{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T12:49:33Z","timestamp":1789476573755,"version":"build-2803163510"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T00:00:00Z","timestamp":1745452800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["eClinicalMedicine"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.eclinm.2025.103243","type":"journal-article","created":{"date-parts":[[2025,5,17]],"date-time":"2025-05-17T04:32:12Z","timestamp":1747456332000},"page":"103243","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["European advances in digital rheumatology: explainable insights and personalized digital health tools for psoriatic arthritis"],"prefix":"10.1016","volume":"84","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9932-9302","authenticated-orcid":false,"given":"Leontios J.","family":"Hadjileontiadis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8007-2343","authenticated-orcid":false,"given":"Vasileios","family":"Charisis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stelios","family":"Hadjidimitriou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8239-583X","authenticated-orcid":false,"given":"Sofia B.","family":"Dias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Apostolidis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giannis","family":"Dimaridis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilias","family":"Kitsas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelos","family":"Karlas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolina-Alexia","family":"Fasoula","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Levi-Schaffer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugo","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodoros","family":"Dimitroulas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Maria","family":"Rodrigues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura C.","family":"Coates","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jolanda","family":"Luime","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilja","family":"Tchetverikov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.eclinm.2025.103243_bib1","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1038\/nbt.3826","article-title":"The asthma mobile health study, a large-scale clinical observational study using ResearchKit","volume":"35","author":"Chan","year":"2017","journal-title":"Nat Biotechnol"},{"issue":"8","key":"10.1016\/j.eclinm.2025.103243_bib2","doi-asserted-by":"crossref","first-page":"e435","DOI":"10.1016\/S2589-7500(20)30142-4","article-title":"Applications of digital technology in COVID-19 pandemic planning and response","volume":"2","author":"Whitelaw","year":"2020","journal-title":"Lancet Digit Health"},{"key":"10.1016\/j.eclinm.2025.103243_bib3","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/s41746-024-01013-y","article-title":"Digital health technologies and machine learning augment patient reported outcomes to remotely characterise rheumatoid arthritis","volume":"7","author":"Creagh","year":"2024","journal-title":"NPJ Digit Med"},{"key":"10.1016\/j.eclinm.2025.103243_bib4","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/s41746-017-0014-0","article-title":"Lab-on-chip technology for chronic disease diagnosis","volume":"1","author":"Wu","year":"2018","journal-title":"NPJ Digit Med"},{"issue":"10136","key":"10.1016\/j.eclinm.2025.103243_bib5","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.1016\/S0140-6736(18)30830-4","article-title":"The pathogenesis of psoriatic arthritis","volume":"391","author":"Veale","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.eclinm.2025.103243_bib6","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2021.662047","article-title":"The molecular pathophysiology of psoriatic arthritis\u2014the complex interplay between genetic predisposition, epigenetics factors, and the microbiome","volume":"8","author":"Carvalho","year":"2021","journal-title":"Front Mol Biosci"},{"key":"10.1016\/j.eclinm.2025.103243_bib7","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1038\/s41584-020-00507-9","article-title":"Applying precision medicine to unmet clinical needs in psoriatic disease","volume":"16","author":"Jadon","year":"2020","journal-title":"Nat Rev Rheumatol"},{"key":"10.1016\/j.eclinm.2025.103243_bib8","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1136\/ard-2022-222626","article-title":"From real-world electronic health record data to real-world results using artificial intelligence","volume":"82","author":"Knevel","year":"2023","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.eclinm.2025.103243_bib9","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/s41584-022-00763-x","article-title":"Telemedicine: a solution for everyone?","volume":"18","author":"Krusche","year":"2022","journal-title":"Nat Rev Rheumatol"},{"issue":"1","key":"10.1016\/j.eclinm.2025.103243_bib10","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1093\/rheumatology\/keaa202","article-title":"Patient adherence with a smartphone app for patient-reported outcomes in rheumatoid arthritis","volume":"60","author":"Colls","year":"2021","journal-title":"Rheumatology"},{"issue":"1","key":"10.1016\/j.eclinm.2025.103243_bib11","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1186\/s13075-021-02500-3","article-title":"Mobile App-based documentation of patient-reported outcomes - 3-months results from a proof-of-concept study on modern rheumatology patient management","volume":"23","author":"Richter","year":"2021","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.eclinm.2025.103243_bib12","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1007\/s11926-020-00968-7","article-title":"Self-management of rheumatoid arthritis: mobile applications","volume":"23","author":"Mollard","year":"2021","journal-title":"Curr Rheumatol Rep"},{"issue":"11","key":"10.1016\/j.eclinm.2025.103243_bib13","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1002\/art.42292","article-title":"Smartphone-assisted patient-initiated care versus usual care in patients with rheumatoid arthritis and low disease activity: a randomized controlled trial","volume":"74","author":"Seppen","year":"2022","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.eclinm.2025.103243_bib14","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1007\/s10067-022-06147-6","article-title":"Daily physical activity measured by a wearable activity monitoring device in patients with rheumatoid arthritis","volume":"41","author":"Tada","year":"2022","journal-title":"Clin Rheumatol"},{"issue":"4","key":"10.1016\/j.eclinm.2025.103243_bib15","doi-asserted-by":"crossref","first-page":"e238343","DOI":"10.1001\/jamanetworkopen.2023.8343","article-title":"Management of rheumatoid arthritis with a digital health application: a multicenter, pragmatic randomized clinical trial","volume":"6","author":"Li","year":"2023","journal-title":"JAMA Netw Open"},{"issue":"10","key":"10.1016\/j.eclinm.2025.103243_bib16","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1056\/NEJMra1505557","article-title":"Psoriatic arthritis","volume":"376","author":"Ritchlin","year":"2017","journal-title":"N Engl J Med"},{"issue":"1","key":"10.1016\/j.eclinm.2025.103243_bib17","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.jaad.2018.06.027","article-title":"Prevalence of psoriatic arthritis in patients with psoriasis: a systematic review and meta-analysis of observational and clinical studies","volume":"80","author":"Alinaghi","year":"2019","journal-title":"J Am Acad Dermatol"},{"issue":"8","key":"10.1016\/j.eclinm.2025.103243_bib18","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/s41584-022-00798-0","article-title":"Group for research and assessment of psoriasis and psoriatic arthritis (GRAPPA): updated treatment recommendations for psoriatic arthritis 2021","volume":"18","author":"Coates","year":"2022","journal-title":"Nat Rev Rheumatol"},{"key":"10.1016\/j.eclinm.2025.103243_bib19","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/s41584-019-0175-0","article-title":"Preventing psoriatic arthritis: focusing on patients with psoriasis at increased risk of transition","volume":"15","author":"Scher","year":"2019","journal-title":"Nat Rev Rheumatol"},{"issue":"3","key":"10.1016\/j.eclinm.2025.103243_bib20","doi-asserted-by":"crossref","first-page":"466","DOI":"10.3899\/jrheum.130949","article-title":"Is the MAdrid Sonographic Enthesitis Index useful for differentiating psoriatic arthritis from psoriasis alone and healthy controls?","volume":"41","author":"Eder","year":"2014","journal-title":"J Rheumatol"},{"key":"10.1016\/j.eclinm.2025.103243_bib21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1136\/ard-2024-225531","article-title":"EULAR recommendations for the management of psoriatic arthritis with pharmacological therapies: 2023 update","volume":"83","author":"Gossec","year":"2024","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.eclinm.2025.103243_bib22","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/s41584-022-00748-w","article-title":"HIPPOCRATES: improving diagnosis and outcomes in psoriatic arthritis","volume":"18","author":"FitzGerald","year":"2022","journal-title":"Nat Rev Rheumatol"},{"key":"10.1016\/j.eclinm.2025.103243_bib23","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1038\/s41584-022-00810-7","article-title":"Sex-and gender-related differences in psoriatic arthritis","volume":"18","author":"Tarannum","year":"2022","journal-title":"Nat Rev Rheumatol"},{"issue":"5","key":"10.1016\/j.eclinm.2025.103243_bib24","doi-asserted-by":"crossref","first-page":"e313","DOI":"10.1016\/S2665-9913(22)00002-9","article-title":"The changing face of psoriatic arthritis","volume":"4","author":"Aydin","year":"2022","journal-title":"Lancet Rheumatol"},{"key":"10.1016\/j.eclinm.2025.103243_bib25","article-title":"Enhancing current guidance for psoriatic arthritis and its comorbidities: recommendations from an expert consensus panel","author":"Coates","year":"2024","journal-title":"Rheumatology"},{"key":"10.1016\/j.eclinm.2025.103243_bib26","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1038\/s41746-024-01190-w","article-title":"Orchestrating explainable artificial intelligence for multimodal and longitudinal data in medical imaging","volume":"7","author":"Pahud de Mortanges","year":"2024","journal-title":"NPJ Digit Med"},{"issue":"2","key":"10.1016\/j.eclinm.2025.103243_bib27","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0212463","article-title":"Data model harmonization for the All of Us research program: transforming i2b2 data into the OMOP common data model","volume":"14","author":"Klann","year":"2019","journal-title":"PLoS One"},{"issue":"12","key":"10.1016\/j.eclinm.2025.103243_bib28","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1038\/s41551-023-01151-w","article-title":"Dermal features derived from optoacoustic tomograms via machine learning correlate microangiopathy phenotypes with diabetes stage","volume":"7","author":"Karlas","year":"2023","journal-title":"Nat Biomed Eng"},{"issue":"9","key":"10.1016\/j.eclinm.2025.103243_bib29","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1002\/art.42917","article-title":"Unveiling metabolic similarities of entheses in patients with psoriasis and psoriatic arthritis using noninvasive in vivo molecular imaging: results from a cross-sectional exploratory study","volume":"76","author":"Fagni","year":"2024","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.eclinm.2025.103243_bib30","article-title":"The burden of psoriasis: a call for awareness","volume":"38","year":"2021","journal-title":"eClinicalMedicine"},{"issue":"9","key":"10.1016\/j.eclinm.2025.103243_bib31","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1002\/ejp.1615","article-title":"Reduced pain and analgesic use after acoustic binaural beats therapy in chronic pain-A double-blind randomized control cross-over trial","volume":"24","author":"Gkolias","year":"2020","journal-title":"Eur J Pain"},{"key":"10.1016\/j.eclinm.2025.103243_bib33","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/s41746-018-0053-1","article-title":"Agile research to complement agile development: a proposal for an mHealth research lifecycle","volume":"1","author":"Wilson","year":"2018","journal-title":"NPJ Digit Med"},{"key":"10.1016\/j.eclinm.2025.103243_bib34","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1038\/s41584-020-0461-x","article-title":"Digital health technologies: opportunities and challenges in rheumatology","volume":"16","author":"Solomon","year":"2020","journal-title":"Nat Rev Rheumatol"},{"key":"10.1016\/j.eclinm.2025.103243_bib35","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1038\/s41746-024-01127-3","article-title":"Generalization\u2014a key challenge for responsible AI in patient-facing clinical applications","volume":"7","author":"Goetz","year":"2024","journal-title":"NPJ Digit Med"},{"issue":"1","key":"10.1016\/j.eclinm.2025.103243_bib36","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1038\/s41746-023-00777-z","article-title":"Digital therapeutics from bench to bedside","volume":"6","author":"Wang","year":"2023","journal-title":"NPJ Digit Med"}],"container-title":["eClinicalMedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589537025001750?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589537025001750?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T20:48:43Z","timestamp":1760215723000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589537025001750"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":35,"alternative-id":["S2589537025001750"],"URL":"https:\/\/doi.org\/10.1016\/j.eclinm.2025.103243","relation":{},"ISSN":["2589-5370"],"issn-type":[{"value":"2589-5370","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"European advances in digital rheumatology: explainable insights and personalized digital health tools for psoriatic arthritis","name":"articletitle","label":"Article Title"},{"value":"eClinicalMedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.eclinm.2025.103243","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"103243"}}