{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T03:58:04Z","timestamp":1781236684875,"version":"3.54.1"},"reference-count":49,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T00:00:00Z","timestamp":1772496000000},"content-version":"am","delay-in-days":367,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017540","name":"National Heart Lung and Blood Institute Division of Intramural Research","doi-asserted-by":"publisher","award":["R01 HL158517"],"award-info":[{"award-number":["R01 HL158517"]}],"id":[{"id":"10.13039\/100017540","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","onlinejase.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the American Society of Echocardiography"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.echo.2024.12.008","type":"journal-article","created":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T15:55:02Z","timestamp":1734364502000},"page":"247-261","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Right Ventricle and Exercise Capacity in Adults with Repaired Tetralogy of Fallot: Passive Bystander or Active Participant?"],"prefix":"10.1016","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-1044-6695","authenticated-orcid":false,"given":"Zachary","family":"Barrett-O\u2019Keefe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chera L.","family":"Maarouf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica A.","family":"Narum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy J.","family":"Fuller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James M.","family":"Welper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William R.","family":"Miranda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. Charles","family":"Jain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidi M.","family":"Connolly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luke J.","family":"Burchill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander C.","family":"Egbe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.echo.2024.12.008_bib1","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1161\/CIRCULATIONAHA.113.008396","article-title":"Lifetime prevalence of congenital heart disease in the general population from 2000 to 2010","volume":"130","author":"Marelli","year":"2014","journal-title":"Circulation"},{"key":"10.1016\/j.echo.2024.12.008_bib2","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1161\/CIRCULATIONAHA.106.627224","article-title":"Congenital heart disease in the general population: changing prevalence and age distribution","volume":"115","author":"Marelli","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.echo.2024.12.008_bib3","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1161\/01.CIR.47.5.1065","article-title":"Hemodynamic abnormalities in response to mild and intense upright exercise following operative correction of an atrial septal defect or tetralogy of Fallot","volume":"47","author":"Epstein","year":"1973","journal-title":"Circulation"},{"key":"10.1016\/j.echo.2024.12.008_bib4","doi-asserted-by":"crossref","first-page":"II250","DOI":"10.1161\/01.CIR.92.9.250","article-title":"Left ventricular dysfunction on exercise long-term after total repair of tetralogy of Fallot","volume":"92","author":"Kondo","year":"1995","journal-title":"Circulation"},{"key":"10.1016\/j.echo.2024.12.008_bib5","doi-asserted-by":"crossref","DOI":"10.1093\/eurheartj\/eht307.126","article-title":"Exercise capacity correlates with ventricle size in adult operated tetralogy of Fallot","volume":"34","author":"Yap","year":"2013","journal-title":"Eur Heart J"},{"key":"10.1016\/j.echo.2024.12.008_bib6","series-title":"Human cardiovascular control","author":"Rowell","year":"1993"},{"key":"10.1016\/j.echo.2024.12.008_bib7","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S0002-8703(43)90325-4","article-title":"The absence of conspicuous increments of venous pressure after severe damage to the right ventricle of the dog, with a discussion of the relation between clinical congestive failure and heart disease","volume":"26","author":"Starr","year":"1943","journal-title":"Am Heart J"},{"key":"10.1016\/j.echo.2024.12.008_bib8","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.ccl.2012.03.009","article-title":"Anatomy and physiology of the right ventricle","volume":"30","author":"Dell'Italia","year":"2012","journal-title":"Cardiol Clin"},{"key":"10.1016\/j.echo.2024.12.008_bib9","doi-asserted-by":"crossref","first-page":"2575","DOI":"10.1113\/JP279759","article-title":"New insights into resting and exertional right ventricular performance in the healthy heart through real-time pressure-volume analysis","volume":"598","author":"Cornwell","year":"2020","journal-title":"J Physiol"},{"key":"10.1016\/j.echo.2024.12.008_bib10","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1161\/CIRCULATIONAHA.106.632208","article-title":"Right ventricular function and failure: report of a National Heart, Lung, and Blood Institute working group on cellular and molecular mechanisms of right heart failure","volume":"114","author":"Voelkel","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.echo.2024.12.008_bib11","first-page":"914","article-title":"Assessment of right ventricular-pulmonary arterial coupling in chronic pulmonary regurgitation","volume":"35","author":"Egbe","year":"2019","journal-title":"Can J Cardiol"},{"key":"10.1016\/j.echo.2024.12.008_bib12","article-title":"Assessing right ventricle pulmonary artery coupling and uncoupling using echocardiography and cardiopulmonary exercise test in post operative TOF patients","volume":"48","author":"Sandeep","year":"2022","journal-title":"Curr Probl Cardiol"},{"key":"10.1016\/j.echo.2024.12.008_bib13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.echo.2014.10.003","article-title":"Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging","volume":"28","author":"Lang","year":"2015","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.echo.2024.12.008_bib14","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.echo.2016.01.011","article-title":"Recommendations for the evaluation of left ventricular diastolic function by echocardiography: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging","volume":"29","author":"Nagueh","year":"2016","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.echo.2024.12.008_bib15","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.echo.2010.05.010","volume":"23","author":"Rudski","year":"2010","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.echo.2024.12.008_bib16","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1161\/01.CIR.64.4.744","article-title":"A new, simplified and accurate method for determining ejection fraction with two-dimensional echocardiography","volume":"64","author":"Quinones","year":"1981","journal-title":"Circulation"},{"key":"10.1016\/j.echo.2024.12.008_bib17","series-title":"The Echo manual","author":"Oh","year":"2019"},{"key":"10.1016\/j.echo.2024.12.008_bib18","series-title":"The echo manual","author":"Oh","year":"2007"},{"key":"10.1016\/j.echo.2024.12.008_bib19","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.1161\/CIRCULATIONAHA.106.659763","article-title":"Cardiac structure and ventricular-vascular function in persons with heart failure and preserved ejection fraction from Olmsted County, Minnesota","volume":"115","author":"Lam","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.echo.2024.12.008_bib20","doi-asserted-by":"crossref","first-page":"2028","DOI":"10.1016\/S0735-1097(01)01651-5","article-title":"Noninvasive single-beat determination of left ventricular end-systolic elastance in humans","volume":"38","author":"Chen","year":"2001","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.echo.2024.12.008_bib21","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1016\/j.jacc.2013.03.085","article-title":"Ventricular-arterial coupling, remodeling, and prognosis in chronic heart failure","volume":"62","author":"Ky","year":"2013","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.echo.2024.12.008_bib22","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/j.echo.2013.06.004","article-title":"Noninvasive evaluation of right atrial pressure","volume":"26","author":"Beigel","year":"2013","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.echo.2024.12.008_bib23","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCIMAGING.120.012315","article-title":"Right ventricular function and region-specific adaptation in athletes engaged in high-dynamic sports: a meta-analysis","volume":"14","author":"Dawkins","year":"2021","journal-title":"Circ Cardiovasc Imaging"},{"key":"10.1016\/j.echo.2024.12.008_bib24","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.jcmg.2015.06.018","article-title":"Accuracy of echocardiography to evaluate pulmonary vascular and RV function during exercise","volume":"9","author":"Claessen","year":"2016","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1016\/j.echo.2024.12.008_bib25","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.echo.2011.11.023","article-title":"Exercise strain rate imaging demonstrates normal right ventricular contractile reserve and clarifies ambiguous resting measures in endurance athletes","volume":"25","author":"La Gerche","year":"2012","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.echo.2024.12.008_bib26","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.1093\/eurheartj\/ehv202","article-title":"Exercise-induced right ventricular dysfunction is associated with ventricular arrhythmias in endurance athletes","volume":"36","author":"La Gerche","year":"2015","journal-title":"Eur Heart J"},{"key":"10.1016\/j.echo.2024.12.008_bib27","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1093\/cvr\/21.2.124","article-title":"Beta adrenergic blockade with propranolol and atenolol in the exercising dog: evidence for beta 2 adrenoceptors in the sinoatrial node","volume":"21","author":"Friedman","year":"1987","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.echo.2024.12.008_bib28","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1161\/CIRCULATIONAHA.107.714428","article-title":"Pathophysiology of congenital heart disease in the adult: part III: complex congenital heart disease","volume":"117","author":"Sommer","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.echo.2024.12.008_bib29","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1093\/cvr\/cvy138","article-title":"Flow-related right ventricular to pulmonary arterial pressure gradients during exercise","volume":"115","author":"Wright","year":"2019","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.echo.2024.12.008_bib30","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1161\/01.CIR.86.2.513","article-title":"Effective arterial elastance as index of arterial vascular load in humans","volume":"86","author":"Kelly","year":"1992","journal-title":"Circulation"},{"key":"10.1016\/j.echo.2024.12.008_bib31","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1016\/j.jacc.2013.07.027","article-title":"Selective heart rate reduction with ivabradine unloads the left ventricle in heart failure patients","volume":"62","author":"Reil","year":"2013","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.echo.2024.12.008_bib32","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1152\/japplphysiol.90600.2008","article-title":"Arterial-ventricular coupling: mechanistic insights into cardiovascular performance at rest and during exercise","volume":"105","author":"Chantler","year":"2008","journal-title":"J Appl Physiol (1985)"},{"key":"10.1016\/j.echo.2024.12.008_bib33","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1161\/01.HYP.0000168053.34306.d4","article-title":"Ventricular arterial stiffening: integrating the pathophysiology","volume":"46","author":"Kass","year":"2005","journal-title":"Hypertension"},{"key":"10.1016\/j.echo.2024.12.008_bib34","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1016\/0002-8703(93)90756-Y","article-title":"Left ventricular-arterial coupling relations in the normal human heart","volume":"125","author":"Starling","year":"1993","journal-title":"Am Heart J"},{"key":"10.1016\/j.echo.2024.12.008_bib35","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.ijcard.2017.04.051","article-title":"Right ventriculo-arterial coupling assessed by two-dimensional strain: a new parameter of right ventricular function independently associated with prognosis in chronic heart failure patients","volume":"241","author":"Iacoviello","year":"2017","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.echo.2024.12.008_bib36","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/0026-2862(89)90040-X","article-title":"Resistance or conductance for expression of arterial vascular tone","volume":"37","author":"Lautt","year":"1989","journal-title":"Microvasc Res"},{"key":"10.1016\/j.echo.2024.12.008_bib37","first-page":"H1817","article-title":"Ventricular stroke work and efficiency both remain nearly optimal despite altered vascular loading","volume":"264","author":"De Tombe","year":"1993","journal-title":"Am J Physiol"},{"key":"10.1016\/j.echo.2024.12.008_bib38","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCIMAGING.120.011823","article-title":"Impaired exercise tolerance in repaired tetralogy of fallot is associated with impaired biventricular contractile reserve: an exercise-stress real-time cardiovascular magnetic resonance study","volume":"14","author":"Steinmetz","year":"2021","journal-title":"Circ Cardiovasc Imaging"},{"key":"10.1016\/j.echo.2024.12.008_bib39","doi-asserted-by":"crossref","first-page":"2214","DOI":"10.1002\/ehf2.12880","article-title":"Revisiting the relationship between left ventricular ejection fraction and ventricular-arterial coupling","volume":"7","author":"Mihaileanu","year":"2020","journal-title":"ESC Heart Fail"},{"key":"10.1016\/j.echo.2024.12.008_bib40","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1161\/01.CIR.61.6.1150","article-title":"Left ventricular function after repair of tetralogy of fallot and its relationship to age at surgery","volume":"61","author":"Borow","year":"1980","journal-title":"Circulation"},{"key":"10.1016\/j.echo.2024.12.008_bib41","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1093\/ehjci\/jeac037","article-title":"The dysfunctional right ventricle: the importance of multi-modality imaging","volume":"23","author":"Surkova","year":"2022","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"10.1016\/j.echo.2024.12.008_bib42","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.ijcard.2014.09.008","article-title":"Mechanisms of maintained exercise capacity in adults with repaired tetralogy of Fallot","volume":"177","author":"O'Meagher","year":"2014","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.echo.2024.12.008_bib43","doi-asserted-by":"crossref","first-page":"2042","DOI":"10.1016\/j.jacc.2021.08.073","article-title":"Effect of beta-blocker withdrawal on functional capacity in heart failure and preserved ejection fraction","volume":"78","author":"Palau","year":"2021","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.echo.2024.12.008_bib44","doi-asserted-by":"crossref","first-page":"2096","DOI":"10.1001\/jama.2023.7946","article-title":"Rate-adaptive atrial pacing for heart failure with preserved ejection fraction-reply","volume":"329","author":"Reddy","year":"2023","journal-title":"JAMA"},{"key":"10.1016\/j.echo.2024.12.008_bib45","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1001\/jama.2023.0675","article-title":"Rate-adaptive atrial pacing for heart failure with preserved ejection fraction: the RAPID-HF Randomized clinical trial","volume":"329","author":"Reddy","year":"2023","journal-title":"JAMA"},{"key":"10.1016\/j.echo.2024.12.008_bib46","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1113\/jphysiol.2011.225334","article-title":"Peripheral vasodilatation determines cardiac output in exercising humans: insight from atrial pacing","volume":"590","author":"Bada","year":"2012","journal-title":"J Physiol"},{"key":"10.1016\/j.echo.2024.12.008_bib47","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1111\/j.1747-0803.2008.00223.x","article-title":"Doppler echocardiographic assessment of pulmonary prostheses: a comprehensive assessment including velocity time integral ratio and prosthesis effective orifice area","volume":"3","author":"Sadeghpour","year":"2008","journal-title":"Congenit Heart Dis"},{"key":"10.1016\/j.echo.2024.12.008_bib48","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1111\/chd.12768","article-title":"Right ventricular and pulmonary vascular function indices for risk stratification of patients with pulmonary regurgitation","volume":"14","author":"Egbe","year":"2019","journal-title":"Congenit Heart Dis"},{"key":"10.1016\/j.echo.2024.12.008_bib49","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1093\/ehjci\/jead119.297","article-title":"Severe pulmonary regurgitation does not influence exercise capacity in patients with repaired Tetralogy of Fallot","volume":"24","author":"Alborikan","year":"2023","journal-title":"Eur Heart J Cardiovasc Imaging"}],"container-title":["Journal of the American Society of Echocardiography"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0894731724006382?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0894731724006382?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T03:22:12Z","timestamp":1781234532000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0894731724006382"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":49,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["S0894731724006382"],"URL":"https:\/\/doi.org\/10.1016\/j.echo.2024.12.008","relation":{},"ISSN":["0894-7317"],"issn-type":[{"value":"0894-7317","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Right Ventricle and Exercise Capacity in Adults with Repaired Tetralogy of Fallot: Passive Bystander or Active Participant?","name":"articletitle","label":"Article Title"},{"value":"Journal of the American Society of Echocardiography","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.echo.2024.12.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"2024 by the American Society of Echocardiography.","name":"copyright","label":"Copyright"}]}}