{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T05:10:56Z","timestamp":1790831456074,"version":"4.1.0"},"reference-count":58,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","theclinics.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Endocrinology and Metabolism Clinics of North America"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1016\/j.ecl.2016.06.012","type":"journal-article","created":{"date-parts":[[2016,10,9]],"date-time":"2016-10-09T15:40:14Z","timestamp":1476027614000},"page":"783-797","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":187,"title":["Lipodystrophy Syndromes"],"prefix":"10.1016","volume":"45","author":[{"given":"Iram","family":"Hussain","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhimanyu","family":"Garg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.ecl.2016.06.012_bib1","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1056\/NEJMra025261","article-title":"Acquired and inherited lipodystrophies","volume":"350","author":"Garg","year":"2004","journal-title":"N\u00a0Engl J Med"},{"issue":"11","key":"10.1016\/j.ecl.2016.06.012_bib2","doi-asserted-by":"crossref","first-page":"3313","DOI":"10.1210\/jc.2011-1159","article-title":"Clinical review#: Lipodystrophies: genetic and acquired body fat disorders","volume":"96","author":"Garg","year":"2011","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.ecl.2016.06.012_bib3","series-title":"Leptin: regulation and clinical applications","first-page":"225","article-title":"Leptin therapy in patients with lipodystrophy and syndromic insulin resistance","author":"Brown","year":"2015"},{"issue":"1","key":"10.1016\/j.ecl.2016.06.012_bib4","doi-asserted-by":"crossref","first-page":"107","DOI":"10.4158\/endp.19.1.v767575m65p5mr06","article-title":"The clinical approach to the detection of lipodystrophy: an AACE consensus statement","volume":"19","author":"Handelsman","year":"2013","journal-title":"Endocr Pract"},{"issue":"5","key":"10.1016\/j.ecl.2016.06.012_bib5","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.1210\/jcem.87.5.8624","article-title":"Serum adiponectin and leptin levels in patients with lipodystrophies","volume":"87","author":"Haque","year":"2002","journal-title":"J\u00a0Clin Endocrinol Metab"},{"issue":"3","key":"10.1016\/j.ecl.2016.06.012_bib6","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1210\/jc.2009-1824","article-title":"Higher adiponectin levels in patients with Berardinelli-Seip congenital lipodystrophy due to seipin as compared with 1-acylglycerol-3-phosphate-o-acyltransferase-2 deficiency","volume":"95","author":"Antuna-Puente","year":"2010","journal-title":"J\u00a0Clin Endocrinol Metab"},{"issue":"10","key":"10.1016\/j.ecl.2016.06.012_bib7","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1136\/jmg.39.10.722","article-title":"Genotype-phenotype relationships in Berardinelli-Seip congenital lipodystrophy","volume":"39","author":"Van Maldergem","year":"2002","journal-title":"J\u00a0Med Genet"},{"issue":"10","key":"10.1016\/j.ecl.2016.06.012_bib8","doi-asserted-by":"crossref","first-page":"4840","DOI":"10.1210\/jc.2003-030855","article-title":"Phenotypic and genetic heterogeneity in congenital generalized lipodystrophy","volume":"88","author":"Agarwal","year":"2003","journal-title":"J\u00a0Clin Endocrinol Metab"},{"issue":"4","key":"10.1016\/j.ecl.2016.06.012_bib9","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1038\/ng585","article-title":"Identification of the gene altered in Berardinelli-Seip congenital lipodystrophy on chromosome 11q13","volume":"28","author":"Magre","year":"2001","journal-title":"Nat Genet"},{"issue":"1","key":"10.1016\/j.ecl.2016.06.012_bib10","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/ng880","article-title":"AGPAT2 is mutated in congenital generalized lipodystrophy linked to chromosome 9q34","volume":"31","author":"Agarwal","year":"2002","journal-title":"Nat Genet"},{"issue":"4","key":"10.1016\/j.ecl.2016.06.012_bib11","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1210\/jc.2007-1328","article-title":"Association of a homozygous nonsense caveolin-1 mutation with Berardinelli-Seip congenital lipodystrophy","volume":"93","author":"Kim","year":"2008","journal-title":"J\u00a0Clin Endocrinol Metab"},{"issue":"9","key":"10.1016\/j.ecl.2016.06.012_bib12","doi-asserted-by":"crossref","first-page":"2623","DOI":"10.1172\/JCI38660","article-title":"Human PTRF mutations cause secondary deficiency of caveolins resulting in muscular dystrophy with generalized lipodystrophy","volume":"119","author":"Hayashi","year":"2009","journal-title":"J\u00a0Clin Invest"},{"issue":"5","key":"10.1016\/j.ecl.2016.06.012_bib13","first-page":"1776","article-title":"Gender differences in the prevalence of metabolic complications in familial partial lipodystrophy (Dunnigan variety)","volume":"85","author":"Garg","year":"2000","journal-title":"J\u00a0Clin Endocrinol Metab"},{"issue":"1","key":"10.1016\/j.ecl.2016.06.012_bib14","first-page":"170","article-title":"Adipose tissue distribution pattern in patients with familial partial lipodystrophy (Dunnigan variety)","volume":"84","author":"Garg","year":"1999","journal-title":"J\u00a0Clin Endocrinol Metab"},{"issue":"1","key":"10.1016\/j.ecl.2016.06.012_bib15","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1111\/j.1399-0004.2009.01350.x","article-title":"Overlapping syndrome with familial partial lipodystrophy, Dunnigan variety and cardiomyopathy due to amino-terminal heterozygous missense lamin A\/C mutations","volume":"78","author":"Subramanyam","year":"2010","journal-title":"Clin Genet"},{"issue":"2","key":"10.1016\/j.ecl.2016.06.012_bib16","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1136\/jmg.23.2.120","article-title":"Familial partial lipodystrophy: two types of an X linked dominant syndrome, lethal in the hemizygous state","volume":"23","author":"Kobberling","year":"1986","journal-title":"J\u00a0Med Genet"},{"issue":"1","key":"10.1016\/j.ecl.2016.06.012_bib17","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1093\/hmg\/9.1.109","article-title":"Nuclear lamin A\/C R482Q mutation in Canadian kindreds with Dunnigan-type familial partial lipodystrophy","volume":"9","author":"Cao","year":"2000","journal-title":"Hum Mol Genet"},{"issue":"2","key":"10.1016\/j.ecl.2016.06.012_bib18","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/72807","article-title":"LMNA, encoding lamin A\/C, is mutated in partial lipodystrophy","volume":"24","author":"Shackleton","year":"2000","journal-title":"Nat Genet"},{"issue":"4","key":"10.1016\/j.ecl.2016.06.012_bib19","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1086\/302836","article-title":"Mutational and haplotype analyses of families with familial partial lipodystrophy (Dunnigan variety) reveal recurrent missense mutations in the globular C-terminal domain of lamin A\/C","volume":"66","author":"Speckman","year":"2000","journal-title":"Am J Hum Genet"},{"issue":"1","key":"10.1016\/j.ecl.2016.06.012_bib20","first-page":"408","article-title":"A\u00a0novel heterozygous mutation in peroxisome proliferator-activated receptor-gamma gene in a patient with familial partial lipodystrophy","volume":"87","author":"Agarwal","year":"2002","journal-title":"J\u00a0Clin Endocrinol Metab"},{"issue":"3","key":"10.1016\/j.ecl.2016.06.012_bib21","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1172\/JCI28003","article-title":"PPAR gamma and human metabolic disease","volume":"116","author":"Semple","year":"2006","journal-title":"J\u00a0Clin Invest"},{"issue":"8","key":"10.1016\/j.ecl.2016.06.012_bib22","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1056\/NEJMoa1007487","article-title":"Perilipin deficiency and autosomal dominant partial lipodystrophy","volume":"364","author":"Gandotra","year":"2011","journal-title":"N\u00a0Engl J Med"},{"issue":"5","key":"10.1016\/j.ecl.2016.06.012_bib23","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1002\/emmm.200900037","article-title":"Partial lipodystrophy and insulin resistant diabetes in a patient with a homozygous nonsense mutation in CIDEC","volume":"1","author":"Rubio-Cabezas","year":"2009","journal-title":"EMBO Mol Med"},{"issue":"24","key":"10.1016\/j.ecl.2016.06.012_bib24","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1056\/NEJMoa1315496","article-title":"Null mutation in hormone-sensitive lipase gene and risk of type 2 diabetes","volume":"370","author":"Albert","year":"2014","journal-title":"N\u00a0Engl J Med"},{"issue":"12","key":"10.1016\/j.ecl.2016.06.012_bib25","first-page":"1649","article-title":"A\u00a0novel LIPE nonsense mutation found using exome sequencing in siblings with late-onset familial partial lipodystrophy","volume":"30","author":"Farhan","year":"2014","journal-title":"Can J Cardiol"},{"issue":"5675","key":"10.1016\/j.ecl.2016.06.012_bib26","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1126\/science.1096706","article-title":"A\u00a0family with severe insulin resistance and diabetes due to a mutation in AKT2","volume":"304","author":"George","year":"2004","journal-title":"Science"},{"issue":"9","key":"10.1016\/j.ecl.2016.06.012_bib27","doi-asserted-by":"crossref","first-page":"e86870","DOI":"10.1172\/jci.insight.86870","article-title":"Whole-exome sequencing identifies ADRA2A mutation in atypical familial partial lipodystrophy","volume":"1","author":"Garg","year":"2016","journal-title":"JCI Insight"},{"issue":"2","key":"10.1016\/j.ecl.2016.06.012_bib28","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1097\/00005792-200303000-00007","article-title":"Clinical features and metabolic derangements in acquired generalized lipodystrophy: case reports and review of the literature","volume":"82","author":"Misra","year":"2003","journal-title":"Medicine (Baltimore)"},{"issue":"1","key":"10.1016\/j.ecl.2016.06.012_bib29","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1097\/01.md.0000111061.69212.59","article-title":"Clinical features and metabolic and autoimmune derangements in acquired partial lipodystrophy: report of 35 cases and review of the literature","volume":"83","author":"Misra","year":"2004","journal-title":"Medicine (Baltimore)"},{"issue":"11","key":"10.1016\/j.ecl.2016.06.012_bib30","doi-asserted-by":"crossref","first-page":"4845","DOI":"10.1210\/jc.2002-020794","article-title":"Clinical review 153: Lipodystrophy in human immunodeficiency virus-infected patients","volume":"87","author":"Chen","year":"2002","journal-title":"J\u00a0Clin Endocrinol Metab"},{"issue":"1","key":"10.1016\/j.ecl.2016.06.012_bib31","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1056\/NEJMra041811","article-title":"Cardiovascular risk and body-fat abnormalities in HIV-infected adults","volume":"352","author":"Grinspoon","year":"2005","journal-title":"N\u00a0Engl J Med"},{"issue":"2","key":"10.1016\/j.ecl.2016.06.012_bib32","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.bbrc.2008.07.033","article-title":"HIV-protease inhibitors block the enzymatic activity of purified Ste24p","volume":"374","author":"Hudon","year":"2008","journal-title":"Biochem Biophys Res Commun"},{"issue":"50","key":"10.1016\/j.ecl.2016.06.012_bib33","doi-asserted-by":"crossref","first-page":"14711","DOI":"10.1021\/bi035596s","article-title":"Toxicity of nucleoside analogues used to treat AIDS and the selectivity of the mitochondrial DNA polymerase","volume":"42","author":"Lee","year":"2003","journal-title":"Biochemistry"},{"issue":"2","key":"10.1016\/j.ecl.2016.06.012_bib34","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0002-9343(99)00414-3","article-title":"Lipodystrophies","volume":"108","author":"Garg","year":"2000","journal-title":"Am J Med"},{"issue":"3","key":"10.1016\/j.ecl.2016.06.012_bib35","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1210\/jcem-57-3-517","article-title":"Eucaloric substitution of medium chain\u00a0triglycerides for dietary long chain fatty acids in acquired total lipodystrophy: effects on hyperlipoproteinemia and endogenous insulin resistance","volume":"57","author":"Wilson","year":"1983","journal-title":"J\u00a0Clin Endocrinol Metab"},{"issue":"8","key":"10.1016\/j.ecl.2016.06.012_bib36","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1056\/NEJMoa012437","article-title":"Leptin-replacement therapy for lipodystrophy","volume":"346","author":"Oral","year":"2002","journal-title":"N\u00a0Engl J Med"},{"issue":"1","key":"10.1016\/j.ecl.2016.06.012_bib37","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s00125-009-1502-9","article-title":"Efficacy of leptin therapy in the different forms of human lipodystrophy","volume":"53","author":"Chong","year":"2010","journal-title":"Diabetologia"},{"issue":"7","key":"10.1016\/j.ecl.2016.06.012_bib38","doi-asserted-by":"crossref","first-page":"1994","DOI":"10.2337\/diabetes.54.7.1994","article-title":"Long-term efficacy of leptin replacement in patients with generalized lipodystrophy","volume":"54","author":"Javor","year":"2005","journal-title":"Diabetes"},{"issue":"4","key":"10.1016\/j.ecl.2016.06.012_bib39","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.metabol.2006.11.010","article-title":"Long-term efficacy of leptin replacement in patients with Dunnigan-type familial partial lipodystrophy","volume":"56","author":"Park","year":"2007","journal-title":"Metabolism"},{"issue":"3","key":"10.1016\/j.ecl.2016.06.012_bib40","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1210\/jc.2011-2229","article-title":"Comparison of efficacy and safety of leptin replacement therapy in moderately and severely hypoleptinemic patients with familial partial lipodystrophy of the Dunnigan variety","volume":"97","author":"Simha","year":"2012","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.ecl.2016.06.012_bib41","first-page":"1391","article-title":"New advances in the treatment of generalized lipodystrophy: role of metreleptin","volume":"11","author":"Rodriguez","year":"2015","journal-title":"Ther Clin Risk Manag"},{"issue":"1","key":"10.1016\/j.ecl.2016.06.012_bib42","doi-asserted-by":"crossref","first-page":"45","DOI":"10.3109\/10428194.2015.1040015","article-title":"Lymphoma in acquired generalized lipodystrophy","volume":"57","author":"Brown","year":"2016","journal-title":"Leuk Lymphoma"},{"issue":"9","key":"10.1016\/j.ecl.2016.06.012_bib43","doi-asserted-by":"crossref","first-page":"2245","DOI":"10.1002\/ajmg.a.33578","article-title":"Congenital generalized lipodystrophy, type 4 (CGL4) associated with myopathy due to novel PTRF mutations","volume":"152A","author":"Shastry","year":"2010","journal-title":"Am J Med Genet A"},{"issue":"3","key":"10.1016\/j.ecl.2016.06.012_bib44","doi-asserted-by":"crossref","first-page":"e1000874","DOI":"10.1371\/journal.pgen.1000874","article-title":"Fatal cardiac arrhythmia and long-QT syndrome in a new form of congenital generalized lipodystrophy with muscle rippling (CGL4) due to PTRF-CAVIN mutations","volume":"6","author":"Rajab","year":"2010","journal-title":"PLoS Genet"},{"issue":"6","key":"10.1016\/j.ecl.2016.06.012_bib45","doi-asserted-by":"crossref","first-page":"2821","DOI":"10.1210\/jc.2002-021575","article-title":"Genetic and phenotypic heterogeneity in patients with mandibuloacral dysplasia-associated lipodystrophy","volume":"88","author":"Simha","year":"2003","journal-title":"J\u00a0Clin Endocrinol Metab"},{"issue":"2","key":"10.1016\/j.ecl.2016.06.012_bib46","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1086\/341908","article-title":"Mandibuloacral dysplasia is caused by a mutation in LMNA-encoding lamin A\/C","volume":"71","author":"Novelli","year":"2002","journal-title":"Am J Hum Genet"},{"issue":"16","key":"10.1016\/j.ecl.2016.06.012_bib47","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1093\/hmg\/ddg213","article-title":"Zinc metalloproteinase, ZMPSTE24, is mutated in mandibuloacral dysplasia","volume":"12","author":"Agarwal","year":"2003","journal-title":"Hum Mol Genet"},{"issue":"9","key":"10.1016\/j.ecl.2016.06.012_bib48","doi-asserted-by":"crossref","first-page":"E58","DOI":"10.1210\/jc.2010-0488","article-title":"An autosomal recessive syndrome of joint contractures, muscular atrophy, microcytic anemia, and panniculitis-associated lipodystrophy","volume":"95","author":"Garg","year":"2010","journal-title":"J\u00a0Clin Endocrinol Metab"},{"issue":"6","key":"10.1016\/j.ecl.2016.06.012_bib49","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1016\/j.ajhg.2010.10.031","article-title":"PSMB8 encoding the beta5i proteasome subunit is mutated in joint contractures, muscle atrophy, microcytic anemia, and panniculitis-induced lipodystrophy syndrome","volume":"87","author":"Agarwal","year":"2010","journal-title":"Am J Hum Genet"},{"issue":"1","key":"10.1016\/j.ecl.2016.06.012_bib50","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.ajhg.2013.05.019","article-title":"PIK3R1 mutations cause syndromic insulin resistance with lipoatrophy","volume":"93","author":"Thauvin-Robinet","year":"2013","journal-title":"Am J Hum Genet"},{"issue":"10","key":"10.1016\/j.ecl.2016.06.012_bib51","doi-asserted-by":"crossref","first-page":"E192","DOI":"10.1210\/jc.2010-0419","article-title":"A\u00a0novel syndrome of mandibular hypoplasia, deafness, and progeroid features associated with lipodystrophy, undescended testes, and male hypogonadism","volume":"95","author":"Shastry","year":"2010","journal-title":"J\u00a0Clin Endocrinol Metab"},{"issue":"8","key":"10.1016\/j.ecl.2016.06.012_bib52","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1038\/ng.2670","article-title":"An in-frame deletion at the polymerase active site of POLD1 causes a multisystem disorder with lipodystrophy","volume":"45","author":"Weedon","year":"2013","journal-title":"Nat Genet"},{"issue":"11","key":"10.1016\/j.ecl.2016.06.012_bib53","doi-asserted-by":"crossref","first-page":"2749","DOI":"10.1002\/ajmg.a.33690","article-title":"Marfan syndrome with neonatal progeroid syndrome-like lipodystrophy associated with a novel frameshift mutation at the 3' terminus of the FBN1-gene","volume":"152A","author":"Graul-Neumann","year":"2010","journal-title":"Am J Med Genet A"},{"issue":"5","key":"10.1016\/j.ecl.2016.06.012_bib54","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1002\/ajmg.a.36449","article-title":"De novo heterozygous FBN1 mutations in the extreme C-terminal region cause progeroid fibrillinopathy","volume":"164A","author":"Garg","year":"2014","journal-title":"Am J Med Genet A"},{"issue":"8","key":"10.1016\/j.ecl.2016.06.012_bib55","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1002\/ajmg.a.37115","article-title":"Whole exome sequencing identifies de novo heterozygous CAV1 mutations associated with a novel neonatal onset lipodystrophy syndrome","volume":"167A","author":"Garg","year":"2015","journal-title":"Am J Med Genet A"},{"issue":"12","key":"10.1016\/j.ecl.2016.06.012_bib56","doi-asserted-by":"crossref","first-page":"4971","DOI":"10.1210\/jc.2009-0472","article-title":"Atypical progeroid syndrome due to heterozygous missense LMNA mutations","volume":"94","author":"Garg","year":"2009","journal-title":"J\u00a0Clin Endocrinol Metab"},{"issue":"6","key":"10.1016\/j.ecl.2016.06.012_bib57","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1056\/NEJMoa0706898","article-title":"Phenotype and course of Hutchinson-Gilford progeria syndrome","volume":"358","author":"Merideth","year":"2008","journal-title":"N\u00a0Engl J Med"},{"issue":"1","key":"10.1016\/j.ecl.2016.06.012_bib58","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1210\/jc.2008-1703","article-title":"Complement abnormalities in acquired lipodystrophy revisited","volume":"94","author":"Savage","year":"2009","journal-title":"J\u00a0Clin Endocrinol Metab"}],"container-title":["Endocrinology and Metabolism Clinics of North America"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889852916300706?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889852916300706?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T09:41:02Z","timestamp":1760175662000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0889852916300706"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":58,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["S0889852916300706"],"URL":"https:\/\/doi.org\/10.1016\/j.ecl.2016.06.012","relation":{},"ISSN":["0889-8529"],"issn-type":[{"value":"0889-8529","type":"print"}],"subject":[],"published":{"date-parts":[[2016,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lipodystrophy Syndromes","name":"articletitle","label":"Article Title"},{"value":"Endocrinology and Metabolism Clinics of North America","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecl.2016.06.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}