{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T09:59:38Z","timestamp":1764755978015,"version":"3.46.0"},"reference-count":24,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["W81XWH2210245","R01 HL162830","R01 HL162828","R01 HL158517","R01 HL160761","R01 HL128526","U01 HL160226"],"award-info":[{"award-number":["W81XWH2210245","R01 HL162830","R01 HL162828","R01 HL158517","R01 HL160761","R01 HL128526","U01 HL160226"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","onlinejase.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the American Society of Echocardiography"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.echo.2025.08.022","type":"journal-article","created":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T23:27:10Z","timestamp":1757114830000},"page":"1179-1188","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impaired Pulmonary Vascular Reserve in Adults with Repaired Coarctation of Aorta: Prevalence, Correlates, and Association with Disease Severity"],"prefix":"10.1016","volume":"38","author":[{"given":"Alexander C.","family":"Egbe","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yogesh N.V.","family":"Reddy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia A.","family":"Pellikka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barry A.","family":"Borlaug","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.echo.2025.08.022_bib1","doi-asserted-by":"crossref","first-page":"2259","DOI":"10.1016\/S0735-1097(03)00480-7","article-title":"Ambulatory blood pressure, left ventricular mass, and conduit artery function late after successful repair of coarctation of the aorta","volume":"41","author":"de Divitiis","year":"2003","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.echo.2025.08.022_bib2","doi-asserted-by":"crossref","first-page":"I165","DOI":"10.1161\/hc37t1.094900","article-title":"Vascular dysfunction after repair of coarctation of the aorta: impact of early surgery","volume":"104","author":"de Divitiis","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.echo.2025.08.022_bib3","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1161\/HYPERTENSIONAHA.116.08763","article-title":"Abnormal wave reflections and left ventricular hypertrophy late after coarctation of the aorta repair","volume":"69","author":"Quail","year":"2017","journal-title":"Hypertension"},{"key":"10.1016\/j.echo.2025.08.022_bib4","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.ahj.2021.07.005","article-title":"Coarctation of aorta is associated with left ventricular stiffness, left atrial dysfunction and pulmonary hypertension","volume":"241","author":"Egbe","year":"2021","journal-title":"Am Heart J"},{"key":"10.1016\/j.echo.2025.08.022_bib5","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.119.006651","article-title":"Determinants of left ventricular diastolic function and exertional symptoms in adults with coarctation of aorta","volume":"13","author":"Egbe","year":"2020","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.echo.2025.08.022_bib6","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/s00246-020-02471-3","article-title":"Impaired left atrial function in adults and adolescents with corrected aortic coarctation","volume":"42","author":"Labombarda","year":"2020","journal-title":"Pediatr Cardiol"},{"key":"10.1016\/j.echo.2025.08.022_bib7","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.ijcard.2014.04.060","article-title":"Pulmonary hypertension in young adults with repaired coarctation of the aorta: an unrecognised factor associated with premature mortality and heart failure","volume":"174","author":"Oliver","year":"2014","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.echo.2025.08.022_bib8","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1161\/CIRCIMAGING.121.013075","article-title":"Right heart dysfunction in adults with coarctation of aorta: prevalence and prognostic implications","volume":"14","author":"Egbe","year":"2021","journal-title":"Circ Cardiovasc imaging"},{"key":"10.1016\/j.echo.2025.08.022_bib9","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1378\/chest.10-0348","article-title":"Right ventricular load at exercise is a cause of persistent exercise limitation in patients with normal resting pulmonary vascular resistance after pulmonary endarterectomy","volume":"139","author":"Bonderman","year":"2011","journal-title":"Chest"},{"key":"10.1016\/j.echo.2025.08.022_bib10","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.114.001602","article-title":"Pulmonary vascular and right ventricular reserve in patients with normalized resting hemodynamics after pulmonary endarterectomy","volume":"4","author":"Claessen","year":"2015","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.echo.2025.08.022_bib11","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1161\/CIRCULATIONAHA.112.000667","article-title":"Pulmonary vascular hemodynamic response to exercise in cardiopulmonary diseases","volume":"128","author":"Lewis","year":"2013","journal-title":"Circulation"},{"key":"10.1016\/j.echo.2025.08.022_bib12","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1161\/CIRCHEARTFAILURE.110.959437","article-title":"Pulmonary vascular response patterns during exercise in left ventricular systolic dysfunction predict exercise capacity and outcomes","volume":"4","author":"Lewis","year":"2011","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.echo.2025.08.022_bib13","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.jcmg.2015.06.018","article-title":"Accuracy of echocardiography to evaluate pulmonary vascular and RV function during exercise","volume":"9","author":"Claessen","year":"2016","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1016\/j.echo.2025.08.022_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.echo.2014.10.003","article-title":"Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging","volume":"28","author":"Lang","year":"2015","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.echo.2025.08.022_bib15","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.echo.2010.05.010","volume":"23","author":"Rudski","year":"2010","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.echo.2025.08.022_bib16","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.echo.2016.01.011","article-title":"Recommendations for the evaluation of left ventricular diastolic function by echocardiography: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging","volume":"29","author":"Nagueh","year":"2016","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.echo.2025.08.022_bib17","doi-asserted-by":"crossref","first-page":"1901617","DOI":"10.1183\/13993003.01617-2019","article-title":"Noninvasive evaluation of pulmonary artery pressure during exercise: the importance of right atrial hypertension","volume":"55","author":"Obokata","year":"2020","journal-title":"Eur Respir J"},{"key":"10.1016\/j.echo.2025.08.022_bib18","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1378\/chest.126.4.1313","article-title":"New formula for predicting mean pulmonary artery pressure using systolic pulmonary artery pressure","volume":"126","author":"Chemla","year":"2004","journal-title":"Chest"},{"key":"10.1016\/j.echo.2025.08.022_bib19","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.echo.2011.11.023","article-title":"Exercise strain rate imaging demonstrates normal right ventricular contractile reserve and clarifies ambiguous resting measures in endurance athletes","volume":"25","author":"La","year":"2012","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.echo.2025.08.022_bib20","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.echo.2007.08.027","article-title":"Echocardiographic assessment of regional right ventricular function: a head-to-head comparison between 2-dimensional and tissue Doppler-derived strain analysis","volume":"21","author":"Teske","year":"2008","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.echo.2025.08.022_bib21","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.cjcpc.2023.05.001","article-title":"Prognostic role of tricuspid annular plane systolic excursion\/right ventricular systolic pressure ratio in coarctation of aorta","volume":"2","author":"Ahmed","year":"2023","journal-title":"CJC Pediatr Congenit Heart Dis"},{"key":"10.1016\/j.echo.2025.08.022_bib22","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1136\/heartjnl-2014-306142","article-title":"RV-pulmonary arterial coupling predicts outcome in patients referred for pulmonary hypertension","volume":"101","author":"Vanderpool","year":"2015","journal-title":"Heart"},{"key":"10.1016\/j.echo.2025.08.022_bib23","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1161\/CIRCULATIONAHA.108.787101","article-title":"Exercise-induced pulmonary arterial hypertension","volume":"118","author":"Tolle","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.echo.2025.08.022_bib24","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.ijcard.2017.05.075","article-title":"Elevated sympathetic activity, endothelial dysfunction, and late hypertension after repair of coarctation of the aorta","volume":"243","author":"Lee","year":"2017","journal-title":"Int J Cardiol"}],"container-title":["Journal of the American Society of Echocardiography"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0894731725004894?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0894731725004894?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T09:54:46Z","timestamp":1764755686000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0894731725004894"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":24,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["S0894731725004894"],"URL":"https:\/\/doi.org\/10.1016\/j.echo.2025.08.022","relation":{},"ISSN":["0894-7317"],"issn-type":[{"type":"print","value":"0894-7317"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impaired Pulmonary Vascular Reserve in Adults with Repaired Coarctation of Aorta: Prevalence, Correlates, and Association with Disease Severity","name":"articletitle","label":"Article Title"},{"value":"Journal of the American Society of Echocardiography","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.echo.2025.08.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"2025 by the American Society of Echocardiography.","name":"copyright","label":"Copyright"}]}}