{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T07:44:23Z","timestamp":1785570263947,"version":"3.56.0"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,1,8]],"date-time":"2022-01-08T00:00:00Z","timestamp":1641600000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000364","name":"Stroke Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000364","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"MRC","doi-asserted-by":"publisher","award":["G0501797"],"award-info":[{"award-number":["G0501797"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002283","name":"Alzheimer\u2019s Research UK","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002283","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","award":["10\/104\/24"],"award-info":[{"award-number":["10\/104\/24"]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017510","name":"UK Dementia Research Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100017510","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000320","name":"Alzheimer's Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000320","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000360","name":"Scottish Funding Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000360","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000355","name":"BUPA Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000355","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["eClinicalMedicine"],"published-print":{"date-parts":[[2022,2]]},"DOI":"10.1016\/j.eclinm.2022.101274","type":"journal-article","created":{"date-parts":[[2022,1,24]],"date-time":"2022-01-24T06:57:46Z","timestamp":1643007466000},"page":"101274","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Effect of continuing versus stopping pre-stroke antihypertensive agents within 12\u00a0h on outcome after stroke: A subgroup analysis of the efficacy of nitric oxide in stroke (ENOS) trial"],"prefix":"10.1016","volume":"44","author":[{"given":"Lisa J.","family":"Woodhouse","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2604-4410","authenticated-orcid":false,"given":"Jason P.","family":"Appleton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Polly","family":"Scutt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Everton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gwenllian","family":"Wilkinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Caso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Czlonkowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Gommans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kailash","family":"Krishnan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann C.","family":"Laska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Ntaios","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serefnur","family":"Ozturk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Phillips","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart","family":"Pocock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kameshwar","family":"Prasad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Szabolcs","family":"Szatmari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna M.","family":"Wardlaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikola","family":"Sprigg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip M.","family":"Bath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9246","key":"10.1016\/j.eclinm.2022.101274_bib0001","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1016\/S0140-6736(00)03307-9","volume":"356","author":"Neal","year":"2000","journal-title":"Lancet"},{"key":"10.1016\/j.eclinm.2022.101274_bib0002","doi-asserted-by":"crossref","first-page":"2741","DOI":"10.1161\/01.STR.0000092488.40085.15","article-title":"Blood pressure reduction and the secondary prevention of stroke and other vascular events: a systematic review","volume":"34","author":"Rashid","year":"2003","journal-title":"Stroke"},{"issue":"suppl 6","key":"10.1016\/j.eclinm.2022.101274_bib0003","first-page":"S35","article-title":"Blood pressure control after acute stroke","volume":"14","author":"Lees","year":"1996","journal-title":"J Hypertens"},{"key":"10.1016\/j.eclinm.2022.101274_bib0004","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1093\/ageing\/29.6.554","article-title":"A trial of blood pressure reduction in acute stroke","volume":"29","author":"Bath","year":"2000","journal-title":"Age Ageing"},{"key":"10.1016\/j.eclinm.2022.101274_bib0005","series-title":"National Clinical Guidelines for Stroke","article-title":"Intercollegiate stroke working party","year":"2016"},{"issue":"8","key":"10.1016\/j.eclinm.2022.101274_bib0006","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/S1474-4422(10)70163-0","article-title":"Effects of antihypertensive treatment after acute stroke in the continue or stop post-stroke antihypertensives collaborative study (COSSACS): a prospective, randomised, open, blinded-endpoint trial","volume":"9","author":"Robinson","year":"2010","journal-title":"Lancet Neurol"},{"issue":"9968","key":"10.1016\/j.eclinm.2022.101274_bib0007","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/S0140-6736(14)61121-1","article-title":"Efficacy of nitric oxide, with or without continuing antihypertensive treatment, for management of high blood pressure in acute stroke (ENOS): a partial-factorial randomised controlled trial","volume":"385","author":"Bath","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.eclinm.2022.101274_bib0008","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1161\/HYPERTENSIONAHA.116.07982","article-title":"Continuing or temporarily stopping prestroke antihypertensive medication in acute stroke: an individual patient data meta-analysis","volume":"69","author":"Woodhouse","year":"2017","journal-title":"Hypertension"},{"key":"10.1016\/j.eclinm.2022.101274_bib0009","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1111\/j.1747-4949.2006.00059.x","article-title":"Glyceryl trinitrate vs. control, and continuing vs. stopping temporarily prior antihypertensive therapy, in acute stroke: rationale and design of the Efficacy of Nitric Oxide in Stroke (ENOS) trial (ISRCTN99414122)","volume":"1","year":"2006","journal-title":"Int J Stroke"},{"issue":"3","key":"10.1016\/j.eclinm.2022.101274_bib0010","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1111\/ijs.12235","article-title":"Statistical analysis plan for the \u2018efficacy of nitric oxide in stroke\u2019 (ENOS) trial","volume":"9","author":"Bath","year":"2014","journal-title":"Int J Stroke"},{"issue":"6","key":"10.1016\/j.eclinm.2022.101274_bib0011","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1111\/ijs.12308","article-title":"Baseline characteristics of the 4011 patients recruited into the \u201cefficacy of Nitric Oxide in Stroke (ENOS) trial","volume":"9","author":"ENOS Investigators","year":"2014","journal-title":"Int J Stroke"},{"key":"10.1016\/j.eclinm.2022.101274_bib0012","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1016\/0140-6736(91)93206-O","article-title":"Classification and natural history of clinically identifiable subtypes of cerebral infarction","volume":"337","author":"Bamford","year":"1991","journal-title":"Lancet"},{"issue":"4","key":"10.1016\/j.eclinm.2022.101274_bib0013","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1161\/STROKEAHA.111.641423","article-title":"Contemporary outcome measures in acute stroke research: choice of primary outcome measure","volume":"43","author":"Lees","year":"2012","journal-title":"Stroke"},{"key":"10.1016\/j.eclinm.2022.101274_bib0014","first-page":"55","article-title":"Evaulation of three devices for self-measurement of blood pressure monitoring according to the revised British hypertension society protocol: the Omron hem-705 cp, Philips hp 5332 and Nissei ds-175","volume":"1","author":"O' Brien","year":"1996","journal-title":"Blood Press Monit"},{"issue":"6","key":"10.1016\/j.eclinm.2022.101274_bib0015","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.jstrokecerebrovasdis.2009.02.003","article-title":"Interconversion of the National Institutes of Health Stroke Scale and Scandinavian Stroke Scale in acute stroke","volume":"18","author":"Gray","year":"2009","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"10.1016\/j.eclinm.2022.101274_bib0016","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1001\/archpsyc.1965.01720310065008","article-title":"A self-rating depression scale","volume":"12","author":"Zung","year":"1965","journal-title":"Arch Gen Psychiatry"},{"issue":"8","key":"10.1016\/j.eclinm.2022.101274_bib0017","doi-asserted-by":"crossref","first-page":"e2852","DOI":"10.1371\/journal.pone.0002852","article-title":"A randomised controlled trial of triple antiplatelet therapy (aspirin, clopidogrel and dipyridamole) in the secondary prevention of stroke: safety, tolerability and feasibility","volume":"3","author":"Sprigg","year":"2008","journal-title":"PLoS One"},{"issue":"7","key":"10.1016\/j.eclinm.2022.101274_bib0018","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1016\/j.jstrokecerebrovasdis.2014.04.022","article-title":"Relationship between poststroke cognition, baseline factors, and functional outcome: data from \u201cEfficacy of Nitric Oxide in Stroke\u201d trial","volume":"23","author":"Ankolekar","year":"2014","journal-title":"J Stroke Cerebrovasc Dis"},{"issue":"6","key":"10.1016\/j.eclinm.2022.101274_bib0019","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1111\/j.1747-4949.2011.00614.x","article-title":"Calculation of numbers-needed-to-treat in parallel group trials assessing ordinal outcomes: case examples from acute stroke and stroke prevention","volume":"6","author":"Bath","year":"2011","journal-title":"Int J Stroke"},{"key":"10.1016\/j.eclinm.2022.101274_bib0020","doi-asserted-by":"crossref","first-page":"e439","DOI":"10.1212\/WNL.0000000000008881","article-title":"Imaging markers of small vessel disease and brain frailty, and outcomes in acute stroke","volume":"94","author":"Appleton","year":"2020","journal-title":"Neurology"},{"issue":"10","key":"10.1016\/j.eclinm.2022.101274_bib0021","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0108784","article-title":"Applications of the Wei-Lachin multivariate one-sided test for multiple outcomes on possibly different scales","volume":"9","author":"Lachin","year":"2014","journal-title":"PLoS One"},{"issue":"14","key":"10.1016\/j.eclinm.2022.101274_bib0022","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1042\/CS20160382","article-title":"Hypercholesterolaemia and vascular dementia","volume":"131","author":"Appleton","year":"2017","journal-title":"Clin Sci"},{"issue":"11","key":"10.1016\/j.eclinm.2022.101274_bib0023","doi-asserted-by":"crossref","first-page":"3064","DOI":"10.1161\/STROKEAHA.119.026389","article-title":"Prehospital transdermal glyceryl trinitrate for ultra-acute intracerebral hemorrhage: data from the RIGHT-2 trial","volume":"50","author":"Bath","year":"2019","journal-title":"Stroke"},{"issue":"5","key":"10.1016\/j.eclinm.2022.101274_bib0024","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1161\/STROKEAHA.118.020750","article-title":"SCIL-STROKE (subcutaneous interleukin-1 receptor antagonist in ischemic stroke): a randomized controlled phase 2 trial","volume":"49","author":"Smith","year":"2018","journal-title":"Stroke"},{"issue":"1S","key":"10.1016\/j.eclinm.2022.101274_bib0025","first-page":"7","article-title":"Therapeutic induced hypertension in acute stroke patients with non-cardioembolic stroke: a randomised controlled trial","volume":"3","author":"Chung","year":"2018","journal-title":"Eur Stroke J"},{"issue":"1S","key":"10.1016\/j.eclinm.2022.101274_bib0026","first-page":"35","article-title":"The enhanced control of hypertension and thrombolysis stroke study (ENCHANTED) blood pressure (BP) arm: comparative effects of intensive- versus standard-BP lowering treatment in large-vessel occlusion","volume":"4","author":"Minhas","year":"2019","journal-title":"Eur Stroke J"},{"issue":"10","key":"10.1016\/j.eclinm.2022.101274_bib0027","doi-asserted-by":"crossref","first-page":"2677","DOI":"10.1161\/STROKEAHA.119.025426","article-title":"Blood pressure drop and penumbral tissue loss in nonrecanalized emergent large vessel occlusion","volume":"50","author":"Jeong","year":"2019","journal-title":"Stroke"},{"issue":"2","key":"10.1016\/j.eclinm.2022.101274_bib0028","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1161\/STROKEAHA.118.023190","article-title":"Effect of glyceryl trinitrate on hemodynamics in acute stroke","volume":"50","author":"Appleton","year":"2019","journal-title":"Stroke"},{"issue":"2","key":"10.1016\/j.eclinm.2022.101274_bib0029","doi-asserted-by":"crossref","first-page":"XLVIII","DOI":"10.1177\/23969873211012133","article-title":"European stroke organisation (ESO) guidelines on blood pressure management in acute ischaemic stroke and intracerebral haemorrhage","volume":"6","author":"Sandset","year":"2021","journal-title":"Eur Stroke J"}],"container-title":["eClinicalMedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589537022000049?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589537022000049?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T19:09:54Z","timestamp":1762888194000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589537022000049"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2]]},"references-count":29,"alternative-id":["S2589537022000049"],"URL":"https:\/\/doi.org\/10.1016\/j.eclinm.2022.101274","relation":{},"ISSN":["2589-5370"],"issn-type":[{"value":"2589-5370","type":"print"}],"subject":[],"published":{"date-parts":[[2022,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of continuing versus stopping pre-stroke antihypertensive agents within 12\u00a0h on outcome after stroke: A subgroup analysis of the efficacy of nitric oxide in stroke (ENOS) trial","name":"articletitle","label":"Article Title"},{"value":"eClinicalMedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.eclinm.2022.101274","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"101274"}}