{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T10:12:37Z","timestamp":1789726357489,"version":"4.0.1"},"reference-count":256,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","theclinics.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Endocrinology and Metabolism Clinics of North America"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1016\/j.ecl.2017.07.008","type":"journal-article","created":{"date-parts":[[2017,9,29]],"date-time":"2017-09-29T16:15:43Z","timestamp":1506701743000},"page":"983-1007","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":38,"title":["The Use of Vitamin D Metabolites and Analogues in the Treatment of Chronic Kidney Disease"],"prefix":"10.1016","volume":"46","author":[{"given":"Ladan","family":"Zand","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajiv","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.ecl.2017.07.008_bib1","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1038\/sj.ki.5000414","article-title":"Definition, evaluation, and classification of renal osteodystrophy: a position statement from kidney disease: improving global outcomes (KDIGO)","volume":"69","author":"Moe","year":"2006","journal-title":"Kidney Int"},{"issue":"1","key":"10.1016\/j.ecl.2017.07.008_bib2","first-page":"21","article-title":"Behavior of the vitamin D endocrine system in the development of renal osteodystrophy","volume":"6","author":"McCarthy","year":"1986","journal-title":"Semin Nephrol"},{"issue":"1","key":"10.1016\/j.ecl.2017.07.008_bib3","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0889-8529(18)30339-6","article-title":"Renal osteodystrophy","volume":"19","author":"McCarthy","year":"1990","journal-title":"Endocrinol Metab Clin North Am"},{"key":"10.1016\/j.ecl.2017.07.008_bib4","series-title":"Vitamin D: basic and clinical aspects","first-page":"611","article-title":"Role of the vitamin D system in the pathogenesis of renal osteodystrophy","author":"McCarthy","year":"1984"},{"issue":"3","key":"10.1016\/j.ecl.2017.07.008_bib5","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1053\/j.ajkd.2003.12.003","article-title":"Diagnosis, assessment, and treatment of bone turnover abnormalities in renal osteodystrophy","volume":"43","author":"Martin","year":"2004","journal-title":"Am J kidney Dis"},{"key":"10.1016\/j.ecl.2017.07.008_bib6","series-title":"Vitamin D: chemical, biochemical and clinical endocrinology of calcium metabolism","first-page":"827","article-title":"Bone disease in uremia: a reappraisal","author":"Coburn","year":"1982"},{"issue":"5","key":"10.1016\/j.ecl.2017.07.008_bib7","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1001\/archinte.1969.00300150061009","article-title":"Calcium, phosphorus, and bone in renal disease and transplantation","volume":"123","author":"Bricker","year":"1969","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.ecl.2017.07.008_bib8","first-page":"48","article-title":"Management of renal osteodystrophy with 1,25(OH)2D3. II. Effects on histopathology of bone: evidence for healing of osteomalacia","volume":"2","author":"Maung","year":"1979","journal-title":"Mineral Elect Metab"},{"issue":"6","key":"10.1016\/j.ecl.2017.07.008_bib9","first-page":"423","article-title":"The new kidney disease: improving global outcomes (KDIGO) guidelines - expert clinical focus on bone and vascular calcification","volume":"74","author":"London","year":"2010","journal-title":"Clin Nephrol"},{"issue":"4","key":"10.1016\/j.ecl.2017.07.008_bib10","first-page":"209","article-title":"Bone disease in renal failure. Introduction","volume":"17","author":"Malluche","year":"1991","journal-title":"Miner Electrolyte Metab"},{"issue":"4","key":"10.1016\/j.ecl.2017.07.008_bib11","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/ki.1976.42","article-title":"Bone histology in incipient and advanced renal failure","volume":"9","author":"Malluche","year":"1976","journal-title":"Kidney Int"},{"issue":"4","key":"10.1016\/j.ecl.2017.07.008_bib12","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1001\/archinte.1969.00300200029005","article-title":"Circulating parathyroid hormone concentration in chronic renal insufficiency","volume":"124","author":"Reiss","year":"1969","journal-title":"Arch Intern Med"},{"issue":"4","key":"10.1016\/j.ecl.2017.07.008_bib13","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1001\/archinte.1969.00300200020003","article-title":"Secondary hyperparathyroidism in chronic renal disease","volume":"124","author":"Potts","year":"1969","journal-title":"Arch Intern Med"},{"issue":"2","key":"10.1016\/j.ecl.2017.07.008_bib14","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/S0022-3476(80)80479-3","article-title":"Early diagnosis of juvenile renal osteodystrophy","volume":"97","author":"Norman","year":"1980","journal-title":"J\u00a0Pediatr"},{"key":"10.1016\/j.ecl.2017.07.008_bib15","series-title":"Vitamin D: chemical, biochemical and clinical endocrinology of calcium metabolism","first-page":"853","article-title":"Histomorphometric classification of juvenile renal osteodystrophy: prevalence of mineralizing defect","author":"Baron","year":"1982"},{"issue":"4","key":"10.1016\/j.ecl.2017.07.008_bib16","doi-asserted-by":"crossref","first-page":"E729","DOI":"10.1152\/ajpendo.00065.2005","article-title":"Acute regulation of parathyroid hormone by dietary phosphate","volume":"289","author":"Martin","year":"2005","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"6","key":"10.1016\/j.ecl.2017.07.008_bib17","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1097\/00000441-199906000-00004","article-title":"The role of phosphorus in the development of secondary hyperparathyroidism and parathyroid cell proliferation in chronic renal failure","volume":"317","author":"Slatopolsky","year":"1999","journal-title":"Am J Med Sci"},{"issue":"121","key":"10.1016\/j.ecl.2017.07.008_bib18","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1038\/ki.2011.23","article-title":"The intact nephron hypothesis: the concept and its implications for phosphate management in CKD-related mineral and bone disorder","author":"Slatopolsky","year":"2011","journal-title":"Kidney Int Suppl"},{"issue":"2","key":"10.1016\/j.ecl.2017.07.008_bib19","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/ki.1973.92","article-title":"The role of phosphorus restriction in the prevention of secondary hyperparathyroidism in chronic renal disease","volume":"4","author":"Slatopolsky","year":"1973","journal-title":"Kidney Int"},{"key":"10.1016\/j.ecl.2017.07.008_bib20","doi-asserted-by":"crossref","first-page":"S14","DOI":"10.1046\/j.1523-1755.1999.07304.x","article-title":"Pathogenesis of secondary hyperparathyroidism","volume":"73","author":"Slatopolsky","year":"1999","journal-title":"Kidney Int Suppl"},{"issue":"1 Suppl 2","key":"10.1016\/j.ecl.2017.07.008_bib21","doi-asserted-by":"crossref","first-page":"S54","DOI":"10.1053\/ajkd.2001.20740","article-title":"Role of phosphorus in the pathogenesis of secondary hyperparathyroidism","volume":"37","author":"Slatopolsky","year":"2001","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.ecl.2017.07.008_bib22","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1159\/000085687","article-title":"Calcium, phosphorus and vitamin D disorders in uremia","volume":"149","author":"Slatopolsky","year":"2005","journal-title":"Contrib Nephrol"},{"issue":"3","key":"10.1016\/j.ecl.2017.07.008_bib23","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1038\/ki.1972.84","article-title":"On the prevention of secondary hyperparathyroidism in experimental chronic renal disease using \u201cproportional reduction\u201d of dietary phosphorus intake","volume":"2","author":"Slatopolsky","year":"1972","journal-title":"Kidney Int"},{"issue":"1\u20133","key":"10.1016\/j.ecl.2017.07.008_bib24","first-page":"91","article-title":"Pathogenesis of secondary hyperparathyroidism","volume":"21","author":"Slatopolsky","year":"1995","journal-title":"Miner Electrolyte Metab"},{"key":"10.1016\/j.ecl.2017.07.008_bib25","series-title":"The principles and practice of nephrology","first-page":"1032","article-title":"Renal osteodystrophy","author":"McCarthy","year":"1995"},{"issue":"1","key":"10.1016\/j.ecl.2017.07.008_bib26","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/0002-9343(75)90531-8","article-title":"The kidney as an endocrine organ involved in the function of vitamin D","volume":"58","author":"DeLuca","year":"1975","journal-title":"Am J Med"},{"issue":"4257","key":"10.1016\/j.ecl.2017.07.008_bib27","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1126\/science.1085035","article-title":"1,25-Dihydroxyvitamin D in biological fluids: a simplified and sensitive assay","volume":"193","author":"Eisman","year":"1976","journal-title":"Science"},{"issue":"11","key":"10.1016\/j.ecl.2017.07.008_bib28","doi-asserted-by":"crossref","first-page":"2060","DOI":"10.1093\/clinchem\/32.11.2060","article-title":"Assay of circulating 1,25-dihydroxyvitamin D involving a novel single-cartridge extraction and purification procedure","volume":"32","author":"Hollis","year":"1986","journal-title":"Clin Chem"},{"issue":"3","key":"10.1016\/j.ecl.2017.07.008_bib29","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1046\/j.1523-1755.1999.0550031019.x","article-title":"Serum levels of 1,25-dihydroxyvitamin D, 24,25-dihydroxyvitamin D, and 25-hydroxyvitamin D in nondialyzed patients with chronic renal failure","volume":"55","author":"Ishimura","year":"1999","journal-title":"Kidney Int"},{"issue":"4","key":"10.1016\/j.ecl.2017.07.008_bib30","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1111\/j.1365-2265.1980.tb03399.x","article-title":"Vitamin D metabolites and their relationship to azotaemic osteodystrophy","volume":"13","author":"Mason","year":"1980","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"3","key":"10.1016\/j.ecl.2017.07.008_bib31","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/0009-8981(84)90270-5","article-title":"A\u00a0sensitive and simplified radioimmunoassay for 1,25-dihydroxyvitamin D3","volume":"142","author":"Scharla","year":"1984","journal-title":"Clin Chim Acta"},{"issue":"1","key":"10.1016\/j.ecl.2017.07.008_bib32","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1620\/tjem.180.45","article-title":"Levels of serum 1,25(OH)2D in patients with pre-dialysis chronic renal failure","volume":"180","author":"Yumita","year":"1996","journal-title":"Tohoku J Exp Med"},{"issue":"4","key":"10.1016\/j.ecl.2017.07.008_bib33","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1038\/ki.1973.40","article-title":"Study of intestinal absorption of calcium in patients with renal failure","volume":"3","author":"Coburn","year":"1973","journal-title":"Kidney Int"},{"issue":"2","key":"10.1016\/j.ecl.2017.07.008_bib34","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/BF02013246","article-title":"Intestinal calcium absorption, serum phosphate, and parathyroid hormone in patients with chronic renal failure and osteodystrophy before and during hemodialysis","volume":"26","author":"Juttmann","year":"1978","journal-title":"Calcif Tissue Res"},{"issue":"3","key":"10.1016\/j.ecl.2017.07.008_bib35","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1111\/j.1365-2362.1976.tb00519.x","article-title":"Effects of haemodialysis on fractional intestinal absorption of calcium in uraemia","volume":"6","author":"Chanard","year":"1976","journal-title":"Eur J Clin Invest"},{"issue":"3","key":"10.1016\/j.ecl.2017.07.008_bib36","first-page":"380","article-title":"Calcium absorption in renal failure: its relationship to blood urea nitrogen, dietary calcium intake, time on dialysis, and other variables","volume":"78","author":"Recker","year":"1971","journal-title":"J\u00a0Lab Clin Med"},{"issue":"11","key":"10.1016\/j.ecl.2017.07.008_bib37","doi-asserted-by":"crossref","first-page":"4393","DOI":"10.1172\/JCI46122","article-title":"FGF23 induces left ventricular hypertrophy","volume":"121","author":"Faul","year":"2011","journal-title":"J\u00a0Clin Invest"},{"issue":"7","key":"10.1016\/j.ecl.2017.07.008_bib38","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1681\/ASN.2005010052","article-title":"Fibroblast growth factor-23 mitigates hyperphosphatemia but accentuates calcitriol deficiency in chronic kidney disease","volume":"16","author":"Gutierrez","year":"2005","journal-title":"J\u00a0Am Soc Nephrol"},{"issue":"19","key":"10.1016\/j.ecl.2017.07.008_bib39","doi-asserted-by":"crossref","first-page":"2545","DOI":"10.1161\/CIRCULATIONAHA.108.844506","article-title":"Fibroblast growth factor 23 and left ventricular hypertrophy in chronic kidney disease","volume":"119","author":"Gutierrez","year":"2009","journal-title":"Circulation"},{"issue":"6","key":"10.1016\/j.ecl.2017.07.008_bib40","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1056\/NEJMoa0706130","article-title":"Fibroblast growth factor 23 and mortality among patients undergoing hemodialysis","volume":"359","author":"Gutierrez","year":"2008","journal-title":"N\u00a0Engl J Med"},{"issue":"23","key":"10.1016\/j.ecl.2017.07.008_bib41","doi-asserted-by":"crossref","first-page":"2432","DOI":"10.1001\/jama.2011.826","article-title":"Fibroblast growth factor 23 and risks of mortality and end-stage renal disease in patients with chronic kidney disease","volume":"305","author":"Isakova","year":"2011","journal-title":"JAMA"},{"issue":"1","key":"10.1016\/j.ecl.2017.07.008_bib42","doi-asserted-by":"crossref","first-page":"p23","DOI":"10.1159\/000093277","article-title":"FGF-23 and sFRP-4 in chronic kidney disease and post-renal transplantation","volume":"104","author":"Pande","year":"2006","journal-title":"Nephron Physiol"},{"issue":"2","key":"10.1016\/j.ecl.2017.07.008_bib43","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/0002-9343(82)90179-6","article-title":"Chronic acidosis with metabolic bone disease. Effect of alkali on bone morphology and vitamin D metabolism","volume":"73","author":"Cunningham","year":"1982","journal-title":"Am J Med"},{"issue":"1\u20132","key":"10.1016\/j.ecl.2017.07.008_bib44","first-page":"72","article-title":"Metabolic acidosis and bone disease","volume":"20","author":"Eiam-ong","year":"1994","journal-title":"Miner Electrolyte Metab"},{"issue":"6","key":"10.1016\/j.ecl.2017.07.008_bib45","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1159\/000182221","article-title":"Acidosis and renal calcium excretion in experimental chronic renal failure","volume":"28","author":"Marone","year":"1981","journal-title":"Nephron"},{"issue":"3","key":"10.1016\/j.ecl.2017.07.008_bib46","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1210\/edrv-1-3-258","article-title":"The metabolism of 1,25-dihydroxyvitamin D3","volume":"1","author":"Kumar","year":"1980","journal-title":"Endocr Rev"},{"issue":"3","key":"10.1016\/j.ecl.2017.07.008_bib47","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1210\/edrv-2-3-264","article-title":"Vitamin D and pregnancy: the maternal-fetal metabolism of vitamin D","volume":"2","author":"Gray","year":"1981","journal-title":"Endocr Rev"},{"issue":"4","key":"10.1016\/j.ecl.2017.07.008_bib48","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1210\/edrv-3-4-331","article-title":"The vitamin D endocrine system: steroid metabolism, hormone receptors, and biological response (calcium binding proteins)","volume":"3","author":"Norman","year":"1982","journal-title":"Endocr Rev"},{"issue":"4","key":"10.1016\/j.ecl.2017.07.008_bib49","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1210\/edrv-6-4-491","article-title":"Evidence that 1,25-dihydroxyvitamin D3 is the physiologically active metabolite of vitamin D3","volume":"6","author":"Brommage","year":"1985","journal-title":"Endocr Rev"},{"issue":"4","key":"10.1016\/j.ecl.2017.07.008_bib50","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1210\/edrv-7-4-434","article-title":"Role of vitamin D in skeletal muscle function","volume":"7","author":"Boland","year":"1986","journal-title":"Endocr Rev"},{"issue":"1","key":"10.1016\/j.ecl.2017.07.008_bib51","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1210\/edrv-10-1-3","article-title":"Vitamin D-dependent calcium binding proteins: chemistry, distribution, functional considerations, and molecular biology","volume":"10","author":"Christakos","year":"1989","journal-title":"Endocr Rev"},{"issue":"1","key":"10.1016\/j.ecl.2017.07.008_bib52","first-page":"3","article-title":"Vitamin D, calcium, and epidermal differentiation","volume":"14","author":"Bikle","year":"1993","journal-title":"Endocr Rev"},{"issue":"2","key":"10.1016\/j.ecl.2017.07.008_bib53","first-page":"156","article-title":"The vitamin D receptor and the syndrome of hereditary 1,25-dihydroxyvitamin D-resistant rickets","volume":"20","author":"Malloy","year":"1999","journal-title":"Endocr Rev"},{"issue":"6","key":"10.1016\/j.ecl.2017.07.008_bib54","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1210\/er.2001-0044","article-title":"Modulation of growth factor\/cytokine synthesis and signaling by 1alpha,25-dihydroxyvitamin D(3): implications in cell growth and differentiation","volume":"23","author":"Gurlek","year":"2002","journal-title":"Endocr Rev"},{"issue":"5","key":"10.1016\/j.ecl.2017.07.008_bib55","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1210\/er.2004-0002","article-title":"Noncalcemic actions of vitamin D receptor ligands","volume":"26","author":"Nagpal","year":"2005","journal-title":"Endocr Rev"},{"issue":"6","key":"10.1016\/j.ecl.2017.07.008_bib56","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1210\/er.2008-0004","article-title":"Vitamin D and human health: lessons from vitamin D receptor null mice","volume":"29","author":"Bouillon","year":"2008","journal-title":"Endocr Rev"},{"issue":"3","key":"10.1016\/j.ecl.2017.07.008_bib57","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1210\/er.2012-1000","article-title":"The nonskeletal effects of vitamin D: an Endocrine Society scientific statement","volume":"33","author":"Rosen","year":"2012","journal-title":"Endocr Rev"},{"issue":"1","key":"10.1016\/j.ecl.2017.07.008_bib58","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1210\/er.2012-1012","article-title":"The roles of vitamin D in skeletal muscle: form, function, and metabolism","volume":"34","author":"Girgis","year":"2013","journal-title":"Endocr Rev"},{"issue":"1","key":"10.1016\/j.ecl.2017.07.008_bib59","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1681\/ASN.V1130","article-title":"Vitamin D metabolism and mechanisms of calcium transport","volume":"1","author":"Kumar","year":"1990","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.ecl.2017.07.008_bib60","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1146\/annurev.nutr.23.011702.073114","article-title":"Vitamin D and its analogs as regulators of immune activation and antigen presentation","volume":"23","author":"Griffin","year":"2003","journal-title":"Annu Rev Nutr"},{"issue":"1","key":"10.1016\/j.ecl.2017.07.008_bib61","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1152\/physrev.00014.2015","article-title":"Vitamin D: metabolism, molecular mechanism of action, and pleiotropic effects","volume":"96","author":"Christakos","year":"2016","journal-title":"Physiol Rev"},{"key":"10.1016\/j.ecl.2017.07.008_bib62","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1146\/annurev.bi.45.070176.003215","article-title":"Metabolism and mechanism of action of vitamin D","volume":"45","author":"DeLuca","year":"1976","journal-title":"Annu Rev Biochem"},{"key":"10.1016\/j.ecl.2017.07.008_bib63","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1146\/annurev.bi.52.070183.002211","article-title":"Vitamin D: recent advances","volume":"52","author":"DeLuca","year":"1983","journal-title":"Annu Rev Biochem"},{"key":"10.1016\/j.ecl.2017.07.008_bib64","first-page":"3","article-title":"Historical overview of vitamin D","volume":"vol. 1","author":"Deluca","year":"2011"},{"issue":"10 Suppl 2","key":"10.1016\/j.ecl.2017.07.008_bib65","doi-asserted-by":"crossref","first-page":"S73","DOI":"10.1111\/j.1753-4887.2008.00105.x","article-title":"Evolution of our understanding of vitamin D","volume":"66","author":"DeLuca","year":"2008","journal-title":"Nutr Rev"},{"issue":"2","key":"10.1016\/j.ecl.2017.07.008_bib66","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s00223-012-9619-0","article-title":"Molecular mechanisms of vitamin D action","volume":"92","author":"Haussler","year":"2013","journal-title":"Calcif Tissue Int"},{"issue":"75","key":"10.1016\/j.ecl.2017.07.008_bib67","doi-asserted-by":"crossref","first-page":"re4","DOI":"10.1126\/scisignal.275re4","article-title":"The vitamin D sterol-vitamin D receptor ensemble model offers unique insights into both genomic and rapid-response signaling","volume":"2","author":"Mizwicki","year":"2009","journal-title":"Sci Signal"},{"issue":"1\u20132","key":"10.1016\/j.ecl.2017.07.008_bib68","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.jsbmb.2005.06.014","article-title":"Multiple potential clinical benefits for 1alpha,25-dihydroxyvitamin D3 analogs in kidney transplant recipients","volume":"97","author":"Griffin","year":"2005","journal-title":"J\u00a0Steroid Biochem Mol Biol"},{"issue":"3","key":"10.1016\/j.ecl.2017.07.008_bib69","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1074\/jbc.M115.684399","article-title":"1alpha,25-Dihydroxyvitamin D3 regulates mitochondrial oxygen consumption and dynamics in human skeletal muscle cells","volume":"291","author":"Ryan","year":"2016","journal-title":"J\u00a0Biol Chem"},{"issue":"4","key":"10.1016\/j.ecl.2017.07.008_bib70","first-page":"299","article-title":"Regulation of osteoblast growth by interactions between transforming growth factor-beta and 1alpha,25-dihydroxyvitamin D3","volume":"11","author":"Gurlek","year":"2001","journal-title":"Crit Rev Eukaryot Gene Expr"},{"key":"10.1016\/j.ecl.2017.07.008_bib71","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S0021-9258(18)85783-0","article-title":"Studies on experimental rickets XXI. An experimental demonstration of the existence of a vitamin which promotes calcium deposition","volume":"53","author":"McCollum","year":"1922","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.ecl.2017.07.008_bib72","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1515\/bchm2.1936.241.1-3.100","article-title":"Uber das antirachitisch wirksame bestrahlungs-produkt aus 7-dehydro-cholesterin","volume":"241","author":"Windaus","year":"1936","journal-title":"Hoppe Seylers Z Physiol Chem"},{"key":"10.1016\/j.ecl.2017.07.008_bib73","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/S0021-9258(18)85139-0","article-title":"Fat-soluble vitamins. XVII. The induction of gross-promoting and calcifying properties in a ration by exposure to ultraviolet light","volume":"61","author":"Steenbock","year":"1924","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.ecl.2017.07.008_bib74","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3181\/00379727-22-3","article-title":"Anti-rachitic properties imparted to lettuce and to growing wheat by ultraviolet irradiation","volume":"22","author":"Hess","year":"1924","journal-title":"Proc Soc Exp Biol Med"},{"key":"10.1016\/j.ecl.2017.07.008_bib75","series-title":"Vitamin D","first-page":"1","article-title":"The metabolism, physiology and function of vitamin D","author":"DeLuca","year":"1984"},{"issue":"2","key":"10.1016\/j.ecl.2017.07.008_bib76","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/S0003-9861(78)80010-1","article-title":"Vitamin D3 from rat skins irradiated in\u00a0vitro with ultraviolet light","volume":"188","author":"Esvelt","year":"1978","journal-title":"Arch Biochem Biophys"},{"issue":"12","key":"10.1016\/j.ecl.2017.07.008_bib77","first-page":"2567","article-title":"The photobiogenesis and metabolism of vitamin D","volume":"37","author":"Holick","year":"1978","journal-title":"Fed Proc"},{"issue":"4466","key":"10.1016\/j.ecl.2017.07.008_bib78","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1126\/science.6251551","article-title":"Photosynthesis of previtamin D3 in human skin and the physiologic consequences","volume":"210","author":"Holick","year":"1980","journal-title":"Science"},{"issue":"6","key":"10.1016\/j.ecl.2017.07.008_bib79","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1021\/bi00573a011","article-title":"Isolation and identification of previtamin D3 from the skin of rats exposed to ultraviolet irradiation","volume":"18","author":"Holick","year":"1979","journal-title":"Biochemistry"},{"key":"10.1016\/j.ecl.2017.07.008_bib80","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1002\/jlac.19324920111","article-title":"Crystalline-vitamin D 2","volume":"492","author":"Windaus","year":"1932","journal-title":"Annalen de Chem"},{"key":"10.1016\/j.ecl.2017.07.008_bib81","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0021-9258(18)76238-8","article-title":"The reaction of the chicken to irradiated ergosterol and irradiated yeast as contrasted with the natural vitamin of fish liver oils","volume":"97","author":"Steenbock","year":"1932","journal-title":"J\u00a0Biol Chem"},{"issue":"7","key":"10.1016\/j.ecl.2017.07.008_bib82","first-page":"1313","article-title":"Defective photoproduction of cholecalciferol in normal and uremic humans","volume":"114","author":"Jacob","year":"1984","journal-title":"J\u00a0Nutr"},{"issue":"10","key":"10.1016\/j.ecl.2017.07.008_bib83","doi-asserted-by":"crossref","first-page":"3317","DOI":"10.1021\/bi00850a001","article-title":"25-hydroxycholecalciferol. A biologically active metabolite of vitamin D3","volume":"7","author":"Blunt","year":"1968","journal-title":"Biochemistry"},{"issue":"2","key":"10.1016\/j.ecl.2017.07.008_bib84","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/0006-291X(69)90264-2","article-title":"25-hydroxyergocalciferol: a biologically active metabolite of vitamin D2","volume":"35","author":"Suda","year":"1969","journal-title":"Biochem Biophys Res Commun"},{"issue":"9","key":"10.1016\/j.ecl.2017.07.008_bib85","doi-asserted-by":"crossref","first-page":"3515","DOI":"10.1021\/bi00837a005","article-title":"The isolation and identification of 25-hydroxyergocalciferol","volume":"8","author":"Suda","year":"1969","journal-title":"Biochemistry"},{"issue":"7","key":"10.1016\/j.ecl.2017.07.008_bib86","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1172\/JCI106093","article-title":"The role of the liver in the metabolism of vitamin D","volume":"48","author":"Ponchon","year":"1969","journal-title":"J\u00a0Clin Invest"},{"issue":"11","key":"10.1016\/j.ecl.2017.07.008_bib87","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.1172\/JCI106168","article-title":"\u201cActivation\u201d of vitamin D by the liver","volume":"48","author":"Ponchon","year":"1969","journal-title":"J\u00a0Clin Invest"},{"issue":"9","key":"10.1016\/j.ecl.2017.07.008_bib88","doi-asserted-by":"crossref","first-page":"2969","DOI":"10.1016\/S0021-9258(19)43995-1","article-title":"The regulation of rat liver calciferol-25-hydroxylase","volume":"248","author":"Bhattacharyya","year":"1973","journal-title":"J\u00a0Biol Chem"},{"issue":"1","key":"10.1016\/j.ecl.2017.07.008_bib89","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/S0003-9861(74)80008-1","article-title":"Subcellular location of rat liver calciferol-25-hydroxylase","volume":"160","author":"Bhattacharyya","year":"1974","journal-title":"Arch Biochem Biophys"},{"issue":"3","key":"10.1016\/j.ecl.2017.07.008_bib90","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1042\/bj1840491","article-title":"Characteristics of the rat liver microsomal enzyme system converting cholecalciferol into 25-hydroxycholecalciferol. Evidence for the participation of cytochrome p-450","volume":"184","author":"Madhok","year":"1979","journal-title":"Biochem J"},{"issue":"20","key":"10.1016\/j.ecl.2017.07.008_bib91","doi-asserted-by":"crossref","first-page":"7711","DOI":"10.1073\/pnas.0402490101","article-title":"Genetic evidence that the human CYP2R1 enzyme is a key vitamin D 25-hydroxylase","volume":"101","author":"Cheng","year":"2004","journal-title":"Proc Natl Acad Sci U\u00a0S\u00a0A"},{"issue":"1","key":"10.1016\/j.ecl.2017.07.008_bib92","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.abb.2012.01.013","article-title":"Vitamin D 25-hydroxylase - Four decades of searching, are we there yet?","volume":"523","author":"Zhu","year":"2012","journal-title":"Arch Biochem Biophys"},{"issue":"39","key":"10.1016\/j.ecl.2017.07.008_bib93","doi-asserted-by":"crossref","first-page":"15650","DOI":"10.1073\/pnas.1315006110","article-title":"CYP2R1 is a major, but not exclusive, contributor to 25-hydroxyvitamin D production in\u00a0vivo","volume":"110","author":"Zhu","year":"2013","journal-title":"Proc Natl Acad Sci U\u00a0S\u00a0A"},{"issue":"142","key":"10.1016\/j.ecl.2017.07.008_bib94","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1097\/00003086-197907000-00040","article-title":"Transport of vitamin D metabolites","author":"Haddad","year":"1979","journal-title":"Clin Orthop Relat Res"},{"issue":"Pt A","key":"10.1016\/j.ecl.2017.07.008_bib95","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.jsbmb.2013.11.006","article-title":"Variability in free 25(OH) vitamin D levels in clinical populations","volume":"144","author":"Schwartz","year":"2014","journal-title":"J\u00a0Steroid Biochem Mol Biol"},{"issue":"183","key":"10.1016\/j.ecl.2017.07.008_bib96","first-page":"1","article-title":"Vitamin D and calcium: a systematic review of health outcomes","author":"Chung","year":"2009","journal-title":"Evid Rep Technol Assess (Full Rep)"},{"issue":"2","key":"10.1016\/j.ecl.2017.07.008_bib97","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.jocd.2011.03.004","article-title":"The 2011 IOM report on vitamin D and calcium requirements for North America: clinical implications for providers treating patients with low bone mineral density","volume":"14","author":"Rosen","year":"2011","journal-title":"J\u00a0Clin Densitom"},{"issue":"7","key":"10.1016\/j.ecl.2017.07.008_bib98","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1210\/jc.2011-0385","article-title":"Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline","volume":"96","author":"Holick","year":"2011","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.ecl.2017.07.008_bib99","series-title":"The National Academies Collection: Reports funded by National Institutes of Health","article-title":"Dietary reference intakes for calcium and vitamin D","year":"2011"},{"issue":"5","key":"10.1016\/j.ecl.2017.07.008_bib100","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.2215\/CJN.01150308","article-title":"Vitamin D and kidney disease","volume":"3","author":"Al-Badr","year":"2008","journal-title":"Clin J Am Soc Nephrol"},{"issue":"4","key":"10.1016\/j.ecl.2017.07.008_bib101","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.beem.2011.05.005","article-title":"Vitamin D in chronic kidney disease","volume":"25","author":"Dusso","year":"2011","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"issue":"8","key":"10.1016\/j.ecl.2017.07.008_bib102","doi-asserted-by":"crossref","first-page":"845","DOI":"10.2169\/internalmedicine.51.6897","article-title":"Risk factors for vitamin D deficiency in patients with chronic kidney disease","volume":"51","author":"Echida","year":"2012","journal-title":"Intern Med"},{"issue":"11","key":"10.1016\/j.ecl.2017.07.008_bib103","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1359\/jbmr.060803","article-title":"25-Hydroxyvitamin D deficiency and diabetes predict reduced BMD in patients with chronic kidney disease","volume":"21","author":"Elder","year":"2006","journal-title":"J\u00a0Bone Miner Res"},{"issue":"5","key":"10.1016\/j.ecl.2017.07.008_bib104","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1159\/000081023","article-title":"Vitamin D insufficiency and deficiency in chronic kidney disease. A single center observational study","volume":"24","author":"Gonzalez","year":"2004","journal-title":"Am J Nephrol"},{"issue":"12","key":"10.1016\/j.ecl.2017.07.008_bib105","doi-asserted-by":"crossref","first-page":"2483","DOI":"10.1007\/s00467-010-1639-2","article-title":"Vitamin D insufficiency and effect of cholecalciferol in children with chronic kidney disease","volume":"25","author":"Hari","year":"2010","journal-title":"Pediatr Nephrol"},{"issue":"5","key":"10.1016\/j.ecl.2017.07.008_bib106","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/ki.2010.168","article-title":"Dysregulation of renal vitamin D metabolism in the uremic rat","volume":"78","author":"Helvig","year":"2010","journal-title":"Kidney Int"},{"issue":"1","key":"10.1016\/j.ecl.2017.07.008_bib107","doi-asserted-by":"crossref","first-page":"50","DOI":"10.2215\/CJN.03940510","article-title":"Vitamin D supplementation in chronic kidney disease: a systematic review and meta-analysis of observational studies and randomized controlled trials","volume":"6","author":"Kandula","year":"2011","journal-title":"Clin J Am Soc Nephrol"},{"issue":"6","key":"10.1016\/j.ecl.2017.07.008_bib108","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1053\/j.ajkd.2005.02.029","article-title":"Prevalence of calcidiol deficiency in CKD: a cross-sectional study across latitudes in the United States","volume":"45","author":"LaClair","year":"2005","journal-title":"Am J Kidney Dis"},{"issue":"4","key":"10.1016\/j.ecl.2017.07.008_bib109","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.2215\/CJN.05781207","article-title":"Hypovitaminosis D in chronic kidney disease","volume":"3","author":"Mehrotra","year":"2008","journal-title":"Clin J Am Soc Nephrol"},{"issue":"1","key":"10.1016\/j.ecl.2017.07.008_bib110","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/ki.2008.501","article-title":"Vitamin D levels and patient outcome in chronic kidney disease","volume":"75","author":"Ravani","year":"2009","journal-title":"Kidney Int"},{"issue":"1","key":"10.1016\/j.ecl.2017.07.008_bib111","first-page":"75","article-title":"Vitamin D insufficiency and treatment with oral vitamin D3 in northern-dwelling patients with chronic kidney disease","volume":"22","author":"Rucker","year":"2009","journal-title":"J\u00a0Nephrol"},{"key":"10.1016\/j.ecl.2017.07.008_bib112","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1186\/1471-2369-14-206","article-title":"Vitamin D insufficiency and deficiency with stages of chronic kidney disease in an Asian population","volume":"14","author":"Satirapoj","year":"2013","journal-title":"BMC Nephrol"},{"issue":"3","key":"10.1016\/j.ecl.2017.07.008_bib113","doi-asserted-by":"crossref","first-page":"c109","DOI":"10.1159\/000108652","article-title":"Cross-sectional analysis of abnormalities of mineral homeostasis, vitamin D and parathyroid hormone in a cohort of pre-dialysis patients. The chronic renal impairment in Birmingham (CRIB) study","volume":"107","author":"Zehnder","year":"2007","journal-title":"Nephron Clin Pract"},{"issue":"2","key":"10.1016\/j.ecl.2017.07.008_bib114","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1097\/MNH.0b013e32802ef494","article-title":"Vitamin D and outcomes in chronic kidney disease","volume":"16","author":"Cheng","year":"2007","journal-title":"Curr Opin Nephrol Hypertens"},{"issue":"9","key":"10.1016\/j.ecl.2017.07.008_bib115","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1038\/ki.2009.288","article-title":"Chronic kidney disease, hypovitaminosis D, and mortality in the United States","volume":"76","author":"Mehrotra","year":"2009","journal-title":"Kidney Int"},{"issue":"3\u20135","key":"10.1016\/j.ecl.2017.07.008_bib116","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.jsbmb.2006.12.078","article-title":"Extra-renal 25-hydroxyvitamin D3-1alpha-hydroxylase in human health and disease","volume":"103","author":"Hewison","year":"2007","journal-title":"J\u00a0Steroid Biochem Mol Biol"},{"issue":"3","key":"10.1016\/j.ecl.2017.07.008_bib117","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1681\/ASN.V133621","article-title":"Synthesis of 1,25-dihydroxyvitamin D(3) by human endothelial cells is regulated by inflammatory cytokines: a novel autocrine determinant of vascular cell adhesion","volume":"13","author":"Zehnder","year":"2002","journal-title":"J\u00a0Am Soc Nephrol"},{"issue":"2","key":"10.1016\/j.ecl.2017.07.008_bib118","first-page":"888","article-title":"Extrarenal expression of 25-hydroxyvitamin d(3)-1 alpha-hydroxylase","volume":"86","author":"Zehnder","year":"2001","journal-title":"J\u00a0Clin Endocrinol Metab"},{"issue":"Spec No","key":"10.1016\/j.ecl.2017.07.008_bib119","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1001\/archinte.1978.03630300025005","article-title":"The efficacy of calcifediol in renal osteodystrophy","volume":"138","author":"Recker","year":"1978","journal-title":"Arch Intern Med"},{"issue":"4","key":"10.1016\/j.ecl.2017.07.008_bib120","doi-asserted-by":"crossref","first-page":"611","DOI":"10.2215\/CJN.06910714","article-title":"Nutritional vitamin D supplementation in dialysis: a randomized trial","volume":"10","author":"Bhan","year":"2015","journal-title":"Clin J Am Soc Nephrol"},{"issue":"4","key":"10.1016\/j.ecl.2017.07.008_bib121","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1073\/pnas.68.4.803","article-title":"Identification of 1,25-dihydroxycholecalciferol, a form of vitamin D3 metabolically active in the intestine","volume":"68","author":"Holick","year":"1971","journal-title":"Proc Natl Acad Sci U\u00a0S\u00a0A"},{"issue":"14","key":"10.1016\/j.ecl.2017.07.008_bib122","doi-asserted-by":"crossref","first-page":"2799","DOI":"10.1021\/bi00790a023","article-title":"Isolation and identification of 1,25-dihydroxycholecalciferol. A metabolite of vitamin D active in intestine","volume":"10","author":"Holick","year":"1971","journal-title":"Biochemistry"},{"issue":"4039","key":"10.1016\/j.ecl.2017.07.008_bib123","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1126\/science.176.4039.1146","article-title":"1,25-dihydroxycholecalciferol: metabolite of vitamin D3 active on bone in anephric rats","volume":"176","author":"Holick","year":"1972","journal-title":"Science"},{"issue":"6","key":"10.1016\/j.ecl.2017.07.008_bib124","doi-asserted-by":"crossref","first-page":"3615","DOI":"10.1016\/S0021-9258(18)32708-X","article-title":"Studies on the site of 1,25-dihydroxyvitamin D3 synthesis in\u00a0vivo","volume":"258","author":"Reeve","year":"1983","journal-title":"J\u00a0Biol Chem"},{"issue":"9","key":"10.1016\/j.ecl.2017.07.008_bib125","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1056\/NEJM197808312990902","article-title":"Response of 1alpha,25-dihydroxyvitamin D3 to hypocalcemia in human subjects","volume":"299","author":"Bilezikian","year":"1978","journal-title":"N\u00a0Engl J Med"},{"issue":"9","key":"10.1016\/j.ecl.2017.07.008_bib126","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1073\/pnas.68.9.2131","article-title":"Regulation by calcium of in\u00a0vivo synthesis of 1,25-dihydroxycholecalciferol and 21,25-dihydroxycholecalciferol","volume":"68","author":"Boyle","year":"1971","journal-title":"Proc Natl Acad Sci U\u00a0S\u00a0A"},{"key":"10.1016\/j.ecl.2017.07.008_bib127","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/978-1-4613-4217-5_22","article-title":"Regulation of vitamin D metabolism in the kidney","volume":"81","author":"DeLuca","year":"1977","journal-title":"Adv Exp Med Biol"},{"issue":"2","key":"10.1016\/j.ecl.2017.07.008_bib128","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1152\/physrev.1984.64.2.478","article-title":"Metabolism of 1,25-dihydroxyvitamin D3","volume":"64","author":"Kumar","year":"1984","journal-title":"Physiol Rev"},{"issue":"5273","key":"10.1016\/j.ecl.2017.07.008_bib129","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1038\/228764a0","article-title":"Unique biosynthesis by kidney of a biological active vitamin D metabolite","volume":"228","author":"Fraser","year":"1970","journal-title":"Nature"},{"issue":"7","key":"10.1016\/j.ecl.2017.07.008_bib130","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1073\/pnas.69.7.1673","article-title":"Control of 25-hydroxycholecalciferol metabolism by parathyroid glands","volume":"69","author":"Garabedian","year":"1972","journal-title":"Proc Natl Acad Sci U\u00a0S\u00a0A"},{"issue":"6","key":"10.1016\/j.ecl.2017.07.008_bib131","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.1073\/pnas.80.6.1746","article-title":"Do tissues other than the kidney produce 1,25-dihydroxyvitamin D3 in\u00a0vivo? A reexamination","volume":"80","author":"Shultz","year":"1983","journal-title":"Proc Natl Acad Sci U\u00a0S\u00a0A"},{"issue":"15","key":"10.1016\/j.ecl.2017.07.008_bib132","doi-asserted-by":"crossref","first-page":"6199","DOI":"10.1073\/pnas.1221255110","article-title":"Sclerostin alters serum vitamin D metabolite and fibroblast growth factor 23 concentrations and the urinary excretion of calcium","volume":"110","author":"Ryan","year":"2013","journal-title":"Proc Natl Acad Sci U\u00a0S\u00a0A"},{"issue":"10","key":"10.1016\/j.ecl.2017.07.008_bib133","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1681\/ASN.2014020166","article-title":"Reduced renal calcium excretion in the absence of sclerostin expression: evidence for a novel calcium-regulating bone kidney axis","volume":"25","author":"Kumar","year":"2014","journal-title":"J\u00a0Am Soc Nephrol"},{"issue":"6 Suppl","key":"10.1016\/j.ecl.2017.07.008_bib134","doi-asserted-by":"crossref","first-page":"1689S","DOI":"10.1093\/ajcn\/80.6.1689S","article-title":"Overview of general physiologic features and functions of vitamin D","volume":"80","author":"DeLuca","year":"2004","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.ecl.2017.07.008_bib135","first-page":"2273","article-title":"The hormonal regulation of calcium metabolism","volume":"vol. 2","author":"Tebben","year":"2013"},{"key":"10.1016\/j.ecl.2017.07.008_bib136","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S0083-6729(08)60017-5","article-title":"Some aspects of vitamin D action; calcium absorption and the vitamin D-dependent calcium-binding protein","volume":"32","author":"Wasserman","year":"1974","journal-title":"Vitam Horm"},{"issue":"7 Suppl","key":"10.1016\/j.ecl.2017.07.008_bib137","first-page":"1971S","article-title":"Vitamin D and intestinal calcium transport: facts, speculations and hypotheses","volume":"125","author":"Wasserman","year":"1995","journal-title":"J\u00a0Nutr"},{"issue":"3","key":"10.1016\/j.ecl.2017.07.008_bib138","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1016\/0016-5085(92)90174-W","article-title":"Vitamin D and mineral deficiencies increase the plasma membrane calcium pump of chicken intestine","volume":"102","author":"Wasserman","year":"1992","journal-title":"Gastroenterology"},{"issue":"3 Suppl","key":"10.1016\/j.ecl.2017.07.008_bib139","first-page":"662","article-title":"Intestinal calcium transport and calcium extrusion processes at the basolateral membrane","volume":"122","author":"Wasserman","year":"1992","journal-title":"J\u00a0Nutr"},{"key":"10.1016\/j.ecl.2017.07.008_bib140","first-page":"185","article-title":"The regulation of calcium, magnesium, and phosphate excretion by the kidney","volume":"vol. 1","author":"Berndt","year":"2015"},{"issue":"6","key":"10.1016\/j.ecl.2017.07.008_bib141","doi-asserted-by":"crossref","first-page":"3196","DOI":"10.1210\/en.2007-1655","article-title":"Active intestinal calcium transport in the absence of transient receptor potential vanilloid type 6 and calbindin-D9k","volume":"149","author":"Benn","year":"2008","journal-title":"Endocrinology"},{"issue":"50","key":"10.1016\/j.ecl.2017.07.008_bib142","doi-asserted-by":"crossref","first-page":"19655","DOI":"10.1073\/pnas.0810761105","article-title":"TRPV6 is not required for 1alpha,25-dihydroxyvitamin D3-induced intestinal calcium absorption in\u00a0vivo","volume":"105","author":"Kutuzova","year":"2008","journal-title":"Proc Natl Acad Sci U\u00a0S\u00a0A"},{"issue":"2","key":"10.1016\/j.ecl.2017.07.008_bib143","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.bone.2010.04.595","article-title":"Trpv6 mediates intestinal calcium absorption during calcium restriction and contributes to bone homeostasis","volume":"47","author":"Lieben","year":"2010","journal-title":"Bone"},{"issue":"1","key":"10.1016\/j.ecl.2017.07.008_bib144","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.bbrc.2015.09.087","article-title":"Deletion of the intestinal plasma membrane calcium pump, isoform 1, Atp2b1, in mice is associated with decreased bone mineral density and impaired responsiveness to 1, 25-dihydroxyvitamin D3","volume":"467","author":"Ryan","year":"2015","journal-title":"Biochem Biophys Res Commun"},{"issue":"23","key":"10.1016\/j.ecl.2017.07.008_bib145","doi-asserted-by":"crossref","first-page":"4251","DOI":"10.1021\/bi00773a009","article-title":"Isolation and identification of 24,25-dihydroxycholecalciferol, a metabolite of vitamin D made in the kidney","volume":"11","author":"Holick","year":"1972","journal-title":"Biochemistry"},{"issue":"24","key":"10.1016\/j.ecl.2017.07.008_bib146","doi-asserted-by":"crossref","first-page":"4851","DOI":"10.1021\/bi00748a007","article-title":"24,25-Dihydroxyvitamin D3. Synthesis and biological activity","volume":"12","author":"Lam","year":"1973","journal-title":"Biochemistry"},{"issue":"2","key":"10.1016\/j.ecl.2017.07.008_bib147","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/0003-9861(75)90157-5","article-title":"Determination of stereochemical configuration of the 24-hydroxyl group of 24,25-dihydroxyvitamin D3 and its biological importance","volume":"170","author":"Tanaka","year":"1975","journal-title":"Arch Biochem Biophys"},{"issue":"2","key":"10.1016\/j.ecl.2017.07.008_bib148","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/0003-9861(73)90010-6","article-title":"The control of 25-hydroxyvitamin D metabolism by inorganic phosphorus","volume":"154","author":"Tanaka","year":"1973","journal-title":"Arch Biochem Biophys"},{"issue":"10","key":"10.1016\/j.ecl.2017.07.008_bib149","doi-asserted-by":"crossref","first-page":"3158","DOI":"10.1016\/S0021-9258(17)33513-5","article-title":"Stimulation of 25-hydroxyvitamin D3-1alpha-hydroxylase by phosphate depletion","volume":"251","author":"Baxter","year":"1976","journal-title":"J\u00a0Biol Chem"},{"issue":"1","key":"10.1016\/j.ecl.2017.07.008_bib150","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/0003-9861(78)90369-7","article-title":"1,25-Dihydroxyvitamin D3 metabolism. The effect of dietary calcium and phosphorus","volume":"188","author":"Ribovich","year":"1978","journal-title":"Arch Biochem Biophys"},{"issue":"5","key":"10.1016\/j.ecl.2017.07.008_bib151","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1210\/jcem-43-5-1056","article-title":"Dietary phosphate deprivation in women and men: effects on mineral and acid balances, parathyroid hormone and the metabolism of 25-OH-vitamin D","volume":"43","author":"Dominguez","year":"1976","journal-title":"J\u00a0Clin Endocrinol Metab"},{"issue":"2","key":"10.1016\/j.ecl.2017.07.008_bib152","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1210\/jcem-45-2-299","article-title":"The importance of phosphate in regulating plasma 1,25-(OH)2-vitamin D levels in humans: studies in healthy subjects in calcium-stone formers and in patients with primary hyperparathyroidism","volume":"45","author":"Gray","year":"1977","journal-title":"J\u00a0Clin Endocrinol Metab"},{"issue":"2","key":"10.1016\/j.ecl.2017.07.008_bib153","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1152\/ajplegacy.1975.229.2.489","article-title":"Phosphatemic action of 1,25-dihydroxyvitamin D3","volume":"229","author":"Steele","year":"1975","journal-title":"Am J Physiol"},{"issue":"5","key":"10.1016\/j.ecl.2017.07.008_bib154","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1007\/BF02409478","article-title":"Control of plasma 1,25-(OH)2-vitamin D concentrations by calcium and phosphorus in the rat: effects of hypophysectomy","volume":"33","author":"Gray","year":"1981","journal-title":"Calcif Tissue Int"},{"issue":"5","key":"10.1016\/j.ecl.2017.07.008_bib155","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1007\/BF02409477","article-title":"Effects of age and sex on the regulation of plasma 1,25-(OH)2-D by phosphorus in the rat","volume":"33","author":"Gray","year":"1981","journal-title":"Calcif Tissue Int"},{"issue":"1","key":"10.1016\/j.ecl.2017.07.008_bib156","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1210\/endo-116-1-189","article-title":"Activation of renal 1,25-dihydroxyvitamin D3 synthesis by phosphate deprivation: evidence for a role for growth hormone","volume":"116","author":"Gray","year":"1985","journal-title":"Endocrinology"},{"issue":"1","key":"10.1016\/j.ecl.2017.07.008_bib157","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1007\/BF02405013","article-title":"Growth hormone and triiodothyronine permit an increase in plasma 1,25(OH)2D concentrations in response to dietary phosphate deprivation in hypophysectomized rats","volume":"35","author":"Gray","year":"1983","journal-title":"Calcif Tissue Int"},{"issue":"6","key":"10.1016\/j.ecl.2017.07.008_bib158","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1007\/BF02405122","article-title":"Regulation of plasma 1,25-(OH)2-D3 by phosphate: evidence against a role for total or acid-soluble renal phosphate content","volume":"35","author":"Gray","year":"1983","journal-title":"Calcif Tissue Int"},{"key":"10.1016\/j.ecl.2017.07.008_bib159","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1159\/000346786","article-title":"Vitamin D and type II sodium-dependent phosphate cotransporters","volume":"180","author":"Kido","year":"2013","journal-title":"Contrib Nephrol"},{"issue":"23","key":"10.1016\/j.ecl.2017.07.008_bib160","doi-asserted-by":"crossref","first-page":"14575","DOI":"10.1074\/jbc.273.23.14575","article-title":"Regulation of type II renal Na+-dependent inorganic phosphate transporters by 1,25-dihydroxyvitamin D3. Identification of a vitamin D-responsive element in the human NAPi-3 gene","volume":"273","author":"Taketani","year":"1998","journal-title":"J\u00a0Biol Chem"},{"issue":"1","key":"10.1016\/j.ecl.2017.07.008_bib161","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s00424-013-1418-6","article-title":"The SLC34 family of sodium-dependent phosphate transporters","volume":"466","author":"Wagner","year":"2014","journal-title":"Pflugers Arch"},{"issue":"10","key":"10.1016\/j.ecl.2017.07.008_bib162","doi-asserted-by":"crossref","first-page":"3294","DOI":"10.1073\/pnas.85.10.3294","article-title":"Cloning and expression of full-length cDNA encoding human vitamin D receptor","volume":"85","author":"Baker","year":"1988","journal-title":"Proc Natl Acad Sci U\u00a0S\u00a0A"},{"issue":"19","key":"10.1016\/j.ecl.2017.07.008_bib163","doi-asserted-by":"crossref","first-page":"10138","DOI":"10.1073\/pnas.94.19.10138","article-title":"Cloning and characterization of the mouse vitamin D receptor promoter","volume":"94","author":"Jehan","year":"1997","journal-title":"Proc Natl Acad Sci U\u00a0S\u00a0A"},{"issue":"1","key":"10.1016\/j.ecl.2017.07.008_bib164","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1006\/abbi.1996.9864","article-title":"Cloning and origin of the two forms of chicken vitamin D receptor","volume":"339","author":"Lu","year":"1997","journal-title":"Arch Biochem Biophys"},{"issue":"12","key":"10.1016\/j.ecl.2017.07.008_bib165","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1016\/0024-3205(73)90120-3","article-title":"1Alpha,25-dihydroxyvitamin D3 receptor: competitive binding of vitamin D analogs","volume":"13","author":"Brumbaugh","year":"1973","journal-title":"Life Sci"},{"issue":"6730","key":"10.1016\/j.ecl.2017.07.008_bib166","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1038\/19783","article-title":"Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex","volume":"398","author":"Rachez","year":"1999","journal-title":"Nature"},{"issue":"3\u20135","key":"10.1016\/j.ecl.2017.07.008_bib167","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.jsbmb.2006.12.003","article-title":"Adaptability of the Vitamin D nuclear receptor to the synthetic ligand Gemini: remodelling the LBP with one side chain rotation","volume":"103","author":"Ciesielski","year":"2007","journal-title":"J\u00a0Steroid Biochem Mol Biol"},{"issue":"4","key":"10.1016\/j.ecl.2017.07.008_bib168","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.chembiol.2008.03.016","article-title":"Structure-based design of a superagonist ligand for the vitamin D nuclear receptor","volume":"15","author":"Hourai","year":"2008","journal-title":"Chem Biol"},{"issue":"2","key":"10.1016\/j.ecl.2017.07.008_bib169","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.abb.2007.01.031","article-title":"Crystal structure of the vitamin D nuclear receptor ligand binding domain in complex with a locked side chain analog of calcitriol","volume":"460","author":"Rochel","year":"2007","journal-title":"Arch Biochem Biophys"},{"issue":"1","key":"10.1016\/j.ecl.2017.07.008_bib170","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S1097-2765(00)80413-X","article-title":"The crystal structure of the nuclear receptor for vitamin D bound to its natural ligand","volume":"5","author":"Rochel","year":"2000","journal-title":"Mol Cell"},{"issue":"15","key":"10.1016\/j.ecl.2017.07.008_bib171","doi-asserted-by":"crossref","first-page":"10516","DOI":"10.1074\/jbc.M513609200","article-title":"Vitamin D receptor agonists specifically modulate the volume of the ligand-binding pocket","volume":"281","author":"Molnar","year":"2006","journal-title":"J\u00a0Biol Chem"},{"issue":"4","key":"10.1016\/j.ecl.2017.07.008_bib172","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1124\/mol.62.4.788","article-title":"Structurally and functionally important amino acids of the agonistic conformation of the human vitamin D receptor","volume":"62","author":"Vaisanen","year":"2002","journal-title":"Mol Pharmacol"},{"issue":"1","key":"10.1016\/j.ecl.2017.07.008_bib173","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1002\/med.10023","article-title":"Structure-function relationships of vitamin D including ligand recognition by the vitamin D receptor","volume":"23","author":"Yamada","year":"2003","journal-title":"Med Res Rev"},{"issue":"4","key":"10.1016\/j.ecl.2017.07.008_bib174","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1073\/pnas.020522697","article-title":"Three-dimensional modeling of and ligand docking to vitamin D receptor ligand binding domain","volume":"97","author":"Yamamoto","year":"2000","journal-title":"Proc Natl Acad Sci U\u00a0S\u00a0A"},{"issue":"2","key":"10.1016\/j.ecl.2017.07.008_bib175","first-page":"89","article-title":"Vitamin D-regulated gene expression","volume":"3","author":"Darwish","year":"1993","journal-title":"Crit Rev Eukaryot Gene Expr"},{"issue":"4","key":"10.1016\/j.ecl.2017.07.008_bib176","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.beem.2011.05.010","article-title":"Vitamin D receptor (VDR)-mediated actions of 1alpha,25(OH)(2)vitamin D(3): genomic and non-genomic mechanisms","volume":"25","author":"Haussler","year":"2011","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"issue":"2","key":"10.1016\/j.ecl.2017.07.008_bib177","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1023\/A:1010062929140","article-title":"Molecular nature of the vitamin D receptor and its role in regulation of gene expression","volume":"2","author":"Jurutka","year":"2001","journal-title":"Rev Endocr Metab Disord"},{"issue":"1","key":"10.1016\/j.ecl.2017.07.008_bib178","first-page":"65","article-title":"Vitamin D-mediated gene expression","volume":"2","author":"Lowe","year":"1992","journal-title":"Crit Rev Eukaryot Gene Expr"},{"issue":"3","key":"10.1016\/j.ecl.2017.07.008_bib179","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1089\/zeb.2013.0899","article-title":"Detection of 1alpha,25-dihydroxyvitamin D-regulated miRNAs in zebrafish by whole transcriptome sequencing","volume":"11","author":"Craig","year":"2014","journal-title":"Zebrafish"},{"issue":"9","key":"10.1016\/j.ecl.2017.07.008_bib180","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1210\/me.2012-1113","article-title":"Research resource: whole transcriptome RNA sequencing detects multiple 1alpha,25-dihydroxyvitamin D(3)-sensitive metabolic pathways in developing zebrafish","volume":"26","author":"Craig","year":"2012","journal-title":"Mol Endocrinol"},{"issue":"1","key":"10.1016\/j.ecl.2017.07.008_bib181","first-page":"45","article-title":"Molecular basis of parathyroid hyperplasia","volume":"17","author":"Dusso","year":"2007","journal-title":"J\u00a0Ren Nutr"},{"issue":"102","key":"10.1016\/j.ecl.2017.07.008_bib182","doi-asserted-by":"crossref","first-page":"S8","DOI":"10.1038\/sj.ki.5001595","article-title":"Pathogenic mechanisms for parathyroid hyperplasia","author":"Dusso","year":"2006","journal-title":"Kidney Int Suppl"},{"issue":"5","key":"10.1016\/j.ecl.2017.07.008_bib183","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1172\/JCI105382","article-title":"The control of phosphate excretion in uremia","volume":"45","author":"Slatopolsky","year":"1966","journal-title":"J\u00a0Clin Invest"},{"issue":"8","key":"10.1016\/j.ecl.2017.07.008_bib184","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1172\/JCI105877","article-title":"Control of phosphate excretion in uremic man","volume":"47","author":"Slatopolsky","year":"1968","journal-title":"J\u00a0Clin Invest"},{"issue":"Spec No","key":"10.1016\/j.ecl.2017.07.008_bib185","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1001\/archinte.1978.03630300016003","article-title":"How important is phosphate in the pathogenesis of renal osteodystrophy?","volume":"138","author":"Slatopolsky","year":"1978","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.ecl.2017.07.008_bib186","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1007\/978-1-4613-4217-5_47","article-title":"The role of phosphate and other factors on the pathogenesis of renal osteodystrophy","volume":"81","author":"Slatopolsky","year":"1977","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.ecl.2017.07.008_bib187","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1038\/bonekey.2013.232","article-title":"Vitamin D and chronic kidney disease-mineral bone disease (CKD-MBD)","volume":"3","author":"Nigwekar","year":"2014","journal-title":"Bonekey Rep"},{"issue":"6","key":"10.1016\/j.ecl.2017.07.008_bib188","doi-asserted-by":"crossref","first-page":"2272","DOI":"10.1046\/j.1523-1755.2003.00328.x","article-title":"Circulating concentration of FGF-23 increases as renal function declines in patients with chronic kidney disease, but does not change in response to variation in phosphate intake in healthy volunteers","volume":"64","author":"Larsson","year":"2003","journal-title":"Kidney Int"},{"issue":"12","key":"10.1016\/j.ecl.2017.07.008_bib189","doi-asserted-by":"crossref","first-page":"3820","DOI":"10.1172\/JCI36479","article-title":"Endocrine functions of bone in mineral metabolism regulation","volume":"118","author":"Quarles","year":"2008","journal-title":"J\u00a0Clin Invest"},{"issue":"4","key":"10.1016\/j.ecl.2017.07.008_bib190","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1172\/JCI200419081","article-title":"Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism","volume":"113","author":"Shimada","year":"2004","journal-title":"J\u00a0Clin Invest"},{"issue":"6","key":"10.1016\/j.ecl.2017.07.008_bib191","doi-asserted-by":"crossref","first-page":"1968","DOI":"10.1172\/JCI114931","article-title":"Regulation of 1,25-dihydroxyvitamin D3 receptor gene expression by 1,25-dihydroxyvitamin D3 in the parathyroid in\u00a0vivo","volume":"86","author":"Naveh-Many","year":"1990","journal-title":"J\u00a0Clin Invest"},{"issue":"4","key":"10.1016\/j.ecl.2017.07.008_bib192","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1172\/JCI118224","article-title":"Parathyroid cell proliferation in normal and chronic renal failure rats. The effects of calcium, phosphate, and vitamin D","volume":"96","author":"Naveh-Many","year":"1995","journal-title":"J\u00a0Clin Invest"},{"issue":"4","key":"10.1016\/j.ecl.2017.07.008_bib193","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1172\/JCI114840","article-title":"Regulation of parathyroid hormone gene expression by hypocalcemia, hypercalcemia, and vitamin D in the rat","volume":"86","author":"Naveh-Many","year":"1990","journal-title":"J\u00a0Clin Invest"},{"issue":"5","key":"10.1016\/j.ecl.2017.07.008_bib194","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1172\/JCI112714","article-title":"Regulation by vitamin D metabolites of parathyroid hormone gene transcription in\u00a0vivo in the rat","volume":"78","author":"Silver","year":"1986","journal-title":"J\u00a0Clin Invest"},{"issue":"12","key":"10.1016\/j.ecl.2017.07.008_bib195","doi-asserted-by":"crossref","first-page":"4270","DOI":"10.1073\/pnas.82.12.4270","article-title":"Regulation by vitamin D metabolites of messenger ribonucleic acid for preproparathyroid hormone in isolated bovine parathyroid cells","volume":"82","author":"Silver","year":"1985","journal-title":"Proc Natl Acad Sci U\u00a0S\u00a0A"},{"issue":"4","key":"10.1016\/j.ecl.2017.07.008_bib196","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1210\/endo.136.4.7895652","article-title":"The roles of calcium and 1,25-dihydroxyvitamin D3 in the regulation of vitamin D receptor expression by rat parathyroid glands","volume":"136","author":"Brown","year":"1995","journal-title":"Endocrinology"},{"issue":"1","key":"10.1016\/j.ecl.2017.07.008_bib197","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/ki.1996.283","article-title":"1,25-dihydroxyvitamin D3 and 22-oxacalcitriol prevent the decrease in vitamin D receptor content in the parathyroid glands of uremic rats","volume":"50","author":"Denda","year":"1996","journal-title":"Kidney Int"},{"issue":"1","key":"10.1016\/j.ecl.2017.07.008_bib198","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1053\/j.semnephrol.2003.08.018","article-title":"Vitamin D receptor and analogs","volume":"24","author":"Dusso","year":"2004","journal-title":"Semin Nephrol"},{"issue":"2 Suppl 2","key":"10.1016\/j.ecl.2017.07.008_bib199","doi-asserted-by":"crossref","first-page":"S40","DOI":"10.1053\/ajkd.1998.v32.pm9808142","article-title":"Effects of 19-nor-1,25(OH)2D2, a new analogue of calcitriol, on secondary hyperparathyroidism in uremic rats","volume":"32","author":"Slatopolsky","year":"1998","journal-title":"Am J Kidney Dis"},{"issue":"1","key":"10.1016\/j.ecl.2017.07.008_bib200","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0272-6386(97)90571-0","article-title":"A\u00a0new analog of 1,25-(OH)2D3, 19-NOR-1,25-(OH)2D2, suppresses serum PTH and parathyroid gland growth in uremic rats without elevation of intestinal vitamin D receptor content","volume":"30","author":"Takahashi","year":"1997","journal-title":"Am J Kidney Dis"},{"issue":"3","key":"10.1016\/j.ecl.2017.07.008_bib201","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1159\/000190286","article-title":"'Pulse oral' versus intravenous calcitriol therapy in chronic hemodialysis patients. A prospective and randomized study","volume":"77","author":"Bacchini","year":"1997","journal-title":"Nephron"},{"issue":"4","key":"10.1016\/j.ecl.2017.07.008_bib202","first-page":"216","article-title":"Comparison of intermittent oral and intravenous calcitriol in hemodialysis patients with secondary hyperparathyroidism","volume":"40","author":"Fischer","year":"1993","journal-title":"Clin Nephrol"},{"issue":"1","key":"10.1016\/j.ecl.2017.07.008_bib203","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1046\/j.1523-1755.2000.00819.x","article-title":"Comparison of treatments for mild secondary hyperparathyroidism in hemodialysis patients. Durham Renal Osteodystrophy Study Group","volume":"57","author":"Indridason","year":"2000","journal-title":"Kidney Int"},{"issue":"3","key":"10.1016\/j.ecl.2017.07.008_bib204","first-page":"97","article-title":"Comparative effect of oral or intravenous calcitriol on secondary hyperparathyroidism in chronic hemodialysis patients","volume":"20","author":"Liou","year":"1994","journal-title":"Miner Electrolyte Metab"},{"issue":"3","key":"10.1016\/j.ecl.2017.07.008_bib205","first-page":"122","article-title":"Intravenous versus oral calcitriol therapy in renal osteodystrophy: results of a prospective, pulsed and dose-comparable study","volume":"20","author":"Mazzaferro","year":"1994","journal-title":"Miner Electrolyte Metab"},{"issue":"6","key":"10.1016\/j.ecl.2017.07.008_bib206","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1038\/ki.1994.223","article-title":"Prospective trial of pulse oral versus intravenous calcitriol treatment of hyperparathyroidism in ESRD","volume":"45","author":"Quarles","year":"1994","journal-title":"Kidney Int"},{"issue":"3","key":"10.1016\/j.ecl.2017.07.008_bib207","doi-asserted-by":"crossref","first-page":"276","DOI":"10.5414\/CNP71276","article-title":"Comparison of intermittent intravenous and oral calcitriol in the treatment of secondary hyperparathyroidism in chronic hemodialysis patients: a meta-analysis of randomized controlled trials","volume":"71","author":"Haiyang","year":"2009","journal-title":"Clin Nephrol"},{"issue":"5","key":"10.1016\/j.ecl.2017.07.008_bib208","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1016\/0272-6386(95)90455-7","article-title":"A\u00a0new analog of calcitriol, 19-nor-1,25-(OH)2D2, suppresses parathyroid hormone secretion in uremic rats in the absence of hypercalcemia","volume":"26","author":"Slatopolsky","year":"1995","journal-title":"Am J Kidney Dis"},{"issue":"6","key":"10.1016\/j.ecl.2017.07.008_bib209","doi-asserted-by":"crossref","first-page":"2020","DOI":"10.1046\/j.1523-1755.2003.00029.x","article-title":"Efficacy of 19-Nor-1,25-(OH)2D2 in the prevention and treatment of hyperparathyroid bone disease in experimental uremia","volume":"63","author":"Slatopolsky","year":"2003","journal-title":"Kidney Int"},{"issue":"8","key":"10.1016\/j.ecl.2017.07.008_bib210","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1681\/ASN.V981427","article-title":"19-Nor-1-alpha-25-dihydroxyvitamin D2 (Paricalcitol) safely and effectively reduces the levels of intact parathyroid hormone in patients on hemodialysis","volume":"9","author":"Martin","year":"1998","journal-title":"J\u00a0Am Soc Nephrol"},{"issue":"2 Suppl 2","key":"10.1016\/j.ecl.2017.07.008_bib211","doi-asserted-by":"crossref","first-page":"S61","DOI":"10.1053\/ajkd.1998.v32.pm9808145","article-title":"Therapy of secondary hyperparathyroidism with 19-nor-1alpha,25-dihydroxyvitamin D2","volume":"32","author":"Martin","year":"1998","journal-title":"Am J Kidney Dis"},{"issue":"4","key":"10.1016\/j.ecl.2017.07.008_bib212","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1046\/j.1523-1755.2003.00878.x","article-title":"Paricalcitol versus calcitriol in the treatment of secondary hyperparathyroidism","volume":"63","author":"Sprague","year":"2003","journal-title":"Kidney Int"},{"issue":"5","key":"10.1016\/j.ecl.2017.07.008_bib213","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1056\/NEJMoa022536","article-title":"Survival of patients undergoing hemodialysis with paricalcitol or calcitriol therapy","volume":"349","author":"Teng","year":"2003","journal-title":"N\u00a0Engl J Med"},{"issue":"Suppl 3","key":"10.1016\/j.ecl.2017.07.008_bib214","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1093\/ndt\/13.suppl_3.68","article-title":"Intermittent oral 1alpha-hydroxyvitamin D2 is effective and safe for the suppression of secondary hyperparathyroidism in haemodialysis patients. 1alphad2 Study Group","volume":"13","author":"Frazao","year":"1998","journal-title":"Nephrol Dial Transplant"},{"issue":"1","key":"10.1016\/j.ecl.2017.07.008_bib215","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/ki.1997.39","article-title":"Effective suppression of parathyroid hormone by 1 alpha-hydroxy-vitamin D2 in hemodialysis patients with moderate to severe secondary hyperparathyroidism","volume":"51","author":"Tan","year":"1997","journal-title":"Kidney Int"},{"issue":"3","key":"10.1016\/j.ecl.2017.07.008_bib216","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1053\/ajkd.2001.22077","article-title":"Efficacy and side effects of intermittent intravenous and oral doxercalciferol (1alpha-hydroxyvitamin D(2)) in dialysis patients with secondary hyperparathyroidism: a sequential comparison","volume":"37","author":"Maung","year":"2001","journal-title":"Am J Kidney Dis"},{"issue":"6","key":"10.1016\/j.ecl.2017.07.008_bib217","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1159\/000089707","article-title":"Inhibition of parathyroid hormone: a dose equivalency study of paricalcitol and doxercalciferol","volume":"25","author":"Zisman","year":"2005","journal-title":"Am J Nephrol"},{"issue":"5","key":"10.1016\/j.ecl.2017.07.008_bib218","doi-asserted-by":"crossref","first-page":"335","DOI":"10.5414\/CNP65335","article-title":"Differential effects of very high doses of doxercalciferol and paricalcitol on serum phosphorus in hemodialysis patients","volume":"65","author":"Joist","year":"2006","journal-title":"Clin Nephrol"},{"issue":"3","key":"10.1016\/j.ecl.2017.07.008_bib219","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1111\/j.1440-1797.2010.01398.x","article-title":"Randomized trial comparing pulse calcitriol and alfacalcidol for the treatment of secondary hyperparathyroidism in haemodialysis patients","volume":"16","author":"Kiattisunthorn","year":"2011","journal-title":"Nephrology (Carlton)"},{"issue":"8","key":"10.1016\/j.ecl.2017.07.008_bib220","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1038\/ki.2011.226","article-title":"No difference between alfacalcidol and paricalcitol in the treatment of secondary hyperparathyroidism in hemodialysis patients: a randomized crossover trial","volume":"80","author":"Hansen","year":"2011","journal-title":"Kidney Int"},{"issue":"10","key":"10.1016\/j.ecl.2017.07.008_bib221","doi-asserted-by":"crossref","first-page":"4410","DOI":"10.1248\/cpb.34.4410","article-title":"Synthetic studies of vitamin D3 analogues. VIII. Synthesis of 22-oxavitamin D3 analogues","volume":"34","author":"Murayama","year":"1986","journal-title":"Chem Pharm Bull (Tokyo)"},{"issue":"6","key":"10.1016\/j.ecl.2017.07.008_bib222","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1111\/j.1774-9987.2004.00191.x","article-title":"Dose-response study of 22-oxacalcitriol in patients with secondary hyperparathyroidism","volume":"8","author":"Akizawa","year":"2004","journal-title":"Ther Apher Dial"},{"issue":"Suppl 10","key":"10.1016\/j.ecl.2017.07.008_bib223","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1093\/ndt\/17.suppl_10.28","article-title":"Long-term effect of 1,25-dihydroxy-22-oxavitamin D(3) on secondary hyperparathyroidism in haemodialysis patients. One-year administration study","volume":"17","author":"Akizawa","year":"2002","journal-title":"Nephrol Dial Transplant"},{"issue":"3 Suppl 1","key":"10.1016\/j.ecl.2017.07.008_bib224","doi-asserted-by":"crossref","first-page":"S108","DOI":"10.1053\/ajkd.2003.50097","article-title":"Multicenter clinical trial of 22-oxa-1,25-dihydroxyvitamin D3 for chronic dialysis patients","volume":"41","author":"Yasuda","year":"2003","journal-title":"Am J Kidney Dis"},{"issue":"3","key":"10.1016\/j.ecl.2017.07.008_bib225","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1007\/s10157-005-0363-x","article-title":"Comparison of the efficacy of an oral calcitriol pulse or intravenous 22-oxacalcitriol therapies in chronic hemodialysis patients","volume":"9","author":"Tamura","year":"2005","journal-title":"Clin Exp Nephrol"},{"key":"10.1016\/j.ecl.2017.07.008_bib226","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1159\/000420143","article-title":"Clinical trial of 26,26,26,27,27,27-hexafluoro-1,25-dihydroxyvitamin D3 in uremic patients on hemodialysis: preliminary report","volume":"90","author":"Nishizawa","year":"1991","journal-title":"Contrib Nephrol"},{"issue":"6","key":"10.1016\/j.ecl.2017.07.008_bib227","doi-asserted-by":"crossref","first-page":"660","DOI":"10.5414\/CNP71660","article-title":"Comparison of oral falecalcitriol and intravenous calcitriol in hemodialysis patients with secondary hyperparathyroidism: a randomized, crossover trial","volume":"71","author":"Ito","year":"2009","journal-title":"Clin Nephrol"},{"issue":"1","key":"10.1016\/j.ecl.2017.07.008_bib228","doi-asserted-by":"crossref","first-page":"E125","DOI":"10.1152\/ajpendo.00224.2004","article-title":"Cardiac hypertrophy in vitamin D receptor knockout mice: role of the systemic and cardiac renin-angiotensin systems","volume":"288","author":"Xiang","year":"2005","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"2","key":"10.1016\/j.ecl.2017.07.008_bib229","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1172\/JCI0215219","article-title":"1,25-Dihydroxyvitamin D(3) is a negative endocrine regulator of the renin-angiotensin system","volume":"110","author":"Li","year":"2002","journal-title":"J\u00a0Clin Invest"},{"issue":"2","key":"10.1016\/j.ecl.2017.07.008_bib230","doi-asserted-by":"crossref","first-page":"622","DOI":"10.2353\/ajpath.2010.091292","article-title":"Therapeutic effects of vitamin D analogs on cardiac hypertrophy in spontaneously hypertensive rats","volume":"177","author":"Kong","year":"2010","journal-title":"Am J Pathol"},{"issue":"43","key":"10.1016\/j.ecl.2017.07.008_bib231","doi-asserted-by":"crossref","first-page":"16810","DOI":"10.1073\/pnas.0611202104","article-title":"Activated vitamin D attenuates left ventricular abnormalities induced by dietary sodium in Dahl salt-sensitive animals","volume":"104","author":"Bodyak","year":"2007","journal-title":"Proc Natl Acad Sci U\u00a0S\u00a0A"},{"issue":"1","key":"10.1016\/j.ecl.2017.07.008_bib232","doi-asserted-by":"crossref","first-page":"c21","DOI":"10.1159\/000088295","article-title":"Calcitriol regresses cardiac hypertrophy and QT dispersion in secondary hyperparathyroidism on hemodialysis","volume":"102","author":"Kim","year":"2006","journal-title":"Nephron Clin Pract"},{"issue":"1","key":"10.1016\/j.ecl.2017.07.008_bib233","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0272-6386(99)70260-X","article-title":"Intravenous calcitriol regresses myocardial hypertrophy in hemodialysis patients with secondary hyperparathyroidism","volume":"33","author":"Park","year":"1999","journal-title":"Am J Kidney Dis"},{"issue":"7","key":"10.1016\/j.ecl.2017.07.008_bib234","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1001\/jama.2012.120","article-title":"Vitamin D therapy and cardiac structure and function in patients with chronic kidney disease: the PRIMO randomized controlled trial","volume":"307","author":"Thadhani","year":"2012","journal-title":"JAMA"},{"issue":"2","key":"10.1016\/j.ecl.2017.07.008_bib235","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1111\/j.1365-2249.1992.tb03077.x","article-title":"Single and combined effects of the vitamin D analogue KH1060 and cyclosporin A on mercuric-chloride-induced autoimmune disease in the BN rat","volume":"88","author":"Lillevang","year":"1992","journal-title":"Clin Exp Immunol"},{"issue":"3","key":"10.1016\/j.ecl.2017.07.008_bib236","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1111\/j.1365-2249.1993.tb08210.x","article-title":"Partial prevention of active Heymann nephritis by 1 alpha, 25 dihydroxyvitamin D3","volume":"94","author":"Branisteanu","year":"1993","journal-title":"Clin Exp Immunol"},{"issue":"6","key":"10.1016\/j.ecl.2017.07.008_bib237","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1046\/j.1523-1755.1998.00951.x","article-title":"Effect of 1,25 (OH)2 vitamin D3 on glomerulosclerosis in subtotally nephrectomized rats","volume":"53","author":"Schwarz","year":"1998","journal-title":"Kidney Int"},{"issue":"4","key":"10.1016\/j.ecl.2017.07.008_bib238","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1177\/039463200501800422","article-title":"Treatment with 1,25-dihydroxyvitamin D3 preserves glomerular slit diaphragm-associated protein expression in experimental glomerulonephritis","volume":"18","author":"Migliori","year":"2005","journal-title":"Int J Immunopathol Pharmacol"},{"issue":"41","key":"10.1016\/j.ecl.2017.07.008_bib239","doi-asserted-by":"crossref","first-page":"15896","DOI":"10.1073\/pnas.0803751105","article-title":"Combination therapy with AT1 blocker and vitamin D analog markedly ameliorates diabetic nephropathy: blockade of compensatory renin increase","volume":"105","author":"Zhang","year":"2008","journal-title":"Proc Natl Acad Sci U\u00a0S\u00a0A"},{"issue":"2","key":"10.1016\/j.ecl.2017.07.008_bib240","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1161\/HYPERTENSIONAHA.108.113159","article-title":"Paricalcitol reduces albuminuria and inflammation in chronic kidney disease: a randomized double-blind pilot trial","volume":"52","author":"Alborzi","year":"2008","journal-title":"Hypertension"},{"issue":"4","key":"10.1016\/j.ecl.2017.07.008_bib241","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1053\/j.ajkd.2009.04.036","article-title":"Oral paricalcitol in the treatment of patients with CKD and proteinuria: a randomized trial","volume":"54","author":"Fishbane","year":"2009","journal-title":"Am J Kidney Dis"},{"issue":"9752","key":"10.1016\/j.ecl.2017.07.008_bib242","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1016\/S0140-6736(10)61032-X","article-title":"Selective vitamin D receptor activation with paricalcitol for reduction of albuminuria in patients with type 2 diabetes (VITAL study): a randomised controlled trial","volume":"376","author":"de Zeeuw","year":"2010","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.ecl.2017.07.008_bib243","doi-asserted-by":"crossref","first-page":"299","DOI":"10.2215\/CJN.07131009","article-title":"A\u00a0randomized trial of cholecalciferol versus doxercalciferol for lowering parathyroid hormone in chronic kidney disease","volume":"5","author":"Moe","year":"2010","journal-title":"Clin J Am Soc Nephrol"},{"issue":"18","key":"10.1016\/j.ecl.2017.07.008_bib244","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.1093\/eurheartj\/ehq246","article-title":"Vitamin D deficiency is associated with sudden cardiac death, combined cardiovascular events, and mortality in haemodialysis patients","volume":"31","author":"Drechsler","year":"2010","journal-title":"Eur Heart J"},{"issue":"3","key":"10.1016\/j.ecl.2017.07.008_bib245","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1093\/ndt\/gfq606","article-title":"Vitamin D status and clinical outcomes in incident dialysis patients: results from the NECOSAD study","volume":"26","author":"Drechsler","year":"2011","journal-title":"Nephrol Dial Transplant"},{"issue":"8","key":"10.1016\/j.ecl.2017.07.008_bib246","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1038\/sj.ki.5002451","article-title":"Vitamin D levels and early mortality among incident hemodialysis patients","volume":"72","author":"Wolf","year":"2007","journal-title":"Kidney Int"},{"issue":"12","key":"10.1016\/j.ecl.2017.07.008_bib247","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1001\/archinte.168.12.1340","article-title":"Independent association of low serum 25-hydroxyvitamin d and 1,25-dihydroxyvitamin d levels with all-cause and cardiovascular mortality","volume":"168","author":"Dobnig","year":"2008","journal-title":"Arch Intern Med"},{"issue":"4","key":"10.1016\/j.ecl.2017.07.008_bib248","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1038\/sj.ki.5001514","article-title":"Survival predictability of time-varying indicators of bone disease in maintenance hemodialysis patients","volume":"70","author":"Kalantar-Zadeh","year":"2006","journal-title":"Kidney Int"},{"issue":"4","key":"10.1016\/j.ecl.2017.07.008_bib249","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1001\/archinternmed.2007.110","article-title":"Association of activated vitamin D treatment and mortality in chronic kidney disease","volume":"168","author":"Kovesdy","year":"2008","journal-title":"Arch Intern Med"},{"issue":"2","key":"10.1016\/j.ecl.2017.07.008_bib250","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1038\/sj.ki.5001542","article-title":"Changes in serum calcium, phosphate, and PTH and the risk of death in incident dialysis patients: a longitudinal study","volume":"70","author":"Melamed","year":"2006","journal-title":"Kidney Int"},{"issue":"8","key":"10.1016\/j.ecl.2017.07.008_bib251","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1681\/ASN.2007111164","article-title":"Association of oral calcitriol with improved survival in nondialyzed CKD","volume":"19","author":"Shoben","year":"2008","journal-title":"J\u00a0Am Soc Nephrol"},{"issue":"1","key":"10.1016\/j.ecl.2017.07.008_bib252","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1093\/ndt\/gfg513","article-title":"Lower risk for cardiovascular mortality in oral 1alpha-hydroxy vitamin D3 users in a haemodialysis population","volume":"19","author":"Shoji","year":"2004","journal-title":"Nephrol Dial Transplant"},{"issue":"4","key":"10.1016\/j.ecl.2017.07.008_bib253","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1681\/ASN.2004070573","article-title":"Activated injectable vitamin D and hemodialysis survival: a historical cohort study","volume":"16","author":"Teng","year":"2005","journal-title":"J\u00a0Am Soc Nephrol"},{"issue":"7","key":"10.1016\/j.ecl.2017.07.008_bib254","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1681\/ASN.2007091002","article-title":"Impact of activated vitamin D and race on survival among hemodialysis patients","volume":"19","author":"Wolf","year":"2008","journal-title":"J\u00a0Am Soc Nephrol"},{"issue":"3","key":"10.1016\/j.ecl.2017.07.008_bib255","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1093\/ndt\/gfn592","article-title":"The survival advantage for haemodialysis patients taking vitamin D is questioned: findings from the Dialysis Outcomes and Practice Patterns Study","volume":"24","author":"Tentori","year":"2009","journal-title":"Nephrol Dial Transplant"},{"issue":"12","key":"10.1016\/j.ecl.2017.07.008_bib256","doi-asserted-by":"crossref","first-page":"840","DOI":"10.7326\/0003-4819-147-12-200712180-00004","article-title":"Meta-analysis: vitamin D compounds in chronic kidney disease","volume":"147","author":"Palmer","year":"2007","journal-title":"Ann Intern Med"}],"container-title":["Endocrinology and Metabolism Clinics of North America"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889852917300701?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889852917300701?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T09:43:19Z","timestamp":1760175799000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0889852917300701"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12]]},"references-count":256,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["S0889852917300701"],"URL":"https:\/\/doi.org\/10.1016\/j.ecl.2017.07.008","relation":{},"ISSN":["0889-8529"],"issn-type":[{"value":"0889-8529","type":"print"}],"subject":[],"published":{"date-parts":[[2017,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Use of Vitamin D Metabolites and Analogues in the Treatment of Chronic Kidney Disease","name":"articletitle","label":"Article Title"},{"value":"Endocrinology and Metabolism Clinics of North America","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecl.2017.07.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}