{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T13:05:02Z","timestamp":1769605502417,"version":"3.49.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","onlinejase.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the American Society of Echocardiography"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1016\/j.echo.2019.05.020","type":"journal-article","created":{"date-parts":[[2019,7,31]],"date-time":"2019-07-31T17:30:59Z","timestamp":1564594259000},"page":"1307-1317","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["Age- and Gender-Specific Prognostic Cutoff Values of Coronary Flow Velocity Reserve in Vasodilator Stress Echocardiography"],"prefix":"10.1016","volume":"32","author":[{"given":"Lauro","family":"Cortigiani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quirino","family":"Ciampi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Lombardo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fausto","family":"Rigo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Bovenzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eugenio","family":"Picano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.echo.2019.05.020_bib1","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/j.echo.2007.07.003","article-title":"American Society of Echocardiography recommendations for performance, interpretation, and application of stress echocardiography","volume":"20","author":"Pellikka","year":"2007","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.echo.2019.05.020_bib2","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1093\/ejechocard\/jen175","article-title":"Stress echocardiography expert consensus statement from the European Association of Echocardiography","volume":"9","author":"Sicari","year":"2008","journal-title":"Eur J Echocardiogr"},{"key":"10.1016\/j.echo.2019.05.020_bib3","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1016\/j.jcmg.2012.08.007","article-title":"Coronary flow reserve during dipyridamole stress echocardiography predicts mortality","volume":"5","author":"Cortigiani","year":"2012","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1016\/j.echo.2019.05.020_bib4","first-page":"653","article-title":"Prognostic value of Doppler echocardiographic derived coronary flow velocity reserve of left anterior descending artery in octogenarians with stress echocardiography negative for wall motion criteria","volume":"16","author":"Cortigiani","year":"2015","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"10.1016\/j.echo.2019.05.020_bib5","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.echo.2016.02.011","article-title":"Coronary flow velocity reserve assessed by transthoracic Doppler: the iPOWER study. Factors influencing feasibility and quality","volume":"29","author":"Michelsen","year":"2016","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.echo.2019.05.020_bib6","series-title":"Sex-Specific Analysis of Cardiovascular Function","first-page":"361","article-title":"Heart function analysis in cardiac patients with focus on sex-specific aspects","author":"Kerkhof","year":"2018"},{"key":"10.1016\/j.echo.2019.05.020_bib7","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/1476-7120-10-20","article-title":"The impact of aging and atherosclerotic risk factors on transthoracic coronary flow reserve in subjects with normal coronary angiography","volume":"10","author":"Galderisi","year":"2012","journal-title":"Cardiovasc Ultrasound"},{"key":"10.1016\/j.echo.2019.05.020_bib8","doi-asserted-by":"crossref","first-page":"1964","DOI":"10.1007\/s00259-018-4046-8","article-title":"Sex differences in the long-term prognostic value of 13N-ammonia myocardial perfusion positron emission tomography","volume":"45","author":"Gebhard","year":"2018","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"10.1016\/j.echo.2019.05.020_bib9","author":"World Health Organization"},{"key":"10.1016\/j.echo.2019.05.020_bib10","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1093\/eurheartj\/eht151","article-title":"2013 ESH\/ESC guidelines for the management of arterial hypertension: the Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC)","volume":"34","author":"Mancia","year":"2013","journal-title":"Eur Heart J"},{"key":"10.1016\/j.echo.2019.05.020_bib11","series-title":"Detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III) final report","year":"2002"},{"key":"10.1016\/j.echo.2019.05.020_bib12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.echo.2014.10.003","article-title":"Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging","volume":"28","author":"Lang","year":"2015","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.echo.2019.05.020_bib13","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.ijcard.2017.09.172","article-title":"Quality control of regional wall motion analysis in stress echo 2020","volume":"249","author":"Ciampi","year":"2017","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.echo.2019.05.020_bib14","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/S0140-6736(97)22010-6","article-title":"Dead is dead\u2014artificial definitions are no substitute","volume":"349","author":"Gottlieb","year":"1997","journal-title":"Lancet"},{"key":"10.1016\/j.echo.2019.05.020_bib15","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/S0735-1097(99)00250-8","article-title":"Cause of death in clinical research: time for a reassessment?","volume":"34","author":"Lauer","year":"1999","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.echo.2019.05.020_bib16","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/j.echo.2017.11.019","article-title":"Integration of wall motion, coronary flow velocity and left ventricular contractile reserve in a single test: Prognostic value of vasodilator stress echocardiography in diabetic patients","volume":"31","author":"Cortigiani","year":"2018","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.echo.2019.05.020_bib17","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1016\/0735-1097(93)90762-P","article-title":"Prognostic value of dipyridamole echocardiography early after myocardial infarction in elderly patients","volume":"22","author":"Camerieri","year":"1993","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.echo.2019.05.020_bib18","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1016\/j.amjcard.2007.01.019","article-title":"Prognostic implication of dipyridamole or dobutamine stress echocardiography for evaluation of patients >or\u00a0= 65 years of age with known or suspected coronary artery disease","volume":"99","author":"Cortigiani","year":"2007","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.echo.2019.05.020_bib19","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1016\/j.ahj.2010.12.017","article-title":"Does the prognostic value of dobutamine stress echocardiography differ among different age groups?","volume":"161","author":"Bernheim","year":"2011","journal-title":"Am Heart J"},{"key":"10.1016\/j.echo.2019.05.020_bib20","doi-asserted-by":"crossref","first-page":"2356","DOI":"10.1016\/j.ijcard.2012.11.044","article-title":"Stress echocardiography for risk assessment in octogenarians","volume":"167","author":"Cortigiani","year":"2013","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.echo.2019.05.020_bib21","doi-asserted-by":"crossref","first-page":"e007322","DOI":"10.1161\/CIRCIMAGING.117.007322","article-title":"Is there an age when myocardial perfusion imaging may no longer be prognostically useful?","volume":"11","author":"Erthal","year":"2018","journal-title":"Circ Cardiovasc Imaging"},{"key":"10.1016\/j.echo.2019.05.020_bib22","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.echo.2016.10.016","article-title":"The clinical use of stress echocardiography in non-ischaemic heart disease: recommendations from the European Association of Cardiovascular Imaging and the American Society of Echocardiography","volume":"30","author":"Lancellotti","year":"2017","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.echo.2019.05.020_bib23","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1016\/j.jacc.2015.12.053","article-title":"Coronary flow reserve and microcirculatory resistance in patients with intermediate coronary stenosis","volume":"67","author":"Lee","year":"2016","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.echo.2019.05.020_bib24","doi-asserted-by":"crossref","first-page":"2518","DOI":"10.1161\/CIRCULATIONAHA.113.008507","article-title":"Effects of sex on coronary microvascular dysfunction and cardiac outcomes","volume":"129","author":"Murthy","year":"2014","journal-title":"Circulation"},{"key":"10.1016\/j.echo.2019.05.020_bib25","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1016\/j.jacc.2007.06.027","article-title":"Additional prognostic value of coronary flow reserve in diabetic and nondiabetic patients with negative dipyridamole stress echocardiography by wall motion criteria","volume":"50","author":"Cortigiani","year":"2007","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.echo.2019.05.020_bib26","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1093\/eurheartj\/ehs310","article-title":"Prognostic implication of Doppler echocardiographic derived coronary flow reserve in patients with left bundle branch block","volume":"34","author":"Cortigiani","year":"2013","journal-title":"Eur Heart J"},{"key":"10.1016\/j.echo.2019.05.020_bib27","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1016\/j.echo.2014.05.009","article-title":"Coronary flow reserve during pharmacologic stress echocardiography with normal contractility adds important prognostic value in diabetic and nondiabetic patients","volume":"27","author":"Lowenstein","year":"2014","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.echo.2019.05.020_bib28","first-page":"1179","article-title":"The additive prognostic value of coronary flow velocity reserve during exercise echocardiography","volume":"18","author":"Zagatina","year":"2017","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"10.1016\/j.echo.2019.05.020_bib29","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1136\/heartjnl-2011-300178","article-title":"Diagnostic and prognostic value of Doppler echocardiographic coronary flow reserve in left anterior descending artery in hypertensive and normotensive patients","volume":"97","author":"Cortigiani","year":"2011","journal-title":"Heart"},{"key":"10.1016\/j.echo.2019.05.020_bib30","doi-asserted-by":"crossref","first-page":"2825","DOI":"10.1016\/j.jacc.2010.01.054","article-title":"Coronary microvascular reactivity to adenosine predicts adverse outcome in women evaluated for suspected ischemia results from the National, Heart, Lung and Blood Institute WISE (Women's Ischemia Syndrome Evaluation) study","volume":"55","author":"Pepine","year":"2010","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.echo.2019.05.020_bib31","doi-asserted-by":"crossref","first-page":"e008062","DOI":"10.1161\/CIRCIMAGING.118.008062","article-title":"Prognosticating in the very elderly","volume":"11","author":"Thompson","year":"2018","journal-title":"Circ Cardiovasc Imaging"},{"key":"10.1016\/j.echo.2019.05.020_bib32","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1016\/S0140-6736(15)60466-4","article-title":"Aging, health, and social care: reframing the discussion","volume":"385","author":"Davis","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.echo.2019.05.020_bib33","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1002\/jhm.2145","article-title":"US population aging and demand for inpatient services","volume":"9","author":"Palin","year":"2014","journal-title":"J Hosp Med"},{"key":"10.1016\/j.echo.2019.05.020_bib34","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s12947-016-0092-1","article-title":"Stress echo 2020: the International stress echo study in ischemic and non-ischemic heart disease","volume":"15","author":"Picano","year":"2017","journal-title":"Cardiovasc Ultrasound"},{"key":"10.1016\/j.echo.2019.05.020_bib35","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1161\/CIRCULATIONAHA.105.603050","article-title":"Evidence of a dominant backward-propagating \u201csuction\u201d wave responsible for diastolic coronary filling in humans, attenuated in left ventricular hypertrophy","volume":"113","author":"Davies","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.echo.2019.05.020_bib36","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1093\/eurheartj\/14.9.1216","article-title":"Enhanced sensitivity for detection of coronary artery disease by addition of atropine to dipyridamole echocardiography","volume":"14","author":"Picano","year":"1993","journal-title":"Eur Heart J"},{"key":"10.1016\/j.echo.2019.05.020_bib37","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/S0002-9149(00)01424-7","article-title":"Safety, feasibility and diagnostic accuracy of accelerated high dose dipyridamole stress echocardiography","volume":"87","author":"Dal Porto","year":"2001","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.echo.2019.05.020_bib38","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1161\/01.CIR.85.4.1604","article-title":"Stress echocardiography: from pathophysiological toy to diagnostic tool","volume":"85","author":"Picano","year":"1992","journal-title":"Circulation"}],"container-title":["Journal of the American Society of Echocardiography"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0894731719307539?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0894731719307539?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T05:05:26Z","timestamp":1760245526000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0894731719307539"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":38,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["S0894731719307539"],"URL":"https:\/\/doi.org\/10.1016\/j.echo.2019.05.020","relation":{},"ISSN":["0894-7317"],"issn-type":[{"value":"0894-7317","type":"print"}],"subject":[],"published":{"date-parts":[[2019,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Age- and Gender-Specific Prognostic Cutoff Values of Coronary Flow Velocity Reserve in Vasodilator Stress Echocardiography","name":"articletitle","label":"Article Title"},{"value":"Journal of the American Society of Echocardiography","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.echo.2019.05.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"2019 by the American Society of Echocardiography.","name":"copyright","label":"Copyright"}]}}