{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T17:02:24Z","timestamp":1765040544244,"version":"build-2065373602"},"reference-count":39,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","onlinejase.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the American Society of Echocardiography"],"published-print":{"date-parts":[[2016,2]]},"DOI":"10.1016\/j.echo.2015.08.012","type":"journal-article","created":{"date-parts":[[2015,9,12]],"date-time":"2015-09-12T07:55:52Z","timestamp":1442044552000},"page":"112-118","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Left Bundle Branch Block Negatively Affects Coronary Flow Velocity Reserve and Myocardial Contractile Reserve in Nonischemic Dilated Cardiomyopathy"],"prefix":"10.1016","volume":"29","author":[{"given":"Quirino","family":"Ciampi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauro","family":"Cortigiani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorenza","family":"Pratali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fausto","family":"Rigo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"Villari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eugenio","family":"Picano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosa","family":"Sicari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.echo.2015.08.012_bib1","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1093\/ejechocard\/jen175","article-title":"Stress echocardiography expert consensus statement. European Association of Echocardiography (EAE) (a registered branch of the ESC)","volume":"9","author":"Sicari","year":"2008","journal-title":"Eur J Echocardiogr"},{"key":"10.1016\/j.echo.2015.08.012_bib2","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/0002-8703(94)90127-9","article-title":"Vasodilatory capacity of coronary resistance vessels in dilated cardiomyopathy","volume":"127","author":"Inoue","year":"1994","journal-title":"Am Heart J"},{"key":"10.1016\/j.echo.2015.08.012_bib3","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1093\/eurheartj\/ehi795","article-title":"The prognostic impact of coronary flow reserve assessed by Doppler echocardiography in non-ischemic dilated cardiomyopathy","volume":"27","author":"Rigo","year":"2006","journal-title":"Eur Heart J"},{"key":"10.1016\/j.echo.2015.08.012_bib4","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1016\/j.amjcard.2006.11.049","article-title":"The independent prognostic value of contractile and coronary flow reserve determined by dipyridamole stress echocardiography in patients with idiopathic dilated cardiomyopathy","volume":"99","author":"Rigo","year":"2007","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.echo.2015.08.012_bib5","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1476-7120-6-7","article-title":"Transthoracic echocardiographic imaging of coronary arteries: tips, traps, and pitfalls","volume":"6","author":"Rigo","year":"2008","journal-title":"Cardiovascular Ultrasound"},{"key":"10.1016\/j.echo.2015.08.012_bib6","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/0002-9149(81)90196-X","article-title":"Comparative features of newly acquired left and right bundle branch block in the general population: the Framingham study","volume":"47","author":"Schneider","year":"1981","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.echo.2015.08.012_bib7","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1159\/000470759","article-title":"Diagnostic accuracy and prognostic significance of quantitative thallium-201 scintigraphy in patients with left bundle branch block","volume":"1","author":"Rothbart","year":"1987","journal-title":"Am J Nonivasive Cardiol"},{"key":"10.1016\/j.echo.2015.08.012_bib8","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/S0002-9343(03)00239-0","article-title":"Prognostic implication of intraventricular conduction defects in patients undergoing stress echocardiography for suspected coronary artery disease","volume":"115","author":"Cortigiani","year":"2003","journal-title":"Am J Med"},{"key":"10.1016\/j.echo.2015.08.012_bib9","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0735-1097(02)02665-7","article-title":"Limitation of cardiac output by total isovolumic time during pharmacologic stress in patients with dilated cardiomyopathy: activation-mediated effects of left bundle branch block and coronary artery disease","volume":"41","author":"Duncan","year":"2003","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.echo.2015.08.012_bib10","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1136\/hrt.66.6.443","article-title":"Effect of left bundle branch block on diastolic function in dilated cardiomyopathy","volume":"66","author":"Xiao","year":"1991","journal-title":"Br Heart J"},{"key":"10.1016\/j.echo.2015.08.012_bib11","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1161\/01.CIR.79.4.845","article-title":"Functional abnormalities in isolated left bundle branch block. The effect of interventricular asynchrony","volume":"79","author":"Grines","year":"1989","journal-title":"Circulation"},{"key":"10.1016\/j.echo.2015.08.012_bib12","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1161\/01.CIR.0000113458.76455.03","article-title":"Ventricular resynchronization: current state of the art","volume":"109","author":"Leclercq","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.echo.2015.08.012_bib13","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1093\/eurheartj\/ehs104","volume":"33","author":"McMurray","year":"2012","journal-title":"Eur Heart J"},{"key":"10.1016\/j.echo.2015.08.012_bib14","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1093\/ehjci\/jev014","article-title":"Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging","volume":"16","author":"Lang","year":"2015","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"10.1016\/j.echo.2015.08.012_bib15","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S0002-9149(02)03153-3","article-title":"Usefulness of coronary flow reserve over regional wall motion when added to dual-imaging dipyridamole echocardiography","volume":"91","author":"Rigo","year":"2003","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.echo.2015.08.012_bib16","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1016\/j.cardfail.2007.07.011","article-title":"Prognostic value of pharmacologic stress echocardiography in patients with idiopathic dilated cardiomyopathy: a prospective, head-to-head comparison between dipyridamole and dobutamine test","volume":"13","author":"Pratali","year":"2007","journal-title":"J Cardiac Fail"},{"key":"10.1016\/j.echo.2015.08.012_bib17","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1093\/eurjhf\/hfp039","article-title":"Identification of responders to cardiac resynchronization therapy by contractile reserve during stress echo","volume":"11","author":"Ciampi","year":"2009","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.echo.2015.08.012_bib18","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0735-1097(99)00499-4","article-title":"Regional myocardial blood flow reserve impairment and metabolic changes suggesting myocardial ischemia in patients with idiopathic dilated cardiomyopathy","volume":"35","author":"van den Heuvel","year":"2000","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.echo.2015.08.012_bib19","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1161\/hc0202.102119","article-title":"Prognostic role of myocardial blood flow impairment in idiopathic left ventricular dysfunction","volume":"105","author":"Neglia","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.echo.2015.08.012_bib20","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1161\/01.CIR.81.3.772","article-title":"Endothelium-dependent dilation of the coronary microvasculature is impaired in dilated cardiomyopathy","volume":"81","author":"Treasure","year":"1990","journal-title":"Circulation"},{"key":"10.1016\/j.echo.2015.08.012_bib21","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1016\/S0735-1097(87)80118-3","article-title":"Dynamic limitation of coronary vasodilator reserve in patients with dilated cardiomyopathy","volume":"10","author":"Cannon","year":"1987","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.echo.2015.08.012_bib22","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1016\/0002-9149(85)90150-X","article-title":"Multifactorial determinants of reduced coronary flow reserve after dipyridamole in dilated cardiomyopathy","volume":"55","author":"Nitenberg","year":"1985","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.echo.2015.08.012_bib23","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/nrcardio.2014.160","article-title":"Coronary microvascular dysfunction: mechanisms and functional assessment","volume":"12","author":"Camici","year":"2015","journal-title":"Nat Rev Cardiol"},{"key":"10.1016\/j.echo.2015.08.012_bib24","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1056\/NEJMra061889","article-title":"Coronary microvascular dysfunction","volume":"356","author":"Camici","year":"2007","journal-title":"N Engl J Med"},{"key":"10.1016\/j.echo.2015.08.012_bib25","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.ijcard.2004.11.013","article-title":"Clinical and functional determinants of coronary flow reserve in non-ischemic dilated cardiomyopathy. An echocardiographic study","volume":"105","author":"Santagata","year":"2005","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.echo.2015.08.012_bib26","first-page":"H817","article-title":"Effects of asynchrony on myocardial relaxation at rest and during exercise in conscious dogs","volume":"254","author":"Heyndrickx","year":"1988","journal-title":"Am J Physiol"},{"key":"10.1016\/j.echo.2015.08.012_bib27","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1016\/0735-1097(93)90234-R","article-title":"Effects of induced asynchrony of left ventricular diastolic function in patients with coronary artery disease","volume":"21","author":"Betocchi","year":"1993","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.echo.2015.08.012_bib28","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S0735-1097(87)80387-X","article-title":"Nonuniformity: a physiologic modulator of contraction and relaxation of the normal heart","volume":"9","author":"Brutsaert","year":"1987","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.echo.2015.08.012_bib29","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1093\/ejechocard\/jep094","article-title":"Effect of intraventricular dyssynchrony on diastolic function and exercise tolerance in patients with heart failure","volume":"10","author":"Ciampi","year":"2009","journal-title":"Eur J Echocardiogr"},{"key":"10.1016\/j.echo.2015.08.012_bib30","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1161\/CIRCIMAGING.109.934638","article-title":"Myocardial structural, perfusion, and metabolic correlates of left bundle branch block mechanical derangement in patients with dilated cardiomyopathy: a tagged cardiac magnetic resonance and positron emission tomography study","volume":"3","author":"Masci","year":"2010","journal-title":"Circ Cardiovasc Imaging"},{"key":"10.1016\/j.echo.2015.08.012_bib31","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1016\/0735-1097(93)90255-Y","article-title":"Assessment of coronary conductance and resistance vessel reactivity in response to nitroglycerin, ergonovine and adenosine: in\u00a0vivo studies with simultaneous intravascular two-dimensional and Doppler ultrasound","volume":"21","author":"Sudhir","year":"1993","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.echo.2015.08.012_bib32","doi-asserted-by":"crossref","first-page":"2027","DOI":"10.1016\/j.jacc.2004.08.051","article-title":"Regional coronary flow and contractile reserve in patients with idiopathic dilated cardiomyopathy","volume":"44","author":"Skalidis","year":"2004","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.echo.2015.08.012_bib33","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1093\/ehjci\/jeu136","article-title":"Prognostic role of coronary flow reserve for left ventricular functional improvement after cardiac resynchronization therapy in patients with dilated cardiomyopathy","volume":"15","author":"Djordjevic Dikic","year":"2014","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"10.1016\/j.echo.2015.08.012_bib34","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1093\/eurheartj\/ehl379","article-title":"Impact of viability and scar tissue on response to cardiac resynchronization therapy in ischaemic heart failure patients","volume":"28","author":"Ypenburg","year":"2007","journal-title":"Eur Heart J"},{"key":"10.1016\/j.echo.2015.08.012_bib35","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1016\/j.jacc.2006.07.046","article-title":"Delayed enhancement magnetic resonance imaging predicts response to cardiac resynchronization therapy in patients with intraventricular dyssynchrony","volume":"48","author":"White","year":"2006","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.echo.2015.08.012_bib36","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1016\/j.ahj.2010.07.019","article-title":"Clinical and Prognostic Role of Pressure-Volume Relationship in the Identification of Responders to Cardiac Resynchronization Therapy","volume":"160","author":"Ciampi","year":"2010","journal-title":"Am Heart J"},{"key":"10.1016\/j.echo.2015.08.012_bib37","doi-asserted-by":"crossref","first-page":"2336","DOI":"10.1161\/01.CIR.0000097111.00170.7B","article-title":"Myocardial contractile reserve by dobutamine stress echocardiography predicts improvement in ejection fraction with beta-blockade in patients with heart failure: the Beta-Blocker Evaluation of Survival Trial (BEST)","volume":"108","author":"Eichhorn","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.echo.2015.08.012_bib38","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/S0735-1097(10)80182-2","article-title":"Stress echocardiography and the human factor: the importance of being expert","volume":"17","author":"Picano","year":"1991","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.echo.2015.08.012_bib39","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1016\/S0140-6736(94)90508-8","article-title":"Safety and tolerability of dobutamine atropine stress echocardiography: a prospective, multicentre study. Echo Dobutamine International Cooperative Study Group","volume":"344","author":"Picano","year":"1994","journal-title":"Lancet"}],"container-title":["Journal of the American Society of Echocardiography"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0894731715006173?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0894731715006173?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T04:59:11Z","timestamp":1760245151000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0894731715006173"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2]]},"references-count":39,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["S0894731715006173"],"URL":"https:\/\/doi.org\/10.1016\/j.echo.2015.08.012","relation":{},"ISSN":["0894-7317"],"issn-type":[{"type":"print","value":"0894-7317"}],"subject":[],"published":{"date-parts":[[2016,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Left Bundle Branch Block Negatively Affects Coronary Flow Velocity Reserve and Myocardial Contractile Reserve in Nonischemic Dilated Cardiomyopathy","name":"articletitle","label":"Article Title"},{"value":"Journal of the American Society of Echocardiography","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.echo.2015.08.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 American Society of Echocardiography. Published by Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}