{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T18:22:18Z","timestamp":1777141338234,"version":"3.51.4"},"reference-count":12,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T00:00:00Z","timestamp":1752451200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100015401","name":"Key Research and Development Projects of Shaanxi Province","doi-asserted-by":"publisher","award":["2023-YBSF-075"],"award-info":[{"award-number":["2023-YBSF-075"]}],"id":[{"id":"10.13039\/501100015401","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017596","name":"Natural Science Basic Research Program of Shaanxi Province","doi-asserted-by":"publisher","award":["2021JM-559"],"award-info":[{"award-number":["2021JM-559"]}],"id":[{"id":"10.13039\/501100017596","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Epilepsy &amp; Behavior Reports"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.ebr.2025.100808","type":"journal-article","created":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T05:23:56Z","timestamp":1752643436000},"page":"100808","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["The role of genetic testing in evaluating surgical outcomes for pediatric focal cortical dysplasia associated with NPRL3 variant"],"prefix":"10.1016","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-6122-4122","authenticated-orcid":false,"given":"Bei","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianyun","family":"Su","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shanshan","family":"Jia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhijing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xia","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0125-7767","authenticated-orcid":false,"given":"Siyu","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.ebr.2025.100808_b0005","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.3390\/diagnostics13071311","article-title":"Pathomorphological diagnostic criteria for focal cortical dysplasias and other common epileptogenic lesions-review of the literature","volume":"13","author":"Metodiev","year":"2023","journal-title":"J Diagnostics (Basel)"},{"key":"10.1016\/j.ebr.2025.100808_b0010","article-title":"Convergent and divergent mechanisms of epileptogenesis in mTORopathies","volume":"15","author":"Nguyen","year":"2021","journal-title":"Front Neuroanat"},{"issue":"8","key":"10.1016\/j.ebr.2025.100808_b0015","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1136\/jmedgenet-2016-103883","article-title":"GATOR1 complex: the common genetic actor in focal epilepsies","volume":"53","author":"Baldassari","year":"2016","journal-title":"J Med Genet"},{"key":"10.1016\/j.ebr.2025.100808_b0020","article-title":"A novel loss-of-function variant in the NPRL3 gene identified in Chinese familial focal epilepsy with variable foci","volume":"12","author":"Li","year":"2021","journal-title":"Front Genet"},{"issue":"11","key":"10.1016\/j.ebr.2025.100808_b0025","doi-asserted-by":"crossref","first-page":"3872","DOI":"10.1093\/brain\/awac044","article-title":"NPRL3 loss alters neuronal morphology, mTOR localization, cortical lamination and seizure threshold","volume":"145","author":"Iffland","year":"2022","journal-title":"Brain"},{"key":"10.1016\/j.ebr.2025.100808_b0030","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.nbd.2018.02.013","article-title":"DEPDC5 and NPRL3 modulate cell size, filopodial outgrowth, and localization of mTOR in neural progenitor cells and neurons","volume":"114","author":"Iffland","year":"2018","journal-title":"Neurobiol Dis"},{"issue":"1","key":"10.1016\/j.ebr.2025.100808_b0035","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1002\/epi4.12856","article-title":"Phenotypic and genotypic characterization of NPRL3-related epilepsy: two case reports and literature review","volume":"9","author":"Yang","year":"2024","journal-title":"Epilepsia Open"},{"key":"10.1016\/j.ebr.2025.100808_b0040","article-title":"Functional screening of GATOR1 complex variants reveals a role for mTORC1 deregulation in FCD and focal epilepsy","volume":"134","author":"Dawson","year":"2019","journal-title":"Neurobiol Dis"},{"issue":"6","key":"10.1016\/j.ebr.2025.100808_b0045","doi-asserted-by":"crossref","first-page":"2452","DOI":"10.1172\/JCI99384","article-title":"Second-hit mosaic mutation in mTORC1 repressor DEPDC5 causes focal cortical dysplasia-associated epilepsy","volume":"128","author":"Ribierre","year":"2018","journal-title":"J Clin Invest"},{"issue":"9","key":"10.1016\/j.ebr.2025.100808_b0050","first-page":"3877","article-title":"Surgical outcomes in patients with GATOR1-complex gene mutations: phenotypic spectrum and implications for surgical management","volume":"146","author":"Sahly","year":"2023","journal-title":"Brain"},{"issue":"10","key":"10.1016\/j.ebr.2025.100808_b0055","doi-asserted-by":"crossref","first-page":"3341","DOI":"10.1111\/ene.15975","article-title":"Everolimus Precision therapy for the GATOR1-related epilepsies: a case series","volume":"30","author":"Moloney","year":"2023","journal-title":"Eur J Neurol"},{"issue":"7","key":"10.1016\/j.ebr.2025.100808_b0060","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/S1474-4422(15)00069-1","article-title":"Neurological and neuropsychiatric aspects of tuberous sclerosis complex","volume":"14","author":"Curatolo","year":"2015","journal-title":"Lancet Neurol"}],"container-title":["Epilepsy &amp; Behavior Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589986425000681?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589986425000681?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T02:27:21Z","timestamp":1765333641000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589986425000681"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":12,"alternative-id":["S2589986425000681"],"URL":"https:\/\/doi.org\/10.1016\/j.ebr.2025.100808","relation":{},"ISSN":["2589-9864"],"issn-type":[{"value":"2589-9864","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The role of genetic testing in evaluating surgical outcomes for pediatric focal cortical dysplasia associated with NPRL3 variant","name":"articletitle","label":"Article Title"},{"value":"Epilepsy & Behavior Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ebr.2025.100808","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"100808"}}