{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T00:15:28Z","timestamp":1768004128562,"version":"3.49.0"},"reference-count":18,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,7,20]],"date-time":"2024-07-20T00:00:00Z","timestamp":1721433600000},"content-version":"vor","delay-in-days":201,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Epilepsy &amp; Behavior Reports"],"published-print":{"date-parts":[[2024]]},"DOI":"10.1016\/j.ebr.2024.100697","type":"journal-article","created":{"date-parts":[[2024,7,21]],"date-time":"2024-07-21T14:44:49Z","timestamp":1721573089000},"page":"100697","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Successful use of Fenfluramine in super-refractory status epilepticus in a patient with tuberous sclerosis complex and Lennox-Gastaut syndrome"],"prefix":"10.1016","volume":"27","author":[{"given":"Thorsten","family":"Wildermann","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felicitas","family":"Becker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Jesse","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hartmut","family":"Baier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Wagner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ebr.2024.100697_b0005","doi-asserted-by":"crossref","unstructured":"Millett D, Pach S. Fenfluramine in the successful treatment of super-refractory status epilepticus in a patient with Dravet syndrome. Epilepsy Behav Rep. 2021 May 31;16:100461. doi: 10.1016\/j.ebr.2021.100461. PMID: 34179745; PMCID: PMC8214086.","DOI":"10.1016\/j.ebr.2021.100461"},{"issue":"5","key":"10.1016\/j.ebr.2024.100697_b0080","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1177\/1535759720928269","article-title":"Treatment of refractory convulsive status epilepticus: A Comprehensive Review by the American Epilepsy Society Treatments Committee","volume":"20","author":"Vossler","year":"2020","journal-title":"Epilepsy Curr"},{"key":"10.1016\/j.ebr.2024.100697_b0010","doi-asserted-by":"crossref","unstructured":"Cornwall CD, Kr\u00f8ig\u00e5rd T, Kristensen JSS, Callesen HE, Beier CP. Outcomes and Treatment Approaches for Super-Refractory Status Epilepticus: A Systematic Review and Meta-Analysis. JAMA Neurol. 2023 Jul 31;80(9):959\u201368. doi: 10.1001\/jamaneurol.2023.2407. Epub ahead of print. PMID: 37523161; PMCID: PMC10391362.","DOI":"10.1001\/jamaneurol.2023.2407"},{"issue":"3","key":"10.1016\/j.ebr.2024.100697_b0015","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1007\/s10072-017-3188-y","article-title":"Lennox-Gastaut syndrome: a comprehensive review","volume":"39","author":"Asadi-Pooya","year":"2018","journal-title":"Neurol Sci"},{"issue":"4","key":"10.1016\/j.ebr.2024.100697_b0020","doi-asserted-by":"crossref","first-page":"e166","DOI":"10.3928\/19382359-20170320-01","article-title":"Tuberous sclerosis complex: A review","volume":"46","author":"Randle","year":"2017","journal-title":"Pediatric Annals"},{"key":"10.1016\/j.ebr.2024.100697_b0025","doi-asserted-by":"crossref","unstructured":"Shehata HS, AbdelGhaffar HM, Nasreldin M, Elmazny A, Abdelalim A, Sabbah A et al. Clinical patterns and outcomes of status epilepticus in patients with tuberous sclerosis complex. Ther Clin Risk Manag. 2017 Jun 30;13:779-785. doi: 10.2147\/TCRM.S138576. PMID: 28721058; PMCID: PMC5501639.","DOI":"10.2147\/TCRM.S138576"},{"issue":"3","key":"10.1016\/j.ebr.2024.100697_b0030","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1055\/s-0035-1552616","article-title":"Epilepsy in tuberous sclerosis phenotypes, mechanisms, and treatments,","volume":"35","author":"Saxena","year":"2015","journal-title":"Semin Neurol"},{"key":"10.1016\/j.ebr.2024.100697_b0035","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1007\/s40265-023-01881-w","article-title":"Fenfluramine: a review in Dravet and Lennox-Gastaut syndromes","volume":"83","author":"Frampton","year":"2023","journal-title":"Drugs"},{"key":"10.1016\/j.ebr.2024.100697_b0040","doi-asserted-by":"crossref","unstructured":"Sourbron J, Smolders I, de Witte P, Lagae L. Pharmacological Analysis of the Anti-epileptic Mechanisms of Fenfluramine in scn1a Mutant Zebrafish. Front Pharmacol. 2017 Apr 6;8:191. doi: 10.3389\/fphar.2017.00191. PMID: 28428755; PMCID: PMC5382218.","DOI":"10.3389\/fphar.2017.00191"},{"key":"#cr-split#-10.1016\/j.ebr.2024.100697_b0045.1","doi-asserted-by":"crossref","unstructured":"Knupp KG, Scheffer IE, Ceulemans B, Sullivan JE, Nickels KC, Lagae L et al. Efficacy and Safety of Fenfluramine for the Treatment of Seizures Associated With Lennox-Gastaut Syndrome: A Randomized Clinical Trial. JAMA Neurol. 2022 Jun 1;79(6):554-564. doi: 10.1001\/jamaneurol.2022.0829. PMID: 35499850","DOI":"10.1001\/jamaneurol.2022.0829"},{"key":"#cr-split#-10.1016\/j.ebr.2024.100697_b0045.2","doi-asserted-by":"crossref","unstructured":"PMCID: PMC9062770.Knupp, et al. Efficacy and safety of fenfluramine for the treatment of seizures associated With Lennox-Gastaut Syndrome. A randomized clinical trial. JAMA Neurol. 2022;79(6):554-564.","DOI":"10.1001\/jamaneurol.2022.0829"},{"key":"10.1016\/j.ebr.2024.100697_b0050","doi-asserted-by":"crossref","unstructured":"Nabbout R, Mistry A, Zuberi S, Villeneuve N, Gil-Nagel A, Sanchez-Carpintero R et al. Fenfluramine for Treatment-Resistant Seizures in Patients With Dravet Syndrome Receiving Stiripentol-Inclusive Regimens: A Randomized Clinical Trial. JAMA Neurol. 2020 Mar 1;77(3):300-308. doi: 10.1001\/jamaneurol.2019.4113. PMID: 31790543; PMCID: PMC6902175.","DOI":"10.1001\/jamaneurol.2019.4113"},{"key":"10.1016\/j.ebr.2024.100697_b0055","doi-asserted-by":"crossref","unstructured":"Lagae L, Sullivan J, Knupp K, Laux L, Polster T, Nikanorova M et al. Fenfluramine hydrochloride for the treatment of seizures in Dravet syndrome: a randomised, double-blind, placebo-controlled trial. Lancet. 2019 Dec 21;394(10216):2243-2254. doi: 10.1016\/S0140-6736(19)32500-0. Epub 2019 Dec 17. PMID: 31862249.","DOI":"10.1016\/S0140-6736(19)32500-0"},{"key":"10.1016\/j.ebr.2024.100697_b0060","doi-asserted-by":"crossref","unstructured":"Sullivan J, Lagae L, Cross JH, Devinsky O, Guerrini R, Knupp KG et al. Fenfluramine in the treatment of Dravet syndrome: Results of a third randomized, placebo-controlled clinical trial. Epilepsia. 2023 Oct;64(10):2653-2666. doi: 10.1111\/epi.17737. Epub 2023 Aug 17. PMID: 37543865.","DOI":"10.1111\/epi.17737"},{"key":"10.1016\/j.ebr.2024.100697_b0065","doi-asserted-by":"crossref","unstructured":"Trowbridge S, Poduri A, Olson H. Early diagnosis and experimental treatment with fenfluramine via the Investigational New Drug mechanism in a boy with Dravet syndrome and recurrent status epilepticus. Epileptic Disord. 2021 Dec 1;23(6):954-956. doi: 10.1684\/epd.2021.1345. PMID: 34668864; PMCID: PMC8842495.","DOI":"10.1684\/epd.2021.1345"},{"issue":"1","key":"10.1016\/j.ebr.2024.100697_b0070","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s42466-023-00306-z","article-title":"Fenfluramine for the treatment of status epilepticus: use in an adult with Lennox-Gastaut syndrome and literature review","volume":"6","author":"Strzelczyk","year":"2024","journal-title":"Neurol Res Pract"},{"issue":"4","key":"10.1016\/j.ebr.2024.100697_b0075","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1111\/epi.16474","article-title":"Successful use of fenfluramine in nonconvulsive status epilepticus of Dravet syndrome","volume":"61","author":"Specchio","year":"2020","journal-title":"Epilepsia"},{"issue":"8","key":"10.1016\/j.ebr.2024.100697_b0085","first-page":"1159","article-title":"Fenfluramine: a review of pharmacology, clinical efficacy, and safety in epilepsy","volume":"9","author":"Samanta","year":"2022","journal-title":"Children (Basel)"}],"container-title":["Epilepsy &amp; Behavior Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589986424000546?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589986424000546?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,8,28]],"date-time":"2024-08-28T13:56:51Z","timestamp":1724853411000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589986424000546"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":18,"alternative-id":["S2589986424000546"],"URL":"https:\/\/doi.org\/10.1016\/j.ebr.2024.100697","relation":{},"ISSN":["2589-9864"],"issn-type":[{"value":"2589-9864","type":"print"}],"subject":[],"published":{"date-parts":[[2024]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Successful use of Fenfluramine in super-refractory status epilepticus in a patient with tuberous sclerosis complex and Lennox-Gastaut syndrome","name":"articletitle","label":"Article Title"},{"value":"Epilepsy & Behavior Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ebr.2024.100697","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"100697"}}