{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T21:05:36Z","timestamp":1776114336478,"version":"3.50.1"},"reference-count":24,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,5]],"date-time":"2024-12-05T00:00:00Z","timestamp":1733356800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100005205","name":"Janssen Research and Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005205","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100021704","name":"Administration for Strategic Preparedness and Response","doi-asserted-by":"publisher","award":["HHSO100201700018C"],"award-info":[{"award-number":["HHSO100201700018C"]}],"id":[{"id":"10.13039\/100021704","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004331","name":"Johnson and Johnson","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004331","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012399","name":"Biomedical Advanced Research and Development Authority","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012399","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["eClinicalMedicine"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.eclinm.2024.103016","type":"journal-article","created":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T14:26:42Z","timestamp":1736260002000},"page":"103016","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Safety, reactogenicity, and immunogenicity of Ad26.COV2.S co-administered with a quadrivalent standard-dose or high-dose seasonal influenza vaccine: a non-inferiority randomised controlled trial"],"prefix":"10.1016","volume":"79","author":[{"given":"Gabriela","family":"Tapia-Calle","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gloria","family":"Aguilar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathalie","family":"Vaissiere","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carla","family":"Truyers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4850-6890","authenticated-orcid":false,"given":"Pedro","family":"Ylisastigui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erik","family":"Buntinx","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathieu","family":"Le Gars","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Struyf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gert","family":"Scheper","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Macaya","family":"Douoguih","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"Ruiz-Gui\u00f1az\u00fa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Patrizi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wai","family":"Ling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanne","family":"de Ridder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marit","family":"de Groot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Grazia","family":"Pau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerald","family":"Weidinger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Srividya","family":"Pradeep","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadine","family":"Salisch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"Cambre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.eclinm.2024.103016_bib1","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.amsu.2020.10.021","article-title":"The intersection of viral illnesses: a seasonal influenza epidemic amidst the COVID-19 pandemic","volume":"60","author":"Ehrlich","year":"2020","journal-title":"Ann Med Surg (Lond)"},{"key":"10.1016\/j.eclinm.2024.103016_bib2","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.ijid.2020.02.040","article-title":"Who and when to vaccinate against influenza","volume":"93","author":"Buchy","year":"2020","journal-title":"Int J Infect Dis"},{"issue":"10328","key":"10.1016\/j.eclinm.2024.103016_bib3","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1016\/S0140-6736(22)00152-0","article-title":"Duration of effectiveness of vaccines against SARS-CoV-2 infection and COVID-19 disease: results of a systematic review and meta-regression","volume":"399","author":"Feikin","year":"2022","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.eclinm.2024.103016_bib4","doi-asserted-by":"crossref","DOI":"10.1080\/21645515.2023.2195786","article-title":"Vaccine co-administration in adults: an effective way to improve vaccination coverage","volume":"19","author":"Bonanni","year":"2023","journal-title":"Hum Vaccin Immunother"},{"issue":"1","key":"10.1016\/j.eclinm.2024.103016_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/21645515.2021.2011652","article-title":"Acceptability of the third dose of anti-SARS-CoV-2 vaccine co-administered with influenza vaccine: preliminary data in a sample of Italian HCWs","volume":"18","author":"Stefanizzi","year":"2022","journal-title":"Hum Vaccin Immunother"},{"issue":"1","key":"10.1016\/j.eclinm.2024.103016_bib6","doi-asserted-by":"crossref","first-page":"e9","DOI":"10.1016\/j.ajic.2017.10.004","article-title":"Vaccination coverage in patients affected by chronic diseases: a 2014 cross-sectional study among subjects hospitalized at Bari Policlinico General Hospital","volume":"46","author":"Gallone","year":"2018","journal-title":"Am J Infect Control"},{"key":"10.1016\/j.eclinm.2024.103016_bib8","series-title":"Coadministration of seasonal inactivated influenza and COVID-19 vaccines","year":"2021"},{"key":"10.1016\/j.eclinm.2024.103016_bib9","article-title":"Timing and sequence of vaccination against COVID-19 and influenza (TACTIC): a single-blind, placebo-controlled randomized clinical trial","volume":"29","author":"Dulfer","year":"2023","journal-title":"Lancet Reg Health Eur"},{"issue":"9","key":"10.1016\/j.eclinm.2024.103016_bib10","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2023.32813","article-title":"Immunogenicity and reactogenicity of coadministration of COVID-19 and influenza vaccines","volume":"6","author":"Gonen","year":"2023","journal-title":"JAMA Netw Open"},{"issue":"36","key":"10.1016\/j.eclinm.2024.103016_bib11","doi-asserted-by":"crossref","first-page":"5356","DOI":"10.1016\/j.vaccine.2022.07.021","article-title":"Immunogenicity and safety of a SARS-CoV-2 inactivated vaccine (CoronaVac) co-administered with an inactivated quadrivalent influenza vaccine: a randomized, open-label, controlled study in healthy adults aged 18 to 59 years in China","volume":"40","author":"Shenyu","year":"2022","journal-title":"Vaccine"},{"issue":"2","key":"10.1016\/j.eclinm.2024.103016_bib12","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S2213-2600(21)00409-4","article-title":"Safety, immunogenicity, and efficacy of a COVID-19 vaccine (NVX-CoV2373) co-administered with seasonal influenza vaccines: an exploratory substudy of a randomised, observer-blinded, placebo-controlled, phase 3 trial","volume":"10","author":"Toback","year":"2022","journal-title":"Lancet Respir Med"},{"issue":"10318","key":"10.1016\/j.eclinm.2024.103016_bib13","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1016\/S0140-6736(21)02329-1","article-title":"Safety and immunogenicity of concomitant administration of COVID-19 vaccines (ChAdOx1 or BNT162b2) with seasonal influenza vaccines in adults in the UK (ComFluCOV): a multicentre, randomised, controlled, phase 4 trial","volume":"398","author":"Lazarus","year":"2021","journal-title":"Lancet"},{"issue":"9","key":"10.1016\/j.eclinm.2024.103016_bib14","doi-asserted-by":"crossref","first-page":"2241","DOI":"10.1007\/s40121-023-00863-5","article-title":"Safety and immunogenicity of the BNT162b2 vaccine coadministered with seasonal inactivated influenza vaccine in adults","volume":"12","author":"Murdoch","year":"2023","journal-title":"Infect Dis Ther"},{"issue":"36","key":"10.1016\/j.eclinm.2024.103016_bib15","doi-asserted-by":"crossref","first-page":"5322","DOI":"10.1016\/j.vaccine.2022.07.033","volume":"40","author":"Chen","year":"2022","journal-title":"Vaccine"},{"issue":"4","key":"10.1016\/j.eclinm.2024.103016_bib16","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/S2213-2600(21)00557-9","article-title":"Safety and immunogenicity of a high-dose quadrivalent influenza vaccine administered concomitantly with a third dose of the mRNA-1273 SARS-CoV-2 vaccine in adults aged >\/=65 years: a phase 2, randomised, open-label study","volume":"10","author":"Izikson","year":"2022","journal-title":"Lancet Respir Med"},{"issue":"38","key":"10.1016\/j.eclinm.2024.103016_bib17","doi-asserted-by":"crossref","first-page":"5655","DOI":"10.1016\/j.vaccine.2023.07.043","article-title":"Safety profile and SARS-CoV-2 breakthrough infections among HCWs receiving anti-SARS-CoV-2 and influenza vaccines simultaneously: an Italian observational study","volume":"41","author":"Moscara","year":"2023","journal-title":"Vaccine"},{"issue":"12","key":"10.1016\/j.eclinm.2024.103016_bib18","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1016\/S1473-3099(22)00506-0","article-title":"Efficacy, safety, and immunogenicity of a booster regimen of Ad26.COV2.S vaccine against COVID-19 (ENSEMBLE2): results of a randomised, double-blind, placebo-controlled, phase 3 trial","volume":"22","author":"Hardt","year":"2022","journal-title":"Lancet Infect Dis"},{"issue":"23","key":"10.1016\/j.eclinm.2024.103016_bib19","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1056\/NEJMoa2101544","article-title":"Safety and efficacy of single-dose Ad26.COV2.S vaccine against Covid-19","volume":"384","author":"Sadoff","year":"2021","journal-title":"N\u00a0Engl J Med"},{"issue":"9","key":"10.1016\/j.eclinm.2024.103016_bib20","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1056\/NEJMoa2117608","article-title":"Final analysis of efficacy and safety of single-dose Ad26.COV2.S","volume":"386","author":"Sadoff","year":"2022","journal-title":"N\u00a0Engl J Med"},{"issue":"4","key":"10.1016\/j.eclinm.2024.103016_bib21","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1128\/JCM.37.4.937-943.1999","article-title":"Detection of antibody to avian influenza A (H5N1) virus in human serum by using a combination of serologic assays","volume":"37","author":"Rowe","year":"1999","journal-title":"J\u00a0Clin Microbiol"},{"issue":"19","key":"10.1016\/j.eclinm.2024.103016_bib22","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.1056\/NEJMoa2034201","article-title":"Interim results of a phase 1-2a trial of Ad26.COV2.S covid-19 vaccine","volume":"384","author":"Sadoff","year":"2021","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.eclinm.2024.103016_bib23","series-title":"Clinical data needed to support the licensure of seasonal inactivated influenza vaccines","year":"2007"},{"issue":"1","key":"10.1016\/j.eclinm.2024.103016_bib24","doi-asserted-by":"crossref","DOI":"10.1080\/21645515.2024.2327736","article-title":"No immunological interference or concerns about safety when seasonal quadrivalent influenza vaccine is co-administered with a COVID-19 mRNA-1273 booster vaccine in adults: a randomized trial","volume":"20","author":"Naficy","year":"2024","journal-title":"Hum Vaccin Immunother"},{"key":"10.1016\/j.eclinm.2024.103016_bib25","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.848582","article-title":"Adaptive immune responses and immunity to SARS-CoV-2","volume":"13","author":"Primorac","year":"2022","journal-title":"Front Immunol"}],"container-title":["eClinicalMedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589537024005959?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589537024005959?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T20:06:59Z","timestamp":1762632419000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589537024005959"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":24,"alternative-id":["S2589537024005959"],"URL":"https:\/\/doi.org\/10.1016\/j.eclinm.2024.103016","relation":{},"ISSN":["2589-5370"],"issn-type":[{"value":"2589-5370","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Safety, reactogenicity, and immunogenicity of Ad26.COV2.S co-administered with a quadrivalent standard-dose or high-dose seasonal influenza vaccine: a non-inferiority randomised controlled trial","name":"articletitle","label":"Article Title"},{"value":"eClinicalMedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.eclinm.2024.103016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"103016"}}