{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T22:27:11Z","timestamp":1790634431699,"version":"4.1.0"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T00:00:00Z","timestamp":1756857600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001655","name":"Deutscher Akademischer Austauschdienst","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001655","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","award":["522518834"],"award-info":[{"award-number":["522518834"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["eClinicalMedicine"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.eclinm.2025.103519","type":"journal-article","created":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T08:36:17Z","timestamp":1758616577000},"page":"103519","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Development and validation of a prediction score for early identification of palliative care needs for patients in the intensive care unit: a multicentre retrospective cohort study"],"prefix":"10.1016","volume":"89","author":[{"given":"Theresa","family":"Tenge","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8954-0297","authenticated-orcid":false,"given":"Rachel","family":"Hadler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Mahal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0264-5959","authenticated-orcid":false,"given":"Elena","family":"Ahrens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca J.","family":"Wachtendorf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0128-7376","authenticated-orcid":false,"given":"Simone","family":"Redaelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophia","family":"Riesemann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0451-3562","authenticated-orcid":false,"given":"B\u00e9la-Simon","family":"Paschold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanqing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharaf","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline","family":"Schwartz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Schallenburger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rae M.","family":"Allain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Neukirchen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8186-4748","authenticated-orcid":false,"given":"Maximilian S.","family":"Schaefer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.eclinm.2025.103519_bib1","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1097\/CCM.0000000000006335","article-title":"Utilization and outcomes in U.S. ICU hospitalizations","volume":"52","author":"Kannan","year":"2024","journal-title":"Crit Care Med"},{"key":"10.1016\/j.eclinm.2025.103519_bib2","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1097\/TA.0000000000002768","article-title":"Epidemiological trends of surgical admissions to the intensive care unit in the United States","volume":"89","author":"Vakayil","year":"2020","journal-title":"J Trauma Acute Care Surg"},{"key":"10.1016\/j.eclinm.2025.103519_bib3","article-title":"In-hospital mortality, comorbidities, and costs of one million mechanically ventilated patients in Germany: a nationwide observational study before, during, and after the COVID-19 pandemic","volume":"42","author":"Karagiannidis","year":"2024","journal-title":"Lancet Reg Health Eur"},{"issue":"1","key":"10.1016\/j.eclinm.2025.103519_bib4","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s13613-023-01159-0","article-title":"Trends in ICU mortality and underlying risk over three decades among mechanically ventilated patients. A group level analysis of cohorts from infection prevention studies","volume":"13","author":"Hurley","year":"2023","journal-title":"Ann Intensive Care"},{"key":"10.1016\/j.eclinm.2025.103519_bib5","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1186\/s13054-015-1124-1","article-title":"Intensive care at the end of life in patients dying due to non-cancer chronic diseases versus cancer: a nationwide study in Denmark","volume":"19","author":"Lyngaa","year":"2015","journal-title":"Crit Care"},{"key":"10.1016\/j.eclinm.2025.103519_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.eclinm.2024.102561","article-title":"Prevalence of aggressive care among patients with cancer near the end of life: a systematic review and meta-analysis","volume":"71","author":"Ma","year":"2024","journal-title":"eClinicalMedicine"},{"key":"10.1016\/j.eclinm.2025.103519_bib7","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1056\/NEJMra2104669","article-title":"Outcomes after critical illness","volume":"388","author":"Herridge","year":"2023","journal-title":"N Engl J Med"},{"key":"10.1016\/j.eclinm.2025.103519_bib8","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1007\/s00134-023-07260-z","article-title":"Palliative care in intensive care","volume":"49","author":"Neukirchen","year":"2023","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.eclinm.2025.103519_bib9","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1007\/s00134-021-06544-6","article-title":"Palliative care interventions in intensive care unit patients","volume":"47","author":"Metaxa","year":"2021","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.eclinm.2025.103519_bib10","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1007\/s00134-022-06729-7","article-title":"Integrating palliative care into the ICU: a lasting and developing legacy","volume":"48","author":"Curtis","year":"2022","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.eclinm.2025.103519_bib11","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1164\/rccm.201307-1229OC","article-title":"Estimates of the need for palliative care consultation across United States intensive care units using a trigger-based model","volume":"189","author":"Hua","year":"2014","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.eclinm.2025.103519_bib12","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1089\/jpm.2013.0409","article-title":"Evidence-based palliative care in the intensive care unit: a systematic review of interventions","volume":"17","author":"Aslakson","year":"2014","journal-title":"J Palliat Med"},{"key":"10.1016\/j.eclinm.2025.103519_bib13","article-title":"Incorporating early palliative medicine consultation into daily morning huddle in the ICU","volume":"3","author":"Babar","year":"2021","journal-title":"Crit Care Explor"},{"key":"10.1016\/j.eclinm.2025.103519_bib14","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1177\/10499091221115732","article-title":"Early versus usual palliative care consultation in the intensive care unit","volume":"40","author":"Helgeson","year":"2023","journal-title":"Am J Hosp Palliat Care"},{"key":"10.1016\/j.eclinm.2025.103519_bib15","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1097\/CCM.0000000000004016","article-title":"Early palliative care consultation in the medical ICU: a cluster randomized crossover trial","volume":"47","author":"Ma","year":"2019","journal-title":"Crit Care Med"},{"issue":"1","key":"10.1016\/j.eclinm.2025.103519_bib16","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1186\/s13054-023-04622-3","article-title":"Recommendations on palliative care aspects in intensive care medicine","volume":"27","author":"Michels","year":"2023","journal-title":"Crit Care"},{"key":"10.1016\/j.eclinm.2025.103519_bib17","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.1097\/01.CCM.0000266533.06543.0C","article-title":"Proactive palliative care in the medical intensive care unit: effects on length of stay for selected high-risk patients","volume":"35","author":"Norton","year":"2007","journal-title":"Crit Care Med"},{"key":"10.1016\/j.eclinm.2025.103519_bib18","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1177\/1049909119864025","article-title":"Palliative care consultation is underutilized in critically ill general surgery patients","volume":"37","author":"Evans","year":"2020","journal-title":"Am J Hosp Palliat Care"},{"key":"10.1016\/j.eclinm.2025.103519_bib19","doi-asserted-by":"crossref","first-page":"e611","DOI":"10.1016\/j.jpainsymman.2022.03.011","article-title":"Utilization and delivery of specialty palliative care in the ICU: insights from the palliative care quality network","volume":"63","author":"Chapman","year":"2022","journal-title":"J Pain Symptom Manage"},{"issue":"11","key":"10.1016\/j.eclinm.2025.103519_bib20","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.1007\/s00134-024-07579-1","article-title":"European society of intensive care medicine guidelines on end of life and palliative care in the intensive care unit","volume":"50","author":"Kesecioglu","year":"2024","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.eclinm.2025.103519_bib21","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/s00134-018-5461-9","article-title":"Will your patient benefit from palliative care? A multicenter exploratory survey about the acceptance of trigger factors for palliative care consultations among ICU physicians","volume":"45","author":"Adler","year":"2019","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.eclinm.2025.103519_bib22","article-title":"Perceptions on specialist palliative care involvement during and after cardiopulmonary resuscitation: a qualitative study","volume":"6","author":"Tenge","year":"2024","journal-title":"Crit Care Explor"},{"issue":"8","key":"10.1016\/j.eclinm.2025.103519_bib23","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0255989","article-title":"Evaluation of automated specialty palliative care in the intensive care unit: a retrospective cohort study","volume":"16","author":"Secunda","year":"2021","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.eclinm.2025.103519_bib24","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2021.44093","article-title":"Assessment of clinical palliative care trigger status vs actual needs among critically ill patients and their family members","volume":"5","author":"Cox","year":"2022","journal-title":"JAMA Netw Open"},{"issue":"1","key":"10.1016\/j.eclinm.2025.103519_bib25","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1186\/s13054-024-04969-1","article-title":"Triggers of intensive care patients with palliative care needs from nurses' perspective: a mixed methods study","volume":"28","author":"Schallenburger","year":"2024","journal-title":"Crit Care"},{"key":"10.1016\/j.eclinm.2025.103519_bib26","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.jcrc.2018.04.014","article-title":"Derivation of data-driven triggers for palliative care consultation in critically ill patients","volume":"46","author":"Hua","year":"2018","journal-title":"J Crit Care"},{"key":"10.1016\/j.eclinm.2025.103519_bib27","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1016\/S0140-6736(07)61602-X","article-title":"The strengthening the reporting of observational studies in epidemiology (STROBE) statement: guidelines for reporting observational studies","volume":"370","author":"von Elm","year":"2007","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.eclinm.2025.103519_bib28","first-page":"134","article-title":"Transparent reporting of a multivariable prediction model for individual prognosis or diagnosis (TRIPOD): the TRIPOD statement","volume":"68","author":"Collins","year":"2015","journal-title":"BMJ"},{"key":"10.1016\/j.eclinm.2025.103519_bib29","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1002\/bimj.200710415","article-title":"Youden index and optimal cut-point estimated from observations affected by a lower limit of detection","volume":"50","author":"Ruopp","year":"2008","journal-title":"Biom J"},{"key":"10.1016\/j.eclinm.2025.103519_bib30","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1002\/(SICI)1097-0258(19970515)16:9<965::AID-SIM509>3.0.CO;2-O","article-title":"A comparison of goodness-of-fit tests for the logistic regression model","volume":"16","author":"Hosmer","year":"1997","journal-title":"Stat Med"},{"key":"10.1016\/j.eclinm.2025.103519_bib31","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1093\/jnci\/95.7.511","article-title":"The central role of receiver operating characteristic (ROC) curves in evaluating tests for the early detection of cancer","volume":"95","author":"Baker","year":"2003","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.eclinm.2025.103519_bib32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1175\/1520-0493(1950)078<0001:VOFEIT>2.0.CO;2","article-title":"Verification of forecasts expressed in terms of probability","volume":"78","author":"Brier","year":"1950","journal-title":"Mon Weather Rev"},{"key":"10.1016\/j.eclinm.2025.103519_bib33","doi-asserted-by":"crossref","first-page":"837","DOI":"10.2307\/2531595","article-title":"Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach","volume":"44","author":"DeLong","year":"1988","journal-title":"Biometrics"},{"key":"10.1016\/j.eclinm.2025.103519_bib34","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1001\/jamasurg.2014.2101","article-title":"Use of palliative care and hospice among surgical and medical specialties in the veterans health administration","volume":"149","author":"Olmsted","year":"2014","journal-title":"JAMA Surg"},{"key":"10.1016\/j.eclinm.2025.103519_bib35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13054-022-04066-1","article-title":"Palliative care practice and moral distress during COVID-19 pandemic (PEOpLE-C19 study): a national, cross-sectional study in intensive care units in the Czech Republic","volume":"26","author":"Prokopov\u00e1","year":"2022","journal-title":"Crit Care"},{"key":"10.1016\/j.eclinm.2025.103519_bib36","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2021.0677","article-title":"Comparison of palliative care delivery in the last year of life between adults with terminal noncancer illness or cancer","volume":"4","author":"Quinn","year":"2021","journal-title":"JAMA Netw Open"},{"key":"10.1016\/j.eclinm.2025.103519_bib37","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1177\/1536867X1201200307","article-title":"A generalized hosmer\u2013lemeshow goodness-of-fit test for multinomial logistic regression models","volume":"12","author":"Fagerland","year":"2012","journal-title":"STATA J"},{"key":"10.1016\/j.eclinm.2025.103519_bib38","doi-asserted-by":"crossref","first-page":"2318","DOI":"10.1097\/CCM.0b013e31828cf12c","article-title":"Choosing and using screening criteria for palliative care consultation in the ICU: a report from the improving palliative care in the ICU (IPAL-ICU) advisory board","volume":"41","author":"Nelson","year":"2013","journal-title":"Crit Care Med"},{"key":"10.1016\/j.eclinm.2025.103519_bib39","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1089\/jpm.2010.0347","article-title":"Identifying patients in need of a palliative care assessment in the hospital setting: a consensus report from the center to advance palliative care","volume":"14","author":"Weissman","year":"2011","journal-title":"J Palliat Med"},{"key":"10.1016\/j.eclinm.2025.103519_bib40","doi-asserted-by":"crossref","first-page":"2418","DOI":"10.1097\/CCM.0000000000000573","article-title":"The changing role of palliative care in the ICU","volume":"42","author":"Aslakson","year":"2014","journal-title":"Crit Care Med"},{"key":"10.1016\/j.eclinm.2025.103519_bib42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13054-021-03633-2","article-title":"Palliative, palliative or palliative?","volume":"25","author":"Robert","year":"2021","journal-title":"Crit Care"},{"key":"10.1016\/j.eclinm.2025.103519_bib43","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13054-014-0604-z","article-title":"Physician-related barriers to communication and patient- and family-centred decision-making towards the end of life in intensive care: a systematic review","volume":"18","author":"Visser","year":"2014","journal-title":"Crit Care"},{"key":"10.1016\/j.eclinm.2025.103519_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.eclinm.2023.102244","article-title":"Effect of a prediction tool and communication skills training on communication of treatment outcomes: a multicenter stepped wedge clinical trial (the SOURCE trial)","volume":"64","author":"van de Water","year":"2023","journal-title":"eClinicalMedicine"},{"key":"10.1016\/j.eclinm.2025.103519_bib45","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13054-023-04463-0","article-title":"ICU without borders","volume":"27","author":"Ostermann","year":"2023","journal-title":"Crit Care"},{"key":"10.1016\/j.eclinm.2025.103519_bib46","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13054-023-04381-1","article-title":"Subjective and objective survival prediction in mechanically ventilated critically ill patients: a prospective cohort study","volume":"27","author":"Boeck","year":"2023","journal-title":"Crit Care"},{"key":"10.1016\/j.eclinm.2025.103519_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.eclinm.2024.102470","article-title":"Early palliative care and overall survival in patients with metastatic upper gastrointestinal cancers (EPIC): a multicentre, open-label, randomised controlled phase 3 trial","volume":"74","author":"Adenis","year":"2024","journal-title":"eClinicalMedicine"},{"key":"10.1016\/j.eclinm.2025.103519_bib48","article-title":"Palliative medicine consultation reduces readmission significantly in certain diagnoses: a retrospective analysis","author":"Depew","year":"2025","journal-title":"Am J Hosp Palliat Care"},{"key":"10.1016\/j.eclinm.2025.103519_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.eclinm.2022.101303","article-title":"Race and birth country are associated with discharge location from hospital: a retrospective cohort study of demographic differences for patients receiving inpatient palliative care","volume":"45","author":"Isenberg","year":"2022","journal-title":"eClinicalMedicine"}],"container-title":["eClinicalMedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589537025004523?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589537025004523?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T05:32:59Z","timestamp":1769059979000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589537025004523"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":48,"alternative-id":["S2589537025004523"],"URL":"https:\/\/doi.org\/10.1016\/j.eclinm.2025.103519","relation":{},"ISSN":["2589-5370"],"issn-type":[{"value":"2589-5370","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Development and validation of a prediction score for early identification of palliative care needs for patients in the intensive care unit: a multicentre retrospective cohort study","name":"articletitle","label":"Article Title"},{"value":"eClinicalMedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.eclinm.2025.103519","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"103519"}}