{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T11:43:32Z","timestamp":1792928612582,"version":"4.5.0"},"reference-count":18,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,11,30]],"date-time":"2023-11-30T00:00:00Z","timestamp":1701302400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004948","name":"Astellas Pharma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004948","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006044","name":"Astellas Pharma Europe Ltd","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006044","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014837","name":"Rudolf Ackermann Stiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014837","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["eClinicalMedicine"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1016\/j.eclinm.2023.102381","type":"journal-article","created":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T07:51:24Z","timestamp":1703231484000},"page":"102381","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Fixed low dose versus concentration-controlled initial tacrolimus dosing with reduced target levels in the course after kidney transplantation: results from a prospective randomized controlled non-inferiority trial (Slow & Low study)"],"prefix":"10.1016","volume":"67","author":[{"given":"Julian","family":"Stumpf","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7929-5942","authenticated-orcid":false,"given":"Klemens","family":"Budde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Witzke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Sommerer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3275-7329","authenticated-orcid":false,"given":"Thomas","family":"Vogel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Schenker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rainer Peter","family":"Woitas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirian","family":"Opgenoorth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelyn","family":"Trips","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Schrezenmeier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5895-3005","authenticated-orcid":false,"given":"Christian","family":"Hugo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Girndt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunter","family":"Wolf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Kurschat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Lopau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Lutz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.eclinm.2023.102381_bib1","doi-asserted-by":"crossref","first-page":"2562","DOI":"10.1056\/NEJMoa067411","article-title":"Reduced exposure to calcineurin inhibitors in renal transplantation","volume":"357","author":"Ekberg","year":"2007","journal-title":"N\u00a0Engl J Med"},{"issue":"Suppl 3","key":"10.1016\/j.eclinm.2023.102381_bib2","first-page":"S1","article-title":"KDIGO clinical practice guideline for the care of kidney transplant recipients","volume":"9","year":"2009","journal-title":"Am J Transplant"},{"issue":"4","key":"10.1016\/j.eclinm.2023.102381_bib3","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1111\/j.1399-0012.2009.01093.x","article-title":"Acute rejection in low-toxicity regimens: clinical impact and risk factors in the Symphony study","volume":"24","author":"Frei","year":"2010","journal-title":"Clin Transplant"},{"issue":"1","key":"10.1016\/j.eclinm.2023.102381_bib4","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1097\/TP.0b013e31821fad06","article-title":"Relationship of tacrolimus exposure and mycophenolate mofetil dose with renal function after renal transplantation","volume":"92","author":"Ekberg","year":"2011","journal-title":"Transplantation"},{"issue":"5","key":"10.1016\/j.eclinm.2023.102381_bib5","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1111\/ajt.12191","article-title":"Tacrolimus predose concentrations do not predict the risk of acute rejection after renal transplantation: a pooled analysis from three randomized-controlled clinical trials","volume":"13","author":"Bouamar","year":"2013","journal-title":"Am J Transplant"},{"issue":"10063","key":"10.1016\/j.eclinm.2023.102381_bib6","doi-asserted-by":"crossref","first-page":"3006","DOI":"10.1016\/S0140-6736(16)32187-0","article-title":"Rabbit-ATG or basiliximab induction for rapid steroid withdrawal after renal transplantation (Harmony): an open-label, multicentre, randomised controlled trial","volume":"388","author":"Thomusch","year":"2016","journal-title":"Lancet"},{"issue":"6","key":"10.1016\/j.eclinm.2023.102381_bib7","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1016\/j.transproceed.2009.05.014","article-title":"De novo kidney transplant recipients need higher doses of Advagraf compared with Prograf to get therapeutic levels","volume":"41","author":"Crespo","year":"2009","journal-title":"Transplant Proc"},{"key":"10.1016\/j.eclinm.2023.102381_bib8","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1111\/j.1600-6143.2006.01688.x","article-title":"Banff \u00b405 Meeting report: differential diagnosis of chronic allograft injury and elimination of chronic allograft nephropathy (\u201cCAN\u201d)","volume":"7","author":"Solez","year":"2007","journal-title":"Am J Transplant"},{"key":"10.1016\/j.eclinm.2023.102381_bib9","doi-asserted-by":"crossref","first-page":"604","DOI":"10.7326\/0003-4819-150-9-200905050-00006","article-title":"A\u00a0new equation to estimate glomerular filtration rate","volume":"150","author":"Levey","year":"2009","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.eclinm.2023.102381_bib10","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1097\/01.tp.0000165847.05787.08","article-title":"A\u00a0randomized trial of three renal transplant induction antibodies: early comparison of tacrolimus, mycophenolate mofetil, and steroid dosing, a newer immune-monitoring","volume":"80","author":"Ciancio","year":"2005","journal-title":"Transplantation"},{"key":"10.1016\/j.eclinm.2023.102381_bib11","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1111\/j.1600-6143.2004.00419.x","article-title":"Steroid-withdrawa at 3 days after renal transplantation with anti-Il-2 Rreceptor \u03b1 therapy: a prospective, randomized, multicenter study","volume":"4","author":"Ter Meulen","year":"2004","journal-title":"Am J Transplant"},{"key":"10.1016\/j.eclinm.2023.102381_bib12","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1111\/j.1600-6143.2004.00583.x","article-title":"Steroid sparing with tacrolimus and mycophenolate mofetil in renal transplantation","volume":"4","author":"Borrows","year":"2004","journal-title":"Am J Transplant"},{"key":"10.1016\/j.eclinm.2023.102381_bib13","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1034\/j.1600-6143.3.s4.11.x","article-title":"Expanded criteria donors for kidney transplantation","volume":"3","author":"Metzger","year":"2003","journal-title":"Am J Transplant"},{"key":"10.1016\/j.eclinm.2023.102381_bib14","doi-asserted-by":"crossref","first-page":"1992","DOI":"10.1111\/ajt.12850","article-title":"Proceedings from an international consensus meeting on posttransplantation diabetes mellitus: recommendations and future directions","volume":"14","author":"Sharif","year":"2014","journal-title":"Am J Transplant"},{"issue":"10","key":"10.1016\/j.eclinm.2023.102381_bib15","doi-asserted-by":"crossref","first-page":"3265","DOI":"10.1016\/j.transproceed.2019.08.030","article-title":"C\/D ratio in long-term renal function","volume":"51","author":"Kwiatkowska","year":"2019","journal-title":"Transplant Proc"},{"issue":"5","key":"10.1016\/j.eclinm.2023.102381_bib16","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1159\/000502290","article-title":"Tacrolimus: influence of the posttransplant concentration\/dose ratio on kidney graft function in a two-year follow-up","volume":"44","author":"Nowicka","year":"2019","journal-title":"Kidney Blood Press Res"},{"issue":"3","key":"10.1016\/j.eclinm.2023.102381_bib17","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1097\/FTD.0000000000000640","article-title":"Therapeutic drug monitoring of tacrolimus-personalized therapy: second consensus report","volume":"41","author":"Brunet","year":"2019","journal-title":"Ther Drug Monit"},{"issue":"2","key":"10.1016\/j.eclinm.2023.102381_bib18","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.kint.2020.04.052","article-title":"The meaning of borderline rejection in kidney transplantation","volume":"98","author":"Nankivell","year":"2020","journal-title":"Kidney Int"}],"container-title":["eClinicalMedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589537023005588?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589537023005588?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T22:21:51Z","timestamp":1762899711000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589537023005588"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":18,"alternative-id":["S2589537023005588"],"URL":"https:\/\/doi.org\/10.1016\/j.eclinm.2023.102381","relation":{},"ISSN":["2589-5370"],"issn-type":[{"value":"2589-5370","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Fixed low dose versus concentration-controlled initial tacrolimus dosing with reduced target levels in the course after kidney transplantation: results from a prospective randomized controlled non-inferiority trial (Slow & Low study)","name":"articletitle","label":"Article Title"},{"value":"eClinicalMedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.eclinm.2023.102381","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"102381"}}