{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T14:18:32Z","timestamp":1781360312380,"version":"3.54.1"},"reference-count":20,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","onlinejase.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the American Society of Echocardiography"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1016\/j.echo.2021.12.013","type":"journal-article","created":{"date-parts":[[2021,12,28]],"date-time":"2021-12-28T12:57:00Z","timestamp":1640696220000},"page":"570-575","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"title":["Reassessment of Vegetation Size as a Sole Indication for Surgery in Left-Sided Infective Endocarditis"],"prefix":"10.1016","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6945-1446","authenticated-orcid":false,"given":"Gonzalo","family":"Cabez\u00f3n","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isidre","family":"Vilacosta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"S\u00e1ez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo Elpidio","family":"Garc\u00eda-Granja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Olmos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adri\u00e1n","family":"Jer\u00f3nimo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1ngela","family":"Guti\u00e9rrez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paloma","family":"Pulido","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"de Miguel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Itz\u00edar","family":"G\u00f3mez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Alberto","family":"San Rom\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.echo.2021.12.013_bib1","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1161\/CIRCULATIONAHA.109.877365","article-title":"Age-dependent profile of left-sided infective endocarditis: a 3-center experience","volume":"121","author":"L\u00f3pez","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.echo.2021.12.013_bib2","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.jacc.2016.10.052","article-title":"Evolution of prognosis in left-sided infective endocarditis: a propensity score analysis of 2 decades","volume":"69","author":"Sevilla","year":"2017","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.echo.2021.12.013_bib3","doi-asserted-by":"crossref","first-page":"3075","DOI":"10.1093\/eurheartj\/ehv319","volume":"36","author":"Habib","year":"2015","journal-title":"Eur Heart J"},{"key":"10.1016\/j.echo.2021.12.013_bib4","first-page":"e35","article-title":"2020 ACC\/AHA guideline for the management of patients with valvular heart disease: executive summary: a report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines","volume":"143","author":"Otto","year":"2021","journal-title":"Circulation"},{"key":"10.1016\/j.echo.2021.12.013_bib5","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1001\/jamainternmed.2017.8653","article-title":"Association of vegetation size with embolic risk in patients with infective endocarditis: a systematic review and meta-analysis","volume":"178","author":"Mohananey","year":"2018","journal-title":"JAMA Intern Med"},{"key":"10.1016\/j.echo.2021.12.013_bib6","doi-asserted-by":"crossref","first-page":"2243","DOI":"10.1093\/eurheartj\/ehz204","article-title":"The association between vegetation size and surgical treatment on 6-month mortality in left-sided infective endocarditis","volume":"40","author":"Fosb\u00f8l","year":"2019","journal-title":"Eur Heart J"},{"key":"10.1016\/j.echo.2021.12.013_bib7","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1086\/313753","article-title":"Proposed modifications to the Duke criteria for the diagnosis of infective endocarditis","volume":"30","author":"Li","year":"2000","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.echo.2021.12.013_bib8","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1093\/eurheartj\/ehs379","article-title":"Prognostic role of persistent positive blood cultures after initiation of antibiotic therapy in left-sided infective endocarditis","volume":"34","author":"L\u00f3pez","year":"2013","journal-title":"Eur Heart J"},{"key":"10.1016\/j.echo.2021.12.013_bib9","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1016\/j.jacc.2015.07.016","article-title":"Critical questions about left-sided infective endocarditis","volume":"66","author":"San Rom\u00e1n","year":"2015","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.echo.2021.12.013_bib10","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1016\/0735-1097(91)90535-H","article-title":"Echocardiographic assessment of patients with infectious endocarditis: prediction of risk for complications","volume":"18","author":"Sanfilippo","year":"1991","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.echo.2021.12.013_bib11","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.ijcard.2008.05.011","article-title":"Vegetation size at diagnosis in infective endocarditis: influencing factors and prognostic implications","volume":"137","author":"Luaces","year":"2009","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.echo.2021.12.013_bib12","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1016\/j.ahj.2007.07.023","article-title":"The relationship between the initiation of antimicrobial therapy and the incidence of stroke in infective endocarditis: an analysis from the ICE Prospective Cohort Study (ICE-PCS)","volume":"154","author":"Dickerman","year":"2007","journal-title":"Am Heart J"},{"key":"10.1016\/j.echo.2021.12.013_bib13","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1016\/S0735-1097(02)01790-4","article-title":"Risk of embolization after institution of antibiotic therapy for infective endocarditis","volume":"39","author":"Vilacosta","year":"2002","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.echo.2021.12.013_bib14","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1136\/hrt.2003.032128","article-title":"Infective endocarditis in Europe: lessons from the Euro Heart Survey","volume":"91","author":"Tornos","year":"2005","journal-title":"Heart"},{"key":"10.1016\/j.echo.2021.12.013_bib15","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1002\/clc.22315","article-title":"Outcome in patients with left-sided native-valve infective endocarditis and isolated large vegetations","volume":"37","author":"Desch","year":"2014","journal-title":"Clin Cardiol"},{"key":"10.1016\/j.echo.2021.12.013_bib16","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1016\/0002-8703(86)90362-5","article-title":"Prognostic significance of vegetations detected by two-dimensional echocardiography in infective endocarditis","volume":"112","author":"Buda","year":"1986","journal-title":"Am Heart J"},{"key":"10.1016\/j.echo.2021.12.013_bib17","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.cmi.2018.08.010","article-title":"Clinical and echocardiographic predictors of embolism in infective endocarditis: systematic review and meta-analysis","volume":"25","author":"Yang","year":"2019","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.echo.2021.12.013_bib18","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1080\/23744235.2017.1392039","article-title":"Staphylococcus aureus bacteraemia and endocarditis\u2014 epidemiology and outcome: a review","volume":"50","author":"Asgeirsson","year":"2018","journal-title":"Infect Dis (Lond)"},{"key":"10.1016\/j.echo.2021.12.013_bib19","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1016\/j.jacc.2013.07.029","article-title":"Prediction of symptomatic embolism in infective endocarditis: construction and validation of a risk calculator in a multicenter cohort","volume":"62","author":"Hubert","year":"2013","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.echo.2021.12.013_bib20","doi-asserted-by":"crossref","first-page":"2466","DOI":"10.1056\/NEJMoa1112843","article-title":"Early surgery versus conventional treatment for infective endocarditis","volume":"366","author":"Kang","year":"2012","journal-title":"N Engl J Med"}],"container-title":["Journal of the American Society of Echocardiography"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0894731721008853?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0894731721008853?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T05:08:41Z","timestamp":1760245721000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0894731721008853"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":20,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["S0894731721008853"],"URL":"https:\/\/doi.org\/10.1016\/j.echo.2021.12.013","relation":{},"ISSN":["0894-7317"],"issn-type":[{"value":"0894-7317","type":"print"}],"subject":[],"published":{"date-parts":[[2022,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Reassessment of Vegetation Size as a Sole Indication for Surgery in Left-Sided Infective Endocarditis","name":"articletitle","label":"Article Title"},{"value":"Journal of the American Society of Echocardiography","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.echo.2021.12.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"2021 by the American Society of Echocardiography.","name":"copyright","label":"Copyright"}]}}