{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T22:24:20Z","timestamp":1794349460010,"version":"4.9.0"},"reference-count":19,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T00:00:00Z","timestamp":1759449600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100014733","name":"Association of Breast Surgery","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014733","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["eClinicalMedicine"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.eclinm.2025.103591","type":"journal-article","created":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T20:11:58Z","timestamp":1761855118000},"page":"103591","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Surgical margins in breast conserving surgery for ductal carcinoma in situ of the breast and clinical outcomes: a national audit with long term follow-up"],"prefix":"10.1016","volume":"90","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6212-3979","authenticated-orcid":false,"given":"John FR.","family":"Robertson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2202-0956","authenticated-orcid":false,"given":"D Mark","family":"Sibbering","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sikhuphukile G.","family":"Ndebele Mahati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashu","family":"Gandhi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah E.","family":"Pinder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Clements","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olive","family":"Kearins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"Bliss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucy","family":"Kilburn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.eclinm.2025.103591_bib1","article-title":"Invasive breast cancer and breast cancer mortality after ductal carcinoma in situ in women attending for breast screening in England, 1988-2014: population based observational cohort study","volume":"369","author":"Mannu","year":"2020","journal-title":"BMJ"},{"key":"10.1016\/j.eclinm.2025.103591_bib2","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.breast.2022.01.001","article-title":"Unresected screen-detected ductal carcinoma in situ: outcomes of 311 women in the forget-me-not 2 study","volume":"61","author":"Maxwell","year":"2022","journal-title":"Breast"},{"issue":"9","key":"10.1016\/j.eclinm.2025.103591_bib3","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1093\/jnci\/djy220","article-title":"Cancer outcomes in DCIS patients without locoregional treatment","volume":"111","author":"Ryser","year":"2019","journal-title":"J Natl Cancer Inst"},{"issue":"13","key":"10.1016\/j.eclinm.2025.103591_bib4","doi-asserted-by":"crossref","first-page":"4264","DOI":"10.1245\/s10434-019-07693-1","article-title":"Impact of age on locoregional and distant recurrence after mastectomy for ductal carcinoma in situ with or without microinvasion","volume":"26","author":"Mamtani","year":"2019","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.eclinm.2025.103591_bib5","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1001\/jamaoncol.2015.2510","article-title":"Breast cancer mortality after a diagnosis of ductal carcinoma in situ","volume":"1","author":"Narod","year":"2015","journal-title":"JAMA Oncol"},{"key":"10.1016\/j.eclinm.2025.103591_bib6","doi-asserted-by":"crossref","first-page":"3811","DOI":"10.1245\/s10434-016-5446-2","article-title":"The association of surgical margins and local recurrence in women with ductal carcinoma in situ treated with breast-conserving therapy: a meta-analysis","volume":"23","author":"Marinovich","year":"2016","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.eclinm.2025.103591_bib7","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1158\/1055-9965.EPI-18-0976","article-title":"Predictors of an invasive breast cancer recurrence after DCIS: a systematic review and meta-analyses","volume":"28","author":"Visser","year":"2019","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1016\/j.eclinm.2025.103591_bib8","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1097\/SLA.0000000000002439","article-title":"Ductal carcinoma in situ and margins conservation","volume":"269","author":"Tadros","year":"2019","journal-title":"Ann Surg"},{"key":"10.1016\/j.eclinm.2025.103591_bib9","doi-asserted-by":"crossref","DOI":"10.1136\/bmj-2022-070346","article-title":"Margin status and survival outcomes after breast cancer conservation surgery: prospectively registered systematic review and meta-analysis","volume":"378","author":"Bundred","year":"2022","journal-title":"BMJ"},{"key":"10.1016\/j.eclinm.2025.103591_bib10","doi-asserted-by":"crossref","first-page":"S84","DOI":"10.1016\/S0960-9776(09)70279-6","article-title":"Breast conservation and negative margins: how much is enough?","volume":"18","author":"Morrow","year":"2009","journal-title":"Breast"},{"issue":"12","key":"10.1016\/j.eclinm.2025.103591_bib11","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2022-061585","article-title":"Cohort profile of the sloane project: methodology for a prospective UK cohort study of >15 000 women with screen-detected non-invasive breast neoplasia","volume":"12","author":"Clements","year":"2022","journal-title":"BMJ Open"},{"key":"10.1016\/j.eclinm.2025.103591_bib12","article-title":"Society of surgical oncology\u2013American society for radiation oncology\u2013American society of clinical oncology consensus guideline on margins for breast-conserving surgery with whole","author":"Morrow","year":"2017","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.eclinm.2025.103591_bib17","doi-asserted-by":"crossref","DOI":"10.1136\/bmj-2023-076022","article-title":"Association of DCIS size and margin status with risk of developing breast cancer post-treatment: multinational, pooled cohort study","volume":"383","author":"Schmitz","year":"2023","journal-title":"BMJ"},{"key":"10.1016\/j.eclinm.2025.103591_bib18","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1038\/s41416-020-01152-5","article-title":"Pathological features of 11,337 patients with primary ductal carcinoma in situ (DCIS) and subsequent events: results from the UK sloane project","volume":"124","author":"Shaaban","year":"2021","journal-title":"Br J Cancer"},{"key":"10.1016\/j.eclinm.2025.103591_bib21","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/s10549-021-06488-x","article-title":"Long-term outcomes of women with large DCIS lesions treated with breast-conserving therapy","volume":"192","author":"Rodin","year":"2022","journal-title":"Breast Cancer Res Treat"},{"key":"10.1016\/j.eclinm.2025.103591_bib22","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.ejca.2018.06.027","article-title":"Sloane project steering group (NHS prospective study of screen-detected Non-invasive neoplasias). Management and 5-year outcomes in 9938 women with screen-detected ductal carcinoma in situ: the UK sloane project","volume":"101","author":"Thompson","year":"2018","journal-title":"Eur J Cancer"},{"issue":"41","key":"10.1016\/j.eclinm.2025.103591_bib23","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1093\/jncimonographs\/lgq039","article-title":"Early breast cancer clinical trialists group (EBCTCG) overview of randomised trials of radiotherapy in ductal carcinoma in situ of the breast","volume":"2010","author":"Correa","year":"2010","journal-title":"J Natl Cancer Inst Monogr"},{"issue":"1","key":"10.1016\/j.eclinm.2025.103591_bib24","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1136\/jclinpath-2016-203800","article-title":"Review of the national external quality assessment (EQA) scheme for breast pathology in the UK","volume":"70","author":"Rakha","year":"2017","journal-title":"J Clin Pathol"},{"key":"10.1016\/j.eclinm.2025.103591_bib25","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S1470-2045(10)70266-7","article-title":"Effect of tamoxifen and radiotherapy in women with locally excised ductal carcinoma in situ: long-term results from the UK\/ANZ DCIS trial","volume":"12","author":"Cuzick","year":"2011","journal-title":"Lancet Oncol"}],"container-title":["eClinicalMedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589537025005243?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589537025005243?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T21:35:04Z","timestamp":1794346504000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589537025005243"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":19,"alternative-id":["S2589537025005243"],"URL":"https:\/\/doi.org\/10.1016\/j.eclinm.2025.103591","relation":{},"ISSN":["2589-5370"],"issn-type":[{"value":"2589-5370","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Surgical margins in breast conserving surgery for ductal carcinoma in situ of the breast and clinical outcomes: a national audit with long term follow-up","name":"articletitle","label":"Article Title"},{"value":"eClinicalMedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.eclinm.2025.103591","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"103591"}}