{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T01:49:23Z","timestamp":1771379363565,"version":"3.50.1"},"reference-count":27,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Theodore F. Hubbard Foundation"},{"name":"Philips Healthcare"},{"DOI":"10.13039\/501100010454","name":"Bracco Diagnostics","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100010454","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","onlinejase.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the American Society of Echocardiography"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1016\/j.echo.2019.04.424","type":"journal-article","created":{"date-parts":[[2019,7,3]],"date-time":"2019-07-03T17:49:15Z","timestamp":1562176155000},"page":"1095-1101","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["The Relationship of Capillary Blood Flow Assessments with Real Time Myocardial Perfusion Echocardiography to Invasively Derived Microvascular and Epicardial Assessments"],"prefix":"10.1016","volume":"32","author":[{"given":"David","family":"Barton","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward","family":"O'Leary","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiannis S.","family":"Chatzizisis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory","family":"Pavlides","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas R.","family":"Porter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.echo.2019.04.424_bib1","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1056\/NEJMoa070829","article-title":"Optimal medical therapy with or without percutaneous intervention for stable coronary artery disease","volume":"356","author":"Bowden","year":"2007","journal-title":"N Engl J Med"},{"key":"10.1016\/j.echo.2019.04.424_bib2","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1161\/CIRCULATIONAHA.107.743963","article-title":"Optimal medical therapy with or without percutaneous coronary intervention to reduce ischemic burden: results from the Clinical Outcomes Utilizing Revascularization and Aggressive Drug Evaluation (COURAGE) Trial Nuclear Subsidy","volume":"117","author":"Shaw","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.echo.2019.04.424_bib3","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1056\/NEJMoa1205361","article-title":"Fractional flow reserve-guided percutaneous coronary intervention versus medical therapy in stable coronary disease","volume":"367","author":"De Bruyne","year":"2012","journal-title":"N Engl J Med"},{"key":"10.1016\/j.echo.2019.04.424_bib4","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1016\/j.jacc.2017.02.001","article-title":"ACC\/AATS\/AHA\/ASE\/ASNC\/SCAI\/SCCT\/STS 2017 appropriate use criteria for coronary revascularization in patients with stable ischemic heart disease","volume":"69","author":"Patel","year":"2017","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.echo.2019.04.424_bib5","first-page":"2541","article-title":"The Task Force on Myocardial Revascularization of the European Society of Cardiology (ESC) and the European Association for Cardio-thoracic Surgery (EACTS)","volume":"35","author":"Windecker","year":"2014","journal-title":"Eur Heart J"},{"key":"10.1016\/j.echo.2019.04.424_bib6","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/j.amjcard.2008.10.033","article-title":"Additive prognostic value of coronary flow reserve in patients with chest pain syndromes and normal or near-normal coronary arteries","volume":"103","author":"Sicori","year":"2009","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.echo.2019.04.424_bib7","doi-asserted-by":"crossref","first-page":"2825","DOI":"10.1016\/j.jacc.2010.01.054","article-title":"Coronary microvascular reactivity to adenosine predicts adverse outcomes in women evaluated for suspected ischemia: results from the National Heart, Lung and Blood Institute WISE Study","volume":"55","author":"Pepine","year":"2010","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.echo.2019.04.424_bib8","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1161\/CIRCINTERVENTIONS.111.966556","article-title":"Coronary microvascular resistance is independent of epicardial stenosis","volume":"5","author":"Yong","year":"2012","journal-title":"Circ Cardiovasc Interv"},{"key":"10.1016\/j.echo.2019.04.424_bib9","doi-asserted-by":"crossref","first-page":"1858","DOI":"10.1161\/CIRCULATIONAHA.112.120402","article-title":"Association between coronary vascular dysfunction and cardiac mortality in patients with and without diabetes mellitus","volume":"126","author":"Murthy","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.echo.2019.04.424_bib10","doi-asserted-by":"crossref","first-page":"2560","DOI":"10.1161\/01.CIR.103.21.2560","article-title":"Noninvasive quantification of coronary blood flow reserve in humans using myocardial contrast echocardiography","volume":"103","author":"Wei","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.echo.2019.04.424_bib11","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1161\/01.CIR.103.2.184","article-title":"Role of variability in microvascular resistance on fractional flow reserve and coronary blood flow velocity reserve in intermediate coronary lesions","volume":"103","author":"Meuwissen","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.echo.2019.04.424_bib12","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1161\/CIRCINTERVENTIONS.113.000926","article-title":"Baseline instantaneous wave-free ratio as a pressure-only estimation of underlying coronary flow reserve: results of the JUSTIFY-CFR Study","volume":"7","author":"Petraco","year":"2014","journal-title":"Circ Cardiovasc Interv"},{"key":"10.1016\/j.echo.2019.04.424_bib13","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1016\/j.jacc.2013.01.034","article-title":"Diagnostic classification of the instantaneous wave-free ratio is equivalent to fractional flow reserve and is not improved with adenosine administration","volume":"61","author":"Sen","year":"2013","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.echo.2019.04.424_bib14","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1161\/CIRCINTERVENTIONS.113.000591","article-title":"Hemodynamic response to intravenous adenosine and its effect on fractional flow reserve assessment: results of the Adenosine for the Functional Evaluation of Coronary Stenosis Severity (AFFECTS) Study","volume":"6","author":"Tarkin","year":"2013","journal-title":"Circ Cardiovasc Interv"},{"key":"10.1016\/j.echo.2019.04.424_bib15","first-page":"H2363","article-title":"Role of capillaries in determining CBF reserve: new insights using myocardial contrast echocardiography","volume":"277","author":"Jayaweera","year":"1999","journal-title":"Am J Physiol"},{"key":"10.1016\/j.echo.2019.04.424_bib16","doi-asserted-by":"crossref","first-page":"H1896","DOI":"10.1152\/ajpheart.2001.280.4.H1896","article-title":"Mechanism of reversible (99m) Tc-sestamibi perfusion defects during pharmacologically induced vasodilatation","volume":"280","author":"Wei","year":"2001","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.echo.2019.04.424_bib17","doi-asserted-by":"crossref","first-page":"e004129","DOI":"10.1161\/CIRCIMAGING.116.004129","article-title":"Comparison of fractional flow reserve assessment with demand stress myocardial contrast echocardiography in angiographically intermediate stenoses","volume":"9","author":"Wu","year":"2016","journal-title":"Circ Cardiovasc Imaging"},{"key":"10.1016\/j.echo.2019.04.424_bib18","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1136\/heartjnl-2013-305124","article-title":"Impact of hyperemic microvascular resistance on fractional flow reserve measurements in patients with stable coronary artery disease: insights from combined stenosis and microvascular resistance assessment","volume":"100","author":"van de Hoef","year":"2014","journal-title":"Heart"},{"key":"10.1016\/j.echo.2019.04.424_bib19","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/j.echo.2014.05.011","article-title":"Guidelines for the cardiac sonographer in the performance of contrast echocardiography: a focused update from the American Society of Echocardiography","volume":"27","author":"Porter","year":"2014","journal-title":"J Am Society of Echocardiogr"},{"key":"10.1016\/j.echo.2019.04.424_bib20","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.echo.2017.11.013","article-title":"Clinical applications of ultrasonic enhancing agents in echocardiography: 2018 American Society of Echocardiography guidelines update","volume":"31","author":"Porter","year":"2018","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.echo.2019.04.424_bib21","doi-asserted-by":"crossref","first-page":"2246","DOI":"10.1016\/j.jacc.2013.04.019","article-title":"Patient outcome following 2 different stress imaging approaches","volume":"61","author":"Porter","year":"2013","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.echo.2019.04.424_bib22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.echo.2014.10.003","article-title":"Recommendations for cardiac chamber quantification by echocardiography in adults: An update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging","volume":"28","author":"Lang","year":"2015","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.echo.2019.04.424_bib23","doi-asserted-by":"crossref","first-page":"H2194","DOI":"10.1152\/ajpheart.01021.2002","article-title":"Association between coronary lesion severity and distal microvascular resistance in patients with coronary artery disease","volume":"285","author":"Chamuleau","year":"2003","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.echo.2019.04.424_bib24","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1161\/CIRCULATIONAHA.112.110031","article-title":"Prognostic Value of High-Dose Dipyrimadole Stress Myocardial Contrast Perfusion Echocardiography\/Clinical Perspective","volume":"126","author":"Gaibazzi","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.echo.2019.04.424_bib25","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.echo.2013.01.016","article-title":"Prognostic value of qualitative and quantitative vasodilator stress myocardial perfusion echocardiography in patients with known or suspected coronary artery disease","volume":"26","author":"Mattoso","year":"2013","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.echo.2019.04.424_bib26","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1067\/mje.2001.115982","article-title":"Quantification of myocardial perfusion and determination of coronary stenosis severity during hyperemia using real-time myocardial contrast echocardiography","volume":"14","author":"Leong-Poi","year":"2001","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.echo.2019.04.424_bib27","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1161\/CIRCULATIONAHA.107.747303","article-title":"Myocardial contrast echocardiography: a 25-year retrospective","volume":"118","author":"Kaul","year":"2008","journal-title":"Circulation"}],"container-title":["Journal of the American Society of Echocardiography"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0894731719306789?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0894731719306789?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T05:05:23Z","timestamp":1760245523000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0894731719306789"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":27,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["S0894731719306789"],"URL":"https:\/\/doi.org\/10.1016\/j.echo.2019.04.424","relation":{},"ISSN":["0894-7317"],"issn-type":[{"value":"0894-7317","type":"print"}],"subject":[],"published":{"date-parts":[[2019,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Relationship of Capillary Blood Flow Assessments with Real Time Myocardial Perfusion Echocardiography to Invasively Derived Microvascular and Epicardial Assessments","name":"articletitle","label":"Article Title"},{"value":"Journal of the American Society of Echocardiography","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.echo.2019.04.424","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"2019 by the American Society of Echocardiography.","name":"copyright","label":"Copyright"}]}}