{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T14:30:36Z","timestamp":1788877836053,"version":"build-2803163510"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,3,4]],"date-time":"2024-03-04T00:00:00Z","timestamp":1709510400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100020940","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020940","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019823","name":"University of Maryland, Baltimore","doi-asserted-by":"publisher","award":["T32AI007524"],"award-info":[{"award-number":["T32AI007524"]}],"id":[{"id":"10.13039\/100019823","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["75N93021C00012"],"award-info":[{"award-number":["75N93021C00012"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HHSN27220130000221"],"award-info":[{"award-number":["HHSN27220130000221"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["eClinicalMedicine"],"published-print":{"date-parts":[[2024,5]]},"DOI":"10.1016\/j.eclinm.2024.102556","type":"journal-article","created":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T19:24:50Z","timestamp":1711653890000},"page":"102556","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Safety and immunogenicity of a single dose of Tdap compared to Td in pregnant women in Mali and 3 its effect on infant immune responses: a single-centre, randomised, double-blind, active-controlled phase 2 study"],"prefix":"10.1016","volume":"71","author":[{"given":"Fadima Cheick","family":"Haidara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6476-3934","authenticated-orcid":false,"given":"Milagritos D.","family":"Tapia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatoumata","family":"Diallo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5210-0797","authenticated-orcid":false,"given":"Susana","family":"Portillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Awa","family":"Traor\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Rotrosen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-1655-8926","authenticated-orcid":false,"given":"Elizabeth","family":"Hensel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mat","family":"Makowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Semhal","family":"Selamawi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan A.","family":"Powell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen L.","family":"Kotloff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcela F.","family":"Pasetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samba O.","family":"Sow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen M.","family":"Neuzil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.eclinm.2024.102556_bib1","first-page":"433","article-title":"Pertussis vaccines: WHO position paper \u2013 August 2015","volume":"90","author":"World Health Organization","year":"2015","journal-title":"Wkly Epidemiol Rec"},{"issue":"1","key":"10.1016\/j.eclinm.2024.102556_bib2","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1186\/s12916-020-01699-3","article-title":"The burden of laboratory-confirmed pertussis in low- and middle-income countries since the inception of the Expanded Programme on Immunisation (EPI) in 1974: a systematic review and meta-analysis","volume":"18","author":"Muloiwa","year":"2020","journal-title":"BMC Med"},{"key":"10.1016\/j.eclinm.2024.102556_bib3","series-title":"2012 Final pertussis surveillance report","year":"2013"},{"issue":"Suppl 1","key":"10.1016\/j.eclinm.2024.102556_bib4","doi-asserted-by":"crossref","first-page":"S32","DOI":"10.1093\/infdis\/jit491","article-title":"Pertussis resurgence: perspectives from the working group meeting on pertussis on the causes, possible paths forward, and gaps in our knowledge","volume":"209","author":"Burns","year":"2014","journal-title":"J\u00a0Infect Dis"},{"issue":"7","key":"10.1016\/j.eclinm.2024.102556_bib5","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1080\/14760584.2020.1791092","article-title":"A\u00a0systematic review of the burden of pertussis disease in infants and the effectiveness of maternal immunization against pertussis","volume":"19","author":"Kandeil","year":"2020","journal-title":"Expet Rev Vaccine"},{"issue":"suppl 4","key":"10.1016\/j.eclinm.2024.102556_bib6","doi-asserted-by":"crossref","first-page":"S187","DOI":"10.1093\/cid\/ciw546","article-title":"Pertussis-associated pneumonia in infants and children from low- and middle-income countries participating in the PERCH study","volume":"63","author":"Barger-Kamate","year":"2016","journal-title":"Clin Infect Dis"},{"issue":"5","key":"10.1016\/j.eclinm.2024.102556_bib7","doi-asserted-by":"crossref","first-page":"F456","DOI":"10.1136\/archdischild-2016-312341","article-title":"Maternal vaccination against pertussis: a systematic review of the recent literature","volume":"102","author":"Gkentzi","year":"2017","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"issue":"4","key":"10.1016\/j.eclinm.2024.102556_bib8","doi-asserted-by":"crossref","first-page":"334.e1","DOI":"10.1016\/j.ajog.2010.11.024","article-title":"Maternal immunization with tetanus-diphtheria-pertussis vaccine: effect on maternal and neonatal serum antibody levels","volume":"204","author":"Gall","year":"2011","journal-title":"Am J Obstet Gynecol"},{"issue":"11","key":"10.1016\/j.eclinm.2024.102556_bib9","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1097\/INF.0b013e3182a09b6a","article-title":"Immune responses in infants whose mothers received Tdap vaccine during pregnancy","volume":"32","author":"Hardy-Fairbanks","year":"2013","journal-title":"Pediatr Infect Dis J"},{"issue":"7","key":"10.1016\/j.eclinm.2024.102556_bib10","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1093\/cid\/ciy244","article-title":"A\u00a0randomized controlled trial of the safety and immunogenicity of tetanus, diphtheria, and acellular pertussis vaccine immunization during pregnancy and subsequent infant immune response","volume":"67","author":"Halperin","year":"2018","journal-title":"Clin Infect Dis"},{"issue":"7","key":"10.1016\/j.eclinm.2024.102556_bib11","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1093\/cid\/ciw027","article-title":"Maternal immunization earlier in pregnancy maximizes antibody transfer and expected infant seropositivity against pertussis","volume":"62","author":"Eberhardt","year":"2016","journal-title":"Clin Infect Dis"},{"issue":"9953","key":"10.1016\/j.eclinm.2024.102556_bib12","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1016\/S0140-6736(14)60686-3","article-title":"Effectiveness of maternal pertussis vaccination in England: an observational study","volume":"384","author":"Amirthalingam","year":"2014","journal-title":"Lancet"},{"issue":"12","key":"10.1016\/j.eclinm.2024.102556_bib13","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1093\/cid\/cix724","article-title":"Impact of the US maternal tetanus, diphtheria, and acellular pertussis vaccination program on preventing pertussis in infants <2 Months of age: a case-control evaluation","volume":"65","author":"Skoff","year":"2017","journal-title":"Clin Infect Dis"},{"issue":"6","key":"10.1016\/j.eclinm.2024.102556_bib14","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1001\/jama.2011.100","article-title":"Maternal HIV infection and antibody responses against vaccine-preventable diseases in uninfected infants","volume":"305","author":"Jones","year":"2011","journal-title":"JAMA"},{"issue":"3 Pt 2","key":"10.1016\/j.eclinm.2024.102556_bib15","first-page":"580","article-title":"The effect of maternal antibody on the serologic response and the incidence of adverse reactions after primary immunization with acellular and whole-cell pertussis vaccines combined with diphtheria and tetanus toxoids","volume":"96","author":"Englund","year":"1995","journal-title":"Pediatrics"},{"issue":"1","key":"10.1016\/j.eclinm.2024.102556_bib16","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1093\/cid\/ciz778","article-title":"Quantity and quality of antibodies after acellular versus whole-cell pertussis vaccines in infants born to mothers who received tetanus, diphtheria, and acellular pertussis vaccine during pregnancy: a randomized trial","volume":"71","author":"Wanlapakorn","year":"2020","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.eclinm.2024.102556_bib17","series-title":"The state of the world's children 2023: For every child, vaccination","year":"2023"},{"key":"10.1016\/j.eclinm.2024.102556_bib18","series-title":"EPIC: maintaining epidemic control","year":"2023"},{"key":"10.1016\/j.eclinm.2024.102556_bib39","doi-asserted-by":"crossref","DOI":"10.1128\/msphere.00527-23","article-title":"Quantitative analysis of pertussis, tetanus and diphtheria antibodies in sera and breast milk from Tdap vaccinated women using a qualified multiplex assay","author":"Portillo","year":"2024","journal-title":"mSphere"},{"issue":"12","key":"10.1016\/j.eclinm.2024.102556_bib19","doi-asserted-by":"crossref","first-page":"1990","DOI":"10.3390\/vaccines10121990","article-title":"Vaccination in pregnancy against pertussis: a consensus statement on behalf of the global pertussis initiative","volume":"10","author":"Abu-Raya","year":"2022","journal-title":"Vaccines (Basel)"},{"key":"10.1016\/j.eclinm.2024.102556_bib20","article-title":"Safety and immunogenicity of pertussis vaccine immunization during pregnancy: a meta-analysis of randomized clinical trials","volume":"2022","author":"Simayi","year":"2022","journal-title":"J\u00a0Trop Med"},{"issue":"5","key":"10.1016\/j.eclinm.2024.102556_bib21","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1016\/j.vaccine.2022.12.061","article-title":"Reactogenicity and safety of second trimester maternal tetanus, diphtheria and acellular pertussis vaccination in the Netherlands","volume":"41","author":"Immink","year":"2023","journal-title":"Vaccine"},{"issue":"7","key":"10.1016\/j.eclinm.2024.102556_bib22","doi-asserted-by":"crossref","first-page":"373","DOI":"10.3390\/toxins11070373","article-title":"Association of pertussis toxin with severe pertussis disease","volume":"11","author":"Scanlon","year":"2019","journal-title":"Toxins"},{"issue":"37","key":"10.1016\/j.eclinm.2024.102556_bib23","doi-asserted-by":"crossref","first-page":"5955","DOI":"10.1016\/j.vaccine.2020.06.050","article-title":"Kinetics of maternal pertussis-specific antibodies in infants of mothers vaccinated with tetanus, diphtheria and acellular pertussis (Tdap) during pregnancy","volume":"38","author":"Healy","year":"2020","journal-title":"Vaccine"},{"issue":"3","key":"10.1016\/j.eclinm.2024.102556_bib24","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1093\/infdis\/161.3.487","article-title":"Natural history of pertussis antibody in the infant and effect on vaccine response","volume":"161","author":"Van Savage","year":"1990","journal-title":"J\u00a0Infect Dis"},{"key":"10.1016\/j.eclinm.2024.102556_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.jvacx.2021.100087","article-title":"Effect of maternal Tdap on infant antibody response to a primary vaccination series with whole cell pertussis vaccine in S\u00e3o Paulo, Brazil","volume":"7","author":"Vaz-de-Lima","year":"2021","journal-title":"Vaccine X"},{"issue":"8","key":"10.1016\/j.eclinm.2024.102556_bib26","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1016\/j.vaccine.2019.10.104","article-title":"Impact of tetanus-diphtheria-acellular pertussis immunization during pregnancy on subsequent infant immunization seroresponses: follow-up from a large randomized placebo-controlled trial","volume":"38","author":"Perrett","year":"2020","journal-title":"Vaccine"},{"issue":"24","key":"10.1016\/j.eclinm.2024.102556_bib27","doi-asserted-by":"crossref","first-page":"3406","DOI":"10.1016\/S0264-410X(03)00342-6","article-title":"Mechanisms by which maternal antibodies influence infant vaccine responses: review of hypotheses and definition of main determinants","volume":"21","author":"Siegrist","year":"2003","journal-title":"Vaccine"},{"issue":"47","key":"10.1016\/j.eclinm.2024.102556_bib28","doi-asserted-by":"crossref","first-page":"6469","DOI":"10.1016\/j.vaccine.2015.07.085","article-title":"Maternal antibodies and infant immune responses to vaccines","volume":"33","author":"Edwards","year":"2015","journal-title":"Vaccine"},{"issue":"49","key":"10.1016\/j.eclinm.2024.102556_bib29","doi-asserted-by":"crossref","first-page":"7050","DOI":"10.1016\/j.vaccine.2022.10.005","volume":"40","author":"Sapuan","year":"2022","journal-title":"Vaccine"},{"issue":"11","key":"10.1016\/j.eclinm.2024.102556_bib30","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1016\/j.vaccine.2021.02.001","article-title":"Impact of maternal diphtheria-tetanus-acellular pertussis vaccination on pertussis booster immune responses in toddlers: follow-up of a randomized trial","volume":"39","author":"Martin\u00f3n-Torres","year":"2021","journal-title":"Vaccine"},{"issue":"31","key":"10.1016\/j.eclinm.2024.102556_bib31","doi-asserted-by":"crossref","first-page":"3613","DOI":"10.1016\/j.vaccine.2016.04.066","article-title":"Pertussis vaccination during pregnancy in Belgium: follow-up of infants until 1 month after the fourth infant pertussis vaccination at 15 months of age","volume":"34","author":"Maertens","year":"2016","journal-title":"Vaccine"},{"key":"10.1016\/j.eclinm.2024.102556_bib32","first-page":"46","article-title":"Australian vaccine preventable disease epidemiological review series: pertussis, 2013-2018","volume":"2022","author":"Marshall","year":"2018","journal-title":"Commun Dis Intell"},{"key":"10.1016\/j.eclinm.2024.102556_bib33","first-page":"173","article-title":"Progress toward maternal and neonatal tetanus elimination - worldwide, 2000\u20132018","volume":"95","author":"World Health Organization","year":"2020","journal-title":"Wkly Epidemiol Rec"},{"key":"10.1016\/j.eclinm.2024.102556_bib34","series-title":"The immunological basis for immunization series module 3: tetanus","author":"World Health Organization","year":"2018"},{"issue":"Suppl 5","key":"10.1016\/j.eclinm.2024.102556_bib35","doi-asserted-by":"crossref","first-page":"S578","DOI":"10.1093\/cid\/civ513","article-title":"Higher tetanus toxoid immunity 2 Years after PsA-TT introduction in Mali","volume":"61 Suppl 5","author":"Basta","year":"2015","journal-title":"Clin Infect Dis"},{"issue":"12","key":"10.1016\/j.eclinm.2024.102556_bib36","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1097\/INF.0000000000001601","article-title":"Pneumococcal immune response in infants whose mothers received tetanus, diphtheria and acellular pertussis vaccination during pregnancy","volume":"36","author":"Maertens","year":"2017","journal-title":"Pediatr Infect Dis J"},{"issue":"7","key":"10.1016\/j.eclinm.2024.102556_bib37","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1001\/jamapediatrics.2017.0638","article-title":"The influence of maternally derived antibody and infant age at vaccination on infant vaccine responses: an individual participant meta-analysis","volume":"171","author":"Voysey","year":"2017","journal-title":"JAMA Pediatr"},{"issue":"4","key":"10.1016\/j.eclinm.2024.102556_bib38","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/S1473-3099(18)30717-5","article-title":"Maternal pertussis vaccination and its effects on the immune response of infants aged up to 12 months in the Netherlands: an open-label, parallel, randomised controlled trial","volume":"19","author":"Barug","year":"2019","journal-title":"Lancet Infect Dis"}],"container-title":["eClinicalMedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589537024001354?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589537024001354?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T21:49:59Z","timestamp":1760737799000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589537024001354"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":39,"alternative-id":["S2589537024001354"],"URL":"https:\/\/doi.org\/10.1016\/j.eclinm.2024.102556","relation":{},"ISSN":["2589-5370"],"issn-type":[{"value":"2589-5370","type":"print"}],"subject":[],"published":{"date-parts":[[2024,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Safety and immunogenicity of a single dose of Tdap compared to Td in pregnant women in Mali and 3 its effect on infant immune responses: a single-centre, randomised, double-blind, active-controlled phase 2 study","name":"articletitle","label":"Article Title"},{"value":"eClinicalMedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.eclinm.2024.102556","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"102556"}}