{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T07:09:31Z","timestamp":1772348971859,"version":"3.50.1"},"reference-count":36,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","onlinejase.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the American Society of Echocardiography"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1016\/j.echo.2019.04.420","type":"journal-article","created":{"date-parts":[[2019,6,22]],"date-time":"2019-06-22T01:59:42Z","timestamp":1561168782000},"page":"1075-1085","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Shock-Wave Therapy Improves Myocardial Blood Flow Reserve in Patients with Refractory Angina: Evaluation by Real-Time Myocardial Perfusion Echocardiography"],"prefix":"10.1016","volume":"32","author":[{"given":"Conrado L.","family":"Ceccon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anderson S.","family":"Duque","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis H.","family":"Gowdak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Wilson","family":"Mathias","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsu Po","family":"Chiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joao C.N.","family":"Sbano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta F.","family":"Lima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis Antonio","family":"Machado Cesar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cecilia B.B.V.","family":"Cruz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulo M.M.","family":"Dourado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio","family":"Meneghetti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeane M.","family":"Tsutsui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.echo.2019.04.420_bib1","first-page":"e29","article-title":"Heart disease and stroke statistics\u20142015 update: a report from the American Heart Association","volume":"131","author":"Mozaffarian","year":"2015","journal-title":"Circulation"},{"key":"10.1016\/j.echo.2019.04.420_bib2","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1007\/s00380-012-0244-7","article-title":"Randomized and double-blind controlled clinical trial of extracorporeal cardiac shock wave therapy for coronary heart disease","volume":"28","author":"Yang","year":"2013","journal-title":"Heart Vessels"},{"key":"10.1016\/j.echo.2019.04.420_bib3","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s12947-017-0102-y","article-title":"Cardiac shock-wave therapy in the treatment of coronary artery disease: systematic review and meta-analysis","volume":"15","author":"Burneikait\u0117","year":"2017","journal-title":"Cardiovasc Ultrasound"},{"key":"10.1016\/j.echo.2019.04.420_bib4","first-page":"22","article-title":"Impact of shock-wave therapy on the clinical and functional status of patients with coronary heart disease","volume":"89","author":"Matskeplishvili","year":"2017","journal-title":"Ter Arkh"},{"key":"10.1016\/j.echo.2019.04.420_bib5","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1111\/eci.12546","article-title":"Clinical effect of cardiac shock wave therapy on patients with ischaemic heart disease: a systematic review and meta-analysis","volume":"45","author":"Wang","year":"2015","journal-title":"Eur J Clin Invest"},{"key":"10.1016\/j.echo.2019.04.420_bib6","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1161\/01.CIR.97.5.473","article-title":"Quantification of myocardial blood flow with ultrasound-induced destruction of microbubbles administered as a constant venous infusion","volume":"97","author":"Wei","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.echo.2019.04.420_bib7","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1016\/j.echo.2010.09.003","article-title":"Detection of coronary artery disease by combined assessment of wall motion, myocardial perfusion and coronary flow reserve: a multiparametric contrast stress-echocardiography study","volume":"23","author":"Gaibazzi","year":"2010","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.echo.2019.04.420_bib8","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1053\/euhj.2001.2706","article-title":"The problem of chronic refractory angina: report from the ESC Joint Study Group on the Treatment of Refractory Angina","volume":"23","author":"Mannheimer","year":"2002","journal-title":"Eur Heart J"},{"key":"10.1016\/j.echo.2019.04.420_bib9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.echo.2014.10.003","article-title":"Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging","volume":"28","author":"Lang","year":"2015","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.echo.2019.04.420_bib10","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1161\/hc0402.102975","article-title":"Standardized myocardial segmentation and nomenclature for tomographic imaging of the heart: a statement for healthcare professionals from the cardiac imaging committee of the council on clinical cardiology of the American Heart Association","volume":"105","author":"Cerqueira","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.echo.2019.04.420_bib11","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.echo.2017.11.013","article-title":"Clinical applications of ultrasonic enhancing agents in echocardiography: 2018 American Society of Echocardiography guidelines update","volume":"31","author":"Porter","year":"2018","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.echo.2019.04.420_bib12","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1067\/mje.2000.103508","article-title":"Assessment of coronary flow reserve with transthoracic Doppler echocardiography: comparison among adenosine, standard-dose dipyridamole, and high-dose dipyridamole","volume":"13","author":"Lim","year":"2000","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.echo.2019.04.420_bib13","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/j.echo.2007.07.003","article-title":"American Society of Echocardiography recommendations for performance, interpretation, and application of stress echocardiography","volume":"20","author":"Pellikka","year":"2007","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.echo.2019.04.420_bib14","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1016\/j.jacc.2004.11.044","article-title":"The quantification of absolute myocardial perfusion in humans by contrast echocardiography: algorithm and validation","volume":"45","author":"Vogel","year":"2005","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.echo.2019.04.420_bib15","first-page":"813","article-title":"Quantitative myocardial contrast echocardiography during pharmacological stress for diagnosis of coronary artery disease: a systematic review and meta-analysis of diagnostic accuracy studies","volume":"10","author":"Abdelmoneim","year":"2009","journal-title":"Eur J Echocardiogr"},{"key":"10.1016\/j.echo.2019.04.420_bib16","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.jacc.2003.07.040","article-title":"Assessment of the physiologic significance of coronary disease with dipyridamole real-time myocardial contrast echocardiography. Comparison with technetium- 99m sestamibi single-photon emission computed tomography and quantitative coronary angiography","volume":"43","author":"Peltier","year":"2004","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.echo.2019.04.420_bib17","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.amjcard.2009.09.009","article-title":"Effects of exercise training on myocardial blood flow reserve in patients with heart failure and left ventricular systolic dysfunction","volume":"105","author":"Santos","year":"2010","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.echo.2019.04.420_bib18","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/j.echo.2007.02.008","article-title":"Head-to-head comparison of dobutamine and adenosine stress real-time myocardial perfusion echocardiography for the detection of coronary artery disease","volume":"20","author":"Kowatsch","year":"2007","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.echo.2019.04.420_bib19","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.echo.2006.11.016","article-title":"Evaluation of blood flow reserve in left anterior descending coronary artery territory by quantitative myocardial contrast and Doppler echocardiography","volume":"20","author":"Osorio","year":"2007","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.echo.2019.04.420_bib20","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s12471-014-0524-1","article-title":"Negative predictive value of SPECT for the occurrence of MACE in a medium-sized clinic in the Netherlands","volume":"22","author":"Bom","year":"2014","journal-title":"Neth Heart J"},{"key":"10.1016\/j.echo.2019.04.420_bib21","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.nuclcard.2004.03.033","article-title":"Prognostic validation of a 17-segment score derived from a 20-segment score for myocardial perfusion SPECT interpretation","volume":"11","author":"Berman","year":"2004","journal-title":"J Nucl Cardiol"},{"key":"10.1016\/j.echo.2019.04.420_bib22","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1007\/s12350-015-0150-3","article-title":"Predictors of high-risk coronary artery disease in subjects with normal SPECT myocardial perfusion imaging","volume":"23","author":"Nakanishi","year":"2016","journal-title":"J Nucl Cardiol"},{"key":"10.1016\/j.echo.2019.04.420_bib23","doi-asserted-by":"crossref","first-page":"3055","DOI":"10.1161\/01.CIR.0000148849.51177.97","article-title":"Extracorporeal cardiac shock wave therapy markedly ameliorates ischemia-induced myocardial dysfunction in pigs in\u00a0vivo","volume":"110","author":"Nishida","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.echo.2019.04.420_bib24","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1097\/MCA.0b013e328089f19b","article-title":"Extracorporeal cardiac shock wave therapy improves left ventricular remodeling after acute myocardial infarction in pigs","volume":"18","author":"Uwatoku","year":"2007","journal-title":"Coron Artery Dis"},{"key":"10.1016\/j.echo.2019.04.420_bib25","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1620\/tjem.214.151","article-title":"Extracorporeal shock wave therapy ameliorates hindlimb ischemia in rabbits","volume":"214","author":"Oi","year":"2008","journal-title":"Tohoku J Exp Med"},{"key":"10.1016\/j.echo.2019.04.420_bib26","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.mayocp.2013.11.017","article-title":"Safety and efficacy of extracorporeal shock wave myocardial revascularization therapy for refractory angina pectoris","volume":"89","author":"Cassar","year":"2014","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.echo.2019.04.420_bib27","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1097\/00019501-200602000-00011","article-title":"Extracorporeal cardiac shock wave therapy ameliorates myocardial ischemia in patients with severe coronary artery disease","volume":"17","author":"Fukumoto","year":"2006","journal-title":"Coron Artery Dis"},{"key":"10.1016\/j.echo.2019.04.420_bib28","doi-asserted-by":"crossref","first-page":"4168","DOI":"10.1016\/j.ijcard.2013.07.112","article-title":"Extracorporeal shock wave stimulates expression of the angiogenic genes via mechanosensory complex in endothelial cells: mimetic effect of fluid shear stress in endothelial cells","volume":"168","author":"Ha","year":"2013","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.echo.2019.04.420_bib29","doi-asserted-by":"crossref","first-page":"850","DOI":"10.2119\/molmed.2016.00108","article-title":"Shock wave therapy enhances angiogenesis through VEGFR2 activation and recycling","volume":"22","author":"Huang","year":"2016","journal-title":"Mol Med"},{"key":"10.1016\/j.echo.2019.04.420_bib30","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0002-9149(74)90743-7","article-title":"Physiologic basis for assessing critical coronary stenosis. Instantaneous flow response and regional distribution during coronary hyperemia as measures of coronary flow reserve","volume":"33","author":"Gould","year":"1974","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.echo.2019.04.420_bib31","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1161\/01.CIR.103.2.184","article-title":"Role of variability in microvascular resistance on fractional flow reserve and coronary blood flow velocity reserve in intermediate coronary lesions","volume":"103","author":"Meuwissen","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.echo.2019.04.420_bib32","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1016\/j.jacc.2005.01.024","article-title":"Safety of dobutamine stress real-time myocardial contrast echocardiography","volume":"45","author":"Tsutsui","year":"2005","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.echo.2019.04.420_bib33","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1161\/CIRCULATIONAHA.105.537134","article-title":"Prognostic value of dobutamine stress myocardial contrast perfusion echocardiography","volume":"112","author":"Tsutsui","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.echo.2019.04.420_bib34","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.echo.2013.01.016","article-title":"Prognostic value of qualitative and quantitative vasodilator stress myocardial perfusion echocardiography in patients with known or suspected coronary artery disease","volume":"26","author":"Mattoso","year":"2013","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.echo.2019.04.420_bib35","doi-asserted-by":"crossref","first-page":"e004129","DOI":"10.1161\/CIRCIMAGING.116.004129","article-title":"Comparison of fractional flow reserve assessment with demand stress myocardial contrast echocardiography in angiographically intermediate coronary stenoses","volume":"9","author":"Wu","year":"2016","journal-title":"Circ Cardiovasc Imaging"},{"key":"10.1016\/j.echo.2019.04.420_bib36","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.carrev.2017.05.006","article-title":"The beneficial effect of extracorporeal shockwave myocardial revascularization: two years of follow-up","volume":"18","author":"Alunni","year":"2017","journal-title":"Cardiovasc Revasc Med"}],"container-title":["Journal of the American Society of Echocardiography"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0894731719306431?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0894731719306431?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T05:04:49Z","timestamp":1760245489000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0894731719306431"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":36,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["S0894731719306431"],"URL":"https:\/\/doi.org\/10.1016\/j.echo.2019.04.420","relation":{},"ISSN":["0894-7317"],"issn-type":[{"value":"0894-7317","type":"print"}],"subject":[],"published":{"date-parts":[[2019,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Shock-Wave Therapy Improves Myocardial Blood Flow Reserve in Patients with Refractory Angina: Evaluation by Real-Time Myocardial Perfusion Echocardiography","name":"articletitle","label":"Article Title"},{"value":"Journal of the American Society of Echocardiography","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.echo.2019.04.420","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"2019 by the American Society of Echocardiography.","name":"copyright","label":"Copyright"}]}}