{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T19:53:37Z","timestamp":1773258817060,"version":"3.50.1"},"reference-count":44,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","theclinics.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Endocrinology and Metabolism Clinics of North America"],"published-print":{"date-parts":[[2015,3]]},"DOI":"10.1016\/j.ecl.2014.10.013","type":"journal-article","created":{"date-parts":[[2014,11,4]],"date-time":"2014-11-04T05:34:55Z","timestamp":1415079295000},"page":"161-170","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"title":["Health-Related Quality of Life in Pituitary Diseases"],"prefix":"10.1016","volume":"44","author":[{"given":"Iris","family":"Crespo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Valassi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alicia","family":"Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan M.","family":"Webb","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecl.2014.10.013_bib1","first-page":"221","article-title":"The Nottingham Health profile: subjective health status and medical consultations","volume":"15A","author":"Hunt","year":"1981","journal-title":"Soc Sci Med"},{"key":"10.1016\/j.ecl.2014.10.013_bib2","series-title":"SF-36 health survey. manual and interpretation guide","author":"Ware","year":"1993"},{"key":"10.1016\/j.ecl.2014.10.013_bib3","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1097\/00005650-199711000-00002","article-title":"Modelling valuations for EuroQol health states","volume":"35","author":"Dolan","year":"1997","journal-title":"Med Care"},{"key":"10.1016\/j.ecl.2014.10.013_bib4","first-page":"78","article-title":"Individual and contextual social-status contributions to psychological well-being","volume":"68","author":"Gray","year":"1983","journal-title":"Sociol Soc Res"},{"key":"10.1016\/j.ecl.2014.10.013_bib5","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1530\/EJE-07-0762","article-title":"Evaluation of health-related quality of life in patients with Cushing\u2019s syndrome with a new questionnaire","volume":"158","author":"Webb","year":"2008","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.ecl.2014.10.013_bib6","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1530\/EJE-12-0325","article-title":"Psychometric performance of the CushingQoL questionnaire in conditions of clinical practice","volume":"167","author":"Santos","year":"2012","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.ecl.2014.10.013_bib7","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1046\/j.1365-2265.2002.01597.x","article-title":"Acromegaly Quality of Life Questionnaire (ACROQOL) a new health-related quality of life questionnaire for patients with acromegaly: development and psychometric properties","volume":"57","author":"Webb","year":"2002","journal-title":"Clin Endocrinol"},{"key":"10.1016\/j.ecl.2014.10.013_bib8","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1023\/A:1008987922774","article-title":"The QoL.AGHDA: an instrument for the assessment of quality of life in adults with growth hormone deficiency","volume":"8","author":"McKenna","year":"1999","journal-title":"Qual Life Res"},{"key":"10.1016\/j.ecl.2014.10.013_bib9","doi-asserted-by":"crossref","first-page":"4158","DOI":"10.1210\/jc.2002-021792","article-title":"Decreased quality of life in adult patients with growth hormone deficiency compared with general populations using the new, validated, self-weighted questionnaire, questions on life satisfaction hypopituitarism module","volume":"88","author":"Blum","year":"2003","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.ecl.2014.10.013_bib10","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1210\/jc.2003-030134","article-title":"Long-term improvement of quality of life during growth hormone (GH) replacement therapy in adults with GH deficiency, as measured by questions on life satisfaction-hypopituitarism (QLS-H)","volume":"89","author":"Rosilio","year":"2004","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.ecl.2014.10.013_bib11","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1023\/B:PITU.0000004798.27230.ed","article-title":"Quality of life in patients with a pituitary adenoma","volume":"6","author":"Johnson","year":"2003","journal-title":"Pituitary"},{"key":"10.1016\/j.ecl.2014.10.013_bib12","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1530\/EJE-12-0308","article-title":"Impaired quality of life in patients in long-term remission of Cushing\u2019s syndrome of both adrenal and pituitary origin: a remaining effect of long-standing hypercortisolism?","volume":"167","author":"Wagenmakers","year":"2012","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.ecl.2014.10.013_bib13","doi-asserted-by":"crossref","first-page":"3279","DOI":"10.1210\/jc.2004-1375","article-title":"Quality of life in patients after long-term biochemical cure of Cushing\u2019s disease","volume":"90","author":"Van Aken","year":"2002","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.ecl.2014.10.013_bib14","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/S0889-8529(18)30087-2","article-title":"Cushing's syndrome from the patient's perspective","volume":"23","author":"Gotch","year":"1994","journal-title":"Endocrinol Metab Clin North Am"},{"key":"10.1016\/j.ecl.2014.10.013_bib15","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1046\/j.1365-2796.1999.00483.x","article-title":"The survival and well-being of patients treated for Cushing\u2019s syndrome","volume":"245","author":"Pikkarainen","year":"1999","journal-title":"J\u00a0Intern Med"},{"key":"10.1016\/j.ecl.2014.10.013_bib16","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1530\/EJE-11-0272","article-title":"The European Registry on Cushing\u2019s syndrome: 2-year experience. Baseline demographic and clinical characteristics","volume":"165","author":"Valassi","year":"2011","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.ecl.2014.10.013_bib17","first-page":"912","article-title":"The longitudinal course of psychopathology in Cushing\u2019s syndrome after correction of hypercortisolism","volume":"82","author":"Dorn","year":"1997","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.ecl.2014.10.013_bib18","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1097\/01.sla.0000251578.03883.2f","article-title":"Improved quality of life after bilateral laparoscopic adrenalectomy for Cushing\u2019s disease: a 10-year experience","volume":"245","author":"Thompson","year":"2007","journal-title":"Ann Surg"},{"key":"10.1016\/j.ecl.2014.10.013_bib19","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1016\/j.surg.2008.08.024","article-title":"Waiting for change: symptom resolution after adrenalectomy for Cushing\u2019s syndrome","volume":"144","author":"Sippel","year":"2008","journal-title":"Surgery"},{"key":"10.1016\/j.ecl.2014.10.013_bib20","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1016\/j.jamcollsurg.2009.02.054","article-title":"Bilateral adrenalectomy for refractory Cushing\u2019s Disease: a safe and definitive therapy","volume":"208","author":"Smith","year":"2009","journal-title":"J\u00a0Am Coll Surg"},{"issue":"11","key":"10.1016\/j.ecl.2014.10.013_bib21","doi-asserted-by":"crossref","first-page":"3550","DOI":"10.1210\/jc.2011-1645","article-title":"Affected illness perceptions and the association with impaired quality of life in patients with long-term remission of acromegaly","volume":"96","author":"Tiemensma","year":"2011","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.ecl.2014.10.013_bib22","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1530\/EJE-08-0896","article-title":"Personality in patients with pituitary adenomas is characterized by increased anxiety related traits: comparison of 70 acromegalic patients to patients with non-functioning pituitary adenomas and age and gender matched controls","volume":"160","author":"Sievers","year":"2009","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.ecl.2014.10.013_bib23","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1530\/EJE-07-0838","article-title":"Impact of musculoskeletal disease on quality of life in long-standing acromegaly","volume":"158","author":"Miller","year":"2008","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.ecl.2014.10.013_bib24","doi-asserted-by":"crossref","first-page":"3853","DOI":"10.1210\/jc.2008-0669","article-title":"Quality of life in acromegalic patients during long-term somatostatin analog treatment with and without pegvisomant","volume":"93","author":"Neggers","year":"2008","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.ecl.2014.10.013_bib25","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1530\/EJE-11-0853","article-title":"Quality of life is impaired in association with the need for prolonged postoperative therapy by somatostatin analogs in patients with acromegaly","volume":"166","author":"Postma","year":"2012","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.ecl.2014.10.013_bib26","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1111\/j.1365-2265.2007.03169.x","article-title":"Previous radiotherapy negatively influences quality of life during 4 years of follow-up in patients cured from acromegaly","volume":"69","author":"Van der Klaauw","year":"2008","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.1016\/j.ecl.2014.10.013_bib27","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1111\/j.1365-2265.2007.03012.x","article-title":"Wide variation in surgical outcomes for acromegaly in the UK","volume":"68","author":"Bates","year":"2008","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.1016\/j.ecl.2014.10.013_bib28","doi-asserted-by":"crossref","first-page":"3891","DOI":"10.1210\/jc.2006-0676","article-title":"Quality of life in treated patients with acromegaly","volume":"91","author":"Kauppinen-M\u00e4kelin","year":"2006","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.ecl.2014.10.013_bib29","doi-asserted-by":"crossref","first-page":"2471","DOI":"10.1210\/jc.2008-2671","article-title":"Growth hormone deficiency is associated with decreased quality of life in patients with prior acromegaly","volume":"94","author":"Wexler","year":"2009","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.ecl.2014.10.013_bib30","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/s11102-008-0091-9","article-title":"Quality of life in women with microprolactinoma treated with dopamine agonists","volume":"11","author":"Cesar de Oliveira Naliato","year":"2008","journal-title":"Pituitary"},{"key":"10.1016\/j.ecl.2014.10.013_bib31","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1530\/EJE-07-0259","article-title":"Quality of life is decreased in female patients treated for microprolactinoma","volume":"157","author":"Kars","year":"2007","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.ecl.2014.10.013_bib32","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1159\/000335996","article-title":"Distinct dopaminergic personality patterns in patients with prolactinomas: a comparison with non-functioning pituitary adenoma patients and age- and gender-matched controls","volume":"96","author":"Athanasoulia","year":"2012","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.ecl.2014.10.013_bib33","first-page":"104","article-title":"Update in prolactinomas","volume":"68","author":"Kars","year":"2010","journal-title":"Neth J Med"},{"key":"10.1016\/j.ecl.2014.10.013_bib34","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1111\/j.1365-2265.2008.03288.x","article-title":"Disease-specific impairments in quality of life during long-term follow-up of patients with different pituitary adenomas","volume":"69","author":"Van der Klaauw","year":"2008","journal-title":"Clin Endocrinol"},{"key":"10.1016\/j.ecl.2014.10.013_bib35","doi-asserted-by":"crossref","first-page":"3364","DOI":"10.1210\/jc.2006-0003","article-title":"Quality of life is decreased after treatment for nonfunctioning pituitary macroadenomas","volume":"91","author":"Dekkers","year":"2006","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.ecl.2014.10.013_bib36","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1111\/j.1365-2265.2012.04449.x","article-title":"Current treatment protocols can offer a normal or near normal quality of life in the majority of patients with non-functioning pituitary adenomas","volume":"78","author":"Capatina","year":"2013","journal-title":"Clin Endocrinol"},{"issue":"3","key":"10.1016\/j.ecl.2014.10.013_bib37","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1007\/s12020-013-0106-9","article-title":"Self-perception of cognitive function among patients with active acromegaly, controlled acromegaly, and non-functional pituitary adenoma: a pilot study","volume":"46","author":"Yedinak","year":"2014","journal-title":"Endocrine"},{"key":"10.1016\/j.ecl.2014.10.013_bib38","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1530\/EJE-11-0566","article-title":"Can we ever stop imaging in surgically treated and radiotherapy-naive patients with non-functioning pituitary adenoma?","volume":"165","author":"Reddy","year":"2011","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.ecl.2014.10.013_bib39","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1210\/jc.2010-2742","article-title":"Patients previously treated for non-functioning pituitary macroadenomas have disturbed sleep characteristics, circadian movement rhythm and subjective sleep quality","volume":"96","author":"Biermasz","year":"2011","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.ecl.2014.10.013_bib40","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1111\/j.1365-2265.1992.tb02347.x","article-title":"The growth hormone deficiency syndrome in adults","volume":"37","author":"Cuneo","year":"1992","journal-title":"Clin Endocrinol"},{"key":"10.1016\/j.ecl.2014.10.013_bib41","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1111\/j.1365-2265.2007.03010.x","article-title":"Growth hormone (GH) replacement in hypopituitary adults with GH deficiency evaluated by a utility-weighted quality of life index: a precursor to cost-utility analysis","volume":"68","author":"Koltowska-H\u00e4ggstr\u00f6m","year":"2008","journal-title":"Clin Endocrinol"},{"key":"10.1016\/j.ecl.2014.10.013_bib42","doi-asserted-by":"crossref","first-page":"3983","DOI":"10.1210\/jc.2012-2477","article-title":"GH replacement improves quality of life and metabolic parameters in cured acromegalic patients with growth hormone deficiency","volume":"97","author":"Giavoli","year":"2012","journal-title":"J\u00a0Clin Endocrinol Metab"},{"issue":"Suppl 1","key":"10.1016\/j.ecl.2014.10.013_bib43","doi-asserted-by":"crossref","first-page":"S51","DOI":"10.1530\/EJE-09-0266","article-title":"Assessment of quality of life in adult patients with GH deficiency: KIMS contribution to clinical practice and pharmacoeconomic evaluations","volume":"161","author":"Koltowska-H\u00e4ggstr\u00f6m","year":"2009","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.ecl.2014.10.013_bib44","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1046\/j.1365-2265.2002.01608.x","article-title":"The effect of long-term untreated growth hormone deficiency (GHD) and 9 years of GH replacement on the quality of life (QoL) of GH-deficient adults","volume":"57","author":"Gilchrist","year":"2002","journal-title":"Clin Endocrinol"}],"container-title":["Endocrinology and Metabolism Clinics of North America"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889852914001078?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889852914001078?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T09:39:22Z","timestamp":1760175562000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0889852914001078"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3]]},"references-count":44,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,3]]}},"alternative-id":["S0889852914001078"],"URL":"https:\/\/doi.org\/10.1016\/j.ecl.2014.10.013","relation":{},"ISSN":["0889-8529"],"issn-type":[{"value":"0889-8529","type":"print"}],"subject":[],"published":{"date-parts":[[2015,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Health-Related Quality of Life in Pituitary Diseases","name":"articletitle","label":"Article Title"},{"value":"Endocrinology and Metabolism Clinics of North America","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecl.2014.10.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}