{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T05:03:06Z","timestamp":1787806986963,"version":"build-2784847793"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,10,28]],"date-time":"2021-10-28T00:00:00Z","timestamp":1635379200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81802593"],"award-info":[{"award-number":["81802593"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["eClinicalMedicine"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1016\/j.eclinm.2021.101200","type":"journal-article","created":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T05:48:09Z","timestamp":1641361689000},"page":"101200","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["Reproductive outcomes and reproductive tract microbiota shift in women with moderate-to-severe intrauterine adhesions following 30-day post-hysteroscopic placement of balloon stents or intrauterine contraceptive devices: A randomized controlled trial"],"prefix":"10.1016","volume":"43","author":[{"given":"Yue","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Cen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0641-6325","authenticated-orcid":false,"given":"Gufeng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.eclinm.2021.101200_bib0001","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.jmig.2010.04.016","article-title":"Review of intrauterine adhesions","volume":"17","author":"Deans","year":"2010","journal-title":"J. Minim. Invasive Gynecol."},{"key":"10.1016\/j.eclinm.2021.101200_bib0002","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1093\/humupd\/dmt045","article-title":"Systematic review and meta-analysis of intrauterine adhesions after miscarriage: prevalence, risk factors and long-term reproductive outcome","volume":"20","author":"Hooker","year":"2014","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.eclinm.2021.101200_bib0003","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.jogc.2016.03.003","article-title":"Intrauterine Adhesions Following Miscarriage: Look and Learn","volume":"38","author":"Gilman","year":"2016","journal-title":"J. Obstet. Gynaecol. Can."},{"key":"10.1016\/j.eclinm.2021.101200_bib0004","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1080\/13625187.2016.1199795","article-title":"Prevalence of intrauterine adhesions after termination of pregnancy: a systematic review","volume":"21","author":"Hooker","year":"2016","journal-title":"Eur. J. Contracept. Reprod. Health Care"},{"issue":"156-164","key":"10.1016\/j.eclinm.2021.101200_bib0005","first-page":"e151","article-title":"Long-term complications and reproductive outcome after the management of retained products of conception: a systematic review","volume":"105","author":"Hooker","year":"2016","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.eclinm.2021.101200_bib0006","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.fertnstert.2008.02.096","article-title":"Ashermen syndrome- one century later","volume":"89","author":"Yu","year":"2008","journal-title":"Fertil Steril"},{"key":"10.1016\/j.eclinm.2021.101200_bib0007","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD011110.pub2","article-title":"Anti-adhesion therapy following operative hysteroscopy for treatment of female subfertility","author":"Bosteels","year":"2015","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.eclinm.2021.101200_bib0008","first-page":"137","article-title":"Adhesions and Anti-Adhesion Systems Highlights","volume":"11","author":"Torres-De La Roche","year":"2019","journal-title":"Facts Views Vis Obgyn"},{"issue":"513-518","key":"10.1016\/j.eclinm.2021.101200_bib0009","first-page":"e512","article-title":"Bacterial colonization with balloon uterine stent placement in the uterus for 30 days: a randomized controlled clinical trial","volume":"103","author":"Lin","year":"2015","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.eclinm.2021.101200_bib0010","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1016\/S0015-0282(16)59942-7","article-title":"The American Fertility Society classifications of adnexal adhesions, distal tubal occlusion, tubal occlusion secondary to tubal ligation, tubal pregnancies, mullerian anomalies and intrauterine adhesions","volume":"49","year":"1988","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.eclinm.2021.101200_bib0011","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.9738\/INTSURG-D-15-00073.1","article-title":"Randomized Comparison of Intramuscular Phloroglucinol Versus Oral Misoprostol for Cervix Pretreatment Before Diagnostic Hysteroscopy","volume":"100","author":"Xu","year":"2015","journal-title":"Int. Surg."},{"key":"10.1016\/j.eclinm.2021.101200_bib0012","doi-asserted-by":"crossref","first-page":"e1002","DOI":"10.1016\/j.fertnstert.2019.01.006","article-title":"The impact of chronic endometritis on endometrial fibrosis and reproductive prognosis in patients with moderate and severe intrauterine adhesions: a prospective cohort study","volume":"111","author":"Liu","year":"2019","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.eclinm.2021.101200_bib0013","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1099\/jmm.0.000821","article-title":"Characterization of pelvic and cervical microbiotas from patients with pelvic inflammatory disease","volume":"67","author":"Wang","year":"2018","journal-title":"J. Med. Microbiol."},{"key":"10.1016\/j.eclinm.2021.101200_bib0014","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1038\/ismej.2013.16","article-title":"Habitat degradation impacts black howler monkey (Alouatta pigra) gastrointestinal microbiomes","volume":"7","author":"Amato","year":"2013","journal-title":"ISME J"},{"key":"10.1016\/j.eclinm.2021.101200_bib0015","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/j.fertnstert.2007.03.070","article-title":"Factors affecting reproductive outcome of hysteroscopic adhesiolysis for Asherman's syndrome","volume":"89","author":"Yu","year":"2008","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.eclinm.2021.101200_bib0016","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/s00404-009-1117-x","article-title":"Reproductive outcome following hysteroscopic adhesiolysis in patients with infertility due to Asherman's syndrome","volume":"281","author":"Roy","year":"2010","journal-title":"Arch. Gynecol. Obstet."},{"key":"10.1016\/j.eclinm.2021.101200_bib0017","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.ejogrb.2016.05.050","article-title":"Prevention of intrauterine post-surgical adhesions in hysteroscopy. A systematic review","volume":"203","author":"Di Spiezio Sardo","year":"2016","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"issue":"267-275","key":"10.1016\/j.eclinm.2021.101200_bib0018","doi-asserted-by":"crossref","first-page":"e267","DOI":"10.1016\/j.ajog.2016.05.001","article-title":"Intrauterine adhesion prevention after hysteroscopy: a systematic review and meta-analysis","volume":"215","author":"Healy","year":"2016","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.eclinm.2021.101200_bib0019","article-title":"Anti-adhesion therapy following operative hysteroscopy for treatment of female subfertility","volume":"11","author":"Bosteels","year":"2017","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.eclinm.2021.101200_bib0020","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.ejogrb.2013.07.018","article-title":"A comparison of intrauterine balloon, intrauterine contraceptive device and hyaluronic acid gel in the prevention of adhesion reformation following hysteroscopic surgery for Asherman syndrome: a cohort study","volume":"170","author":"Lin","year":"2013","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"10.1016\/j.eclinm.2021.101200_bib0021","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.fertnstert.2015.04.008","article-title":"Randomized, controlled trial comparing the efficacy of intrauterine balloon and intrauterine contraceptive device in the prevention of adhesion reformation after hysteroscopic adhesiolysis","volume":"104","author":"Lin","year":"2015","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.eclinm.2021.101200_bib0022","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.ijsu.2017.11.040","article-title":"Effect of early second-look hysteroscopy on reproductive outcomes after hysteroscopic adhesiolysis in patients with intrauterine adhesion, a retrospective study in China","volume":"50","author":"Xu","year":"2018","journal-title":"Int. J. Surg."},{"key":"10.1016\/j.eclinm.2021.101200_bib0023","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1002\/biof.85","article-title":"Influence of copper on early development: prenatal and postnatal considerations","volume":"36","author":"Uriu-Adams","year":"2010","journal-title":"Biofactors"},{"key":"10.1016\/j.eclinm.2021.101200_bib0024","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.ejogrb.2020.09.051","article-title":"Liquid-based cervical cytology and microbiological analyses in women using cooper intrauterine device and levonorgestrel-releasing intrauterine system","volume":"255","author":"Eleuterio","year":"2020","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"10.1016\/j.eclinm.2021.101200_bib0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajog.2018.02.017","article-title":"Impact of contraceptive initiation on vaginal microbiota","volume":"218","author":"Achilles","year":"2018","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.eclinm.2021.101200_bib0026","article-title":"Elevated Risk of Bacterial Vaginosis among Users of the Copper Intrauterine Device: A Prospective Longitudinal Cohort Study","author":"Peebles","year":"2020","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.eclinm.2021.101200_bib0027","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.rbmo.2010.11.018","article-title":"Management of Asherman's syndrome","volume":"23","author":"March","year":"2011","journal-title":"Reprod. Biomed. Online"},{"key":"10.1016\/j.eclinm.2021.101200_bib0028","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.contraception.2008.05.008","article-title":"Comparative study on contraceptive efficacy and clinical performance of the copper\/low-density polyethylene nanocomposite IUD and the copper T220C IUD","volume":"78","author":"Yu","year":"2008","journal-title":"Contraception"},{"key":"10.1016\/j.eclinm.2021.101200_bib0029","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1038\/s41467-017-00901-0","article-title":"The microbiota continuum along the female reproductive tract and its relation to uterine-related diseases","volume":"8","author":"Chen","year":"2017","journal-title":"Nat Commun"},{"key":"10.1016\/j.eclinm.2021.101200_bib0030","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s10815-015-0614-z","article-title":"Endometrial microbiome at the time of embryo transfer: next-generation sequencing of the 16S ribosomal subunit","volume":"33","author":"Franasiak","year":"2016","journal-title":"J. Assist. Reprod. Genet."},{"key":"10.1016\/j.eclinm.2021.101200_bib0031","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1093\/humupd\/dmy012","article-title":"How uterine microbiota might be responsible for a receptive, fertile endometrium","volume":"24","author":"Benner","year":"2018","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.eclinm.2021.101200_bib0032","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.fertnstert.2011.10.036","article-title":"Comprehensive management of severe Asherman syndrome and amenorrhea","volume":"97","author":"Myers","year":"2012","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.eclinm.2021.101200_bib0033","article-title":"Effects of Aspirin and Intrauterine Balloon on Endometrial Repair and Reproductive Prognosis in Patients with Severe Intrauterine Adhesion: A Prospective Cohort Study","volume":"2017","author":"Chen","year":"2017","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.eclinm.2021.101200_bib0034","doi-asserted-by":"crossref","first-page":"63","DOI":"10.3343\/alm.2020.40.1.63","article-title":"Comparison of 16S Ribosomal RNA Targeted Sequencing and Culture for Bacterial Identification in Normally Sterile Body Fluid Samples: Report of a 10-Year Clinical Laboratory Review","volume":"40","author":"Yoo","year":"2020","journal-title":"Ann. Lab. Med."}],"container-title":["eClinicalMedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589537021004818?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589537021004818?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T19:10:13Z","timestamp":1762888213000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589537021004818"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":34,"alternative-id":["S2589537021004818"],"URL":"https:\/\/doi.org\/10.1016\/j.eclinm.2021.101200","relation":{},"ISSN":["2589-5370"],"issn-type":[{"value":"2589-5370","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Reproductive outcomes and reproductive tract microbiota shift in women with moderate-to-severe intrauterine adhesions following 30-day post-hysteroscopic placement of balloon stents or intrauterine contraceptive devices: A randomized controlled trial","name":"articletitle","label":"Article Title"},{"value":"eClinicalMedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.eclinm.2021.101200","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"101200"}}