{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T18:39:34Z","timestamp":1792521574705,"version":"4.5.0"},"reference-count":31,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T00:00:00Z","timestamp":1750809600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000871","name":"Mayo Clinic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007048","name":"Mayo Foundation for Medical Education and Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007048","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","onlinejase.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the American Society of Echocardiography"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.echo.2025.06.009","type":"journal-article","created":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T19:27:53Z","timestamp":1750447673000},"page":"902-915","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Effect of Detection of Subclinical Atherosclerosis on Carotid Ultrasound on Cardiovascular Events in a Primary Prevention Clinical Setting"],"prefix":"10.1016","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3160-9025","authenticated-orcid":false,"given":"Tasneem Z.","family":"Naqvi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chieh-Ju","family":"Chao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J.","family":"Butterfield","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songnan","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.echo.2025.06.009_bib1","doi-asserted-by":"crossref","first-page":"e50","DOI":"10.1016\/j.jacc.2010.09.001","article-title":"2010 ACCF\/AHA guideline for assessment of cardiovascular risk in asymptomatic adults","volume":"56","author":"Greenland","year":"2010","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.echo.2025.06.009_bib2","first-page":"S49","article-title":"2013 ACC\/AHA guideline on the assessment of cardiovascular risk: a report of the American College of cardiology\/American Heart Association Task Force on practice guidelines","volume":"129","author":"Goff","year":"2013","journal-title":"Circulation"},{"key":"10.1016\/j.echo.2025.06.009_bib3","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1067\/mhj.2002.123317","article-title":"A comparison of the Framingham and European Society of Cardiology coronary heart disease risk prediction models in the Normative Aging Study","volume":"144","author":"Orford","year":"2002","journal-title":"Am Heart J"},{"key":"10.1016\/j.echo.2025.06.009_bib4","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/j.echo.2010.05.005","article-title":"High prevalence of ultrasound detected carotid atherosclerosis in subjects with low Framingham risk score: potential implications for screening for subclinical atherosclerosis","volume":"23","author":"Naqvi","year":"2010","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.echo.2025.06.009_bib5","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1016\/j.echo.2010.06.003","article-title":"Carotid ultrasound identifies high risk subclinical atherosclerosis in adults with low Framingham risk scores","volume":"23","author":"Eleid","year":"2010","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.echo.2025.06.009_bib6","doi-asserted-by":"crossref","first-page":"2979","DOI":"10.1016\/j.jacc.2017.10.024","article-title":"Normal LDL-cholesterol levels are associated with subclinical atherosclerosis in the absence of risk factors","volume":"70","author":"Fern\u00e1ndez-Friera","year":"2017","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.echo.2025.06.009_bib7","doi-asserted-by":"crossref","first-page":"2104","DOI":"10.1161\/CIRCULATIONAHA.114.014310","article-title":"Prevalence, vascular distribution, and multiterritorial extent of subclinical atherosclerosis in a middle-aged cohort: the PESA (Progression of Early Subclinical Atherosclerosis) study","volume":"131","author":"Fern\u00e1ndez-Friera","year":"2015","journal-title":"Circulation"},{"key":"10.1016\/j.echo.2025.06.009_bib8","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.jcmg.2012.03.013","article-title":"Carotid plaque burden as a measure of subclinical atherosclerosis: comparison with other tests for subclinical arterial disease in the High-Risk Plaque Bioimage Study","volume":"5","author":"Sillesen","year":"2012","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1016\/j.echo.2025.06.009_bib9","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1016\/j.jcmg.2013.11.014","article-title":"Carotid intima-media thickness and plaque in cardiovascular risk assessment","volume":"7","author":"Naqvi","year":"2014","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1016\/j.echo.2025.06.009_bib10","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.echo.2007.11.011","volume":"21","author":"Stein","year":"2008","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.echo.2025.06.009_bib11","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1001\/jama.2012.9630","article-title":"Common carotid intima-media thickness measurements in cardiovascular risk prediction a meta-analysis","volume":"308","author":"Den Ruijter","year":"2012","journal-title":"JAMA"},{"key":"10.1016\/j.echo.2025.06.009_bib12","doi-asserted-by":"crossref","first-page":"3227","DOI":"10.1093\/eurheartj\/ehab484","article-title":"2021 ESC guidelines on cardiovascular disease prevention in clinical practice","volume":"42","author":"Visseren","year":"2021","journal-title":"Eur Heart J"},{"key":"10.1016\/j.echo.2025.06.009_bib13","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1161\/CIRCULATIONAHA.107.699579","article-title":"General cardiovascular risk profile for use in primary care: the Framingham Heart Study","volume":"117","author":"D'agostino","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.echo.2025.06.009_bib14","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1093\/oxfordjournals.aje.a009302","article-title":"Association of coronary heart disease incidence with carotid arterial wall thickness and major risk factors: the Atherosclerosis Risk in Communities (ARIC) study, 1987-1993","volume":"146","author":"Chambless","year":"1997","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.echo.2025.06.009_bib16","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1093\/eurheartj\/ehr192","article-title":"Common carotid artery intima-media thickness is as good as carotid intima-media thickness of all carotid artery segments in improving prediction of coronary heart disease risk in the Atherosclerosis Risk In Communities (ARIC) study","volume":"33","author":"Nambi","year":"2012","journal-title":"Eur Heart J"},{"key":"10.1016\/j.echo.2025.06.009_bib15","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1161\/CIRCULATIONAHA.106.645606","article-title":"Association of carotid artery intima-media thickness, plaques, and C-reactive protein with future cardiovascular disease and all-cause mortality: the Cardiovascular Health Study","volume":"116","author":"Cao","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.echo.2025.06.009_bib17","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1161\/01.STR.0000196964.24024.ea","article-title":"Carotid intima-media thickening indicates a higher vascular risk across a wide age range: prospective data from the Carotid Atherosclerosis Progression Study (CAPS)","volume":"37","author":"Lorenz","year":"2006","journal-title":"Stroke"},{"key":"10.1016\/j.echo.2025.06.009_bib18","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.113.000087","article-title":"The value of carotid artery plaque and intima-media thickness for incident cardiovascular disease: the multi-ethnic study of atherosclerosis","volume":"2","author":"Polak","year":"2013","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.echo.2025.06.009_bib19","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.3390\/biomedicines12112435","article-title":"Reversal of atherosclerotic plaque growth and vulnerability: effects of lipid-modifying and anti-inflammatory therapeutic agents","volume":"12","author":"Papafaklis","year":"2024","journal-title":"Biomedicines"},{"key":"10.1016\/j.echo.2025.06.009_bib20","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1093\/ehjci\/jeae153","article-title":"Carotid plaque score is associated with 10-year major adverse cardiovascular events in low\u2013intermediate risk patients referred to a general cardiology community clinic","volume":"26","author":"Matangi","year":"2025","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"10.1016\/j.echo.2025.06.009_bib21","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1016\/j.jacc.2009.11.075","article-title":"Carotid intima-media thickness and presence or absence of plaque improves prediction of coronary heart disease risk: the ARIC (atherosclerosis risk in communities) study","volume":"55","author":"Nambi","year":"2010","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.echo.2025.06.009_bib22","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/S0021-9150(00)00665-1","article-title":"Carotid and femoral ultrasound morphology screening and cardiovascular events in low-risk subjects: a 10-year follow-up study (the CAFES-CAVE Study (1))","volume":"156","author":"Belcaro","year":"2001","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.echo.2025.06.009_bib23","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1161\/STROKEAHA.110.589754","article-title":"Carotid plaque area and intima-media thickness in prediction of first-ever ischemic stroke: a 10-year follow-up of 6584 men and women: the Troms\u00f8 Study","volume":"42","author":"Mathiesen","year":"2011","journal-title":"Stroke"},{"key":"10.1016\/j.echo.2025.06.009_bib24","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1212\/01.wnl.0000303969.63165.34","article-title":"Carotid plaque, a subclinical precursor of vascular events: the Northern Manhattan Study","volume":"70","author":"Rundek","year":"2008","journal-title":"Neurology"},{"key":"10.1016\/j.echo.2025.06.009_bib25","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1093\/ehjci\/jex239","article-title":"Carotid plaque thickness and carotid plaque burden predict future cardiovascular events in asymptomatic adult Americans","volume":"19","author":"Sillesen","year":"2018","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"10.1016\/j.echo.2025.06.009_bib26","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1016\/j.jacc.2015.01.017","article-title":"Prevalence, impact, and predictive value of detecting subclinical coronary and carotid atherosclerosis in asymptomatic adults: the BioImage Study","volume":"65","author":"Baber","year":"2015","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.echo.2025.06.009_bib27","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1161\/01.CIR.0000120708.59903.1B","article-title":"Predictive value of noninvasive measures of atherosclerosis for incident myocardial infarction: the Rotterdam Study","volume":"109","author":"van der Meer","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.echo.2025.06.009_bib28","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1056\/NEJM199605093341902","article-title":"Atherosclerotic disease of the aortic arch as a risk factor for recurrent ischemic stroke","volume":"334","author":"Amarenco","year":"1996","journal-title":"N Engl J Med"},{"key":"10.1016\/j.echo.2025.06.009_bib29","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/S0735-1097(99)00250-8","article-title":"Cause of death in clinical research: time for a reassessment?","volume":"34","author":"Lauer","year":"1999","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.echo.2025.06.009_bib30","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1016\/j.compbiomed.2013.06.012","article-title":"Inter- and intra-observer variability analysis of completely automated cIMT measurement software (AtheroEdge\u2122) and its benchmarking against commercial ultrasound scanner and expert readers","volume":"43","author":"Saba","year":"2013","journal-title":"Comput Biol Med"},{"key":"10.1016\/j.echo.2025.06.009_bib31","first-page":"e596","article-title":"2019 ACC\/AHA guideline on the primary prevention of cardiovascular disease: a report of the American College of Cardiology\/American Heart Association Task Force on clinical practice guidelines","volume":"140","author":"Arnett","year":"2019","journal-title":"Circulation"}],"container-title":["Journal of the American Society of Echocardiography"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0894731725003359?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0894731725003359?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T18:11:46Z","timestamp":1772820706000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0894731725003359"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":31,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["S0894731725003359"],"URL":"https:\/\/doi.org\/10.1016\/j.echo.2025.06.009","relation":{},"ISSN":["0894-7317"],"issn-type":[{"value":"0894-7317","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of Detection of Subclinical Atherosclerosis on Carotid Ultrasound on Cardiovascular Events in a Primary Prevention Clinical Setting","name":"articletitle","label":"Article Title"},{"value":"Journal of the American Society of Echocardiography","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.echo.2025.06.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"2025 The Authors. Published by Elsevier Inc. on behalf of the American Society of Echocardiography.","name":"copyright","label":"Copyright"}]}}