{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T18:10:20Z","timestamp":1790100620548,"version":"4.0.1"},"reference-count":14,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T00:00:00Z","timestamp":1788652800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Epilepsy &amp; Behavior Reports"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.ebr.2026.100895","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T18:06:44Z","timestamp":1789495604000},"page":"100895","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Effect of Fenfluramine on convulsive seizures and rescue medication usage: A case series of adults within the Lennox-Gastaut syndrome spectrum"],"prefix":"10.1016","volume":"36","author":[{"given":"Lisa","family":"Chilson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boubker","family":"Zaaimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanika","family":"Samarasekera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.ebr.2026.100895_bb0005","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1111\/j.1528-1167.1966.tb06263.x","article-title":"Childhood epileptic encephalopathy with diffuse slow spike-waves (otherwise known as \u201cpetit mal variant\u201d) or Lennox syndrome","volume":"7","author":"Gastraut","year":"1966","journal-title":"Epilepsia"},{"key":"10.1016\/j.ebr.2026.100895_bb0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.yebeh.2020.107647","article-title":"Epidemiology, healthcare resource use, and mortality in patients with probable Lennox-Gastaut syndrome: a population-based study on German health insurance data","volume":"115","author":"Strzelczyk","year":"2021","journal-title":"Epilepsy Behav"},{"issue":"20","key":"10.1016\/j.ebr.2026.100895_bb0015","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1056\/NEJMoa1714631","article-title":"Effect of cannabidiol on drop seizures in the Lennox-Gastaut syndrome","volume":"378","author":"Devinsky","year":"2018","journal-title":"N Engl J Med"},{"issue":"10125","key":"10.1016\/j.ebr.2026.100895_bb0020","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1016\/S0140-6736(18)30136-3","article-title":"Cannabidiol in patients with seizures associated with Lennox-Gastaut syndrome (GWPCARE4): a randomised, double-blind, placebo-controlled phase 3 trial","volume":"391","author":"Thiele","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.ebr.2026.100895_bb0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.yebeh.2024.109904","article-title":"Is adjunctive cannabidiol effective in controlling seizures for adult patients with Lennox-Gastaut syndrome? - a single centre long term follow up study","volume":"157","author":"Elbadri","year":"2024","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.ebr.2026.100895_bb0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.yebeh.2025.110302","article-title":"Real-world experience of cannabidiol in conjunction with clobazam for the treatment of seizures associated with Lennox-Gastaut syndrome and Dravet syndrome: results from a retrospective multicentre chart review in Germany","volume":"166","author":"Strzelczyk","year":"2025","journal-title":"Epilepsy Behav"},{"issue":"10216","key":"10.1016\/j.ebr.2026.100895_bb0035","doi-asserted-by":"crossref","first-page":"2243","DOI":"10.1016\/S0140-6736(19)32500-0","article-title":"Fenfluramine hydrochloride for the treatment of seizures in Dravet syndrome: a randomised, double-blind, placebo-controlled trial","volume":"394","author":"Lagae","year":"2019","journal-title":"Lancet"},{"issue":"7","key":"10.1016\/j.ebr.2026.100895_bb0040","doi-asserted-by":"crossref","first-page":"e98","DOI":"10.1111\/epi.16923","article-title":"Effect of fenfluramine on convulsive seizures in CDKL5 deficiency disorder","volume":"62","author":"Devinsky","year":"2021","journal-title":"Epilepsia"},{"issue":"3","key":"10.1016\/j.ebr.2026.100895_bb0045","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1002\/epi4.12623","article-title":"Effect of fenfluramine on seizures and comorbidities in SCN8A-developmental and epileptic encephalopathy: a case series","volume":"7","author":"Aledo-Serrano","year":"2022","journal-title":"Epilepsia Open"},{"issue":"2","key":"10.1016\/j.ebr.2026.100895_bb0050","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1007\/s40120-025-00713-1","article-title":"Expert-agreed practical recommendations on the use of fenfluramine in developmental and epileptic encephalopathies based on clinical experience and literature review","volume":"14","author":"Villanueva","year":"2025","journal-title":"Neurol Ther"},{"key":"10.1016\/j.ebr.2026.100895_bb0055","doi-asserted-by":"crossref","first-page":"505","DOI":"10.3389\/fneur.2017.00505","article-title":"Expert opinion on the management of Lennox-Gastaut Syndrome: treatment algorithms and practical considerations","volume":"8","author":"Cross","year":"2017","journal-title":"Front Neurol"},{"issue":"6","key":"10.1016\/j.ebr.2026.100895_bb0060","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1111\/epi.17241","article-title":"International league against epilepsy classification and definition of epilepsy syndromes with onset in childhood: position paper by the ILAE task force on nosology and definitions","volume":"63","author":"Specchio","year":"2022","journal-title":"Epilepsia"},{"issue":"7","key":"10.1016\/j.ebr.2026.100895_bb0065","first-page":"28","article-title":"The clinical global impressions scale: applying a research tool in clinical practice","volume":"4","author":"Busner","year":"2007","journal-title":"Psychiatry (Edgmont)"},{"key":"10.1016\/j.ebr.2026.100895_bb0070","series-title":"Diagnostic and statistical manual of mental disorders DSM-5","author":"Ewer","year":"2013"}],"container-title":["Epilepsy &amp; Behavior Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589986426000493?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589986426000493?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T17:53:47Z","timestamp":1790099627000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589986426000493"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":14,"alternative-id":["S2589986426000493"],"URL":"https:\/\/doi.org\/10.1016\/j.ebr.2026.100895","relation":{},"ISSN":["2589-9864"],"issn-type":[{"value":"2589-9864","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of Fenfluramine on convulsive seizures and rescue medication usage: A case series of adults within the Lennox-Gastaut syndrome spectrum","name":"articletitle","label":"Article Title"},{"value":"Epilepsy & Behavior Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ebr.2026.100895","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Crown Copyright \u00a9 2026 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"100895"}}