a missing link?","volume":"5","author":"Scharfman","year":"2005","journal-title":"Epilepsy Curr"},{"key":"10.1016\/j.ebr.2023.100642_b0260","doi-asserted-by":"crossref","first-page":"1275924","DOI":"10.3389\/fnmol.2023.1275924","article-title":"Molecular mechanisms underlying physical exercise-induced brain BDNF overproduction","volume":"16","author":"Cefis","year":"2023","journal-title":"Front Mol Neurosci"},{"key":"10.1016\/j.ebr.2023.100642_b0265","article-title":"Effectiveness of high-intensity interval training on peripheral brain-derived neurotrophic factor in adults: A systematic review and network meta-analysis","author":"Rodriguez-Gutierrez","year":"2023","journal-title":"Scand J Med Sci Sports"},{"issue":"1","key":"10.1016\/j.ebr.2023.100642_b0270","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1186\/s12974-018-1192-7","article-title":"The role of inflammation in the development of epilepsy","volume":"15","author":"Rana","year":"2018","journal-title":"J Neuroinflammation"},{"issue":"4","key":"10.1016\/j.ebr.2023.100642_b0275","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1111\/ane.13616","article-title":"Blood biomarkers in epilepsy","volume":"146","author":"Banote","year":"2022","journal-title":"Acta Neurol Scand"},{"issue":"1","key":"10.1016\/j.ebr.2023.100642_b0280","doi-asserted-by":"crossref","DOI":"10.3390\/cells10010143","article-title":"Exercise Ameliorates Spinal Cord Injury by Changing DNA Methylation","volume":"10","author":"Davaa","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.ebr.2023.100642_b0285","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.neubiorev.2017.06.012","article-title":"Physical exercise as an epigenetic modulator of brain plasticity and cognition","volume":"80","author":"Fernandes","year":"2017","journal-title":"Neurosci Biobehav Rev"},{"issue":"1","key":"10.1016\/j.ebr.2023.100642_b0290","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1007\/s12035-016-0344-y","article-title":"Voluntary Physical Exercise Induces Expression and Epigenetic Remodeling of VegfA in the Rat Hippocampus","volume":"55","author":"Solvsten","year":"2018","journal-title":"Mol Neurobiol"},{"issue":"3","key":"10.1016\/j.ebr.2023.100642_b0295","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.yebeh.2012.07.025","article-title":"Experimental and clinical findings from physical exercise as complementary therapy for epilepsy","volume":"26","author":"Arida","year":"2013","journal-title":"Epilepsy Behav"},{"issue":"1","key":"10.1016\/j.ebr.2023.100642_b0300","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0920-1211(99)00032-7","article-title":"Effect of physical exercise on seizure occurrence in a model of temporal lobe epilepsy in rats","volume":"37","author":"Arida","year":"1999","journal-title":"Epilepsy Res"},{"issue":"4","key":"10.1016\/j.ebr.2023.100642_b0305","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.yebeh.2010.01.013","article-title":"The potential role of physical exercise in the treatment of epilepsy","volume":"17","author":"Arida","year":"2010","journal-title":"Epilepsy Behav"},{"issue":"12","key":"10.1016\/j.ebr.2023.100642_b0310","article-title":"Epigenetics and Epilepsy","volume":"5","author":"Henshall","year":"2015","journal-title":"Cold Spring Harb Perspect Med"},{"issue":"12","key":"10.1016\/j.ebr.2023.100642_b0315","doi-asserted-by":"crossref","first-page":"e0226575","DOI":"10.1371\/journal.pone.0226575","article-title":"Neuronal and glial DNA methylation and gene expression changes in early epileptogenesis","volume":"14","author":"Berger","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.ebr.2023.100642_b0320","doi-asserted-by":"crossref","first-page":"25668","DOI":"10.1038\/srep25668","article-title":"Etiology matters - Genomic DNA Methylation Patterns in Three Rat Models of Acquired Epilepsy","volume":"6","author":"Debski","year":"2016","journal-title":"Sci Rep"},{"issue":"5","key":"10.1016\/j.ebr.2023.100642_b0325","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1523\/JNEUROSCI.5180-11.2012","article-title":"Differential DNA methylation patterns define status epilepticus and epileptic tolerance","volume":"32","author":"Miller-Delaney","year":"2012","journal-title":"J Neurosci"},{"key":"10.1016\/j.ebr.2023.100642_b0330","doi-asserted-by":"crossref","first-page":"97","DOI":"10.3389\/fnmol.2020.00097","article-title":"Sarcosine Suppresses Epileptogenesis in Rats With Effects on Hippocampal DNA Methylation","volume":"13","author":"Shen","year":"2020","journal-title":"Front Mol Neurosci"},{"key":"10.1016\/j.ebr.2023.100642_b0335","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/j.neuroscience.2013.06.029","article-title":"Status epilepticus triggers early and late alterations in brain-derived neurotrophic factor and NMDA glutamate receptor Grin2b DNA methylation levels in the hippocampus","volume":"248","author":"Parrish","year":"2013","journal-title":"Neuroscience"},{"issue":"10","key":"10.1016\/j.ebr.2023.100642_b0340","doi-asserted-by":"crossref","first-page":"E912","DOI":"10.1152\/ajpendo.00289.2014","article-title":"Exercise training alters DNA methylation patterns in genes related to muscle growth and differentiation in mice","volume":"308","author":"Kanzleiter","year":"2015","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"12","key":"10.1016\/j.ebr.2023.100642_b0345","doi-asserted-by":"crossref","first-page":"3322","DOI":"10.2337\/db11-1653","article-title":"Impact of an exercise intervention on DNA methylation in skeletal muscle from first-degree relatives of patients with type 2 diabetes","volume":"61","author":"Nitert","year":"2012","journal-title":"Diabetes"},{"issue":"23","key":"10.1016\/j.ebr.2023.100642_b0350","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222312989","article-title":"Physical Activity and DNA Methylation in Humans","volume":"22","author":"Swiatowy","year":"2021","journal-title":"Int J Mol Sci"},{"issue":"2","key":"10.1016\/j.ebr.2023.100642_b0355","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.exger.2012.11.011","article-title":"Exercise induces age-dependent changes on epigenetic parameters in rat hippocampus: a preliminary study","volume":"48","author":"Elsner","year":"2013","journal-title":"Exp Gerontol"},{"key":"10.1016\/j.ebr.2023.100642_b0360","doi-asserted-by":"crossref","first-page":"45","DOI":"10.3389\/fcell.2018.00045","article-title":"Hippocampal TET1 and TET2 Expression and DNA Hydroxymethylation Are Affected by Physical Exercise in Aged Mice","volume":"6","author":"Jessop","year":"2018","journal-title":"Front Cell Dev Biol"},{"key":"10.1016\/j.ebr.2023.100642_b0365","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.bbr.2015.08.038","article-title":"Physical exercise affects the epigenetic programming of rat brain and modulates the adaptive response evoked by repeated restraint stress","volume":"296","author":"Kashimoto","year":"2016","journal-title":"Behav Brain Res"},{"issue":"5","key":"10.1016\/j.ebr.2023.100642_b0370","doi-asserted-by":"crossref","first-page":"385","DOI":"10.2217\/epi-2019-0370","article-title":"Forced running exercise mitigates radiation-induced cognitive deficits via regulated DNA hydroxymethylation","volume":"12","author":"Zhang","year":"2020","journal-title":"Epigenomics"},{"issue":"1","key":"10.1016\/j.ebr.2023.100642_b0375","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1038\/embor.2011.233","article-title":"DNA methylation: TET proteins-guardians of CpG islands?","volume":"13","author":"Williams","year":"2011","journal-title":"EMBO Rep"},{"issue":"6","key":"10.1016\/j.ebr.2023.100642_b0380","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1128\/MCB.01061-13","article-title":"TET2 plays an essential role in erythropoiesis by regulating lineage-specific genes via DNA oxidative demethylation in a zebrafish model","volume":"34","author":"Ge","year":"2014","journal-title":"Mol Cell Biol"},{"issue":"6","key":"10.1016\/j.ebr.2023.100642_b0385","doi-asserted-by":"crossref","first-page":"R81","DOI":"10.1186\/gb-2014-15-6-r81","article-title":"Distinct and overlapping control of 5-methylcytosine and 5-hydroxymethylcytosine by the TET proteins in human cancer cells","volume":"15","author":"Putiri","year":"2014","journal-title":"Genome Biol"},{"issue":"6","key":"10.1016\/j.ebr.2023.100642_b0390","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1016\/j.neuron.2013.08.032","article-title":"TET1 controls CNS 5-methylcytosine hydroxylation, active DNA demethylation, gene transcription, and memory formation","volume":"79","author":"Kaas","year":"2013","journal-title":"Neuron"},{"issue":"1","key":"10.1016\/j.ebr.2023.100642_b0395","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1038\/s41591-018-0275-4","article-title":"Exercise-linked FNDC5\/irisin rescues synaptic plasticity and memory defects in Alzheimer's models","volume":"25","author":"Lourenco","year":"2019","journal-title":"Nat Med"},{"key":"10.1016\/j.ebr.2023.100642_b0400","unstructured":"Neri MFGZPMDMPMLM. Role of physical exercise in the regulation of epigenetic mechanisms in inflammation, cancer, neurodegenerative diseases, and aging process. 2019."},{"issue":"7889","key":"10.1016\/j.ebr.2023.100642_b0405","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1038\/s41586-021-04183-x","article-title":"Exercise plasma boosts memory and dampens brain inflammation via clusterin","volume":"600","author":"De Miguel","year":"2021","journal-title":"Nature"},{"issue":"10","key":"10.1016\/j.ebr.2023.100642_b0410","doi-asserted-by":"crossref","first-page":"2580","DOI":"10.1111\/j.1460-9568.2004.03720.x","article-title":"Hippocampal BDNF mediates the efficacy of exercise on synaptic plasticity and cognition","volume":"20","author":"Vaynman","year":"2004","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.ebr.2023.100642_b0415","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.nlm.2014.08.002","article-title":"Epigenetic mechanisms of memory formation and reconsolidation","volume":"115","author":"Jarome","year":"2014","journal-title":"Neurobiol Learn Mem"},{"key":"10.1016\/j.ebr.2023.100642_b0420","doi-asserted-by":"crossref","first-page":"54","DOI":"10.3389\/fnmol.2015.00054","article-title":"NF-kappaB mediates Gadd45beta expression and DNA demethylation in the hippocampus during fear memory formation","volume":"8","author":"Jarome","year":"2015","journal-title":"Front Mol Neurosci"},{"key":"10.1016\/j.ebr.2023.100642_b0425","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.nepig.2015.10.002","article-title":"Tet1 Oxidase Regulates Neuronal Gene Transcription, Active DNA Hydroxy-methylation, Object Location Memory, and Threat Recognition Memory","volume":"4","author":"Kumar","year":"2015","journal-title":"Neuroepigenetics"},{"key":"10.1016\/j.ebr.2023.100642_b0430","doi-asserted-by":"crossref","DOI":"10.1177\/25168657211072499","article-title":"DNA Methylation and Establishing Memory","volume":"15","author":"Bernstein","year":"2022","journal-title":"Epigenet Insights"},{"issue":"3","key":"10.1016\/j.ebr.2023.100642_b0435","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/s41583-019-0121-9","article-title":"How the epigenome integrates information and reshapes the synapse","volume":"20","author":"Campbell","year":"2019","journal-title":"Nat Rev Neurosci"},{"issue":"14","key":"10.1016\/j.ebr.2023.100642_b0440","doi-asserted-by":"crossref","first-page":"6052","DOI":"10.1523\/JNEUROSCI.22-14-06052.2002","article-title":"Relations between brain pathology and temporal lobe epilepsy","volume":"22","author":"Zhang","year":"2002","journal-title":"J Neurosci"},{"issue":"5","key":"10.1016\/j.ebr.2023.100642_b0445","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1046\/j.1535-7597.2003.03506.x","article-title":"Role of Neuronal Loss in the Pathogenesis of Recurrent Spontaneous Seizures","volume":"3","author":"Kapur","year":"2003","journal-title":"Epilepsy Curr"},{"issue":"8","key":"10.1016\/j.ebr.2023.100642_b0450","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22083860","article-title":"Synaptic Reshaping and Neuronal Outcomes in the Temporal Lobe Epilepsy","volume":"22","author":"Ren","year":"2021","journal-title":"Int J Mol Sci"},{"issue":"1","key":"10.1016\/j.ebr.2023.100642_b0455","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1093\/nar\/gkt838","article-title":"Differences in DNA methylation between human neuronal and glial cells are concentrated in enhancers and non-CpG sites","volume":"42","author":"Kozlenkov","year":"2014","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.ebr.2023.100642_b0460","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s13072-017-0123-7","article-title":"Comprehensive evaluation of genome-wide 5-hydroxymethylcytosine profiling approaches in human DNA","volume":"10","author":"Skvortsova","year":"2017","journal-title":"Epigenetics Chromatin"},{"key":"10.1016\/j.ebr.2023.100642_b0465","doi-asserted-by":"crossref","first-page":"100","DOI":"10.3389\/fgene.2017.00100","article-title":"New Insights into 5hmC DNA Modification: Generation","volume":"8","author":"Shi","year":"2017","journal-title":"Distribution and Function Front Genet"},{"key":"10.1016\/j.ebr.2023.100642_b0470","article-title":"The emerging role of exosomes in communication between the periphery and the central nervous system","volume":"2023;4(6):e410","author":"Han","year":"2020","journal-title":"MedComm"},{"issue":"6","key":"10.1016\/j.ebr.2023.100642_b0475","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1016\/j.bbamem.2016.02.011","article-title":"Exosomes and other extracellular vesicles in neural cells and neurodegenerative diseases","volume":"1858","author":"Janas","year":"2016","journal-title":"BBA"}],"container-title":["Epilepsy & Behavior Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589986423000606?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589986423000606?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T00:10:01Z","timestamp":1762906201000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589986423000606"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":94,"alternative-id":["S2589986423000606"],"URL":"https:\/\/doi.org\/10.1016\/j.ebr.2023.100642","relation":{},"ISSN":["2589-9864"],"issn-type":[{"value":"2589-9864","type":"print"}],"subject":[],"published":{"date-parts":[[2024]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Aerobic exercise alters DNA hydroxymethylation levels in an experimental rodent model of temporal lobe epilepsy","name":"articletitle","label":"Article Title"},{"value":"Epilepsy & Behavior Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ebr.2023.100642","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"100642"}}