{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T20:32:45Z","timestamp":1776457965176,"version":"3.51.2"},"reference-count":29,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2006,6,1]],"date-time":"2006-06-01T00:00:00Z","timestamp":1149120000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,6,1]],"date-time":"2006-06-01T00:00:00Z","timestamp":1149120000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100007048","name":"Mayo Foundation for Medical Education and Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007048","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","onlinejase.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the American Society of Echocardiography"],"published-print":{"date-parts":[[2006,6]]},"DOI":"10.1016\/j.echo.2006.01.005","type":"journal-article","created":{"date-parts":[[2006,6,8]],"date-time":"2006-06-08T14:34:40Z","timestamp":1149777280000},"page":"788-795","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":56,"title":["Use of Echocardiography in Patients with Hypertrophic Cardiomyopathy: Clinical Implications of Massive Hypertrophy"],"prefix":"10.1016","volume":"19","author":[{"given":"Paul","family":"Sorajja","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rick A.","family":"Nishimura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steve R.","family":"Ommen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael J.","family":"Ackerman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. Jamil","family":"Tajik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernard J.","family":"Gersh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.echo.2006.01.005_bib1","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1161\/01.CIR.92.4.785","article-title":"Prevalence of hypertrophic cardiomyopathy in a general population of young adults","volume":"92","author":"Maron","year":"1995","journal-title":"Circulation"},{"key":"10.1016\/j.echo.2006.01.005_bib2","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1161\/01.CIR.93.5.841","article-title":"Report of the World Health Organization\/International Society and Federation of Cardiology task force on the definition and classification of cardiomyopathies","volume":"93","author":"McKenna","year":"1996","journal-title":"Circulation"},{"key":"10.1016\/j.echo.2006.01.005_bib3","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1016\/0002-9149(79)90160-7","article-title":"Hypertrophic cardiomyopathy","volume":"43","author":"Maron","year":"1979","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.echo.2006.01.005_bib4","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/S0735-1097(83)80269-1","article-title":"Distribution of left ventricular hypertrophy in hypertrophic cardiomyopathy","volume":"2","author":"Shapiro","year":"1983","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.echo.2006.01.005_bib5","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1001\/jama.287.10.1308","article-title":"Hypertrophic cardiomyopathy","volume":"287","author":"Maron","year":"2002","journal-title":"JAMA"},{"key":"10.1016\/j.echo.2006.01.005_bib6","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1056\/NEJM199703133361107","article-title":"Management of hypertrophic cardiomyopathy","volume":"336","author":"Spirito","year":"1997","journal-title":"N Engl J Med"},{"key":"10.1016\/j.echo.2006.01.005_bib7","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1056\/NEJM200002103420601","article-title":"Efficacy of implantable cardioverter-defibrillators for the prevention of sudden death in patients with hypertrophic cardiomyopathy","volume":"342","author":"Maron","year":"2000","journal-title":"N Engl J Med"},{"key":"10.1016\/j.echo.2006.01.005_bib8","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1056\/NEJM200006153422403","article-title":"Magnitude of left ventricular hypertrophy and risk of sudden death in hypertrophic cardiomyopathy","volume":"342","author":"Spirito","year":"2000","journal-title":"N Engl J Med"},{"key":"10.1016\/j.echo.2006.01.005_bib9","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/S0140-6736(00)04005-8","article-title":"Relation between severity of left-ventricular hypertrophy and prognosis in patients with hypertrophic cardiomyopathy","volume":"357","author":"Elliott","year":"2001","journal-title":"Lancet"},{"key":"10.1016\/j.echo.2006.01.005_bib10","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/S0735-1097(02)02713-4","article-title":"Maximum left ventricular thickness and risk of sudden death in patients with hypertrophic cardiomyopathy","volume":"41","author":"Olivotto","year":"2003","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.echo.2006.01.005_bib11","doi-asserted-by":"crossref","first-page":"2517","DOI":"10.1161\/hc4601.097997","article-title":"Impact of atrial fibrillation on the clinical course of hypertrophic cardiomyopathy","volume":"104","author":"Olivotto","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.echo.2006.01.005_bib12","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/S0735-1097(01)01727-2","article-title":"Clinical profile of stroke in 900 patients with hypertrophic cardiomyopathy","volume":"29","author":"Maron","year":"2002","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.echo.2006.01.005_bib13","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1016\/0002-9149(94)90291-7","article-title":"Clinical and morphologic expression of hypertrophic cardiomyopathy in patients > or = 65 years of age","volume":"73","author":"Lewis","year":"1994","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.echo.2006.01.005_bib14","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/0735-1097(89)90222-2","article-title":"Relation between extent of left ventricular hypertrophy and age in hypertrophic cardiomyopathy","volume":"13","author":"Spirito","year":"1989","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.echo.2006.01.005_bib15","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1161\/01.CIR.80.5.1259","article-title":"Electrophysiologic abnormalities in patients with hypertrophic cardiomyopathy","volume":"80","author":"Fananapazir","year":"1989","journal-title":"Circulation"},{"key":"10.1016\/j.echo.2006.01.005_bib16","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1016\/S0735-1097(00)01003-2","article-title":"Sudden death in hypertrophic cardiomyopathy","volume":"36","author":"Elliott","year":"2000","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.echo.2006.01.005_bib17","doi-asserted-by":"crossref","first-page":"933","DOI":"10.2307\/2529873","article-title":"Cancer survival corrected for heterogeneity in patient withdrawal","volume":"38","author":"Hakulinen","year":"1982","journal-title":"Biometrics"},{"key":"10.1016\/j.echo.2006.01.005_bib18","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1161\/01.CIR.102.8.858","article-title":"Epidemiology of hypertrophic cardiomyopathy-related death","volume":"102","author":"Maron","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.echo.2006.01.005_bib19","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1016\/0735-1097(95)00353-3","article-title":"Hypertrophic cardiomyopathy in Tuscany","volume":"26","author":"Cecchi","year":"1995","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.echo.2006.01.005_bib20","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1001\/jama.281.7.650","article-title":"Clinical course of hypertrophic cardiomyopathy in a regional United States cohort","volume":"281","author":"Maron","year":"1999","journal-title":"JAMA"},{"key":"10.1016\/j.echo.2006.01.005_bib21","doi-asserted-by":"crossref","first-page":"2488","DOI":"10.1161\/01.CIR.92.9.2488","article-title":"Natural history of hypertrophic cardiomyopathy","volume":"92","author":"Cannan","year":"1995","journal-title":"Circulation"},{"key":"10.1016\/j.echo.2006.01.005_bib22","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0735-1097(86)80092-4","article-title":"Hypertrophic cardiomyopathy with extreme increase in left ventricular wall thickness","volume":"8","author":"Louie","year":"1986","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.echo.2006.01.005_bib23","doi-asserted-by":"crossref","first-page":"2342","DOI":"10.1161\/01.CIR.0000097110.55312.BF","article-title":"Adverse prognosis of patients with hypertrophic cardiomyopathy who have epicardial coronary artery disease","volume":"108","author":"Sorajja","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.echo.2006.01.005_bib24","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1136\/heart.84.5.476","article-title":"Hypertrophic cardiomyopathy","volume":"84","author":"Varnava","year":"2000","journal-title":"Heart"},{"key":"10.1016\/j.echo.2006.01.005_bib25","doi-asserted-by":"crossref","first-page":"2156","DOI":"10.1016\/S0735-1097(02)02602-5","article-title":"Myocardial scarring in asymptomatic or mildly symptomatic patients with hypertrophic cardiomyopathy","volume":"40","author":"Choudhury","year":"2002","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.echo.2006.01.005_bib26","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1136\/hrt.63.5.287","article-title":"Hypertrophic cardiomyopathy without hypertrophy","volume":"63","author":"McKenna","year":"1990","journal-title":"Br Heart J"},{"key":"10.1016\/j.echo.2006.01.005_bib27","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1056\/NEJM199504203321603","article-title":"Mutations in the genes for cardiac troponin T and alpha-tropomyosin in hypertrophic cardiomyopathy","volume":"332","author":"Watkins","year":"1995","journal-title":"N Engl J Med"},{"key":"10.1016\/j.echo.2006.01.005_bib28","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.jacc.2005.02.090","article-title":"Long-term effects of surgical septal myectomy on survival in patients with obstructive hypertrophic cardiomyopathy","volume":"46","author":"Ommen","year":"2005","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.echo.2006.01.005_bib29","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.jacc.2005.02.090","article-title":"The prognostic impact of septal myectomy in obstructive hypertrophic cardiomyopathy","volume":"46","author":"Watkins","year":"2005","journal-title":"J Am Coll Cardiol"}],"container-title":["Journal of the American Society of Echocardiography"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0894731706000885?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0894731706000885?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T04:38:39Z","timestamp":1760243919000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0894731706000885"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,6]]},"references-count":29,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2006,6]]}},"alternative-id":["S0894731706000885"],"URL":"https:\/\/doi.org\/10.1016\/j.echo.2006.01.005","relation":{},"ISSN":["0894-7317"],"issn-type":[{"value":"0894-7317","type":"print"}],"subject":[],"published":{"date-parts":[[2006,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Use of Echocardiography in Patients with Hypertrophic Cardiomyopathy: Clinical Implications of Massive Hypertrophy","name":"articletitle","label":"Article Title"},{"value":"Journal of the American Society of Echocardiography","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.echo.2006.01.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 American Society of Echocardiography. Published by Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}