{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T13:57:19Z","timestamp":1791813439745,"version":"4.3.4"},"reference-count":39,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","onlinejase.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the American Society of Echocardiography"],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.1016\/j.echo.2021.02.017","type":"journal-article","created":{"date-parts":[[2021,3,13]],"date-time":"2021-03-13T21:55:09Z","timestamp":1615672509000},"page":"744-756","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Recurrence of Functional Versus Organic Mitral Regurgitation After Transcatheter Mitral Valve Repair: Implications from Three-Dimensional Echocardiographic Analysis of Mitral Valve Geometry and Left Ventricular Dilation for a Point of No Return"],"prefix":"10.1016","volume":"34","author":[{"given":"Thomas","family":"Buck","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nora","family":"Eiswirth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Farah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heike","family":"Kahlert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Polykarpos C.","family":"Patsalis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Kahlert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bj\u00f6rn","family":"Plicht","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.echo.2021.02.017_bib1","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/S0140-6736(06)69208-8","article-title":"Burden of valvular heart diseases: a population-based study","volume":"368","author":"Nkomo","year":"2006","journal-title":"Lancet"},{"key":"10.1016\/j.echo.2021.02.017_bib2","first-page":"239","article-title":"Chronic aortic and mitral regurgitation","volume":"9","author":"Zile","year":"1991","journal-title":"Clin Cardiol"},{"key":"10.1016\/j.echo.2021.02.017_bib3","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/S0022-5223(19)37942-5","article-title":"Reconstructive surgery of mitral valve incompetence: ten-year appraisal","volume":"79","author":"Carpentier","year":"1980","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.echo.2021.02.017_bib4","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1016\/j.jacc.2009.03.077","article-title":"Percutaneous mitral repair with the MitraClip system: safety and midterm durability in the initial EVEREST (Endovascular Valve Edge-to-Edge Repair Study) cohort","volume":"54","author":"Feldman","year":"2009","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.echo.2021.02.017_bib5","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1093\/eurheartj\/ehv627","article-title":"One-year outcomes and predictors of mortality after MitraClip therapy in contemporary clinical practice: results from the German transcatheter mitral valve interventions registry","volume":"37","author":"Puls","year":"2016","journal-title":"Eur Heart J"},{"key":"10.1016\/j.echo.2021.02.017_bib6","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1016\/j.jacc.2013.02.094","article-title":"Percutaneous mitral valve interventions in the real world: early and 1-year results from the ACCESS-EU, a prospective, multicenter, nonrandomized post-approval study of the MitraClip therapy in Europe","volume":"62","author":"Maisano","year":"2013","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.echo.2021.02.017_bib7","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.amjcard.2006.02.056","article-title":"Echocardiographic predictors of successful versus unsuccessful mitral valve repair in ischemic mitral regurgitation","volume":"98","author":"Kongsaerepong","year":"2006","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.echo.2021.02.017_bib8","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1093\/ejechocard\/jeq031","article-title":"European Association of Echocardiography recommendations for the assessment of valvular regurgitation. Part 2: mitral and tricuspid regurgitation (native valve disease)","volume":"11","author":"Lancellotti","year":"2010","journal-title":"Eur J Echocardiogr"},{"key":"10.1016\/j.echo.2021.02.017_bib9","first-page":"110","article-title":"2017 ESC\/EACTS guidelines for the management of valvular heart disease","volume":"71","author":"Baumgartner","year":"2018","journal-title":"Rev Esp Cardiol (Engl Ed)"},{"key":"10.1016\/j.echo.2021.02.017_bib10","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.jcmg.2008.01.011","article-title":"The role of imaging in chronic degenerative mitral regurgitation","volume":"1","author":"O\u2019Gara","year":"2008","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1016\/j.echo.2021.02.017_bib11","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1016\/j.echo.2009.07.007","article-title":"A framework for systematic characterization of the mitral valve by real-time three-dimensional transesophageal echocardiography","volume":"22","author":"Salcedo","year":"2009","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.echo.2021.02.017_bib12","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1161\/CIRCIMAGING.109.924332","article-title":"Characterization of degenerative mitral valve disease using morphologic analysis of real-time three-dimensional echocardiographic images: objective insight into complexity and planning of mitral valve repair","volume":"4","author":"Chandra","year":"2011","journal-title":"Circ Cardiovasc Imaging"},{"key":"10.1016\/j.echo.2021.02.017_bib13","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1093\/ejcts\/ezr040","article-title":"Can three-dimensional echocardiography accurately predict complexity of mitral valve repair?","volume":"41","author":"Chikwe","year":"2012","journal-title":"Eur J Cardiothorac Surg"},{"key":"10.1016\/j.echo.2021.02.017_bib14","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1161\/CIRCIMAGING.112.974691","article-title":"Analysis of procedural effects of percutaneous edge-to-edge mitral valve repair by 2D and 3D echocardiography","volume":"5","author":"Altiok","year":"2012","journal-title":"Circ Cardiovasc Imaging"},{"key":"10.1016\/j.echo.2021.02.017_bib15","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1093\/ehjci\/jes293","article-title":"Immediate effect of the MitraClip procedure on mitral ring geometry in primary and secondary mitral regurgitation","volume":"14","author":"Schmidt","year":"2013","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"10.1016\/j.echo.2021.02.017_bib16","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s40001-017-0273-x","article-title":"Acute reverse annular remodeling during MitraClip","volume":"22","author":"Herbrand","year":"2017","journal-title":"Eur J Med Res"},{"key":"10.1016\/j.echo.2021.02.017_bib17","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1161\/CIRCINTERVENTIONS.113.001098","article-title":"Acute changes of mitral valve geometry during interventional edge-to-edge repair with the MitraClip system are associated with midterm outcomes in patients with functional valve disease: preliminary results from a prospective single-center study","volume":"7","author":"Schueler","year":"2014","journal-title":"Circ Cardiovasc Interv"},{"key":"10.1016\/j.echo.2021.02.017_bib18","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.4244\/EIJY15M09_09","article-title":"Acute effect of MitraClip implantation on mitral valve geometry in patients with functional mitral regurgitation: insights from three-dimensional transoesophageal echocardiography","volume":"11","author":"Al Amri","year":"2016","journal-title":"EuroIntervention"},{"key":"10.1016\/j.echo.2021.02.017_bib19","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1016\/j.amjcard.2018.06.036","article-title":"Comprehensive assessment of mitral valve geometry and cardiac remodeling with 3-dimensional echocardiography after percutaneous mitral valve repair","volume":"122","author":"Mantegazza","year":"2018","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.echo.2021.02.017_bib20","doi-asserted-by":"crossref","first-page":"84","DOI":"10.4244\/EIJV9I1A13","article-title":"Acute outcomes after MitraClip therapy in highly aged patients: results from the German Transcatheter Mitral Valve Interventions (TRAMI) registry","volume":"9","author":"Schillinger","year":"2013","journal-title":"EuroIntervention"},{"key":"10.1016\/j.echo.2021.02.017_bib21","doi-asserted-by":"crossref","first-page":"2438","DOI":"10.1016\/j.jacc.2014.02.537","article-title":"2014 AHA\/ACC guideline for the management of patients with valvular heart disease: executive summary: a report of the American College of Cardiology\/American Heart Association Task Force on Practice Guidelines","volume":"63","author":"Nishimura","year":"2014","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.echo.2021.02.017_bib22","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1016\/j.echo.2008.02.003","article-title":"Direct assessment of size and shape of noncircular vena contracta area in functional versus organic mitral regurgitation using real-time three-dimensional echocardiography","volume":"21","author":"Kahlert","year":"2008","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.echo.2021.02.017_bib23","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.echo.2017.01.007","article-title":"Recommendations for noninvasive evaluation of native valvular regurgitation: a report from the American Society of Echocardiography developed in collaboration with the Society for Cardiovascular Magnetic Resonance","volume":"30","author":"Zoghbi","year":"2017","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.echo.2021.02.017_bib24","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/j.jcin.2016.12.280","article-title":"Elevated mitral valve pressure gradient after mitraclip implantation deteriorates long-term outcome in patients with severe mitral regurgitation and severe heart failure","volume":"10","author":"Neuss","year":"2017","journal-title":"JACC Cardiovasc Interv"},{"key":"10.1016\/j.echo.2021.02.017_bib25","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.jcmg.2012.03.008","article-title":"Direct measurement of multiple vena contracta areas for assessing the severity of mitral regurgitation using 3D TEE","volume":"5","author":"Hyodo","year":"2012","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1016\/j.echo.2021.02.017_bib26","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1161\/CIRCULATIONAHA.112.121590","article-title":"Quantitation of mitral regurgitation","volume":"126","author":"Grayburn","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.echo.2021.02.017_bib27","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1016\/j.athoracsur.2007.05.005","article-title":"Mitral valve tenting index for assessment of subvalvular remodeling","volume":"84","author":"Ryan","year":"2007","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.echo.2021.02.017_bib28","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1056\/NEJMoa1806640","article-title":"Transcatheter mitral-valve repair in patients with heart failure","volume":"379","author":"Stone","year":"2018","journal-title":"N Engl J Med"},{"key":"10.1016\/j.echo.2021.02.017_bib29","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1056\/NEJMoa1312808","article-title":"Mitral-valve repair versus replacement for severe ischemic mitral regurgitation","volume":"370","author":"Acker","year":"2014","journal-title":"N Engl J Med"},{"key":"10.1016\/j.echo.2021.02.017_bib30","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1016\/j.echo.2012.07.015","article-title":"Left cardiac chambers reverse remodeling after percutaneous mitral valve repair with the MitraClip system","volume":"25","author":"Scandura","year":"2012","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.echo.2021.02.017_bib31","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1093\/ehjci\/jex173","article-title":"Improved mitral valve coaptation and reduced mitral valve annular size after percutaneous mitral valve repair (PMVR) using the MitraClip system","volume":"19","author":"Patzelt","year":"2017","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"10.1016\/j.echo.2021.02.017_bib32","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.ijcard.2016.12.081","article-title":"Impact of interventional edge-to-edge repair on mitral valve geometry","volume":"230","author":"Schueler","year":"2017","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.echo.2021.02.017_bib33","doi-asserted-by":"crossref","first-page":"2298","DOI":"10.1161\/CIRCULATIONAHA.107.755942","article-title":"Left ventricular response to mitral regurgitation: implications for management","volume":"118","author":"Gaasch","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.echo.2021.02.017_bib34","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1159\/000351094","article-title":"Floppy mitral valve (FMV)\/mitral valve prolapse (MVP) and the FMV\/MVP syndrome: pathophysiologic mechanisms and pathogenesis of symptoms","volume":"126","author":"Boudoulas","year":"2013","journal-title":"Cardiology"},{"key":"10.1016\/j.echo.2021.02.017_bib35","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.1056\/NEJMoa1805374","article-title":"Percutaneous repair or medical treatment for secondary mitral regurgitation","volume":"379","author":"Obadia","year":"2018","journal-title":"N Engl J Med"},{"key":"10.1016\/j.echo.2021.02.017_bib36","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/j.ejcts.2004.12.031","article-title":"Preoperative left ventricular dimensions predict reverse remodeling following restrictive mitral annuloplasty in ischemic mitral regurgitation","volume":"27","author":"Braun","year":"2005","journal-title":"Eur J Cardiothorac Surg"},{"key":"10.1016\/j.echo.2021.02.017_bib37","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1510\/icvts.2006.146274","article-title":"Recurrence of functional mitral regurgitation in patients with dilated cardiomyopathy undergoing mitral valve repair: how to predict it","volume":"6","author":"Digiammarco","year":"2007","journal-title":"Interact Cardiovasc Thorac Surg"},{"key":"10.1016\/j.echo.2021.02.017_bib38","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1016\/j.echo.2019.05.022","article-title":"Changes in intraventricular flow patterns after MitraClip implant in patients with functional severe mitral regurgitation","volume":"32","author":"Filomena","year":"2019","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.echo.2021.02.017_bib39","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1007\/s12471-017-0992-1","article-title":"Current MitraClip experience, safety and feasibility in The Netherlands","volume":"25","author":"Rahhab","year":"2017","journal-title":"Neth Heart J"}],"container-title":["Journal of the American Society of Echocardiography"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0894731721001243?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0894731721001243?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T05:07:20Z","timestamp":1760245640000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0894731721001243"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":39,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["S0894731721001243"],"URL":"https:\/\/doi.org\/10.1016\/j.echo.2021.02.017","relation":{},"ISSN":["0894-7317"],"issn-type":[{"value":"0894-7317","type":"print"}],"subject":[],"published":{"date-parts":[[2021,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Recurrence of Functional Versus Organic Mitral Regurgitation After Transcatheter Mitral Valve Repair: Implications from Three-Dimensional Echocardiographic Analysis of Mitral Valve Geometry and Left Ventricular Dilation for a Point of No Return","name":"articletitle","label":"Article Title"},{"value":"Journal of the American Society of Echocardiography","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.echo.2021.02.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"2021 Published by Elsevier Inc. on behalf of the American Society of Echocardiography.","name":"copyright","label":"Copyright"}]}}