{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T10:44:48Z","timestamp":1788777888528,"version":"build-2803163510"},"reference-count":20,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","onlinejase.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the American Society of Echocardiography"],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1016\/j.echo.2021.12.002","type":"journal-article","created":{"date-parts":[[2021,12,13]],"date-time":"2021-12-13T20:01:48Z","timestamp":1639425708000},"page":"378-386.e3","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["The Association of Moderate Aortic Stenosis with Poor Survival Is Modified by Age and Left Ventricular Function: Insights from SHEBAHEART Big Data"],"prefix":"10.1016","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0142-0253","authenticated-orcid":false,"given":"Edward","family":"Itelman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ori","family":"Vatury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raphael","family":"Kuperstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sagit","family":"Ben-Zekry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Fefer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Israel","family":"Barbash","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Klempfner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit","family":"Segev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micha","family":"Feinberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Guetta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5087-0464","authenticated-orcid":false,"given":"Elad","family":"Maor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.echo.2021.12.002_bib1","doi-asserted-by":"crossref","first-page":"135","DOI":"10.4330\/wjc.v2.i6.135","article-title":"Aortic stenosis: an update","volume":"2","author":"Nathaniel","year":"2010","journal-title":"World J Cardiol"},{"key":"10.1016\/j.echo.2021.12.002_bib2","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1016\/S0195-668X(03)00201-X","article-title":"A prospective survey of patients with valvular heart disease in Europe: the Euro Heart Survey on Valvular Heart Disease","volume":"24","author":"Iung","year":"2003","journal-title":"Eur Heart J"},{"key":"10.1016\/j.echo.2021.12.002_bib3","doi-asserted-by":"crossref","first-page":"2739","DOI":"10.1093\/eurheartj\/ehx391","article-title":"2017 ESC\/EACTS guidelines for the management of valvular heart disease","volume":"38","author":"Baumgartner","year":"2017","journal-title":"Eur Heart J"},{"key":"10.1016\/j.echo.2021.12.002_bib4","first-page":"e521","article-title":"2014 AHA\/ACC guideline for the management of patients with valvular heart disease: a report of the American College of Cardiology\/American Heart Association Task Force on Practice Guidelines","volume":"129","author":"Nishimura","year":"2014","journal-title":"Circulation"},{"key":"10.1016\/j.echo.2021.12.002_bib5","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.echo.2020.11.015","article-title":"Excess mortality associated with progression rate in asymptomatic aortic valve stenosis","volume":"34","author":"Benfari","year":"2021","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.echo.2021.12.002_bib6","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.echo.2020.12.017","article-title":"Markers of elevated left ventricular filling pressure are associated with increased mortality in nonsevere aortic stenosis","volume":"34","author":"Giudicatti","year":"2021","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.echo.2021.12.002_bib7","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1016\/j.jacc.2019.08.004","article-title":"Poor long-term survival in patients with moderate aortic stenosis","volume":"74","author":"Strange","year":"2019","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.echo.2021.12.002_bib8","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.1016\/j.jacc.2017.03.023","article-title":"Prognostic implications of moderate aortic stenosis in patients with left ventricular systolic dysfunction","volume":"69","author":"van Gils","year":"2017","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.echo.2021.12.002_bib9","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1016\/j.jtcvs.2012.05.013","article-title":"The natural history of moderate aortic stenosis in a veteran population","volume":"145","author":"Yechoor","year":"2013","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.echo.2021.12.002_bib10","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1093\/oxfordjournals.eurheartj.a062307","article-title":"Spontaneous course of aortic valve disease","volume":"8","author":"Turina","year":"1987","journal-title":"Eur Heart J"},{"key":"10.1016\/j.echo.2021.12.002_bib11","doi-asserted-by":"crossref","first-page":"e011036","DOI":"10.1161\/JAHA.118.011036","article-title":"Characteristics and prognosis of patients with moderate aortic stenosis and preserved left ventricular ejection fraction","volume":"8","author":"Delesalle","year":"2019","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.echo.2021.12.002_bib12","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.ehj.2003.12.002","article-title":"Mild and moderate aortic stenosis. Natural history and risk stratification by echocardiography","volume":"25","author":"Rosenhek","year":"2004","journal-title":"Eur Heart J"},{"key":"10.1016\/j.echo.2021.12.002_bib13","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.ijcard.2004.03.027","article-title":"Visually estimated left ventricular ejection fraction by echocardiography is closely correlated with formal quantitative methods","volume":"101","author":"Gudmundsson","year":"2005","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.echo.2021.12.002_bib14","first-page":"221","article-title":"Using Israel\u2019s National Cancer Registry database to track progress in the war against cancer: a challenge for health services","volume":"19","author":"Robinson","year":"2017","journal-title":"Isr Med Assoc J"},{"key":"10.1016\/j.echo.2021.12.002_bib15","doi-asserted-by":"crossref","first-page":"791","DOI":"10.4070\/kcj.2020.0037","article-title":"Early surgery versus watchful waiting in patients with moderate aortic stenosis and left ventricular systolic dysfunction","volume":"50","author":"Moon","year":"2020","journal-title":"Korean Circ J"},{"key":"10.1016\/j.echo.2021.12.002_bib16","doi-asserted-by":"crossref","first-page":"e009958","DOI":"10.1161\/CIRCIMAGING.119.009958","article-title":"Left ventricular global longitudinal strain is associated with long-term outcomes in moderate aortic stenosis","volume":"13","author":"Zhu","year":"2020","journal-title":"Circ Cardiovasc Imaging"},{"key":"10.1016\/j.echo.2021.12.002_bib17","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1016\/j.amjcard.2020.02.004","article-title":"Prognostic value of N-terminal pro-form B-type natriuretic peptide in patients with moderate aortic stenosis","volume":"125","author":"Ito","year":"2020","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.echo.2021.12.002_bib18","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.ahj.2016.08.009","article-title":"Rationale and design of the Transcatheter Aortic Valve Replacement to Unload the Left Ventricle in Patients with Advanced Heart Failure (TAVR UNLOAD) trial","volume":"182","author":"Spitzer","year":"2016","journal-title":"Am Heart J"},{"key":"10.1016\/j.echo.2021.12.002_bib19","series-title":"Leading causes of death in Israel 2000\u20132016","author":"Goldberger","year":"2019"},{"key":"10.1016\/j.echo.2021.12.002_bib20","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/1476-7120-7-41","article-title":"Visually estimated ejection fraction by two dimensional and triplane echocardiography is closely correlated with quantitative ejection fraction by real-time three dimensional echocardiography","volume":"7","author":"Shahgaldi","year":"2009","journal-title":"Cardiovasc Ultrasound"}],"container-title":["Journal of the American Society of Echocardiography"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0894731721008646?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0894731721008646?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T05:09:17Z","timestamp":1760245757000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0894731721008646"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":20,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["S0894731721008646"],"URL":"https:\/\/doi.org\/10.1016\/j.echo.2021.12.002","relation":{},"ISSN":["0894-7317"],"issn-type":[{"value":"0894-7317","type":"print"}],"subject":[],"published":{"date-parts":[[2022,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Association of Moderate Aortic Stenosis with Poor Survival Is Modified by Age and Left Ventricular Function: Insights from SHEBAHEART Big Data","name":"articletitle","label":"Article Title"},{"value":"Journal of the American Society of Echocardiography","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.echo.2021.12.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"2021 by the American Society of Echocardiography.","name":"copyright","label":"Copyright"}]}}