{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T01:45:16Z","timestamp":1790646316132,"version":"4.1.0"},"reference-count":31,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","onlinejase.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the American Society of Echocardiography"],"published-print":{"date-parts":[[2018,1]]},"DOI":"10.1016\/j.echo.2017.09.007","type":"journal-article","created":{"date-parts":[[2017,10,27]],"date-time":"2017-10-27T11:01:01Z","timestamp":1509102061000},"page":"71-78","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"title":["Abnormal Coronary Flow Velocity Reserve and Decreased Myocardial Contractile Reserve Are Main Factors in Relation to Physical Exercise Capacity in Cardiac Amyloidosis"],"prefix":"10.1016","volume":"31","author":[{"given":"Tor Skibsted","family":"Clemmensen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Eiskj\u00e6r","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henning","family":"M\u00f8lgaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders Hostrup","family":"Larsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Soerensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niels Frost","family":"Andersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars Poulsen","family":"Tolbod","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hendrik J.","family":"Harms","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steen Hvitfeldt","family":"Poulsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.echo.2017.09.007_bib1","doi-asserted-by":"crossref","first-page":"e178","DOI":"10.1161\/CIRCULATIONAHA.111.069195","article-title":"Cardiac amyloidosis","volume":"126","author":"Quarta","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.echo.2017.09.007_bib2","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1161\/CIRCULATIONAHA.110.010447","article-title":"Cardiac amyloidosis: a treatable disease, often overlooked","volume":"124","author":"Falk","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.echo.2017.09.007_bib3","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1056\/NEJM199709253371306","article-title":"The systemic amyloidoses","volume":"337","author":"Falk","year":"1997","journal-title":"N Engl J Med"},{"key":"10.1016\/j.echo.2017.09.007_bib4","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.carpath.2006.09.011","article-title":"Deposition of amyloid proteins in the epicardial coronary arteries of 58 patients with primary systemic amyloidosis","volume":"16","author":"Wittich","year":"2007","journal-title":"Cardiovasc Pathol"},{"key":"10.1016\/j.echo.2017.09.007_bib5","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1016\/j.amjmed.2005.06.017","article-title":"Obstructive intramural coronary amyloidosis and myocardial ischemia are common in primary amyloidosis","volume":"118","author":"Neben-Wittich","year":"2005","journal-title":"Am J Med"},{"key":"10.1016\/j.echo.2017.09.007_bib6","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0002-9343(00)00471-X","article-title":"Symptomatic ischemic heart disease resulting from obstructive intramural coronary amyloidosis","volume":"109","author":"Mueller","year":"2000","journal-title":"Am J Med"},{"key":"10.1016\/j.echo.2017.09.007_bib7","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1016\/S0002-9149(99)00497-X","article-title":"Comparison of usefulness between exercise capacity and echocardiographic indexes of left ventricular function in cardiac amyloidosis","volume":"84","author":"Trikas","year":"1999","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.echo.2017.09.007_bib8","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.echo.2010.03.027","article-title":"Independent predictors of survival in primary systemic (Al) amyloidosis, including cardiac biomarkers and left ventricular strain imaging: an observational cohort study","volume":"23","author":"Bellavia","year":"2010","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.echo.2017.09.007_bib9","doi-asserted-by":"crossref","first-page":"1840","DOI":"10.1161\/CIRCULATIONAHA.113.006242","article-title":"Left ventricular structure and function in transthyretin-related versus light-chain cardiac amyloidosis","volume":"129","author":"Quarta","year":"2014","journal-title":"Circulation"},{"key":"10.1016\/j.echo.2017.09.007_bib10","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/j.jacc.2012.04.043","article-title":"Longitudinal left ventricular function for prediction of survival in systemic light-chain amyloidosis: incremental value compared with clinical and biochemical markers","volume":"60","author":"Buss","year":"2012","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.echo.2017.09.007_bib11","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.jcmg.2009.11.013","article-title":"Prognostic significance of strain Doppler imaging in light-chain amyloidosis","volume":"3","author":"Koyama","year":"2010","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1016\/j.echo.2017.09.007_bib12","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1016\/j.amjcard.2007.11.047","article-title":"Evidence of impaired left ventricular systolic function by Doppler myocardial imaging in patients with systemic amyloidosis and no evidence of cardiac involvement by standard two-dimensional and Doppler echocardiography","volume":"101","author":"Bellavia","year":"2008","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.echo.2017.09.007_bib13","doi-asserted-by":"crossref","first-page":"2446","DOI":"10.1161\/01.CIR.0000068313.67758.4F","article-title":"Longitudinal myocardial function assessed by tissue velocity, strain, and strain rate tissue Doppler echocardiography in patients with AL (primary) cardiac amyloidosis","volume":"107","author":"Koyama","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.echo.2017.09.007_bib14","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.jcmg.2015.05.014","article-title":"Causes and Consequences of longitudinal LV dysfunction assessed by 2D strain echocardiography in cardiac amyloidosis","volume":"9","author":"Ternacle","year":"2016","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1016\/j.echo.2017.09.007_bib15","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1136\/heartjnl-2012-302353","article-title":"Relative apical sparing of longitudinal strain using two-dimensional speckle-tracking echocardiography is both sensitive and specific for the diagnosis of cardiac amyloidosis","volume":"98","author":"Phelan","year":"2012","journal-title":"Heart"},{"key":"10.1016\/j.echo.2017.09.007_bib16","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1016\/j.echo.2016.07.017","article-title":"Cumulative burden of myocardial dysfunction in cardiac amyloidosis assessed using four-chamber cardiac strain","volume":"29","author":"Kado","year":"2016","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.echo.2017.09.007_bib17","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.jchf.2014.03.009","article-title":"Coronary microvascular dysfunction is related to abnormalities in myocardial structure and function in cardiac amyloidosis","volume":"2","author":"Dorbala","year":"2014","journal-title":"JACC Heart Fail"},{"key":"10.1016\/j.echo.2017.09.007_bib18","doi-asserted-by":"crossref","first-page":"213","DOI":"10.2967\/jnumed.111.102053","article-title":"In\u00a0vivo visualization of amyloid deposits in the heart with 11C-PIB and PET","volume":"54","author":"Antoni","year":"2013","journal-title":"J Nucl Med"},{"key":"10.1016\/j.echo.2017.09.007_bib19","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.jcmg.2014.09.018","article-title":"11C-Pittsburgh B PET imaging in cardiac amyloidosis","volume":"8","author":"Lee","year":"2015","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1016\/j.echo.2017.09.007_bib20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.echo.2014.10.003","article-title":"Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging","volume":"28","author":"Lang","year":"2015","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.echo.2017.09.007_bib21","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.echo.2004.02.011","article-title":"Global longitudinal strain: a novel index of left ventricular systolic function","volume":"17","author":"Reisner","year":"2004","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.echo.2017.09.007_bib22","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1161\/hc0402.102975","article-title":"Standardized myocardial segmentation and nomenclature for tomographic imaging of the heart. A statement for healthcare professionals from the Cardiac Imaging Committee of the Council on Clinical Cardiology of the American Heart Association","volume":"105","author":"Cerqueira","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.echo.2017.09.007_bib23","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/j.echo.2005.04.012","article-title":"The accuracy of left ventricular mass determined by real-time three-dimensional echocardiography in chronic animal and clinical studies: a comparison with postmortem examination and magnetic resonance imaging","volume":"18","author":"Qin","year":"2005","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.echo.2017.09.007_bib24","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1016\/j.jacc.2004.05.050","article-title":"Reproducibility and accuracy of echocardiographic measurements of left ventricular parameters using real-time three-dimensional echocardiography","volume":"44","author":"Jenkins","year":"2004","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.echo.2017.09.007_bib25","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1136\/hrt.2005.060889","article-title":"Improved quantification of left ventricular mass based on endocardial and epicardial surface detection with real time three dimensional echocardiography","volume":"92","author":"Caiani","year":"2006","journal-title":"Heart"},{"key":"10.1016\/j.echo.2017.09.007_bib26","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.1161\/01.CIR.0000142670.65971.5F","article-title":"Fast measurement of left ventricular mass with real-time three-dimensional echocardiography: comparison with magnetic resonance imaging","volume":"110","author":"Mor-Avi","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.echo.2017.09.007_bib27","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1249\/00005768-198315060-00015","article-title":"A category-ratio perceived exertion scale: relationship to blood and muscle lactates and heart rate","volume":"15","author":"Noble","year":"1983","journal-title":"Med Sci Sports Exerc"},{"key":"10.1016\/j.echo.2017.09.007_bib28","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/0002-9149(74)90092-7","article-title":"Effects of coronary stenoses on coronary flow reserve and resistance","volume":"34","author":"Gould","year":"1974","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.echo.2017.09.007_bib29","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1093\/ehjci\/jes009","article-title":"Comparison of right ventricular longitudinal strain imaging, tricuspid annular plane systolic excursion, and cardiac biomarkers for early diagnosis of cardiac involvement and risk stratification in primary systematic (AL) amyloidosis: a 5-year cohort study","volume":"13","author":"Bellavia","year":"2012","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"10.1016\/j.echo.2017.09.007_bib30","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1093\/ejechocard\/jer289","article-title":"Right ventricular function in AL amyloidosis: characteristics and prognostic implication","volume":"13","author":"Cappelli","year":"2012","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"10.1016\/j.echo.2017.09.007_bib31","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1136\/heartjnl-2014-305710","article-title":"Cardiac magnetic resonance evaluation of left ventricular remodelling distribution in cardiac amyloidosis","volume":"100","author":"Pozo","year":"2014","journal-title":"Heart"}],"container-title":["Journal of the American Society of Echocardiography"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0894731717306624?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0894731717306624?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T05:02:25Z","timestamp":1760245345000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0894731717306624"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["S0894731717306624"],"URL":"https:\/\/doi.org\/10.1016\/j.echo.2017.09.007","relation":{},"ISSN":["0894-7317"],"issn-type":[{"value":"0894-7317","type":"print"}],"subject":[],"published":{"date-parts":[[2018,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Abnormal Coronary Flow Velocity Reserve and Decreased Myocardial Contractile Reserve Are Main Factors in Relation to Physical Exercise Capacity in Cardiac Amyloidosis","name":"articletitle","label":"Article Title"},{"value":"Journal of the American Society of Echocardiography","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.echo.2017.09.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"2017 by the American Society of Echocardiography.","name":"copyright","label":"Copyright"}]}}