{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T01:17:01Z","timestamp":1788916621805,"version":"build-2803163510"},"reference-count":36,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","onlinejase.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the American Society of Echocardiography"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1016\/j.echo.2019.05.012","type":"journal-article","created":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T16:56:02Z","timestamp":1562000162000},"page":"1151-1160","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Therapeutic Ultrasound Increases Myocardial Blood Flow in Ischemic Myocardium and Cardiac Endothelial Cells: Results of In\u00a0Vivo and In\u00a0Vitro Experiments"],"prefix":"10.1016","volume":"32","author":[{"given":"Brian","family":"Mott","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azzdine Y.","family":"Ammi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. Elizabeth","family":"Le","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Davis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor V.","family":"Dykan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathew","family":"Nugent","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Minnier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohanika","family":"Gowda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nabil J.","family":"Alkayed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjiv","family":"Kaul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.echo.2019.05.012_bib1","first-page":"100","article-title":"Effect of ultrasonic energy on blood flow","volume":"33","author":"Imig","year":"1954","journal-title":"Am J Phys Med"},{"key":"10.1016\/j.echo.2019.05.012_bib2","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1161\/01.CIR.84.4.1783","article-title":"Ultrasonic energy: effects on vascular function and integrity","volume":"84","author":"Fischell","year":"1991","journal-title":"Circulation"},{"key":"10.1016\/j.echo.2019.05.012_bib3","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1016\/0735-1097(92)90032-I","article-title":"Clinical demonstration that catheter-delivered ultrasound energy reverses arterial vasoconstriction","volume":"20","author":"Siegel","year":"1992","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.echo.2019.05.012_bib4","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1093\/oxfordjournals.eurheartj.a060505","article-title":"Catheter-delivered high intensity, low frequency ultrasound induces vasodilation in\u00a0vivo","volume":"15","author":"Steffen","year":"1994","journal-title":"Eur Heart J"},{"key":"10.1016\/j.echo.2019.05.012_bib5","doi-asserted-by":"crossref","first-page":"2296","DOI":"10.1161\/01.CIR.101.19.2296","article-title":"Effect of 40-Khz ultrasound on acute thrombotic ischemia in a rabbit femoral artery thrombosis model: enhancement of thrombolysis and improvement in capillary muscle perfusion","volume":"101","author":"Suchkova","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.echo.2019.05.012_bib6","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1055\/s-0037-1613315","article-title":"Ultrasound improves tissue perfusion in ischemic tissue through a nitric oxide dependent mechanism","volume":"88","author":"Suchkova","year":"2002","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.echo.2019.05.012_bib7","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1016\/j.jacc.2004.06.062","article-title":"Ultrasound energy improves myocardial perfusion in the presence of coronary occlusion","volume":"44","author":"Siegel","year":"2004","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.echo.2019.05.012_bib8","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1016\/j.ultrasmedbio.2007.03.008","article-title":"Ultrasound at 27 khz increases tissue expression and activity of nitric oxide synthases in acute limb ischemia in rabbits","volume":"33","author":"Atar","year":"2007","journal-title":"Ultrasound Med Biol"},{"key":"10.1016\/j.echo.2019.05.012_bib9","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1080\/10739680701410280","article-title":"The use of diagnostic frequency continuous ultrasound to improve microcirculatory function after ischemia-reperfusion injury","volume":"14","author":"Hightower","year":"2007","journal-title":"Microcirculation"},{"key":"10.1016\/j.echo.2019.05.012_bib10","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.ultsonch.2008.05.007","article-title":"Early iNOS impairment and late eNOS enhancement during reperfusion following 2.49 MHz continuous ultrasound exposure after ischemia","volume":"16","author":"Hightower","year":"2009","journal-title":"Ultrasonics Sonochemistry"},{"key":"10.1016\/j.echo.2019.05.012_bib11","doi-asserted-by":"crossref","first-page":"H583","DOI":"10.1152\/ajpheart.00690.2014","article-title":"Ultrasound stimulates formation and release of vasoactive compounds in brain endothelial cells","volume":"309","author":"Davis","year":"2015","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.echo.2019.05.012_bib12","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1160\/TH14-03-0286","article-title":"Efficacy and spatial distribution of ultrasound-mediated clot lysis in the absence of thrombolytics","volume":"113","author":"Ammi","year":"2015","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.echo.2019.05.012_bib13","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1016\/S0735-1097(10)80154-8","article-title":"Relation between anterograde blood flow through a coronary artery and the perfusion bed it supplies: experimental and clinical implications","volume":"17","author":"Kaul","year":"1991","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.echo.2019.05.012_bib14","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1016\/S0735-1097(84)80149-7","article-title":"Contrast echocardiography in acute myocardial ischemia: I- In-vivo determination of total left ventricular \u201carea at risk\u201d","volume":"4","author":"Kaul","year":"1984","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.echo.2019.05.012_bib15","doi-asserted-by":"crossref","first-page":"2471","DOI":"10.1161\/hc4501.098954","article-title":"Noninvasive prediction of ultimate infarct size at the time of acute coronary occlusion based on the extent and magnitude of collateral-derived myocardial blood flow","volume":"104","author":"Coggins","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.echo.2019.05.012_bib16","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1161\/01.CIR.97.5.473","article-title":"Quantification of myocardial blood flow with ultrasound-induced destruction of microbubbles administered as a constant venous infusion","volume":"97","author":"Wei","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.echo.2019.05.012_bib17","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0894-7317(14)80100-4","article-title":"A computer-aided approach for the quantitation of regional left ventricular function using two-dimensional echocardiography","volume":"5","author":"Sklenar","year":"1992","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.echo.2019.05.012_bib18","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/0002-8703(81)90226-X","article-title":"Early phase acute myocardial infarct size quantification: validation of the triphenyl tetrazolium chloride tissue enzyme staining technique","volume":"101","author":"Fishbein","year":"1981","journal-title":"Am Heart J"},{"key":"10.1016\/j.echo.2019.05.012_bib19","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.jcin.2009.11.020","article-title":"Adjunctive transcutaneous ultrasound with thrombolysis: results of the PLUS (Perfusion by Thrombolytic and Ultrasound) trial","volume":"3","author":"Hudson","year":"2010","journal-title":"JACC Cardiovasc Interv"},{"key":"10.1016\/j.echo.2019.05.012_bib20","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0008-6363(99)00301-6","article-title":"ST segment elevation in the electrocardiogram: a sign of myocardial ischemia","volume":"45","author":"Kleber","year":"2000","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.echo.2019.05.012_bib21","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/S0002-9149(02)03243-5","article-title":"Myocardial contrast echocardiography, single photon emission computed tomography and regional function analysis for coronary stenosis detection during vasodilator stress","volume":"91","author":"Lepper","year":"2003","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.echo.2019.05.012_bib22","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1111\/j.1538-7836.2004.00655.x","article-title":"Low-intensity ultrasound increases endothelial cell nitric oxide synthase activity and nitric oxide synthesis","volume":"2","author":"Altland","year":"2004","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.echo.2019.05.012_bib23","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.ultrasmedbio.2007.08.008","article-title":"Nitric oxide generation directly responds to ultrasound exposure","volume":"34","author":"Sugita","year":"2008","journal-title":"Ultrasound Med Biol"},{"key":"10.1016\/j.echo.2019.05.012_bib24","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1023\/A:1007209321969","article-title":"Cardioprotective effects of adenosine a1 and a3 receptor activation during hypoxia in isolated rat cardiac myocytes","volume":"217","author":"Safran","year":"2001","journal-title":"Mol Cell Biochem"},{"key":"10.1016\/j.echo.2019.05.012_bib25","first-page":"H501","article-title":"A novel cardioprotective function of adenosine a1 and a3 receptors during prolonged simulated ischemia","volume":"273","author":"Stambaugh","year":"1997","journal-title":"Am J Physiol"},{"key":"10.1016\/j.echo.2019.05.012_bib26","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1097\/00005344-200403000-00013","article-title":"Post-ischemic cardioprotection by A2A adenosine receptors: dependent of phosphatidylinositol 3-kinase pathway","volume":"43","author":"Boucher","year":"2004","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.1016\/j.echo.2019.05.012_bib27","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/0002-8703(92)90643-A","article-title":"The effects of intravenous infusions of selective adenosine a1-receptor and a2-receptor agonists on myocardial reperfusion injury","volume":"123","author":"Norton","year":"1992","journal-title":"Am Heart J"},{"key":"10.1016\/j.echo.2019.05.012_bib28","first-page":"H441","article-title":"Endogenous adenosine protects preconditioned heart during early minutes of reperfusion by activating akt","volume":"290","author":"Solenkova","year":"2006","journal-title":"Am J Physiol"},{"key":"10.1016\/j.echo.2019.05.012_bib29","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.cardiores.2005.02.015","article-title":"Postconditioning reduces infarct size via adenosine receptor activation by endogenous adenosine","volume":"67","author":"Kin","year":"2005","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.echo.2019.05.012_bib30","first-page":"H1660","article-title":"Beneficial effects of adenosine a(2a) agonist cgs-21680 in infarcted and stunned porcine myocardium","volume":"280","author":"Lasley","year":"2001","journal-title":"Am J Physiol"},{"key":"10.1016\/j.echo.2019.05.012_bib31","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/j.yjmcc.2009.08.009","article-title":"Adenosine a2a and a2b receptors work in concert to induce a strong protection against reperfusion injury in rat hearts","volume":"47","author":"Xi","year":"2009","journal-title":"J Mol CellCardiol"},{"key":"10.1016\/j.echo.2019.05.012_bib32","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1124\/jpet.113.210120","article-title":"20-hete regulates the angiogenic functions of human endothelial progenitor cells and contributes to angiogenesis in\u00a0vivo","volume":"348","author":"Chen","year":"2014","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.echo.2019.05.012_bib33","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1152\/physrev.00021.2001","article-title":"P-450 metabolites of arachidonic acid in the control of cardiovascular function","volume":"82","author":"Roman","year":"2002","journal-title":"Physiol Rev"},{"key":"10.1016\/j.echo.2019.05.012_bib34","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.prostaglandins.2006.05.017","article-title":"Role of epoxyeicosatrienoic acids in protecting the myocardium following ischemia\/reperfusion injury","volume":"82","author":"Seubert","year":"2007","journal-title":"Prostaglandins Other Lipid Mediat"},{"key":"10.1016\/j.echo.2019.05.012_bib35","first-page":"H537","article-title":"Epoxyeicosatrienoic acids in cardioprotection: ischemic versus reperfusion injury","volume":"291","author":"Nithipatikom","year":"2006","journal-title":"Am J Physiol"},{"key":"10.1016\/j.echo.2019.05.012_bib36","doi-asserted-by":"crossref","first-page":"2648","DOI":"10.1074\/jbc.M306849200","article-title":"20-Hydroxyeicosatetraenoic acid (20-HETE) metabolism in coronary endothelial cells","volume":"279","author":"Kaduce","year":"2004","journal-title":"J Biol Chem"}],"container-title":["Journal of the American Society of Echocardiography"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0894731719306881?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0894731719306881?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T05:05:43Z","timestamp":1760245543000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0894731719306881"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":36,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["S0894731719306881"],"URL":"https:\/\/doi.org\/10.1016\/j.echo.2019.05.012","relation":{},"ISSN":["0894-7317"],"issn-type":[{"value":"0894-7317","type":"print"}],"subject":[],"published":{"date-parts":[[2019,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Therapeutic Ultrasound Increases Myocardial Blood Flow in Ischemic Myocardium and Cardiac Endothelial Cells: Results of In\u00a0Vivo and In\u00a0Vitro Experiments","name":"articletitle","label":"Article Title"},{"value":"Journal of the American Society of Echocardiography","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.echo.2019.05.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"2019 Published by Elsevier Inc. on behalf of the American Society of Echocardiography.","name":"copyright","label":"Copyright"}]}}