{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T21:10:46Z","timestamp":1792271446990,"version":"4.4.0"},"reference-count":16,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,9,23]],"date-time":"2020-09-23T00:00:00Z","timestamp":1600819200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012947","name":"Institut de Recherche pour le D\u00e9veloppement","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012947","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016195","name":"United Nations Development Programme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016195","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004423","name":"World Health Organization","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004423","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004421","name":"World Bank Group","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004421","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["EClinicalMedicine"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1016\/j.eclinm.2020.100582","type":"journal-article","created":{"date-parts":[[2020,10,9]],"date-time":"2020-10-09T23:11:39Z","timestamp":1602285099000},"page":"100582","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"special_numbering":"C","title":["Individual risk of post-ivermectin serious adverse events in subjects infected with Loa loa"],"prefix":"10.1016","volume":"28","author":[{"given":"C\u00e9dric B.","family":"Chesnais","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien D.","family":"Pion","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Boull\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Gardon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Gardon-Wendel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00ebl","family":"Fokom-Domgue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Kamgno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Boussinesq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.eclinm.2020.100582_bib0001","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/S0140-6736(96)11094-1","article-title":"Serious reactions after mass treatment of onchocerciasis with ivermectin in an area endemic for Loa loa infection","volume":"350","author":"Gardon","year":"1997","journal-title":"Lancet"},{"key":"10.1016\/j.eclinm.2020.100582_bib0002","doi-asserted-by":"crossref","first-page":"2044","DOI":"10.1056\/NEJMoa1705026","article-title":"A test-and-not-treat strategy for onchocerciasis in Loa loa-endemic areas","volume":"377","author":"Kamgno","year":"2017","journal-title":"N Engl J Med"},{"key":"10.1016\/j.eclinm.2020.100582_bib0003","doi-asserted-by":"crossref","first-page":"i40","DOI":"10.1093\/inthealth\/ihx054","article-title":"Alternative treatment strategies to accelerate the elimination of onchocerciasis","volume":"10","author":"Boussinesq","year":"2018","journal-title":"Int Health"},{"key":"10.1016\/j.eclinm.2020.100582_bib0004","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1093\/cid\/ciz461","article-title":"A test-and-not-treat strategy for onchocerciasis elimination in Loa loa co-endemic areas: cost analysis of a pilot in the Soa health district, Cameroon","volume":"70","author":"Lenk","year":"2019","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.eclinm.2020.100582_bib0005","unstructured":"World Health Organization. Report of the second Meeting of the WHO Onchocerciasis Technical Advisory Subgroup, WHO, Geneva, Switzerland, 12-14 February 2018. WHO\/CDS\/NTD\/PCT\/2018.11. 2018 https:\/\/apps.who.int\/iris\/bitstream\/handle\/10665\/277238\/WHO-CDS-NTD-PCT-2018.11-eng.pdf."},{"key":"10.1016\/j.eclinm.2020.100582_bib0006","doi-asserted-by":"crossref","first-page":"335","DOI":"10.4269\/ajtmh.13-0189","article-title":"Absence of an association between Plasmodium falciparum infection and post-ivermectin Loa-related non-neurologic serious adverse events","volume":"90","author":"Fokom-Domgue","year":"2014","journal-title":"Am J Tropical Medicine Hyg"},{"key":"10.1016\/j.eclinm.2020.100582_bib0007","unstructured":"Anonymous. Central nervous system (CNS) complications of loiasis and adverse events following treatment. Report of an invited consultation: 2-3 October 1995. 1996."},{"key":"10.1016\/j.eclinm.2020.100582_bib0008","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1076\/0928-6586(200003)711-2FT027","article-title":"Ocular findings after ivermectin treatment of patients with high Loa loa microfilaremia","volume":"7","author":"Fobi","year":"2000","journal-title":"Ophthalmic Epidemiol"},{"key":"10.1016\/j.eclinm.2020.100582_bib0009","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.4269\/ajtmh.2009.09-0356","article-title":"Loa loa microfilarial periodicity in ivermectin-treated patients: comparison between those developing and those free of serious adverse events","volume":"81","author":"Kamgno","year":"2009","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.eclinm.2020.100582_bib0010","doi-asserted-by":"crossref","first-page":"382","DOI":"10.4269\/ajtmh.17-0042","article-title":"Serious neurological adverse events after ivermectin - Do they occur beyond the indication of onchocerciasis?","volume":"98","author":"Chandler","year":"2018","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.eclinm.2020.100582_bib0011","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1097\/00008571-200111000-00012","article-title":"Ivermectin sensitivity in collies is associated with a deletion mutation of the mdr1 gene","volume":"11","author":"Mealey","year":"2001","journal-title":"Pharmacogenetics"},{"key":"10.1016\/j.eclinm.2020.100582_bib0012","doi-asserted-by":"crossref","first-page":"684","DOI":"10.2460\/ajvr.1987.48.04.684","article-title":"Clinical observations in collies given ivermectin orally","volume":"48","author":"Paul","year":"1987","journal-title":"Am J Vet Res"},{"key":"10.1016\/j.eclinm.2020.100582_bib0013","doi-asserted-by":"crossref","first-page":"952","DOI":"10.2174\/138920112800399176","article-title":"Toxicity in animals: target species","volume":"13","author":"Woodward","year":"2012","journal-title":"Curr Pharm Biotechnol"},{"key":"10.1016\/j.eclinm.2020.100582_bib0014","doi-asserted-by":"crossref","first-page":"28","DOI":"10.4269\/ajtmh.2010.09-0734","article-title":"Analysis of the mdr-1 gene in patients co-infected with Onchocerca volvulus and Loa loa who experienced a post-ivermectin serious adverse event","volume":"83","author":"Bourguinat","year":"2010","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.eclinm.2020.100582_bib0015","doi-asserted-by":"crossref","first-page":"116","DOI":"10.4269\/ajtmh.18-0163","article-title":"In Southern Nigeria Loa loa blood microfilaria density is very low even in areas with high prevalence of loiasis: results of a survey using the new LoaScope technology","volume":"99","author":"Emukah","year":"2018","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.eclinm.2020.100582_bib0016","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/S1473-3099(19)30554-7","article-title":"Implications for annual retesting after a test-and-not-treat strategy for onchocerciasis elimination in areas co-endemic with Loa loa infection: an observational cohort study","volume":"20","author":"Pion","year":"2020","journal-title":"Lancet Infect Dis"}],"container-title":["EClinicalMedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589537020303266?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589537020303266?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T19:02:45Z","timestamp":1762887765000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589537020303266"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":16,"alternative-id":["S2589537020303266"],"URL":"https:\/\/doi.org\/10.1016\/j.eclinm.2020.100582","relation":{},"ISSN":["2589-5370"],"issn-type":[{"value":"2589-5370","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Individual risk of post-ivermectin serious adverse events in subjects infected with Loa loa","name":"articletitle","label":"Article Title"},{"value":"EClinicalMedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.eclinm.2020.100582","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"100582"}}