{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:04:14Z","timestamp":1761059054325,"version":"build-2065373602"},"reference-count":150,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2010,6,1]],"date-time":"2010-06-01T00:00:00Z","timestamp":1275350400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,6,1]],"date-time":"2010-06-01T00:00:00Z","timestamp":1275350400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","theclinics.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Endocrinology and Metabolism Clinics of North America"],"published-print":{"date-parts":[[2010,6]]},"DOI":"10.1016\/j.ecl.2010.02.003","type":"journal-article","created":{"date-parts":[[2010,6,5]],"date-time":"2010-06-05T04:33:33Z","timestamp":1275712413000},"page":"447-472","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":40,"title":["Vitamin D Analogs"],"prefix":"10.1016","volume":"39","author":[{"given":"Glenville","family":"Jones","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecl.2010.02.003_bib1","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1056\/NEJMra070553","article-title":"Vitamin D deficiency","volume":"357","author":"Holick","year":"2007","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ecl.2010.02.003_bib2","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1111\/j.1525-139X.2007.00302.x","article-title":"Expanding role for vitamin D in chronic kidney disease: importance of blood 25-OH-D levels and extra-renal 1\u03b1-hydroxylase in the classical and non-classical actions of 1\u03b1,25-dihydroxyvitamin D3","volume":"20","author":"Jones","year":"2007","journal-title":"Semin Dial"},{"key":"10.1016\/j.ecl.2010.02.003_bib3","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1152\/physrev.1998.78.4.1193","article-title":"Current understanding of the molecular actions of vitamin D","volume":"78","author":"Jones","year":"1998","journal-title":"Physiol Rev"},{"key":"10.1016\/j.ecl.2010.02.003_bib4","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/0006-291X(81)91628-4","article-title":"1\u03b1,25-dihydroxyvitamin D3 induces differentiation of human myeloid leukemia cells","volume":"102","author":"Miyaura","year":"1981","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.ecl.2010.02.003_bib5","first-page":"200","article-title":"Structure-function relationships in the vitamin D endocrine system","volume":"16","author":"Bouillon","year":"1995","journal-title":"Endocr Rev"},{"key":"10.1016\/j.ecl.2010.02.003_bib6","series-title":"Principles of bone biology. Third edition. Section: pharmacological mechanisms of therapeutics","first-page":"1777","article-title":"Vitamin D and analogues","author":"Jones","year":"2008"},{"key":"10.1016\/j.ecl.2010.02.003_bib7","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1158\/1535-7163.MCT-05-0539","article-title":"The promise of vitamin D analogs in the treatment of hyperproliferative conditions","volume":"5","author":"Masuda","year":"2006","journal-title":"Mol Cancer Ther"},{"key":"10.1016\/j.ecl.2010.02.003_bib8","series-title":"Vitamin D","first-page":"995","article-title":"The pharmacology of Vitamin D, including fortification strategies","author":"Vieth","year":"2005"},{"key":"10.1016\/j.ecl.2010.02.003_bib9","doi-asserted-by":"crossref","first-page":"5387","DOI":"10.1210\/jc.2004-0360","article-title":"Vitamin D2 is much less effective than vitamin D3 in humans","volume":"89","author":"Armas","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.ecl.2010.02.003_bib10","first-page":"1","article-title":"The hypercalcemic activity of dihydrotachysterol-2 and dihydrotachysterol-3 and of the vitamins D2 and D3: comparative experiments in rats","volume":"2","author":"Roborgh","year":"1960","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.ecl.2010.02.003_bib11","doi-asserted-by":"crossref","first-page":"432","DOI":"10.3181\/00379727-178-42028","article-title":"1\u03b1-Hydroxyvitamin D2 is less toxic than 1\u03b1-hydroxyvitamin D3 in the rat","volume":"178","author":"Sj\u00f6den","year":"1985","journal-title":"Proc Soc Exp Biol Med"},{"key":"10.1016\/j.ecl.2010.02.003_bib12","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1007\/s00223-003-0083-8","article-title":"Effect of vitamins D2 and D3 supplement use on serum 25OHD concentration in elderly women in summer and winter","volume":"74","author":"Rapuri","year":"2004","journal-title":"Calcif Tissue Int"},{"key":"10.1016\/j.ecl.2010.02.003_bib13","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1210\/jc.2007-2308","article-title":"Vitamin D2 is as effective as vitamin D3 in maintaining circulating concentrations of 25-hydroxyvitamin D","volume":"93","author":"Holick","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.ecl.2010.02.003_bib14","doi-asserted-by":"crossref","first-page":"3314","DOI":"10.1210\/jc.2009-0018","article-title":"The effect of vitamin D2 and vitamin D3 on intestinal calcium absorption in Nigerian children with rickets","volume":"94","author":"Thacher","year":"2009","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.ecl.2010.02.003_bib15","doi-asserted-by":"crossref","first-page":"2748","DOI":"10.1021\/ja00789a090","article-title":"A convenient synthesis of 1\u03b1-hydroxy-vitamin D3","volume":"95","author":"Barton","year":"1973","journal-title":"J Am Chem Soc"},{"key":"10.1016\/j.ecl.2010.02.003_bib16","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.1073\/pnas.75.5.2080","article-title":"Direct C-1 hydroxylation of vitamin D compounds: convenient preparation of 1\u03b1-hydroxyvitamin D3, 1\u03b1,25-dihydroxyvitamin D3, and 1\u03b1-hydroxyvitamin D2","volume":"75","author":"Paaren","year":"1978","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ecl.2010.02.003_bib17","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.1093\/jnci\/92.22.1836","article-title":"Prevention of N-methyl-N-nitrosourea-induced mammary carcinogenesis in rats by 1alpha-hydroxyvitamin D5","volume":"92","author":"Mehta","year":"2000","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.ecl.2010.02.003_bib18","doi-asserted-by":"crossref","first-page":"23S","DOI":"10.1016\/8756-3282(95)00203-P","article-title":"Present and future of osteoporosis therapy","volume":"17","author":"Seeman","year":"1995","journal-title":"Bone"},{"key":"10.1016\/j.ecl.2010.02.003_bib19","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1056\/NEJM199208273270908","article-title":"The prevention and treatment of osteoporosis","volume":"327","author":"Riggs","year":"1992","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ecl.2010.02.003_bib20","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1038\/367284a0","article-title":"Prediction of bone density from vitamin D receptor alleles","volume":"367","author":"Morrison","year":"1994","journal-title":"Nature"},{"key":"10.1016\/j.ecl.2010.02.003_bib21","series-title":"Vitamin D","first-page":"1121","article-title":"Analog metabolism","author":"Uitterlinden","year":"2005"},{"key":"10.1016\/j.ecl.2010.02.003_bib22","first-page":"47","article-title":"Reduced occurrence of vertebral crush fractures in senile osteoporosis treated with 1\u03b1(OH)-vitamin D3","volume":"3","author":"Orimo","year":"1987","journal-title":"Bone Miner"},{"key":"10.1016\/j.ecl.2010.02.003_bib23","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1002\/jbmr.5650090504","article-title":"Effects of increasing doses of 1\u03b1-hydroxyvitamin D2 on calcium homeostasis in postmenopausal osteopenic women","volume":"9","author":"Gallagher","year":"1994","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.ecl.2010.02.003_bib24","doi-asserted-by":"crossref","first-page":"287","DOI":"10.3181\/00379727-191-42922","article-title":"The effect of calcitriol on patients with postmenopausal osteoporosis with special reference to fracture frequency","volume":"191","author":"Gallagher","year":"1989","journal-title":"Proc Soc Exp Biol Med"},{"key":"10.1016\/j.ecl.2010.02.003_bib25","doi-asserted-by":"crossref","first-page":"267","DOI":"10.7326\/0003-4819-110-4-267","article-title":"Calcitriol treatment is not effective in post-menopausal osteoporosis","volume":"110","author":"Ott","year":"1989","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.ecl.2010.02.003_bib26","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1056\/NEJM199202063260601","article-title":"Treatment of post-menopausal osteoporosis with calcium","volume":"326","author":"Tilyard","year":"1992","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ecl.2010.02.003_bib27","doi-asserted-by":"crossref","first-page":"7070","DOI":"10.1021\/bi00418a060","article-title":"Isolation and identification of seven metabolites of 25-hydroxydihydrotachysterol3 formed in the isolated perfused rat kidney: a model for the study of side-chain metabolism of vitamin D","volume":"27","author":"Jones","year":"1988","journal-title":"Biochemistry"},{"key":"10.1016\/j.ecl.2010.02.003_bib28","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/S0021-9258(18)54147-8","article-title":"In vivo metabolism of the vitamin D analog, dihydrotachysterol. Evidence for formation of 1\u03b1,25-and 1\u03b2,25-dihydroxydihydrotachysterol metabolites and studies of their biological activity","volume":"268","author":"Qaw","year":"1993","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.ecl.2010.02.003_bib29","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0140-6736(91)92157-W","article-title":"Double-blind, right\/left comparison of calcipotriol and betamethasone valerate in treatment of psoriasis vulgaris","volume":"337","author":"Kragballe","year":"1991","journal-title":"Lancet"},{"issue":"Suppl","key":"10.1016\/j.ecl.2010.02.003_bib30","doi-asserted-by":"crossref","first-page":"S190","DOI":"10.1007\/BF01621903","article-title":"The development of vitamin D analogues for the treatment of osteoporosis","volume":"1","author":"Nishii","year":"1993","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.ecl.2010.02.003_bib31","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1042\/bj3100233","article-title":"1\u03b1,24(S)-dihydroxyvitamin D2: a biologically active product of 1\u03b1-hydroxyvitamin D2 made in the human hepatoma, Hep3B","volume":"310","author":"Strugnell","year":"1995","journal-title":"Biochem J"},{"key":"10.1016\/j.ecl.2010.02.003_bib32","first-page":"58160d","article-title":"Cholecalciferol 23-yne derivatives, their pharmaceutical compositions, their use in the treatment of calcium related diseases, and their antitumor activity, US 4,804,502","volume":"111","author":"Baggiolini","year":"1989","journal-title":"Chem Abstr"},{"key":"10.1016\/j.ecl.2010.02.003_bib33","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1016\/j.chembiol.2008.08.008","article-title":"Superagonistic fluorinated vitamin D3 analogs stabilize helix 12 of the vitamin D receptor","volume":"15","author":"Eelen","year":"2008","journal-title":"Chem Biol"},{"key":"10.1016\/j.ecl.2010.02.003_bib34","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1359\/jbmr.2000.15.2.237","article-title":"Biological activity of CD-ring modified 1\u03b1,25-dihydroxyvitamin D analogues: C-ring and five-membered D-ring analogues","volume":"15","author":"Verstuyf","year":"2000","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.ecl.2010.02.003_bib35","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.jsbmb.2006.12.088","article-title":"ED-71, a new active vitamin D3, increases bone mineral density regardless of serum 25(OH)D levels in osteoporotic subjects","volume":"103","author":"Matsumoto","year":"2007","journal-title":"J Steroid Biochem Mol Biol"},{"key":"10.1016\/j.ecl.2010.02.003_bib36","doi-asserted-by":"crossref","first-page":"8760","DOI":"10.1021\/jo010375i","article-title":"Efficient and versatile synthesis of novel 2\u03b1-substituted 1\u03b1,25-dihydroxyvitamin D3 analogues and their docking to vitamin D receptors","volume":"66","author":"Suhara","year":"2001","journal-title":"J Org Chem"},{"key":"10.1016\/j.ecl.2010.02.003_bib37","doi-asserted-by":"crossref","first-page":"13487","DOI":"10.1073\/pnas.202471299","article-title":"A potent analog of 1\u03b1,25-dihydroxyvitamin D3 selectively induces bone formation","volume":"99","author":"Shevde","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ecl.2010.02.003_bib38","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1530\/eje.0.1500591","article-title":"Inhibition of prostate cell growth by BXL-628, a calcitriol analogue selected for a phase II clinical trial in patients with benign prostate hyperplasia","volume":"150","author":"Crescioli","year":"2004","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.ecl.2010.02.003_bib39","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.jsbmb.2006.12.065","article-title":"Inhibition of prostate growth and inflammation by the vitamin D receptor agonist BXL-628 (elocalcitol)","volume":"103","author":"Adorini","year":"2007","journal-title":"J Steroid Biochem Mol Biol"},{"key":"10.1016\/j.ecl.2010.02.003_bib40","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S1074-5521(99)80072-6","article-title":"Novel nonsecosteroidal vitamin D mimics exert VDR-modulating activities with less calcium mobilization than 1,25-dihydroxyvitamin D3","volume":"6","author":"Boehm","year":"1999","journal-title":"Chem Biol"},{"key":"10.1016\/j.ecl.2010.02.003_bib41","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1172\/JCI25901","article-title":"Identification and characterization of noncalcemic, tissue-selective, nonsecosteroidal vitamin D receptor modulators","volume":"116","author":"Ma","year":"2006","journal-title":"J Clin Invest"},{"key":"10.1016\/j.ecl.2010.02.003_bib42","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1210\/en.2004-1140","article-title":"(23S)-25-Dehydro-1\u03b1-hydroxyvitamin D3-26,23-lactone, a vitamin D receptor antagonist that inhibits osteoclast formation and bone resorption in bone marrow cultures from patients with Paget's disease","volume":"146","author":"Ishizuka","year":"2005","journal-title":"Endocrinology"},{"key":"10.1016\/j.ecl.2010.02.003_bib43","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1002\/cbic.200600054","article-title":"Highly potent vitamin D receptor antagonists: design, synthesis, and biological evaluation","volume":"7","author":"Saito","year":"2006","journal-title":"Chembiochem"},{"key":"10.1016\/j.ecl.2010.02.003_bib44","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1124\/mol.59.6.1478","article-title":"Different molecular mechanisms of vitamin D3 receptor antagonists","volume":"59","author":"Toell","year":"2001","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.ecl.2010.02.003_bib45","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1016\/j.tibs.2004.10.005","article-title":"Enzymes involved in the activation and inactivation of vitamin D","volume":"29","author":"Prosser","year":"2004","journal-title":"Trends Biochem Sci"},{"key":"10.1016\/j.ecl.2010.02.003_bib46","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/S0039-128X(00)00166-5","article-title":"Selective inhibitors of CYP24: mechanistic tools to explore vitamin D metabolism in human keratinocytes","volume":"66","author":"Schuster","year":"2001","journal-title":"Steroids"},{"key":"10.1016\/j.ecl.2010.02.003_bib47","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.jsbmb.2004.03.044","article-title":"Potent low-calcemic selective inhibitors of CYP24 hydroxylase: 24-sulphone analogs of the hormone 1\u03b1,25-dihydroxyvitamin D3","volume":"89-90","author":"Posner","year":"2004","journal-title":"J Steroid Biochem Mol Biol"},{"key":"10.1016\/j.ecl.2010.02.003_bib48","unstructured":"Posner G, Petkovich M. Vitamin D analogues targeting CYP24 in chronic kidney disease [abstract]. Proceedings of the 14th Workshop on Vitamin D. Brugge, Belgium, October 4\u20138, 2009. p. 7."},{"key":"10.1016\/j.ecl.2010.02.003_bib49","first-page":"765","article-title":"Clinical counterpoint: vitamin D: new actions, new analogs, new therapeutic potential","volume":"13","author":"Bikle","year":"1992","journal-title":"Endocr Rev"},{"key":"10.1016\/j.ecl.2010.02.003_bib50","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1093\/ajcn\/84.1.18","article-title":"Estimation of optimal serum concentrations of 25-hydroxyvitamin D for multiple health outcomes","volume":"84","author":"Bischoff-Ferrari","year":"2006","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.ecl.2010.02.003_bib51","doi-asserted-by":"crossref","first-page":"3820","DOI":"10.1172\/JCI36479","article-title":"Endocrine functions of bone in mineral metabolism regulation","volume":"118","author":"Quarles","year":"2008","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.ecl.2010.02.003_bib52","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1172\/JCI114022","article-title":"Parathyroid hormone suppression by intravenous 1,25-dihydroxyvitamin D. A role for increased sensitivity to calcium","volume":"83","author":"Delmez","year":"1989","journal-title":"J Clin Invest"},{"issue":"Suppl 3","key":"10.1016\/j.ecl.2010.02.003_bib53","article-title":"K\/DOQI clinical practise guidelines for bone metabolism and disease in chronic kidney disease","volume":"42","year":"2003","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.ecl.2010.02.003_bib54","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1159\/000081023","article-title":"Vitamin D insufficiency and deficiency in chronic kidney disease. A single center observational study","volume":"24","author":"Gonzalez","year":"2004","journal-title":"Am J Nephrol"},{"key":"10.1016\/j.ecl.2010.02.003_bib55","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1053\/j.ajkd.2007.04.010","article-title":"Changes in serum 25-hydroxyvitamin D and plasma intact PTH levels following treatment with ergocalciferol in patients with CKD","volume":"50","author":"Al-Aly","year":"2007","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.ecl.2010.02.003_bib56","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1159\/000098561","article-title":"Impact of ergocalciferol treatment of vitamin D deficiency on serum parathyroid hormone concentrations in chronic kidney disease","volume":"27","author":"Zisman","year":"2007","journal-title":"Am J Nephrol."},{"key":"10.1016\/j.ecl.2010.02.003_bib57","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1038\/ki.1988.190","article-title":"Extra-renal production of calcitriol in chronic renal failure","volume":"34","author":"Dusso","year":"1988","journal-title":"Kidney Int"},{"key":"10.1016\/j.ecl.2010.02.003_bib58","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1093\/ndt\/gfl692","article-title":"Impact of calcium and vitamin D therapy on arterial and cardiac disease in young adults with childhood-onset end stage renal disease","volume":"22","author":"Fournier","year":"2007","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.ecl.2010.02.003_bib59","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1681\/ASN.2004070573","article-title":"Activated injectable vitamin D and hemodialysis survival: a historical cohort study","volume":"16","author":"Teng","year":"2005","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.ecl.2010.02.003_bib60","doi-asserted-by":"crossref","first-page":"1858","DOI":"10.1038\/sj.ki.5001868","article-title":"Mortality risk among hemodialysis patients receiving different vitamin D analogs","volume":"70","author":"Tentori","year":"2006","journal-title":"Kidney Int"},{"key":"10.1016\/j.ecl.2010.02.003_bib61","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1681\/ASN.2007080902","article-title":"Vitamin D receptor activators can protect against vascular calcification","volume":"19","author":"Mathew","year":"2008","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.ecl.2010.02.003_bib62","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1097\/MAJ.0b013e3181aaee91","article-title":"Vitamin D deficiency and risk for cardiovascular disease","volume":"338","author":"Judd","year":"2009","journal-title":"Am J Med Sci"},{"key":"10.1016\/j.ecl.2010.02.003_bib63","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1023\/A:1024962316691","article-title":"Effects of Seocalcitol (EB1089) on nitrosomethyl urea-induced rat mammary tumors","volume":"80","author":"Colston","year":"2003","journal-title":"Breast Cancer Res Treat"},{"key":"10.1016\/j.ecl.2010.02.003_bib64","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1038\/bjc.1998.434","article-title":"A phase I study of the vitamin D analogue EB 1089 in patients with advanced breast and colorectal cancer","volume":"78","author":"Gulliford","year":"1998","journal-title":"Br J Cancer"},{"key":"10.1016\/j.ecl.2010.02.003_bib65","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/sj.bjc.6600162","article-title":"A phase II trial of the vitamin D analogue Seocalcitol (EB1089) in patients with inoperable pancreatic cancer","volume":"86","author":"Evans","year":"2002","journal-title":"Br J Cancer"},{"key":"10.1016\/j.ecl.2010.02.003_bib66","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1038\/sj.bjc.6601104","article-title":"A phase II study of the vitamin D analogue, Seocalcitol in patients with inoperable hepatocellular carcinoma","volume":"89","author":"Dalhoff","year":"2003","journal-title":"Br J Cancer"},{"key":"10.1016\/j.ecl.2010.02.003_bib67","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.1158\/1055-9965.2225.13.12","article-title":"Randomized study of high-dose pulse calcitriol or placebo prior to radical prostatectomy","volume":"13","author":"Beer","year":"2004","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1016\/j.ecl.2010.02.003_bib68","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.jsbmb.2004.03.068","article-title":"Anti-tumor activity of calcitriol: pre-clinical and clinical studies","volume":"89-90","author":"Trump","year":"2004","journal-title":"J Steroid Biochem Mol Biol"},{"key":"10.1016\/j.ecl.2010.02.003_bib69","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1038\/nrc2196","article-title":"Vitamin D signalling pathways in cancer: potential for anticancer therapeutics","volume":"7","author":"Deeb","year":"2007","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.ecl.2010.02.003_bib70","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1002\/jbmr.5650091219","article-title":"Activation of the human osteocalcin gene by 24R,25-dihydroxyvitamin D3 occurs through the vitamin D receptor and the vitamin D-responsive element","volume":"9","author":"Uchida","year":"1994","journal-title":"J Bone Miner Res"},{"issue":"Suppl","key":"10.1016\/j.ecl.2010.02.003_bib71","doi-asserted-by":"crossref","first-page":"582S","DOI":"10.1093\/ajcn\/88.2.582S","article-title":"Pharmacokinetics of Vitamin D toxicity","volume":"88","author":"Jones","year":"2008","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.ecl.2010.02.003_bib72","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1016\/S0022-2275(20)41484-1","article-title":"Recent progress in enzymology and molecular biology of enzymes involved in vitamin D metabolism","volume":"36","author":"Okuda","year":"1995","journal-title":"J Lipid Res"},{"key":"10.1016\/j.ecl.2010.02.003_bib73","doi-asserted-by":"crossref","first-page":"7711","DOI":"10.1073\/pnas.0402490101","article-title":"Genetic evidence that the human CYP2R1 enzyme is a key vitamin D 25-hydroxylase","volume":"101","author":"Cheng","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ecl.2010.02.003_bib74","first-page":"2589","article-title":"Hepatic activation and inactivation of clinically-relevant vitamin D Analogs and prodrugs","volume":"26","author":"Jones","year":"2006","journal-title":"Anticancer Res"},{"key":"10.1016\/j.ecl.2010.02.003_bib75","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.jmb.2008.03.065","article-title":"Structural analysis of CYP2R1 in complex with vitamin D3","volume":"380","author":"Strushkevich","year":"2008","journal-title":"J Mol Biol"},{"key":"10.1016\/j.ecl.2010.02.003_bib76","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1084\/jem.161.4.755","article-title":"Characterization of 1\u03b1-hydroxylation of vitamin D3 sterols by cultured alveolar macrophages from patients with sarcoidosis","volume":"161","author":"Adams","year":"1985","journal-title":"J Exp Med"},{"key":"10.1016\/j.ecl.2010.02.003_bib77","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1359\/jbmr.1997.12.10.1552","article-title":"The 25-hydroxyvitamin D 1-\u03b1-hydroxylase gene maps to the pseudovitamin D-deficiency rickets (PDDR) disease locus","volume":"12","author":"St. Arnaud","year":"1997","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.ecl.2010.02.003_bib78","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1126\/science.277.5333.1827","article-title":"25-Hydroxyvitamin D3 1\u03b1-hydroxylase and vitamin D synthesis","volume":"277","author":"Takeyama","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.ecl.2010.02.003_bib79","first-page":"1961","article-title":"Cloning of human 25-hydroxyvitamin D-1\u03b1-hydroxylase and mutations causing vitamin D-dependent rickets type 1","volume":"11","author":"Fu","year":"1997","journal-title":"Mol Endocrinol"},{"key":"10.1016\/j.ecl.2010.02.003_bib80","doi-asserted-by":"crossref","first-page":"3303","DOI":"10.1210\/endo.140.7.6799","article-title":"Expression and activity of vitamin D-metabolizing cytochrome P450s (CYP1\u03b1 and CYP24) in human non-small cell lung carcinomas","volume":"140","author":"Jones","year":"1999","journal-title":"Endocrinology"},{"key":"10.1016\/j.ecl.2010.02.003_bib81","series-title":"Vitamin D","first-page":"1379","article-title":"Extra-renal 1\u03b1-Hydroxylase activity and human disease","author":"Hewison","year":"2005"},{"key":"10.1016\/j.ecl.2010.02.003_bib82","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1002\/jbmr.5650061006","article-title":"Vitamin D analogs with low affinity for the vitamin D binding protein: enhanced in vitro and decreased in vivo activity","volume":"6","author":"Bouillon","year":"1991","journal-title":"J\u00a0Bone Miner Res"},{"key":"10.1016\/j.ecl.2010.02.003_bib83","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/BF03021403","article-title":"Pharmacokinetic studies of vitamin D analogues: Relationship to vitamin D binding protein (DBP)","volume":"3","author":"Kissmeyer","year":"1995","journal-title":"Endocrine"},{"key":"10.1016\/j.ecl.2010.02.003_bib84","series-title":"Vitamin D: gene regulation structure-function analysis and clinical application","first-page":"312","article-title":"A novel vitamin D3 analogue, 22-oxacalcitriol (OCT): its different behaviour from calcitriol in plasma transport system","author":"Tsugawa","year":"1991"},{"key":"10.1016\/j.ecl.2010.02.003_bib85","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/0006-2952(94)90409-X","article-title":"Increased biological activity of 20-epi-1,25-dihydroxyvitamin D3 is due to reduced catabolism and altered protein binding","volume":"47","author":"Dilworth","year":"1994","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.ecl.2010.02.003_bib86","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1172\/JCI5244","article-title":"Osteopathy and resistance to vitamin D toxicity in mice null for vitamin D binding protein","volume":"103","author":"Safadi","year":"1999","journal-title":"J Clin Invest"},{"key":"10.1016\/j.ecl.2010.02.003_bib87","series-title":"Vitamin D","first-page":"219","article-title":"Nuclear receptor: structure-function, molecular control of gene transcription and novel bioactions","author":"Whitfield","year":"2005"},{"key":"10.1016\/j.ecl.2010.02.003_bib88","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1046\/j.1432-1327.2001.01953.x","article-title":"Functional and structural characterization of the insertion region in the ligand binding domain of the vitamin D nuclear receptor","volume":"268","author":"Rochel","year":"2001","journal-title":"Eur J Biochem"},{"key":"10.1016\/j.ecl.2010.02.003_bib89","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0378-1119(00)00052-4","article-title":"Mechanisms of gene regulation by vitamin D3 receptor: a network of coactivator interactions","volume":"246","author":"Rachez","year":"2000","journal-title":"Gene"},{"key":"10.1016\/j.ecl.2010.02.003_bib90","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1038\/ng0897-391","article-title":"Mice lacking the vitamin D receptor exhibit impaired bone formation, uterine hypoplasia and growth retardation after weaning","volume":"16","author":"Yoshizawa","year":"1997","journal-title":"Nat Genet"},{"key":"10.1016\/j.ecl.2010.02.003_bib91","doi-asserted-by":"crossref","first-page":"9831","DOI":"10.1073\/pnas.94.18.9831","article-title":"Targeted ablation of the vitamin D receptor: an animal model of vitamin D-dependent rickets type II with alopecia","volume":"94","author":"Li","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ecl.2010.02.003_bib92","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF02409404","article-title":"A monolog on analogs. In vitro effects of vitamin D metabolites and consideration of the mineralisation question","volume":"33","author":"Stern","year":"1981","journal-title":"Calcif Tissue Int"},{"key":"10.1016\/j.ecl.2010.02.003_bib93","doi-asserted-by":"crossref","first-page":"16838","DOI":"10.1074\/jbc.274.24.16838","article-title":"20-Epi analogues of 1,25-dihydroxyvitamin D3 are highly potent inducers of DRIP coactivator complex binding to the vitamin D3 receptor","volume":"274","author":"Yang","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ecl.2010.02.003_bib94","doi-asserted-by":"crossref","first-page":"5485","DOI":"10.1210\/endo.138.12.5594","article-title":"The vitamin D analog, KH1060 is rapidly degraded both in vivo and in vitro via several pathways: principal metabolites generated retain significant biological activity","volume":"138","author":"Dilworth","year":"1997","journal-title":"Endocrinology"},{"key":"10.1016\/j.ecl.2010.02.003_bib95","doi-asserted-by":"crossref","first-page":"3448","DOI":"10.1210\/en.2009-0113","article-title":"The enhanced hypercalcemic response to 20-epi-1,25-dihydroxyvitamin D3 results from a selective and prolonged induction of intestinal calcium-regulating genes","volume":"150","author":"Zella","year":"2009","journal-title":"Endocrinology"},{"key":"10.1016\/j.ecl.2010.02.003_bib96","first-page":"1814","article-title":"Vitamin D3-retinoid X receptor dimerization, DNA binding, and transactivation are differentially affected by analogs of 1,25-dihydroxyvitamin D3","volume":"9","author":"Cheskis","year":"1995","journal-title":"Mol Endocrinol"},{"key":"10.1016\/j.ecl.2010.02.003_bib97","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1038\/19783","article-title":"Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex","volume":"398","author":"Rachez","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.ecl.2010.02.003_bib98","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1128\/MCB.19.2.1049","article-title":"Selective interaction of vitamin D receptor with transcriptional coactivators by a vitamin D analog","volume":"19","author":"Takeyama","year":"1999","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.ecl.2010.02.003_bib99","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1359\/jbmr.2002.17.5.879","article-title":"Vitamin D analogue-specific recruitment of vitamin D receptor coactivators","volume":"17","author":"Issa","year":"2000","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.ecl.2010.02.003_bib100","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1002\/jcb.10344","article-title":"Evidence for tissue- and cell-type selective activation of the vitamin D receptor by Ro-26-9228, a noncalcemic analog of vitamin D3","volume":"88","author":"Peleg","year":"2003","journal-title":"J Cell Biochem"},{"issue":"Suppl 2","key":"10.1016\/j.ecl.2010.02.003_bib101","doi-asserted-by":"crossref","first-page":"V16","DOI":"10.1359\/jbmr.07s207","article-title":"Molecular actions of 1,25-dihydroxyvitamin D3 on genes involved in calcium homeostasis","volume":"22","author":"Pike","year":"2007","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.ecl.2010.02.003_bib102","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1042\/bj2620173","article-title":"Target cell metabolism of 1,25-dihydroxyvitamin D3 to calcitroic acid. Evidence for a pathway in kidney and bone involving 24-oxidation","volume":"262","author":"Makin","year":"1989","journal-title":"Biochem J"},{"key":"10.1016\/j.ecl.2010.02.003_bib103","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1111\/j.1432-1033.1994.00335.x","article-title":"Further oxidation of hydroxycalcidiol by calcidiol 24-hydroxylase\u2014a study with the mature enzyme expressed in Escherichia coli","volume":"224","author":"Akiyoshi-Shibata","year":"1994","journal-title":"Eur J Biochem"},{"issue":"Special Issue","key":"10.1016\/j.ecl.2010.02.003_bib104","doi-asserted-by":"crossref","first-page":"75","DOI":"10.3177\/jnsv.38.Special_75","article-title":"Further metabolism of 1\u03b1,25-dihydroxyvitamin D3 in target cells","author":"Lohnes","year":"1992","journal-title":"J Nutr Sci Vitaminol"},{"key":"10.1016\/j.ecl.2010.02.003_bib105","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1007\/BF03346420","article-title":"1\u03b1,24(S)(OH)2D2 normalizes bone morphology and serum parathyroid hormone without hypercalcemia in 25-hydroxyvitamin D-1-hydroxylase (CYP27B1)-deficient mice, an animal model of vitamin D deficiency with secondary hyperparathyroidism","volume":"31","author":"St-Arnaud","year":"2008","journal-title":"J Endocrinol Invest"},{"key":"10.1016\/j.ecl.2010.02.003_bib106","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1210\/en.2004-1116","article-title":"Altered pharmacokinetics of 1\u03b1,25-dihydroxyvitamin D3 and 25-hydroxyvitamin D3 in the blood and tissues of the 25-hydroxyvitamin D-24-hydroxylase (CYP24A1) null mouse","volume":"146","author":"Masuda","year":"2005","journal-title":"Endocrinology"},{"key":"10.1016\/j.ecl.2010.02.003_bib107","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/BF02556834","article-title":"Stimulation of undermineralized matrix formation by 1,25-dihydroxyvitamin D3 in long bones of rats","volume":"38","author":"Hock","year":"1986","journal-title":"Calcif Tissue Int"},{"key":"10.1016\/j.ecl.2010.02.003_bib108","doi-asserted-by":"crossref","first-page":"2658","DOI":"10.1210\/endo.141.7.7579","article-title":"Deficient mineralization of intramembranous bone in vitamin D-24-hydroxylase-ablated mice is due to elevated 1,25-dihydroxyvitamin D and not to the absence of 24,25-dihydroxyvitamin D","volume":"141","author":"St Arnaud","year":"2000","journal-title":"Endocrinology"},{"key":"10.1016\/j.ecl.2010.02.003_bib109","unstructured":"St Arnaud. 24(R),25-(OH)2D3 administration corrects bone defect in cyp24-null mouse. 14th Workshop on Vitamin D. Brugge, Belgium, October 4\u20138, 2009."},{"key":"10.1016\/j.ecl.2010.02.003_bib110","doi-asserted-by":"crossref","first-page":"4794","DOI":"10.1016\/S0021-9258(17)37614-7","article-title":"In vitro metabolism of the anti-psoriatic vitamin D analog, calcipotriol, in two cultured human keratinocyte models","volume":"269","author":"Masuda","year":"1994","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.ecl.2010.02.003_bib111","doi-asserted-by":"crossref","first-page":"8700","DOI":"10.1074\/jbc.271.15.8700","article-title":"In vitro metabolism of the vitamin D analog, 22-oxacalcitriol, using cultured osteosarcoma, hepatoma and keratinocyte cell lines","volume":"271","author":"Masuda","year":"1996","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ecl.2010.02.003_bib112","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/S0006-2952(96)00815-5","article-title":"Metabolism of the vitamin D analog EB1089 by cultured human cells: redirection of hydroxylation site to distal carbons of the side chain","volume":"53","author":"Shankar","year":"1997","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.ecl.2010.02.003_bib113","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0960-0760(99)00130-2","article-title":"Enhanced biological activity of 1\u03b1,25-dihydroxy-20-epi-vitamin D3, the C-20 epimer of 1\u03b1,25-dihydroxyvitamin D3, is in part due to its metabolism into stable intermediary metabolites with significant biological activity","volume":"71","author":"Siu-Caldera","year":"1999","journal-title":"J Steroid Biochem Mol Biol"},{"key":"10.1016\/j.ecl.2010.02.003_bib114","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/S0006-2952(01)00546-9","article-title":"Metabolism of a 20-methyl substituted series of vitamin D analogs by cultured human cells: apparent reduction of 23-hydroxylation of the side chain by 20-methyl group","volume":"61","author":"Shankar","year":"2001","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.ecl.2010.02.003_bib115","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/0006-2952(90)90039-N","article-title":"In vitro metabolism of calcipotriol (MC 903), a vitamin D analogue","volume":"39","author":"Sorensen","year":"1990","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.ecl.2010.02.003_bib116","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1016\/S0006-2952(96)00816-7","article-title":"The metabolism of the vitamin D analog EB 1089: identification of in vivo and in vitro metabolites and their biological activities","volume":"53","author":"Kissmeyer","year":"1997","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.ecl.2010.02.003_bib117","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1016\/S0960-894X(00)80462-X","article-title":"Identification and synthesis of a metabolite of KH1060, a new potent 1\u03b1,25-dihydroxyvitamin D3 analogue","volume":"2","author":"Rastrup-Anderson","year":"1992","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.ecl.2010.02.003_bib118","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1124\/mol.105.017392","article-title":"Intestinal and hepatic CYP3A4 catalyze hydroxylation of 1\u03b1,25-dihydroxyvitamin D3: implications for drug-induced osteomalacia","volume":"69","author":"Xu","year":"2005","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.ecl.2010.02.003_bib119","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1124\/mol.60.6.1399","article-title":"Transcriptional control of intestinal cytochrome P-450 3A by 1\u03b1,25-dihydroxy vitamin D3","volume":"60","author":"Thummel","year":"2001","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.ecl.2010.02.003_bib120","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s00223-001-0020-7","article-title":"Phenytoin-induced bone loss and its prevention with alfacalcidol or calcitriol in growing rats","volume":"69","author":"Onodera","year":"2001","journal-title":"Calcif Tissue Int"},{"key":"10.1016\/j.ecl.2010.02.003_bib121","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1080\/07315724.1984.10720035","article-title":"Effect of increasing doses of phenytoin on the plasma 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D concentrations","volume":"3","author":"Gascon-Barre","year":"1984","journal-title":"J Am Coll Nutr"},{"key":"10.1016\/j.ecl.2010.02.003_bib122","article-title":"Comparison of 1,25-dihydroxyvitamin D2 and calcitriol effects in an adenine-induced uremic model of CKD reveals differential control over calcium and phosphate [abstract]","author":"Helvig","year":"2008","journal-title":"Amer Soc Bone Mineral Soc"},{"key":"10.1016\/j.ecl.2010.02.003_bib123","series-title":"Vitamin D","first-page":"381","article-title":"1,25(OH)2-Vitamin D3-mediated rapid and genomic responses","author":"Norman","year":"2005"},{"key":"10.1016\/j.ecl.2010.02.003_bib124","doi-asserted-by":"crossref","first-page":"23750","DOI":"10.1016\/S0021-9258(17)31579-X","article-title":"Identification of a specific binding protein for 1\u03b1,25-dihydroxyvitamin D3 in basal-lateral membranes of chick intestinal epithelium and relationship to transcaltachia","volume":"269","author":"Nemere","year":"1994","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ecl.2010.02.003_bib125","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1002\/(SICI)1097-4644(20000701)78:1<34::AID-JCB4>3.0.CO;2-Z","article-title":"Annexin II is the membrane receptor that mediates the rapid actions of 1\u03b1,25-dihydroxyvitamin D3","volume":"78","author":"Baran","year":"2000","journal-title":"J Cell Biochem"},{"key":"10.1016\/j.ecl.2010.02.003_bib126","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.steroids.2005.02.016","article-title":"Identification and characterization of 1,25D3-membrane-associated rapid response, steroid (1,25D3-MARRS)-binding protein in rat IEC-6 cells","volume":"70","author":"Rohe","year":"2005","journal-title":"Steroids"},{"key":"10.1016\/j.ecl.2010.02.003_bib127","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1529\/biophysj.105.069369","article-title":"Molecular modelling of CYP27A1 and site-directed mutational analyses affecting vitamin D hydroxylation","volume":"90","author":"Prosser","year":"2006","journal-title":"Biophys J"},{"key":"10.1016\/j.ecl.2010.02.003_bib128","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1124\/mol.106.023275","article-title":"Structure-function analysis of vitamin D 24-hydroxylase (CYP24A1) by site-directed mutagenesis: amino acid residues responsible for species-based difference of CYP24A1 between humans and rats","volume":"70","author":"Hamamoto","year":"2006","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.ecl.2010.02.003_bib129","doi-asserted-by":"crossref","first-page":"12673","DOI":"10.1073\/pnas.0702093104","article-title":"Single A326G mutation converts hCYP24A1 from a 25-OH-D3-24-hydroxylase into -23-hydroxylase generating 1\u03b1,25-(OH)2D3-26,23-lactone","volume":"104","author":"Prosser","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ecl.2010.02.003_bib130","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1002\/jcb.10365","article-title":"Inhibitors of vitamin D hydroxylases: structure-activity relationships","volume":"88","author":"Schuster","year":"2003","journal-title":"J Cell Biochem"},{"key":"10.1016\/j.ecl.2010.02.003_bib131","first-page":"407","article-title":"Experimental investigation on rickets","volume":"196","author":"Mellanby","year":"1919","journal-title":"Lancet"},{"key":"10.1016\/j.ecl.2010.02.003_bib132","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S0021-9258(18)85783-0","article-title":"Studies on experimental rickets. XXI. A demonstration of the existence of a vitamin which promotes calcium deposition","volume":"53","author":"McCollum","year":"1922","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ecl.2010.02.003_bib133","doi-asserted-by":"crossref","first-page":"3317","DOI":"10.1021\/bi00850a001","article-title":"25-Hydroxycholecalciferol. A biologically active metabolite of vitamin D3","volume":"7","author":"Blunt","year":"1968","journal-title":"Biochemistry"},{"key":"10.1016\/j.ecl.2010.02.003_bib134","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1038\/228764a0","article-title":"Unique biosynthesis by kidney of a biologically active vitamin D metabolite","volume":"228","author":"Fraser","year":"1970","journal-title":"Nature"},{"key":"10.1016\/j.ecl.2010.02.003_bib135","doi-asserted-by":"crossref","first-page":"2799","DOI":"10.1021\/bi00790a023","article-title":"Isolation and identification of 1,25-dihydroxycholecalciferol: a metabolite of vitamin D active in intestine","volume":"10","author":"Holick","year":"1971","journal-title":"Biochemistry"},{"key":"10.1016\/j.ecl.2010.02.003_bib136","doi-asserted-by":"crossref","first-page":"4251","DOI":"10.1021\/bi00773a009","article-title":"Isolation and identification of 24,25-dihydroxycholecalciferol: a metabolite of vitamin D3 made in the kidney","volume":"11","author":"Holick","year":"1972","journal-title":"Biochemistry"},{"key":"10.1016\/j.ecl.2010.02.003_bib137","doi-asserted-by":"crossref","first-page":"6691","DOI":"10.1016\/S0021-9258(19)43408-X","article-title":"1,24,25-Trihydroxyvitamin D3. A metabolite of vitamin D3 effective on intestine","volume":"248","author":"Holick","year":"1973","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ecl.2010.02.003_bib138","doi-asserted-by":"crossref","first-page":"4776","DOI":"10.1021\/bi00816a025","article-title":"25,26-dihydroxyvitamin D3, a metabolite of vitamin D3 with intestinal transport activity","volume":"9","author":"Suda","year":"1970","journal-title":"Biochemistry"},{"key":"10.1016\/j.ecl.2010.02.003_bib139","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/0006-291X(79)90976-8","article-title":"25-OHD3-26,23-lactone: a metabolite of vitamin D3 that is 5 times more potent than 25-OHD3 in the rat plasma competitive protein binding radioassay","volume":"89","author":"Horst","year":"1979","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.ecl.2010.02.003_bib140","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1001\/jama.1940.72810310011009a","article-title":"The therapy of rickets","volume":"94","author":"Park","year":"1940","journal-title":"JAMA"},{"key":"10.1016\/j.ecl.2010.02.003_bib141","series-title":"Vitamin D: chemical, biochemical and clinical endocrinology of calcium metabolism","first-page":"1089","article-title":"Preparation of 1\u03b1-hydroxylated vitamin D metabolites by total synthesis","author":"Baggiolini","year":"1982"},{"key":"10.1016\/j.ecl.2010.02.003_bib142","doi-asserted-by":"crossref","first-page":"4297","DOI":"10.1248\/cpb.30.4297","article-title":"Studies on organic fluorine compounds. XXXIX. Studies on steroids. LXXIX. Synthesis of 1\u03b1,25-dihydroxy-26,26,26,27,27,27-hexaflurovitamin D3","volume":"30","author":"Kobayashi","year":"1982","journal-title":"Chem Pharm Bull (Tokyo)"},{"key":"10.1016\/j.ecl.2010.02.003_bib143","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1016\/S0040-4039(00)98795-1","article-title":"1\u03b1,25-Dihydroxy-19-nor-vitamin D3, a novel vitamin D-related compound with potential therapeutic activity","volume":"31","author":"Perlman","year":"1990","journal-title":"Tetrahedron Lett"},{"key":"10.1016\/j.ecl.2010.02.003_bib144","doi-asserted-by":"crossref","first-page":"4410","DOI":"10.1248\/cpb.34.4410","article-title":"Synthetic studies of vitamin D analogues. VIII. Synthesis of 22-oxavitamin D3 analogues","volume":"34","author":"Murayama","year":"1986","journal-title":"Chem Pharm Bull (Tokyo)"},{"key":"10.1016\/j.ecl.2010.02.003_bib145","doi-asserted-by":"crossref","first-page":"4609","DOI":"10.1016\/S0040-4020(01)86903-9","article-title":"Synthesis of MC-903, a biologically active vitamin D metabolite analog","volume":"43","author":"Calverley","year":"1987","journal-title":"Tetrahedron"},{"key":"10.1016\/j.ecl.2010.02.003_bib146","series-title":"Vitamin D: proceedings of the 8th workshop on vitamin D, Paris, France","first-page":"192","article-title":"Synthesis and biological activity of 1\u03b1-hydroxylated vitamin D analogues with poly-unsaturated side chains","author":"Binderup","year":"1991"},{"key":"10.1016\/j.ecl.2010.02.003_bib147","series-title":"Vitamin D: proceedings of the 8th Workshop on Vitamin D, Paris, France","first-page":"163","article-title":"The 20-epi modification in the vitamin D series: Selective enhancement of \u201cnon-classical\u201d receptor-mediated effects","author":"Calverley","year":"1991"},{"key":"10.1016\/j.ecl.2010.02.003_bib148","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1007\/s00432-006-0086-8","article-title":"The vitamin D analogue BXL-628 inhibits growth factor-stimulated proliferation and invasion of DU145 prostate cancer cells","volume":"132","author":"Marchiani","year":"2006","journal-title":"J Cancer Res Clin Oncol"},{"issue":"1","key":"10.1016\/j.ecl.2010.02.003_bib149","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1039\/P19750001421","article-title":"Synthesis of active forms of vitamin D. Part IX. Synthesis of 1\u03b1,24-dihydroxycholecalciferol","volume":"1","author":"Morisaki","year":"1975","journal-title":"J Chem Soc Perkin 1"},{"key":"10.1016\/j.ecl.2010.02.003_bib150","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1210\/me.2004-0234","article-title":"Molecular mechanism of the vitamin D antagonistic actions of (23S)-25-dehydro-1alpha-hydroxyvitamin D3-26,23-lactone depends on the primary structure of the carboxyl-terminal region of the vitamin D receptor","volume":"19","author":"Ochiai","year":"2005","journal-title":"Mol Endocrinol"}],"container-title":["Endocrinology and Metabolism Clinics of North America"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889852910000058?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889852910000058?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T09:34:07Z","timestamp":1760175247000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0889852910000058"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,6]]},"references-count":150,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010,6]]}},"alternative-id":["S0889852910000058"],"URL":"https:\/\/doi.org\/10.1016\/j.ecl.2010.02.003","relation":{},"ISSN":["0889-8529"],"issn-type":[{"type":"print","value":"0889-8529"}],"subject":[],"published":{"date-parts":[[2010,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Vitamin D Analogs","name":"articletitle","label":"Article Title"},{"value":"Endocrinology and Metabolism Clinics of North America","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecl.2010.02.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}