{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T20:00:02Z","timestamp":1794081602948,"version":"4.8.0"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,1,21]],"date-time":"2022-01-21T00:00:00Z","timestamp":1642723200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01NS055349"],"award-info":[{"award-number":["R01NS055349"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007114","name":"Ralph W and Grace M Showalter Research Trust Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007114","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000061","name":"Fogarty International Center","doi-asserted-by":"publisher","award":["D43 TW010928"],"award-info":[{"award-number":["D43 TW010928"]}],"id":[{"id":"10.13039\/100000061","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["eClinicalMedicine"],"published-print":{"date-parts":[[2022,2]]},"DOI":"10.1016\/j.eclinm.2022.101292","type":"journal-article","created":{"date-parts":[[2022,2,11]],"date-time":"2022-02-11T22:41:56Z","timestamp":1644619316000},"page":"101292","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":81,"special_numbering":"C","title":["Acute kidney injury, persistent kidney disease, and post-discharge morbidity and mortality in severe malaria in children: A prospective cohort study"],"prefix":"10.1016","volume":"44","author":[{"given":"Ruth","family":"Namazzi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7463-5277","authenticated-orcid":false,"given":"Anthony","family":"Batte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert O.","family":"Opoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Bangirana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew L.","family":"Schwaderer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachary","family":"Berrens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dibyadyuti","family":"Datta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Goings","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John M.","family":"Ssenkusu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart L.","family":"Goldstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chandy C.","family":"John","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5328-6511","authenticated-orcid":false,"given":"Andrea L.","family":"Conroy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9987","key":"10.1016\/j.eclinm.2022.101292_bib0001","doi-asserted-by":"crossref","first-page":"2616","DOI":"10.1016\/S0140-6736(15)60126-X","article-title":"International Society of Nephrology's 0by25 initiative for acute kidney injury (zero preventable deaths by 2025): a human rights case for nephrology","volume":"385","author":"Mehta","year":"2015","journal-title":"Lancet"},{"issue":"3","key":"10.1016\/j.eclinm.2022.101292_bib0002","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/ki.2013.153","article-title":"Raising awareness of acute kidney injury: a global perspective of a silent killer","volume":"84","author":"Lewington","year":"2013","journal-title":"Kidney Int"},{"issue":"1","key":"10.1016\/j.eclinm.2022.101292_bib0003","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1056\/NEJMoa1611391","article-title":"Epidemiology of acute kidney injury in critically ill children and young adults","volume":"376","author":"Kaddourah","year":"2017","journal-title":"N Engl J Med"},{"key":"10.1016\/j.eclinm.2022.101292_bib0004","doi-asserted-by":"crossref","first-page":"235","DOI":"10.2147\/IJNRD.S239157","article-title":"Malaria-associated acute kidney injury in african children: prevalence, pathophysiology, impact, and management challenges","volume":"14","author":"Batte","year":"2021","journal-title":"Int J Nephrol Renovasc Dis"},{"issue":"12","key":"10.1016\/j.eclinm.2022.101292_bib0005","doi-asserted-by":"crossref","first-page":"2241","DOI":"10.1097\/CCM.0000000000002007","article-title":"Acute kidney injury in pediatric severe sepsis: an independent risk factor for death and new disability","volume":"44","author":"Fitzgerald","year":"2016","journal-title":"Crit Care Med"},{"issue":"1","key":"10.1016\/j.eclinm.2022.101292_bib0006","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1186\/s12916-019-1332-7","article-title":"Acute kidney injury is associated with impaired cognition and chronic kidney disease in a prospective cohort of children with severe malaria","volume":"17","author":"Conroy","year":"2019","journal-title":"BMC Med"},{"issue":"4","key":"10.1016\/j.eclinm.2022.101292_bib0007","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1053\/j.ajkd.2011.10.048","article-title":"Long-term risk of CKD in children surviving episodes of acute kidney injury in the intensive care unit: a prospective cohort study","volume":"59","author":"Mammen","year":"2012","journal-title":"Am J Kidney Dis"},{"issue":"4","key":"10.1016\/j.eclinm.2022.101292_bib0008","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/nrneph.2017.2","article-title":"Acute kidney disease and renal recovery: consensus report of the Acute Disease Quality Initiative (ADQI) 16 workgroup","volume":"13","author":"Chawla","year":"2017","journal-title":"Nat Rev Nephrol"},{"issue":"10","key":"10.1016\/j.eclinm.2022.101292_bib0009","doi-asserted-by":"crossref","first-page":"2534","DOI":"10.1097\/01.ASN.0000088027.54400.C6","article-title":"Identification of neutrophil gelatinase-associated lipocalin as a novel early urinary biomarker for ischemic renal injury","volume":"14","author":"Mishra","year":"2003","journal-title":"J Am Soc Nephrol JASN"},{"issue":"2","key":"10.1016\/j.eclinm.2022.101292_bib0010","doi-asserted-by":"crossref","first-page":"337","DOI":"10.2215\/CJN.03530708","article-title":"Neutrophil gelatinase-associated lipocalin (NGAL) and progression of chronic kidney disease","volume":"4","author":"Bolignano","year":"2009","journal-title":"Clin J Am Soc Nephrol"},{"issue":"10225","key":"10.1016\/j.eclinm.2022.101292_bib0011","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/S0140-6736(20)30045-3","article-title":"Global, regional, and national burden of chronic kidney disease, 1990\u20132017: a systematic analysis for the Global Burden of Disease Study 2017","volume":"395","author":"Bikbov","year":"2020","journal-title":"The Lancet"},{"issue":"9753","key":"10.1016\/j.eclinm.2022.101292_bib0012","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1016\/S0140-6736(10)61924-1","article-title":"Artesunate versus quinine in the treatment of severe falciparum malaria in African children (AQUAMAT): an open-label, randomised trial","volume":"376","author":"Dondorp","year":"2010","journal-title":"Lancet"},{"issue":"Suppl. 1","key":"10.1016\/j.eclinm.2022.101292_bib0013","first-page":"7","article-title":"Severe malaria","volume":"19","year":"2014","journal-title":"Trop Med Int Health"},{"issue":"10","key":"10.1016\/j.eclinm.2022.101292_bib0014","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1016\/j.ekir.2020.07.019","article-title":"Validity of urine NGALds dipstick for acute kidney injury in a malawian trauma cohort","volume":"5","author":"Bjornstad","year":"2020","journal-title":"Kidney Int Rep"},{"key":"10.1016\/j.eclinm.2022.101292_bib0015","unstructured":"KDIGO. KDIGO clinical practice guideline for acute kidney injury. Kidney Int Suppl (2011)2012; 2(1): 1\u2013138."},{"key":"10.1016\/j.eclinm.2022.101292_bib0016","doi-asserted-by":"crossref","unstructured":"Batte A, Starr MC, Schwaderer AL, et\u00a0al. Methods to estimate baseline creatinine and define acute kidney injury in lean Ugandan children with severe malaria: a prospective cohort study. 2020.","DOI":"10.1186\/s12882-020-02076-1"},{"issue":"1391","key":"10.1016\/j.eclinm.2022.101292_bib0017","article-title":"Immunopathology of acute kidney injury in severe malaria","volume":"12","author":"Katsoulis","year":"2021","journal-title":"Front Immunol"},{"issue":"6","key":"10.1016\/j.eclinm.2022.101292_bib0018","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1164\/rccm.201604-0799OC","article-title":"Recovery after acute kidney injury","volume":"195","author":"Kellum","year":"2017","journal-title":"Am J Respir Crit Care Med"},{"issue":"8","key":"10.1016\/j.eclinm.2022.101292_bib0019","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1097\/CCM.0000000000001102","article-title":"Persistent acute kidney injury","volume":"43","author":"Kellum","year":"2015","journal-title":"Crit Care Med"},{"issue":"6","key":"10.1016\/j.eclinm.2022.101292_bib0020","doi-asserted-by":"crossref","first-page":"e66698","DOI":"10.1371\/journal.pone.0066698","article-title":"Pediatric post-discharge mortality in resource poor countries: a systematic review","volume":"8","author":"Wiens","year":"2013","journal-title":"PLoS ONE"},{"issue":"6","key":"10.1016\/j.eclinm.2022.101292_bib0021","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1093\/cid\/ciz325","article-title":"Elevated cerebrospinal fluid tau protein concentrations on admission are associated with long-term neurologic and cognitive impairment in Ugandan children with cerebral malaria","volume":"70","author":"Datta","year":"2020","journal-title":"Clin Infect Dis"},{"issue":"9","key":"10.1016\/j.eclinm.2022.101292_bib0022","doi-asserted-by":"crossref","first-page":"e734","DOI":"10.1097\/CCM.0000000000004469","article-title":"Endothelial activation, acute kidney injury, and cognitive impairment in pediatric severe malaria","volume":"48","author":"Ouma","year":"2020","journal-title":"Crit Care Med"},{"issue":"3","key":"10.1016\/j.eclinm.2022.101292_bib0023","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1681\/ASN.2012050536","article-title":"Cognitive disorders and dementia in CKD: the neglected kidney-brain axis","volume":"24","author":"Bugnicourt","year":"2013","journal-title":"J Am Soc Nephrol JASN"},{"issue":"7","key":"10.1016\/j.eclinm.2022.101292_bib0024","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1093\/cid\/cix003","article-title":"High frequency of blackwater fever among children presenting to hospital with severe febrile illnesses in Eastern Uganda","volume":"64","author":"Olupot-Olupot","year":"2017","journal-title":"Clin Infect Dis"},{"issue":"1","key":"10.1016\/j.eclinm.2022.101292_bib0025","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1186\/s12879-017-2373-1","article-title":"Cell-free hemoglobin mediated oxidative stress is associated with acute kidney injury and renal replacement therapy in severe falciparum malaria: an observational study","volume":"17","author":"Plewes","year":"2017","journal-title":"BMC Infect Dis"},{"issue":"11","key":"10.1016\/j.eclinm.2022.101292_bib0026","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1016\/j.freeradbiomed.2011.02.011","article-title":"Postoperative acute kidney injury is associated with hemoglobinemia and an enhanced oxidative stress response","volume":"50","author":"Billings","year":"2011","journal-title":"Free Radic Biol Med"},{"issue":"16","key":"10.1016\/j.eclinm.2022.101292_bib0027","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1056\/NEJM199310143291618","article-title":"Rhabdomyolysis in Malaria","volume":"329","author":"Knochel","year":"1993","journal-title":"N Engl J Med"},{"issue":"7","key":"10.1016\/j.eclinm.2022.101292_bib0028","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1093\/cid\/ciy213","article-title":"Acetaminophen as a renoprotective adjunctive treatment in patients with severe and moderately severe falciparum malaria: a randomized, controlled, open-label trial","volume":"67","author":"Plewes","year":"2018","journal-title":"Clin Infect Dis"},{"issue":"7","key":"10.1016\/j.eclinm.2022.101292_bib0029","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1001\/jamapediatrics.2018.0614","article-title":"Association between early postoperative acetaminophen exposure and acute kidney injury in pediatric patients undergoing cardiac surgery","volume":"172","author":"Van Driest","year":"2018","journal-title":"JAMA Pediatr"},{"issue":"4","key":"10.1016\/j.eclinm.2022.101292_bib0030","doi-asserted-by":"crossref","first-page":"e242","DOI":"10.1016\/S2214-109X(15)00322-8","article-title":"Outcomes of acute kidney injury in children and adults in sub-Saharan Africa: a systematic review","volume":"4","author":"Olowu","year":"2016","journal-title":"Lancet Glob Health"}],"container-title":["eClinicalMedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589537022000220?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589537022000220?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T19:10:51Z","timestamp":1762888251000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589537022000220"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2]]},"references-count":30,"alternative-id":["S2589537022000220"],"URL":"https:\/\/doi.org\/10.1016\/j.eclinm.2022.101292","relation":{},"ISSN":["2589-5370"],"issn-type":[{"value":"2589-5370","type":"print"}],"subject":[],"published":{"date-parts":[[2022,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Acute kidney injury, persistent kidney disease, and post-discharge morbidity and mortality in severe malaria in children: A prospective cohort study","name":"articletitle","label":"Article Title"},{"value":"eClinicalMedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.eclinm.2022.101292","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"101292"}}