{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T23:07:57Z","timestamp":1792192077335,"version":"4.4.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004281","name":"National Science Centre Poland","doi-asserted-by":"publisher","award":["UMO-2018\/29\/B\/NZ5\/01172"],"award-info":[{"award-number":["UMO-2018\/29\/B\/NZ5\/01172"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["2008129"],"award-info":[{"award-number":["2008129"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","onlinejase.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the American Society of Echocardiography"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1016\/j.echo.2024.04.014","type":"journal-article","created":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T00:10:39Z","timestamp":1715472639000},"page":"872-883","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Association of Reduced Left Atrial Reserve With Exercise Intolerance and Outcome in Hypertension"],"prefix":"10.1016","volume":"37","author":[{"given":"Ewelina","family":"Jasic-Szpak","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Serafin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas H.","family":"Marwick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wojciech","family":"Kosowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna K.","family":"Woznicka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomasz","family":"Kotwica","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Przewlocka-Kosmala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr","family":"Ponikowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3807-8201","authenticated-orcid":false,"given":"Wojciech","family":"Kosmala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.echo.2024.04.014_bib1","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1093\/eurheartj\/ehq426","article-title":"Heart failure with preserved ejection fraction: pathophysiology, diagnosis, and treatment","volume":"32","author":"Borlaug","year":"2011","journal-title":"Eur Heart J"},{"key":"10.1016\/j.echo.2024.04.014_bib2","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.jacc.2015.10.096","article-title":"Contributions of nondiastolic factors to exercise intolerance in heart failure with preserved ejection fraction","volume":"67","author":"Kosmala","year":"2016","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.echo.2024.04.014_bib3","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.jchf.2017.04.012","article-title":"The transition from hypertension to heart failure: contemporary update","volume":"5","author":"Messerli","year":"2017","journal-title":"JACC Heart Fail"},{"key":"10.1016\/j.echo.2024.04.014_bib4","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.jchf.2015.10.007","article-title":"Myocardial microvascular inflammatory endothelial activation in heart failure with preserved ejection fraction","volume":"4","author":"Franssen","year":"2016","journal-title":"JACC Heart Fail"},{"key":"10.1016\/j.echo.2024.04.014_bib5","article-title":"Influence of left atrial function on exercise capacity and left ventricular function in patients with heart failure and preserved ejection fraction","volume":"10","author":"von Roeder","year":"2017","journal-title":"Circ Cardiovasc Imaging"},{"key":"10.1016\/j.echo.2024.04.014_bib6","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1002\/ejhf.1399","article-title":"Impaired left atrial strain predicts abnormal exercise haemodynamics in heart failure with preserved ejection fraction","volume":"21","author":"Telles","year":"2019","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.echo.2024.04.014_bib7","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1016\/j.jcmg.2016.09.021","article-title":"Left atrial function dynamics during exercise in heart failure: pathophysiological implications on the right heart and exercise ventilation inefficiency","volume":"10","author":"Sugimoto","year":"2017","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1016\/j.echo.2024.04.014_bib8","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1016\/j.echo.2020.07.020","article-title":"Left atrial strain in evaluation of heart failure with preserved ejection fraction","volume":"33","author":"Ye","year":"2020","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.echo.2024.04.014_bib9","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s10554-021-02375-0","article-title":"Determinants of exercise intolerance symptoms considered non-specific for heart failure in patients with stage A and B: role of the left atrium in the transition phase to overt heart failure","volume":"38","author":"Maffeis","year":"2022","journal-title":"Int J Cardiovasc Imaging"},{"key":"10.1016\/j.echo.2024.04.014_bib10","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.echo.2020.08.015","article-title":"Cardiac reserve and exercise capacity: insights from combined cardiopulmonary and exercise echocardiography stress testing","volume":"34","author":"Pugliese","year":"2021","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.echo.2024.04.014_bib11","doi-asserted-by":"crossref","first-page":"2199","DOI":"10.1016\/j.jacc.2017.11.005","volume":"19","author":"Whelton","year":"2018","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.echo.2024.04.014_bib12","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.cardfail.2021.01.022","volume":"27","author":"Bozkurt","year":"2021","journal-title":"J Card Fail"},{"key":"10.1016\/j.echo.2024.04.014_bib13","doi-asserted-by":"crossref","first-page":"3297","DOI":"10.1093\/eurheartj\/ehz641","article-title":"How to diagnose heart failure with preserved ejection fraction: the HFA-PEFF diagnostic algorithm: a consensus recommendation from the Heart Failure Association (HFA) of the European Society of Cardiology (ESC)","volume":"40","author":"Pieske","year":"2019","journal-title":"Eur Heart J"},{"key":"10.1016\/j.echo.2024.04.014_bib14","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1161\/CIRCULATIONAHA.118.034646","article-title":"A simple, evidence-based approach to help guide diagnosis of heart failure with preserved ejection fraction","volume":"138","author":"Reddy","year":"2018","journal-title":"Circulation"},{"key":"10.1016\/j.echo.2024.04.014_bib15","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.echo.2016.01.011","article-title":"Recommendation for the evaluation of left ventricular diastolic function by echocardiography: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging","volume":"29","author":"Nagueh","year":"2016","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.echo.2024.04.014_bib16","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1093\/ehjci\/jev014","article-title":"Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging","volume":"16","author":"Lang","year":"2015","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"10.1016\/j.echo.2024.04.014_bib17","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/s41440-020-00551-8","article-title":"Left atrial stiffness index as a marker of early target organ damage in hypertension","volume":"44","author":"Zhao","year":"2021","journal-title":"Hypertens Res"},{"key":"10.1016\/j.echo.2024.04.014_bib18","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1016\/S0735-1097(02)02164-2","volume":"40","author":"Gibbons","year":"2002","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.echo.2024.04.014_bib19","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1093\/ehjci\/jeaa072","article-title":"COVID-19 pandemic and cardiac imaging: EACVI recommendations on precautions, indications, prioritization, and protection for patients and healthcare personnel","volume":"21","author":"Skulstad","year":"2020","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"10.1016\/j.echo.2024.04.014_bib20","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1093\/ehjci\/jey042","article-title":"Standardization of left atrial, right ventricular, and right atrial deformation imaging using two-dimensional speckle tracking echocardiography: a consensus document of the EACVI\/ASE\/Industry Task Force to standardize deformation imaging","volume":"19","author":"Badano","year":"2018","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"10.1016\/j.echo.2024.04.014_bib21","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.115.002763","article-title":"Prognostic relevance of left atrial dysfunction in heart failure with preserved ejection fraction","volume":"9","author":"Santos","year":"2016","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.echo.2024.04.014_bib22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1161\/CIRCIMAGING.115.003754","article-title":"Prognostic utility and clinical significance of cardiac mechanics in heart failure with preserved ejection fraction: importance of left atrial strain","volume":"9","author":"Freed","year":"2016","journal-title":"Circ Cardiovasc Imaging"},{"key":"10.1016\/j.echo.2024.04.014_bib23","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.jcmg.2020.07.040","article-title":"Prediction of AF in heart failure with preserved ejection fraction: incremental value of left atrial strain","volume":"14","author":"Jasic-Szpak","year":"2021","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1016\/j.echo.2024.04.014_bib24","doi-asserted-by":"crossref","first-page":"e34","DOI":"10.1093\/ehjci\/jeab154","article-title":"Multimodality imaging in patients with heart failure and preserved ejection fraction: an expert consensus document of the European Association of Cardiovascular Imaging","volume":"23","author":"Smiseth","year":"2022","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"10.1016\/j.echo.2024.04.014_bib25","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.jcmg.2022.10.011","article-title":"Left atrial strain for assessment of left ventricular diastolic function: focus on populations with normal LVEF","volume":"16","author":"Nagueh","year":"2022","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1016\/j.echo.2024.04.014_bib26","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1161\/CIRCIMAGING.108.813071","article-title":"Left atrial function in diastolic heart failure","volume":"2","author":"Kurt","year":"2009","journal-title":"Circ Cardiovasc Imaging"},{"key":"10.1016\/j.echo.2024.04.014_bib27","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.cardfail.2021.10.010","article-title":"Left atrial stiffness index independently predicts exercise intolerance and quality of life in older, obese patients with heart failure with preserved ejection fraction","volume":"28","author":"Singleton","year":"2022","journal-title":"J Card Fail"},{"key":"10.1016\/j.echo.2024.04.014_bib28","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1177\/2047487319870344","article-title":"Oxidative stress and inflammation in the evolution of heart failure: from pathophysiology to therapeutic strategies","volume":"27","author":"Aimo","year":"2020","journal-title":"Eur J Prev Cardiol"},{"key":"10.1016\/j.echo.2024.04.014_bib29","doi-asserted-by":"crossref","first-page":"2142","DOI":"10.1161\/CIRCULATIONAHA.117.030226","article-title":"Six-year changes in physical activity and the risk of incident heart failure: ARIC study","volume":"137","author":"Florido","year":"2018","journal-title":"Circulation"},{"key":"10.1016\/j.echo.2024.04.014_bib30","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1016\/S0735-1097(02)02132-0","article-title":"Attenuated cardiovascular reserve during prolonged submaximal cycle exercise in healthy older subjects","volume":"40","author":"Correia","year":"2002","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.echo.2024.04.014_bib31","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.jchf.2019.08.020","article-title":"Healthy aging and cardiovascular function: invasive hemodynamics during rest and exercise in 104 healthy volunteers","volume":"8","author":"Pandey","year":"2020","journal-title":"JACC Heart Fail"},{"key":"10.1016\/j.echo.2024.04.014_bib32","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.jacc.2021.04.082","article-title":"Associations of cardiac mechanics with exercise capacity: the multi-ethnic study of atherosclerosis","volume":"78","author":"Patel","year":"2021","journal-title":"J Am Coll Cardiol. 2021"},{"key":"10.1016\/j.echo.2024.04.014_bib33","doi-asserted-by":"crossref","first-page":"638","DOI":"10.3389\/fphys.2019.00638","article-title":"Heart failure with preserved ejection fraction: a review of cardiac and noncardiac pathophysiology","volume":"10","author":"Gevaert","year":"2019","journal-title":"Front Physiol"},{"key":"10.1016\/j.echo.2024.04.014_bib34","doi-asserted-by":"crossref","first-page":"1952","DOI":"10.1016\/j.jacc.2017.01.064","article-title":"The aging cardiovascular system: understanding it at the cellular and clinical levels","volume":"69","author":"Paneni","year":"2017","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.echo.2024.04.014_bib35","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1002\/ejhf.2862","article-title":"Diagnostic value of reduced left atrial compliance during ergometry exercise in heart failure with preserved ejection fraction","volume":"25","author":"Harada","year":"2023","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.echo.2024.04.014_bib36","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1016\/j.jcmg.2017.07.028","article-title":"Association of abnormal left ventricular functional reserve with outcome in heart failure with preserved ejection fraction","volume":"11","author":"Kosmala","year":"2018","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1016\/j.echo.2024.04.014_bib37","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.jchf.2019.09.009","article-title":"Clinical phenogroups in heart failure with preserved ejection fraction: detailed phenotypes, prognosis, and response to spironolactone","volume":"8","author":"Cohen","year":"2020","journal-title":"JACC Heart Fail"},{"key":"10.1016\/j.echo.2024.04.014_bib38","doi-asserted-by":"crossref","first-page":"3403","DOI":"10.1093\/cvr\/cvac179","article-title":"Phenomapping in heart failure with preserved ejection fraction: insights, limitations, and future directions","volume":"118","author":"Peters","year":"2023","journal-title":"Cardiovasc Res"}],"container-title":["Journal of the American Society of Echocardiography"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0894731724002190?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0894731724002190?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T14:34:06Z","timestamp":1725374046000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0894731724002190"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":38,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["S0894731724002190"],"URL":"https:\/\/doi.org\/10.1016\/j.echo.2024.04.014","relation":{},"ISSN":["0894-7317"],"issn-type":[{"value":"0894-7317","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association of Reduced Left Atrial Reserve With Exercise Intolerance and Outcome in Hypertension","name":"articletitle","label":"Article Title"},{"value":"Journal of the American Society of Echocardiography","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.echo.2024.04.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"2024 by the American Society of Echocardiography.","name":"copyright","label":"Copyright"}]}}