{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T09:41:48Z","timestamp":1767174108035,"version":"3.48.0"},"reference-count":34,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","onlinejase.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the American Society of Echocardiography"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.echo.2025.09.012","type":"journal-article","created":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T02:46:13Z","timestamp":1758768373000},"page":"71-79","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Left Ventricular Global Longitudinal Strain: An Imaging Marker Associated with Outcomes in Paradoxical Low-Flow, Low-Gradient Severe Aortic Stenosis"],"prefix":"10.1016","volume":"39","author":[{"given":"Nathanael","family":"Tran","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shani","family":"Dahan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jagdip","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael H.","family":"Picard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacob P.","family":"Dal-Bianco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3737-7584","authenticated-orcid":false,"given":"Judy","family":"Hung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.echo.2025.09.012_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.echo.2008.11.029","article-title":"Echocardiographic assessment of valve stenosis: EAE\/ASE recommendations for clinical practice","volume":"22","author":"Baumgartner","year":"2009","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.echo.2025.09.012_bib2","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.echo.2017.02.009","article-title":"Recommendations on the echocardiographic assessment of aortic valve stenosis: a focused update from the European Association of Cardiovascular Imaging and the American Society of Echocardiography","volume":"30","author":"Baumgartner","year":"2017","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.echo.2025.09.012_bib3","doi-asserted-by":"crossref","first-page":"2856","DOI":"10.1161\/CIRCULATIONAHA.106.668681","article-title":"Paradoxical low-flow, low-gradient severe aortic stenosis despite preserved ejection fraction is associated with higher afterload and reduced survival","volume":"115","author":"Hachicha","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.echo.2025.09.012_bib4","first-page":"e72","article-title":"2020 ACC\/AHA guideline for the management of patients with valvular heart disease: a report of the American College of Cardiology\/American Heart Association joint committee on clinical practice guidelines","volume":"143","author":"Otto","year":"2021","journal-title":"Circulation"},{"key":"10.1016\/j.echo.2025.09.012_bib5","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1093\/eurheartj\/ehab395","article-title":"2021 ESC\/EACTS Guidelines for the management of valvular heart disease","volume":"43","author":"Vahanian","year":"2022","journal-title":"Eur Heart J"},{"key":"10.1016\/j.echo.2025.09.012_bib6","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.117.005798","article-title":"Reversibility of cardiac function predicts outcome after transcatheter aortic valve replacement in patients with severe aortic stenosis","volume":"6","author":"Sato","year":"2017","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.echo.2025.09.012_bib7","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.jcmg.2023.01.005","article-title":"Prognostic value of preprocedural LV global longitudinal strain for post-TAVR-related morbidity and mortality: a meta-analysis","volume":"16","author":"Stens","year":"2023","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1016\/j.echo.2025.09.012_bib8","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/j.echo.2022.04.013","article-title":"Incremental prognostic value of left ventricular global longitudinal strain in patients with preserved ejection fraction undergoing transcatheter aortic valve Implantation","volume":"35","author":"Lee","year":"2022","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.echo.2025.09.012_bib9","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1056\/NEJMra072139","article-title":"Cardiac plasticity","volume":"358","author":"Hill","year":"2008","journal-title":"N Engl J Med"},{"key":"10.1016\/j.echo.2025.09.012_bib10","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.jcmg.2019.05.020","article-title":"Relative contribution of afterload and interstitial fibrosis to myocardial function in severe aortic stenosis","volume":"13","author":"Slimani","year":"2020","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1016\/j.echo.2025.09.012_bib11","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1093\/eurheartj\/ehr084","article-title":"Alterations in multidirectional myocardial functions in patients with aortic stenosis and preserved ejection fraction: a two-dimensional speckle tracking analysis","volume":"32","author":"Ng","year":"2011","journal-title":"Eur Heart J"},{"key":"10.1016\/j.echo.2025.09.012_bib12","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1148\/radiol.14141120","article-title":"Assessment of Diffuse myocardial fibrosis by using MR imaging in asymptomatic patients with aortic stenosis","volume":"274","author":"Lee","year":"2015","journal-title":"Radiology"},{"key":"10.1016\/j.echo.2025.09.012_bib13","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1161\/CIRCULATIONAHA.108.847772","article-title":"Impact of myocardial fibrosis in patients with symptomatic severe aortic stenosis","volume":"120","author":"Weidemann","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.echo.2025.09.012_bib14","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1016\/j.jacc.2020.02.046","article-title":"Transvalvular flow rate determines prognostic value of aortic valve area in aortic stenosis","volume":"75","author":"Namasivayam","year":"2020","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.echo.2025.09.012_bib15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.echo.2014.10.003","article-title":"Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging","volume":"28","author":"Lang","year":"2015","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.echo.2025.09.012_bib16","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1016\/j.jacc.2012.06.051","article-title":"Low-flow, low-gradient aortic stenosis with normal and depressed left ventricular ejection fraction","volume":"60","author":"Pibarot","year":"2012","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.echo.2025.09.012_bib17","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/S0735-1097(99)00630-0","article-title":"Cardiac remodeling--concepts and clinical implications: a consensus paper from an international forum on cardiac remodeling. Behalf of an International Forum on Cardiac Remodeling","volume":"35","author":"Cohn","year":"2000","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.echo.2025.09.012_bib18","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1093\/eurheartj\/9.suppl_E.19","article-title":"Left ventricular systolic function in aortic stenosis","volume":"9","author":"Krayenbuehl","year":"1988","journal-title":"Eur Heart J"},{"key":"10.1016\/j.echo.2025.09.012_bib19","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/S0735-1097(85)80418-6","article-title":"Afterload mismatch in aortic and mitral valve disease: implications for surgical therapy","volume":"5","author":"Ross","year":"1985","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.echo.2025.09.012_bib20","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.1161\/CIRCULATIONAHA.117.032839","article-title":"Myocardial scar and mortality in severe aortic stenosis","volume":"138","author":"Musa","year":"2018","journal-title":"Circulation"},{"key":"10.1016\/j.echo.2025.09.012_bib21","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.jacc.2014.02.612","article-title":"Prognostic significance of LGE by CMR in aortic stenosis patients undergoing valve replacement","volume":"64","author":"Barone-Rochette","year":"2014","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.echo.2025.09.012_bib22","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1016\/j.jacc.2011.03.064","article-title":"Midwall fibrosis is an independent predictor of mortality in patients with aortic stenosis","volume":"58","author":"Dweck","year":"2011","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.echo.2025.09.012_bib23","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.jcmg.2018.11.005","article-title":"Distribution and prognostic significance of left ventricular global longitudinal strain in asymptomatic significant aortic stenosis","volume":"12","author":"Magne","year":"2019","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1016\/j.echo.2025.09.012_bib24","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1136\/heartjnl-2014-305538","article-title":"Prognostic implications of global LV dysfunction: a systematic review and meta-analysis of global longitudinal strain and ejection fraction","volume":"100","author":"Kalam","year":"2014","journal-title":"Heart"},{"key":"10.1016\/j.echo.2025.09.012_bib25","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1136\/hrt.45.3.248","article-title":"Left ventricular fibre architecture in man","volume":"45","author":"Greenbaum","year":"1981","journal-title":"Heart"},{"key":"10.1016\/j.echo.2025.09.012_bib26","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1161\/CIRCIMAGING.113.000989","article-title":"Myocardial strain analysis by 2-dimensional speckle tracking echocardiography improves diagnostics of coronary artery stenosis in stable angina pectoris","volume":"7","author":"Biering-S\u00f8rensen","year":"2014","journal-title":"Circ Cardiovasc Imaging"},{"key":"10.1016\/j.echo.2025.09.012_bib27","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1093\/ejechocard\/jep041","article-title":"Longitudinal 2D strain at rest predicts the presence of left main and three vessel coronary artery disease in patients without regional wall motion abnormality","volume":"10","author":"Choi","year":"2009","journal-title":"Eur J Echocardiogr"},{"key":"10.1016\/j.echo.2025.09.012_bib28","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1161\/CIRCIMAGING.111.967554","article-title":"Low-flow, low-gradient severe aortic stenosis despite normal ejection fraction is associated with severe left ventricular dysfunction as assessed by speckle-tracking echocardiography","volume":"5","author":"Adda","year":"2012","journal-title":"Circ Cardiovasc Imaging"},{"key":"10.1016\/j.echo.2025.09.012_bib29","doi-asserted-by":"crossref","first-page":"3351","DOI":"10.1093\/eurheartj\/ehx381","article-title":"Staging classification of aortic stenosis based on the extent of cardiac damage","volume":"38","author":"G\u00e9n\u00e9reux","year":"2017","journal-title":"Eur Heart J"},{"key":"10.1016\/j.echo.2025.09.012_bib30","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/S0735-1097(96)00563-3","article-title":"Clinical factors associated with calcific aortic valve disease. Cardiovascular Health Study","volume":"29","author":"Stewart","year":"1997","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.echo.2025.09.012_bib31","doi-asserted-by":"crossref","first-page":"2491","DOI":"10.1016\/j.jacc.2010.03.019","article-title":"Associations of long-term and early adult atherosclerosis risk factors with aortic and mitral valve calcium","volume":"55","author":"Thanassoulis","year":"2010","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.echo.2025.09.012_bib32","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1001\/jamacardio.2018.2288","article-title":"Association of left ventricular global longitudinal strain with asymptomatic severe aortic stenosis: Natural course and prognostic value","volume":"3","author":"Vollema","year":"2018","journal-title":"JAMA Cardiol"},{"key":"10.1016\/j.echo.2025.09.012_bib33","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1016\/j.echo.2019.03.002","article-title":"Predictive value of left ventricular myocardial deformation for left ventricular remodeling in patients with classical low-flow, low-gradient aortic stenosis undergoing transcatheter aortic valve replacement","volume":"32","author":"D\u2019Andrea","year":"2019","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.echo.2025.09.012_bib34","doi-asserted-by":"crossref","first-page":"2750","DOI":"10.1253\/circj.CJ-14-0726","article-title":"Prognostic value of global longitudinal strain in paradoxical low-flow, low-gradient severe aortic stenosis with preserved ejection fraction","volume":"78","author":"Sato","year":"2014","journal-title":"Circ J"}],"container-title":["Journal of the American Society of Echocardiography"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0894731725005322?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0894731725005322?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T09:37:18Z","timestamp":1767173838000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0894731725005322"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["S0894731725005322"],"URL":"https:\/\/doi.org\/10.1016\/j.echo.2025.09.012","relation":{},"ISSN":["0894-7317"],"issn-type":[{"type":"print","value":"0894-7317"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Left Ventricular Global Longitudinal Strain: An Imaging Marker Associated with Outcomes in Paradoxical Low-Flow, Low-Gradient Severe Aortic Stenosis","name":"articletitle","label":"Article Title"},{"value":"Journal of the American Society of Echocardiography","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.echo.2025.09.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"2025 by the American Society of Echocardiography.","name":"copyright","label":"Copyright"}]}}