{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T23:19:08Z","timestamp":1791674348968,"version":"4.3.4"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,6,9]],"date-time":"2023-06-09T00:00:00Z","timestamp":1686268800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004336","name":"Novartis AG","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004336","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["eClinicalMedicine"],"published-print":{"date-parts":[[2023,7]]},"DOI":"10.1016\/j.eclinm.2023.102062","type":"journal-article","created":{"date-parts":[[2023,7,4]],"date-time":"2023-07-04T16:56:59Z","timestamp":1688489819000},"page":"102062","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":42,"special_numbering":"C","title":["Mortality risk factors in primary Sj\u00f6gren syndrome: a\u00a0real-world, retrospective, cohort study"],"prefix":"10.1016","volume":"61","author":[{"given":"Pilar","family":"Brito-Zer\u00f3n","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandra","family":"Flores-Ch\u00e1vez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ildiko Fanny","family":"Horv\u00e1th","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Astrid","family":"Rasmussen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Olsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arjan","family":"Vissink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Priori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berkan","family":"Armagan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"Hernandez-Molina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonja","family":"Praprotnik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Quartuccio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nevsun","family":"Inan\u00e7","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Burcug\u00fcl","family":"\u00d6zk\u0131z\u0131lta\u015f","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4776-2136","authenticated-orcid":false,"given":"Elena","family":"Bartoloni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agata","family":"Sebastian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasco C.","family":"Rom\u00e3o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roser","family":"Solans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra G.","family":"Pasoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maureen","family":"Rischmueller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Galisteo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasunori","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia Fernandes Mo\u00e7a","family":"Trevisani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Fugmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9s","family":"Gonz\u00e1lez-Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1958-5136","authenticated-orcid":false,"given":"Francesco","family":"Carubbi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ciprian","family":"Jurcut","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshimasa","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soledad","family":"Retamozo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiola","family":"Atzeni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedikt","family":"Hofauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheila","family":"Melchor-D\u00edaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamer","family":"Gheita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"L\u00f3pez-Dupla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Fonseca-Aizpuru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Giacomelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos","family":"V\u00e1zquez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Consani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Akasbi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ant\u00f3nia","family":"Sz\u00e1nt\u00f3","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3009-2017","authenticated-orcid":false,"given":"A. Darise","family":"Farris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0486-7774","authenticated-orcid":false,"given":"Li","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Mandl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelica","family":"Gattamelata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Levent","family":"Kilic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katja Perdan","family":"Pirkmajer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerem","family":"Abacar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdurrahman","family":"Tufan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"de Vita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hendrika","family":"Bootsma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5709-6734","authenticated-orcid":false,"given":"Manuel","family":"Ramos-Casals","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Arends","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Treppo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Longhino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Manfr\u00e8","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Rizzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Baldini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Bombardieri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Bandeira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Silv\u00e9iro-Ant\u00f3nio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Seror","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.","family":"Mariette","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Nordmark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Danda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Wiland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Gerli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.K.","family":"Kwok","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.H.","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Kvarnstrom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Wahren-Herlenius","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Downie-Doyle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Sene","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Isenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Valim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Devauchelle-Pensec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Saraux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Morel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Morcillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.E.","family":"D\u00edaz Cuiza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.E.","family":"Herrera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Gonz\u00e1lez-de-Paz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Sis\u00f3-Almirall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.eclinm.2023.102062_bib1","article-title":"Sj\u00f6gren syndrome","volume":"2","author":"Brito-Zer\u00f3n","year":"2016","journal-title":"Nat Rev Dis Prim"},{"key":"10.1016\/j.eclinm.2023.102062_bib2","doi-asserted-by":"crossref","DOI":"10.1136\/rmdopen-2018-000885","article-title":"Pain and depression are associated with both physical and mental fatigue independently of comorbidities and medications in primary Sj\u00f6gren's syndrome","volume":"5","author":"Hackett","year":"2019","journal-title":"RMD Open"},{"key":"10.1016\/j.eclinm.2023.102062_bib3","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1093\/rheumatology\/ket427","article-title":"Primary Sjogren's syndrome as a multiorgan disease: impact of the serological profile on the clinical presentation of the disease in a large cohort of Italian patients","volume":"53","author":"Baldini","year":"2013","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.eclinm.2023.102062_bib4","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1586\/1744666X.2016.1109449","article-title":"Early diagnosis of primary Sj\u00f6grens syndrome: EULAR-SS task force clinical recommendations","volume":"12","author":"Brito-Zer\u00f3n","year":"2016","journal-title":"Expet Rev Clin Immunol"},{"key":"10.1016\/j.eclinm.2023.102062_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaut.2012.01.013","article-title":"Outcome measures for primary Sj\u00f6gren's syndrome","volume":"39","author":"Seror","year":"2012","journal-title":"J\u00a0Autoimmun"},{"key":"10.1016\/j.eclinm.2023.102062_bib6","doi-asserted-by":"crossref","DOI":"10.1136\/annrheumdis-2014-206418","article-title":"Systemic activity and mortality in primary Sj\u00f6gren syndrome: predicting survival using the EULAR-SS Disease Activity Index (ESSDAI) in 1045 patients","volume":"75","author":"Brito-Zer\u00f3n","year":"2016","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.eclinm.2023.102062_bib7","first-page":"450","article-title":"Rate, risk factors and causes of mortality in patients with Sjogren's syndrome: a systematic review and meta-analysis of cohort studies","volume":"55","author":"Singh","year":"2016","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.eclinm.2023.102062_bib8","doi-asserted-by":"crossref","first-page":"4029","DOI":"10.1093\/rheumatology\/keab364","article-title":"Mortality in patients with primary Sj\u00f6gren's syndrome: a systematic review and meta-analysis","volume":"60","author":"Huang","year":"2021","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.eclinm.2023.102062_bib9","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1016\/j.mayocp.2017.01.020","article-title":"Incidence and mortality of physician-diagnosed primary Sj\u00f6gren syndrome: time trends over a 40-year period in a population-based US cohort","volume":"92","author":"Maciel","year":"2017","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.eclinm.2023.102062_bib10","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1002\/art.20176","article-title":"Mortality and causes of death in primary Sjogren's syndrome: a prospective cohort study","volume":"50","author":"Theander","year":"2004","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.eclinm.2023.102062_bib11","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.semarthrit.2017.03.004","article-title":"Incidence, mortality, and causes of death in physician-diagnosed primary Sj\u00f6gren's syndrome in Korea: a nationwide, population-based study","volume":"47","author":"Kim","year":"2017","journal-title":"Semin Arthritis Rheum"},{"key":"10.1016\/j.eclinm.2023.102062_bib12","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/S0049-0172(00)80016-5","article-title":"Clinical evolution, and morbidity and mortality of primary Sj\u00f6gren's syndrome","volume":"29","author":"Skopouli","year":"2000","journal-title":"Semin Arthritis Rheum"},{"key":"10.1016\/j.eclinm.2023.102062_bib13","doi-asserted-by":"crossref","DOI":"10.1177\/1759720X211020179","article-title":"Ten-year survival analysis of patients with primary Sj\u00f6gren's syndrome in China: a national prospective cohort study","volume":"13","author":"Qian","year":"2021","journal-title":"Ther Adv Musculoskelet Dis"},{"key":"10.1016\/j.eclinm.2023.102062_bib14","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1002\/art.10221","article-title":"Long-term risk of mortality and lymphoproliferative disease and predictive classification of primary Sjogren's syndrome","volume":"46","author":"Ioannidis","year":"2002","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.eclinm.2023.102062_bib15","article-title":"Clinical course, prognosis, and cause of death in primary Sj\u00f6gren's syndrome","volume":"2014","author":"Horvath","year":"2014","journal-title":"J\u00a0Immunol Res"},{"key":"10.1016\/j.eclinm.2023.102062_bib16","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/s10067-019-04744-6","article-title":"Survival analysis of patients with Sj\u00f6gren's syndrome in Turkey: a tertiary hospital-based study","volume":"39","author":"Yazisiz","year":"2020","journal-title":"Clin Rheumatol"},{"key":"10.1016\/j.eclinm.2023.102062_bib17","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1136\/annrheumdis-2014-206418","article-title":"Systemic activity and mortality in primary Sjogren syndrome: predicting survival using the EULAR-SS Disease Activity Index (ESSDAI) in 1045 patients","volume":"75","author":"Brito-Zeron","year":"2016","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.eclinm.2023.102062_bib18","article-title":"The Big Data Sj\u00f6gren consortium: a project for a new data science era","volume":"37","author":"Acar-Denizli","year":"2019","journal-title":"Clin Exp Rheumatol"},{"key":"10.1016\/j.eclinm.2023.102062_bib19","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1136\/ard.61.6.554","article-title":"Classification criteria for Sj\u00f6gren's syndrome: a revised version of the European criteria proposed by the American-European Consensus Group","volume":"61","author":"Vitali","year":"2002","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.eclinm.2023.102062_bib20","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1136\/annrheumdis-2016-210571","article-title":"2016 American College of rheumatology\/European league against rheumatism classification criteria for primary Sj\u00f6gren's syndrome","volume":"76","author":"Shiboski","year":"2017","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.eclinm.2023.102062_bib21","doi-asserted-by":"crossref","DOI":"10.1093\/rheumatology\/kem079","article-title":"Predicting adverse outcomes in primary Sj\u00f6gren's syndrome: identification of prognostic factors","volume":"46","author":"Brito-Zer\u00f3n","year":"2007","journal-title":"Rheumatology"},{"issue":"Suppl 1","key":"10.1016\/j.eclinm.2023.102062_bib22","first-page":"198","article-title":"Phenotyping Sjogren's syndrome: towards a personalised management of the disease","volume":"36","author":"Brito-Zeron","year":"2018","journal-title":"Clin Exp Rheumatol"},{"key":"10.1016\/j.eclinm.2023.102062_bib23","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1136\/annrheumdis-2014-206008","article-title":"Defining disease activity states and clinically meaningful improvement in primary Sjogren's syndrome with EULAR primary Sjogren's syndrome disease activity (ESSDAI) and patient-reported indexes (ESSPRI)","volume":"75","author":"Seror","year":"2016","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.eclinm.2023.102062_bib24","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1136\/annrheumdis-2015-208504","article-title":"Development of the ClinESSDAI: a clinical score without biological domain. A tool for biological studies","volume":"75","author":"Seror","year":"2016","journal-title":"Ann Rheum Dis"},{"issue":"1","key":"10.1016\/j.eclinm.2023.102062_bib25","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1093\/rheumatology\/keac205","article-title":"Characterization and outcomes of 414 patients with primary SS who developed hematological malignancies","volume":"62","author":"Hern\u00e1ndez-Molina","year":"2022","journal-title":"Rheumatology (Oxford)"},{"issue":"10","key":"10.1016\/j.eclinm.2023.102062_bib26","doi-asserted-by":"crossref","first-page":"4558","DOI":"10.1093\/rheumatology\/keab032","article-title":"Childhood-onset of primary Sj\u00f6gren's syndrome: phenotypic characterization at diagnosis of 158 children","volume":"60","author":"Ramos-Casals","year":"2021","journal-title":"Rheumatology (Oxford)"},{"issue":"Suppl 1","key":"10.1016\/j.eclinm.2023.102062_bib27","doi-asserted-by":"crossref","first-page":"166","DOI":"10.55563\/clinexprheumatol\/egnd1i","article-title":"Influence of the age at diagnosis in the disease expression of primary Sj\u00f6gren syndrome. Analysis of 12,753 patients from the Sj\u00f6gren Big Data Consortium","volume":"39","author":"Retamozo","year":"2021","journal-title":"Clin Exp Rheumatol"},{"key":"10.1016\/j.eclinm.2023.102062_bib28","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1093\/rheumatology\/ket427","article-title":"Primary Sjogren's syndrome as a multiorgan disease: impact of the serological profile on the clinical presentation of the disease in a large cohort of Italian patients","volume":"53","author":"Baldini","year":"2014","journal-title":"Rheumatology (Oxford)"},{"issue":"Suppl 1","key":"10.1016\/j.eclinm.2023.102062_bib29","first-page":"121","article-title":"Severe, life-threatening phenotype of primary Sj\u00f6gren's syndrome: clinical characterisation and outcomes in 1580 patients (GEAS-SS Registry)","volume":"36","author":"Flores-Ch\u00e1vez","year":"2018","journal-title":"Clin Exp Rheumatol"},{"key":"10.1016\/j.eclinm.2023.102062_bib30","doi-asserted-by":"crossref","first-page":"3576","DOI":"10.1093\/rheumatology\/keab939","article-title":"Clinical picture, outcome and predictive factors of lymphoma in primary Sj\u00f6gren's syndrome: results from a harmonized dataset (1981-2021)","volume":"61","author":"Chatzis","year":"2022","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.eclinm.2023.102062_bib31","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/s13045-017-0464-5","article-title":"Characterization and risk estimate of cancer in patients with primary Sj\u00f6gren syndrome","volume":"10","author":"Brito-Zer\u00f3n","year":"2017","journal-title":"J\u00a0Hematol Oncol"},{"key":"10.1016\/j.eclinm.2023.102062_bib32","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1136\/annrheumdis-2011-200402","article-title":"Incidence of cancer in a nationwide population cohort of 7852 patients with primary Sjogren's syndrome in Taiwan","volume":"71","author":"Weng","year":"2012","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.eclinm.2023.102062_bib33","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.1080\/07853890.2022.2126517","article-title":"Hospitalizations for infections in primary Sj\u00f6gren's syndrome patients: a nationwide incidence study","volume":"54","author":"Goulabchand","year":"2022","journal-title":"Ann Med"},{"key":"10.1016\/j.eclinm.2023.102062_bib34","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1186\/s13075-019-1997-5","article-title":"Comparing the burdens of opportunistic infections among patients with systemic rheumatic diseases: a nationally representative cohort study","volume":"21","author":"Hsu","year":"2019","journal-title":"Arthritis Res Ther"},{"issue":"Suppl 1","key":"10.1016\/j.eclinm.2023.102062_bib35","first-page":"47","article-title":"Serious infections in Sj\u00f6gren's syndrome\u00a0patients: a national U.S. study","volume":"38","author":"Singh","year":"2020","journal-title":"Clin Exp Rheumatol"},{"key":"10.1016\/j.eclinm.2023.102062_bib36","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/S0140-6736(22)01349-6","article-title":"Autoimmune diseases and cardiovascular risk: a population-based study on 19 autoimmune diseases and 12 cardiovascular diseases in 22 million individuals in the UK","volume":"400","author":"Conrad","year":"2022","journal-title":"Lancet"},{"key":"10.1016\/j.eclinm.2023.102062_bib37","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1177\/0961203310367504","article-title":"Cardiovascular risk factors in primary Sj\u00f6gren's syndrome: a case-control study in 624 patients","volume":"19","author":"P\u00e9rez-De-Lis","year":"2010","journal-title":"Lupus"},{"key":"10.1016\/j.eclinm.2023.102062_bib38","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.879516","article-title":"Cardiovascular involvement in Sj\u00f6gren's syndrome","volume":"13","author":"Atzeni","year":"2022","journal-title":"Front Immunol"},{"key":"10.1016\/j.eclinm.2023.102062_bib39","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1111\/joim.12988","article-title":"Interplay of anti-SSA\/SSB status and hypertension in determining cardiovascular risk in primary Sj\u00f6gren's syndrome","volume":"287","author":"Bartoloni","year":"2020","journal-title":"J\u00a0Intern Med"},{"key":"10.1016\/j.eclinm.2023.102062_bib40","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1111\/joim.12888","article-title":"Infections increase the risk\u00a0of\u00a0developing Sj\u00f6gren's syndrome","volume":"285","author":"Mofors","year":"2019","journal-title":"J\u00a0Intern Med"},{"key":"10.1016\/j.eclinm.2023.102062_bib41","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1093\/rheumatology\/kew194","article-title":"Cryoglobulinaemic vasculitis at diagnosis predicts mortality in primary Sj\u00f6gren syndrome: analysis of 515 patients","volume":"55","author":"Retamozo","year":"2016","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.eclinm.2023.102062_bib42","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1097\/00005792-200007000-00005","article-title":"Clinically significant and biopsy-documented renal involvement in primary Sj\u00f6gren syndrome","volume":"79","author":"Goules","year":"2000","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.eclinm.2023.102062_bib43","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.jaut.2013.10.002","article-title":"Biomarkers of lymphoma in Sjogren's syndrome and evaluation of the lymphoma risk in prelymphomatous conditions: results of a multicenter study","volume":"51","author":"Quartuccio","year":"2014","journal-title":"J\u00a0Autoimmun"},{"key":"10.1016\/j.eclinm.2023.102062_bib44","first-page":"S48","article-title":"Performance of the preliminary classification criteria for cryoglobulinaemic vasculitis and clinical manifestations in hepatitis C virus-unrelated cryoglobulinaemic vasculitis","volume":"30","author":"Quartuccio","year":"2012","journal-title":"Clin Exp Rheumatol"},{"key":"10.1016\/j.eclinm.2023.102062_bib45","doi-asserted-by":"crossref","DOI":"10.1002\/art.22476","article-title":"Characterization of B cell lymphoma in patients with Sj\u00f6gren's syndrome and hepatitis C virus infection","volume":"57","author":"Ramos-Casals","year":"2007","journal-title":"Arthritis Care Res"},{"key":"10.1016\/j.eclinm.2023.102062_bib46","doi-asserted-by":"crossref","first-page":"585","DOI":"10.3899\/jrheum.090835","article-title":"Clinical and prognostic significance of parotid scintigraphy in 405 patients with primary Sjogren's syndrome","volume":"37","author":"Ramos-Casals","year":"2010","journal-title":"J\u00a0Rheumatol"},{"key":"10.1016\/j.eclinm.2023.102062_bib47","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1093\/rheumatology\/keh407","article-title":"Hypocomplementaemia as an immunological marker of morbidity and mortality in patients with primary Sjogren's syndrome","volume":"44","author":"Ramos-Casals","year":"2005","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.eclinm.2023.102062_bib48","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1136\/annrheumdis-2016-209952","article-title":"Influence of geolocation and ethnicity on the phenotypic expression of primary Sjogren's syndrome at diagnosis in 8310 patients: a cross-sectional study from the Big Data Sjogren Project Consortium","volume":"76","author":"Brito-Zeron","year":"2017","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.eclinm.2023.102062_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2015.03.027","article-title":"How we are treating our systemic patients with primary Sj\u00f6gren syndrome? Analysis of 1120 patients","volume":"27","author":"Gheitasi","year":"2015","journal-title":"Int Immunopharmacol"}],"container-title":["eClinicalMedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589537023002390?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589537023002390?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T22:20:08Z","timestamp":1762899608000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589537023002390"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7]]},"references-count":49,"alternative-id":["S2589537023002390"],"URL":"https:\/\/doi.org\/10.1016\/j.eclinm.2023.102062","relation":{},"ISSN":["2589-5370"],"issn-type":[{"value":"2589-5370","type":"print"}],"subject":[],"published":{"date-parts":[[2023,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mortality risk factors in primary Sj\u00f6gren syndrome: a\u00a0real-world, retrospective, cohort study","name":"articletitle","label":"Article Title"},{"value":"eClinicalMedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.eclinm.2023.102062","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"102062"}}