{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T02:02:30Z","timestamp":1790474550321,"version":"4.1.0"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,27]],"date-time":"2025-03-27T00:00:00Z","timestamp":1743033600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["K99HD111572"],"award-info":[{"award-number":["K99HD111572"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["OPP1181807"],"award-info":[{"award-number":["OPP1181807"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000016","name":"U.S. Department of Health and Human Services","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000016","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000865","name":"Gates Foundation","doi-asserted-by":"publisher","award":["OPP1181807"],"award-info":[{"award-number":["OPP1181807"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["eClinicalMedicine"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.eclinm.2025.103202","type":"journal-article","created":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T16:48:31Z","timestamp":1745945311000},"page":"103202","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Dihydroartemisinin-piperaquine versus sulfadoxine-pyrimethamine for intermittent preventive treatment of malaria in pregnancy: a systematic review and individual participant data meta-analysis"],"prefix":"10.1016","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6268-0801","authenticated-orcid":false,"given":"Michelle E.","family":"Roh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie R.","family":"Gutman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0332-4388","authenticated-orcid":false,"given":"Maxwell","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny","family":"Hill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mywayiwawo","family":"Madanitsa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abel","family":"Kakuru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hellen C.","family":"Barsosio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Kariuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John P.A.","family":"Lusingu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Mosha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Kajubi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moses R.","family":"Kamya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Don","family":"Mathanga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jobiba","family":"Chinkhumba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam K.","family":"Laufer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eulambius","family":"Mlugu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Appolinary A.R.","family":"Kamuhabwa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleni","family":"Aklillu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omary","family":"Minzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6391-5000","authenticated-orcid":false,"given":"Roland Nnaemeka","family":"Okoro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ado Danazumi","family":"Geidam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John David","family":"Ohieku","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meghna","family":"Desai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prasanna","family":"Jagannathan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grant","family":"Dorsey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feiko O.","family":"ter Kuile","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.eclinm.2025.103202_bib1","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S1473-3099(07)70021-X","article-title":"Epidemiology and burden of malaria in pregnancy","volume":"7","author":"Desai","year":"2007","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.eclinm.2025.103202_bib2","series-title":"World malaria report 2023","year":"2024"},{"key":"10.1016\/j.eclinm.2025.103202_bib3","series-title":"WHO guidelines for malaria, 3 June 2022","year":"2022"},{"issue":"3","key":"10.1016\/j.eclinm.2025.103202_bib4","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1093\/cid\/civ881","article-title":"Impact of sulfadoxine-pyrimethamine resistance on effectiveness of intermittent preventive therapy for malaria in pregnancy at clearing infections and preventing low birth weight","volume":"62","author":"Desai","year":"2015","journal-title":"Clin Infect Dis"},{"issue":"1","key":"10.1016\/j.eclinm.2025.103202_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-017-06708-9","article-title":"Mapping sulphadoxine-pyrimethamine-resistant Plasmodium falciparum malaria in infected humans and in parasite populations in Africa","volume":"7","author":"Okell","year":"2017","journal-title":"Sci Rep"},{"issue":"4","key":"10.1016\/j.eclinm.2025.103202_bib6","doi-asserted-by":"crossref","first-page":"e119","DOI":"10.1016\/S1473-3099(18)30064-1","article-title":"Prevention of malaria in pregnancy","volume":"18","author":"Desai","year":"2018","journal-title":"Lancet Infect Dis"},{"issue":"10012","key":"10.1016\/j.eclinm.2025.103202_bib7","doi-asserted-by":"crossref","first-page":"2507","DOI":"10.1016\/S0140-6736(15)00310-4","volume":"386","author":"Desai","year":"2015","journal-title":"Lancet"},{"issue":"10","key":"10.1016\/j.eclinm.2025.103202_bib8","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1056\/NEJMoa1509150","article-title":"Dihydroartemisinin\u2013piperaquine for the prevention of malaria in pregnancy","volume":"374","author":"Kakuru","year":"2016","journal-title":"N Engl J Med"},{"issue":"1","key":"10.1016\/j.eclinm.2025.103202_bib9","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1186\/s12936-016-1169-x","article-title":"Malaria Policy Advisory Committee to the WHO: conclusions and recommendations of eighth biannual meeting (September 2015)","volume":"15","year":"2016","journal-title":"Malar J"},{"issue":"10179","key":"10.1016\/j.eclinm.2025.103202_bib10","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1016\/S0140-6736(18)32224-4","article-title":"Monthly sulfadoxine-pyrimethamine versus dihydroartemisinin-piperaquine for intermittent preventive treatment of malaria in pregnancy: a randomized controlled trial","volume":"393","author":"Kajubi","year":"2019","journal-title":"Lancet"},{"issue":"6","key":"10.1016\/j.eclinm.2025.103202_bib11","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1002\/cpt.2273","article-title":"Effectiveness of intermittent preventive treatment with dihydroartemisinin-piperaqunine against malaria in pregnancy in Tanzania: a Randomized Controlled Trial","volume":"10","author":"Mlugu","year":"2021","journal-title":"Clin Pharmacol Ther"},{"issue":"10381","key":"10.1016\/j.eclinm.2025.103202_bib12","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1016\/S0140-6736(22)02535-1","volume":"401","author":"Madanitsa","year":"2023","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.eclinm.2025.103202_bib13","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s43094-023-00460-w","article-title":"Superiority trial of intermittent treatment with dihydroartemisinin\u2013piperaquine versus sulfadoxine\u2013pyrimethamine for the prevention of malaria during pregnancy","volume":"9","author":"Okoro","year":"2023","journal-title":"Futur J Pharm Sci"},{"issue":"7","key":"10.1016\/j.eclinm.2025.103202_bib14","doi-asserted-by":"crossref","first-page":"e942","DOI":"10.1016\/S2214-109X(20)30119-4","article-title":"Overall, anti-malarial, and non-malarial effect of intermittent preventive treatment during pregnancy with sulfadoxine-pyrimethamine on birthweight: a mediation analysis","volume":"8","author":"Roh","year":"2020","journal-title":"Lancet Glob Health"},{"issue":"1","key":"10.1016\/j.eclinm.2025.103202_bib15","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1186\/s12936-023-04757-2","article-title":"Safety and tolerability of repeated doses of dihydroartemisinin-piperaquine for intermittent preventive treatment of malaria in pregnancy: a systematic review and an aggregated data meta-analysis of randomized controlled trials","volume":"22","author":"Muthoka","year":"2023","journal-title":"Malar J"},{"key":"10.1016\/j.eclinm.2025.103202_bib16","article-title":"RoB 2: a revised tool for assessing risk of bias in randomised trials","volume":"366","author":"Sterne","year":"2019","journal-title":"BMJ"},{"issue":"9946","key":"10.1016\/j.eclinm.2025.103202_bib17","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/S0140-6736(14)60932-6","article-title":"International standards for newborn weight, length, and head circumference by gestational age and sex: the Newborn Cross-Sectional Study of the INTERGROWTH-21st Project","volume":"384","author":"Villar","year":"2014","journal-title":"Lancet"},{"key":"10.1016\/j.eclinm.2025.103202_bib18","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1111\/j.1651-2227.2006.tb02378.x","article-title":"WHO Child Growth Standards based on length\/height, weight and age","volume":"95","author":"de Onis","year":"2006","journal-title":"Acta Paediatr"},{"key":"10.1016\/j.eclinm.2025.103202_bib19","series-title":"Package zscorer: Child anthropometry z-score calculator","author":"Myatt","year":"2019"},{"issue":"3","key":"10.1016\/j.eclinm.2025.103202_bib20","first-page":"40","article-title":"meta: an R package for meta-analysis","volume":"7","author":"Schwarzer","year":"2007","journal-title":"R News"},{"issue":"3","key":"10.1016\/j.eclinm.2025.103202_bib21","first-page":"1","article-title":"Conducting meta-analyses in R with the metafor package","volume":"36","author":"Viechtbauer","year":"2010","journal-title":"J Open Sourc Softw"},{"issue":"7","key":"10.1016\/j.eclinm.2025.103202_bib22","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1093\/aje\/kwh090","article-title":"A modified Poisson regression approach to prospective studies with binary data","volume":"159","author":"Zou","year":"2004","journal-title":"Am J Epidemiol"},{"issue":"69","key":"10.1016\/j.eclinm.2025.103202_bib23","article-title":"medoutcon: nonparametric efficient causal mediation analysis with machine learning in R","volume":"7","author":"Hejazi","year":"2022","journal-title":"J Open Sourc Softw"},{"key":"10.1016\/j.eclinm.2025.103202_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2021\/8840089","article-title":"Single nucleotide polymorphisms of Pfdhfr and Pfdhps genes: implications for malaria prophylactic strategies in Maiduguri, Northeast Nigeria","volume":"2021","author":"Balogun","year":"2021","journal-title":"J Trop Med"},{"key":"10.1016\/j.eclinm.2025.103202_bib25","series-title":"A prospective randomized open-label study on the efficacy and safety of intermittent preventive treatment in pregnancy (IPTp) with dihydroartemisinin-piperaquine (DP) versus IPTp with sulfadoxine-pyrimethamine (SP) in Malawi","author":"Gutman","year":"2016"},{"key":"10.1016\/j.eclinm.2025.103202_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2024.105397","article-title":"Intermittent preventive treatment for malaria in pregnancy and infant growth: a mediation analysis of a randomised trial","volume":"109","author":"Tong","year":"2024","journal-title":"EBioMedicine"},{"issue":"6","key":"10.1016\/j.eclinm.2025.103202_bib27","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a025551","article-title":"Malaria during pregnancy","volume":"7","author":"Fried","year":"2017","journal-title":"Cold Spring Harbor Perspect Med"},{"key":"10.1016\/j.eclinm.2025.103202_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2022.103871","article-title":"The positive effect of malaria IPTp-SP on birthweight is mediated by gestational weight gain but modifiable by maternal carriage of enteric pathogens","volume":"77","author":"Waltmann","year":"2022","journal-title":"EBioMedicine"},{"issue":"4","key":"10.1016\/j.eclinm.2025.103202_bib29","doi-asserted-by":"crossref","DOI":"10.1093\/ofid\/ofae143","article-title":"Monthly sulfadoxine-pyrimethamine during pregnancy prevents febrile respiratory illnesses: a secondary analysis of a malaria chemoprevention trial in Uganda","volume":"11","author":"Lee","year":"2024","journal-title":"Open Forum Infect Dis"},{"key":"10.1016\/j.eclinm.2025.103202_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2023.104921","article-title":"Direct therapeutic effect of sulfadoxine-pyrimethamine on nutritional deficiency-induced enteric dysfunction in a human Intestine Chip","volume":"99","author":"Kim","year":"2024","journal-title":"EBioMedicine"},{"key":"10.1016\/j.eclinm.2025.103202_bib31","article-title":"Weekly dihydroartemisinin-piperaquine versus monthly sulfadoxine-pyrimethamine for malaria chemoprevention in children with sickle cell anaemia in Uganda and Malawi (CHEMCHA): a randomised, double-blind, placebo-controlled trial","author":"Idro","year":"2024","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.eclinm.2025.103202_bib32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12874-015-0024-z","article-title":"The heterogeneity statistic I 2 can be biased in small meta-analyses","volume":"15","author":"von Hippel","year":"2015","journal-title":"BMC Med Res Methodol"}],"container-title":["eClinicalMedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589537025001348?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589537025001348?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T04:04:47Z","timestamp":1778904287000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589537025001348"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":32,"alternative-id":["S2589537025001348"],"URL":"https:\/\/doi.org\/10.1016\/j.eclinm.2025.103202","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2024.11.23.24315401","asserted-by":"object"}]},"ISSN":["2589-5370"],"issn-type":[{"value":"2589-5370","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dihydroartemisinin-piperaquine versus sulfadoxine-pyrimethamine for intermittent preventive treatment of malaria in pregnancy: a systematic review and individual participant data meta-analysis","name":"articletitle","label":"Article Title"},{"value":"eClinicalMedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.eclinm.2025.103202","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"103202"}}