{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T22:23:30Z","timestamp":1794349410612,"version":"4.9.0"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T00:00:00Z","timestamp":1762387200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","award":["445297796"],"award-info":[{"award-number":["445297796"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["eClinicalMedicine"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.eclinm.2025.103663","type":"journal-article","created":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T16:13:25Z","timestamp":1764346405000},"page":"103663","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Efficacy of a mechanism-based psychological intervention for persistent gastrointestinal symptoms in ulcerative colitis and irritable bowel syndrome: results of a three-arm randomised controlled trial (SOMA.GUT-RCT)"],"prefix":"10.1016","volume":"90","author":[{"given":"Kerstin","family":"Maehder","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa","family":"Peters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sina","family":"H\u00fcbener","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Matysiak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Huber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Toussaint","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8467-0508","authenticated-orcid":false,"given":"Antonia","family":"Zapf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3737-6402","authenticated-orcid":false,"given":"Eik","family":"Vettorazzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Weber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Stahlmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viola","family":"Andresen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvonne","family":"Nestoriuc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ansgar W.","family":"Lohse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4220-3378","authenticated-orcid":false,"given":"Bernd","family":"L\u00f6we","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"S1","key":"10.1016\/j.eclinm.2025.103663_bib1","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1111\/apt.16582","article-title":"Review article: epidemiology of IBS and other bowel disorders of gut\u2013brain interaction (DGBI)","volume":"54","author":"Sperber","year":"2021","journal-title":"Aliment Pharmacol Ther"},{"issue":"10114","key":"10.1016\/j.eclinm.2025.103663_bib2","doi-asserted-by":"crossref","first-page":"2769","DOI":"10.1016\/S0140-6736(17)32448-0","article-title":"Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies","volume":"390","author":"Ng","year":"2017","journal-title":"Lancet"},{"issue":"26","key":"10.1016\/j.eclinm.2025.103663_bib3","doi-asserted-by":"crossref","first-page":"2566","DOI":"10.1056\/NEJMra1607547","article-title":"Irritable bowel syndrome","volume":"376","author":"Ford","year":"2017","journal-title":"N Engl J Med"},{"issue":"4","key":"10.1016\/j.eclinm.2025.103663_bib4","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1093\/ecco-jcc\/jjx152","article-title":"Irritable bowel-like symptoms in ulcerative colitis are as common in patients in deep remission as in inflammation: results from a population-based study [the IBSEN Study]","volume":"12","author":"Henriksen","year":"2018","journal-title":"J Crohns Colitis"},{"issue":"1","key":"10.1016\/j.eclinm.2025.103663_bib5","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2021-057596","article-title":"Persistent SOMAtic symptoms ACROSS diseases \u2014 from risk factors to modification: scientific framework and overarching protocol of the interdisciplinary SOMACROSS research unit (RU 5211)","volume":"12","author":"L\u00f6we","year":"2022","journal-title":"BMJ Open"},{"issue":"10444","key":"10.1016\/j.eclinm.2025.103663_bib6","doi-asserted-by":"crossref","first-page":"2649","DOI":"10.1016\/S0140-6736(24)00623-8","article-title":"Persistent physical symptoms: definition, genesis, and management","volume":"403","author":"L\u00f6we","year":"2024","journal-title":"Lancet"},{"issue":"6","key":"10.1016\/j.eclinm.2025.103663_bib7","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2021-059529","article-title":"Persistence of gastrointestinal symptoms in irritable bowel syndrome and ulcerative colitis: study protocol for a three-arm randomised controlled trial (SOMA.GUT-RCT)","volume":"12","author":"L\u00f6we","year":"2022","journal-title":"BMJ Open"},{"issue":"8","key":"10.1016\/j.eclinm.2025.103663_bib8","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1136\/gutjnl-2020-321191","article-title":"Efficacy of psychological therapies for irritable bowel syndrome: systematic review and network meta-analysis","volume":"69","author":"Black","year":"2020","journal-title":"Gut"},{"issue":"4","key":"10.1016\/j.eclinm.2025.103663_bib9","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1111\/bjhp.12250","article-title":"The journey between brain and gut: a systematic review of psychological mechanisms of treatment effect in irritable bowel syndrome","volume":"22","author":"Windgassen","year":"2017","journal-title":"Br J Health Psychol"},{"issue":"9","key":"10.1016\/j.eclinm.2025.103663_bib10","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1038\/ajg.2016.255","article-title":"The development of irritable bowel syndrome: a prospective community-based cohort study","volume":"111","author":"L\u00f6we","year":"2016","journal-title":"Am J Gastroenterol"},{"issue":"4","key":"10.1016\/j.eclinm.2025.103663_bib11","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1002\/smi.3226","article-title":"Systematic review with meta-analysis: stress-Management interventions for patients with irritable bowel syndrome","volume":"39","author":"Horn","year":"2023","journal-title":"Stress Health"},{"issue":"4","key":"10.1016\/j.eclinm.2025.103663_bib12","doi-asserted-by":"crossref","first-page":"856","DOI":"10.14309\/ajg.0000000000003059","article-title":"Internet-delivered exposure-based cognitive behavior therapy for irritable bowel syndrome: a clinical effectiveness study","volume":"120","author":"Wall\u00e9n","year":"2025","journal-title":"Am J Gastroenterol"},{"issue":"5","key":"10.1016\/j.eclinm.2025.103663_bib13","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1037\/ccp0000648","article-title":"Specific and common mediators of gastrointestinal symptom improvement in patients undergoing education\/support vs. cognitive behavioral therapy for irritable bowel syndrome","volume":"89","author":"Lackner","year":"2021","journal-title":"J Consult Clin Psychol"},{"key":"10.1016\/j.eclinm.2025.103663_bib14","doi-asserted-by":"crossref","DOI":"10.3389\/fpsyt.2022.824468","article-title":"Positive treatment expectations shape perceived medication efficacy in a translational placebo paradigm for the gut-brain axis","volume":"13","author":"Benson","year":"2022","journal-title":"Front Psychiatry"},{"issue":"2","key":"10.1016\/j.eclinm.2025.103663_bib15","doi-asserted-by":"crossref","DOI":"10.1002\/cpp.70075","article-title":"Predictors of treatment success of psychotherapy in functional disorders: a systematic review of the literature","volume":"32","author":"Rometsch","year":"2025","journal-title":"Clin Psychol Psychother"},{"issue":"10","key":"10.1016\/j.eclinm.2025.103663_bib16","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/S2468-1253(23)00186-3","article-title":"Efficacy of psychological therapies in people with inflammatory bowel disease: a systematic review and meta-analysis","volume":"8","author":"Riggott","year":"2023","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"10.1016\/j.eclinm.2025.103663_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2023.114653","article-title":"Effects of cognitive behavioral therapy on mental health and quality of life in inflammatory bowel disease patients: a meta-analysis of randomized controlled trials","volume":"454","author":"Wang","year":"2023","journal-title":"Behav Brain Res"},{"issue":"4","key":"10.1016\/j.eclinm.2025.103663_bib18","first-page":"Cd006913","article-title":"Psychological interventions for treatment of inflammatory bowel disease","volume":"4","author":"Tiles-Sar","year":"2025","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.eclinm.2025.103663_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2023.104910","article-title":"Do interventions for mood improve inflammatory biomarkers in inflammatory bowel disease?: a systematic review and meta-analysis","volume":"100","author":"Seaton","year":"2024","journal-title":"eBioMedicine"},{"issue":"9","key":"10.1016\/j.eclinm.2025.103663_bib20","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1136\/gutjnl-2021-325985","article-title":"Bidirectional brain-gut axis effects influence mood and prognosis in IBD: a systematic review and meta-analysis","volume":"71","author":"Fairbrass","year":"2022","journal-title":"Gut"},{"issue":"13","key":"10.1016\/j.eclinm.2025.103663_bib21","doi-asserted-by":"crossref","first-page":"2823","DOI":"10.1016\/j.cell.2023.05.001","article-title":"The enteric nervous system relays psychological stress to intestinal inflammation","volume":"186","author":"Schneider","year":"2023","journal-title":"Cell"},{"issue":"6","key":"10.1016\/j.eclinm.2025.103663_bib22","doi-asserted-by":"crossref","DOI":"10.1111\/nmo.14809","article-title":"Predictors of irritable bowel syndrome-like symptoms in quiescent inflammatory bowel disease","volume":"36","author":"Ahmed","year":"2024","journal-title":"Neurogastroenterol Motil"},{"key":"10.1016\/j.eclinm.2025.103663_bib23","doi-asserted-by":"crossref","DOI":"10.1093\/ecco-jcc\/jjae183","article-title":"Modifiable psychological factors are associated with clusters of pain, fatigue, faecal incontinence and IBS-type symptoms in inflammatory bowel disease: a latent profile analysis","volume":"19","author":"Wileman","year":"2025","journal-title":"J Crohns Colitis"},{"key":"10.1016\/j.eclinm.2025.103663_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpsychores.2023.111567","article-title":"Pre-treatment expectations and their influence on subjective symptom change in Crohn's disease","volume":"176","author":"Basedow","year":"2024","journal-title":"J Psychosom Res"},{"issue":"1","key":"10.1016\/j.eclinm.2025.103663_bib25","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s12916-016-0767-3","article-title":"Preoperative optimization of patient expectations improves long-term outcome in heart surgery patients: results of the randomized controlled PSY-HEART trial","volume":"15","author":"Rief","year":"2017","journal-title":"BMC Med"},{"issue":"1","key":"10.1016\/j.eclinm.2025.103663_bib26","doi-asserted-by":"crossref","DOI":"10.32872\/cpe.v2i1.2695","article-title":"Optimizing expectations about endocrine treatment for breast cancer: results of the randomized controlled PSY-BREAST trial","volume":"2","author":"Shedden-Mora","year":"2020","journal-title":"Clin Psychol Eur"},{"issue":"2","key":"10.1016\/j.eclinm.2025.103663_bib27","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1046\/j.1365-2036.1997.142318000.x","article-title":"The irritable bowel severity scoring system: a simple method of monitoring irritable bowel syndrome and its progress","volume":"11","author":"Francis","year":"1997","journal-title":"Aliment Pharmacol Ther"},{"issue":"10","key":"10.1016\/j.eclinm.2025.103663_bib28","first-page":"1171","article-title":"[Validation of the IBS-SSS]","volume":"51","author":"Betz","year":"2013","journal-title":"Z Gastroenterol"},{"issue":"5","key":"10.1016\/j.eclinm.2025.103663_bib29","first-page":"769","article-title":"[Updated Guideline for Ulcerative Colitis]","volume":"62","author":"Kucharzik","year":"2024","journal-title":"Z Gastroenterol"},{"issue":"12","key":"10.1016\/j.eclinm.2025.103663_bib30","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1055\/a-1591-4794","volume":"59","author":"Layer","year":"2021","journal-title":"Z Gastroenterol"},{"issue":"1","key":"10.1016\/j.eclinm.2025.103663_bib31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/tbm\/ibz166","article-title":"Impact of eHealth technologies on patient outcomes: a meta-analysis of chronic gastrointestinal illness interventions","volume":"11","author":"Rohde","year":"2021","journal-title":"Transl Behav Med"},{"key":"10.1016\/j.eclinm.2025.103663_bib32","series-title":"Internationale Skalen f\u00fcr Hypochondrie","author":"Hiller","year":"2004"},{"issue":"2","key":"10.1016\/j.eclinm.2025.103663_bib33","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1097\/00006842-200203000-00008","article-title":"The PHQ-15: validity of a new measure for evaluating the severity of somatic symptoms","volume":"64","author":"Kroenke","year":"2002","journal-title":"Psychosom Med"},{"issue":"12","key":"10.1016\/j.eclinm.2025.103663_bib34","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1097\/00005650-200412000-00006","article-title":"Monitoring depression treatment outcomes with the patient health questionnaire-9","volume":"42","author":"L\u00f6we","year":"2004","journal-title":"Med Care"},{"issue":"10","key":"10.1016\/j.eclinm.2025.103663_bib35","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1001\/archinte.166.10.1092","article-title":"A brief measure for assessing generalized anxiety disorder: the GAD-7","volume":"166","author":"Spitzer","year":"2006","journal-title":"Arch Intern Med"},{"issue":"1","key":"10.1016\/j.eclinm.2025.103663_bib36","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1097\/PSY.0000000000000240","article-title":"Development and validation of the somatic symptom disorder-B criteria scale (SSD-12)","volume":"78","author":"Toussaint","year":"2016","journal-title":"Psychosom Med"},{"issue":"2","key":"10.1016\/j.eclinm.2025.103663_bib37","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/0304-3959(90)90068-O","article-title":"The pain disability index: psychometric properties","volume":"40","author":"Tait","year":"1990","journal-title":"Pain"},{"issue":"3","key":"10.1016\/j.eclinm.2025.103663_bib38","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1097\/00005650-199603000-00003","article-title":"A 12-Item short-form health survey: construction of scales and preliminary tests of reliability and validity","volume":"34","author":"Ware","year":"1996","journal-title":"Med Care"},{"issue":"1","key":"10.1016\/j.eclinm.2025.103663_bib39","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1136\/gut.43.1.29","article-title":"A simple clinical colitis activity index","volume":"43","author":"Walmsley","year":"1998","journal-title":"Gut"},{"issue":"4","key":"10.1016\/j.eclinm.2025.103663_bib40","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/s00132-012-1901-3","article-title":"[Comorbidity from the patient perspective - does it work? Validity of a questionnaire on self-estimation of comorbidity (SCQ-D)]","volume":"41","author":"Streibelt","year":"2012","journal-title":"Orthopade"},{"key":"10.1016\/j.eclinm.2025.103663_bib41","series-title":"R: a language and environment for statistical computing","year":"2023"},{"issue":"4","key":"10.1016\/j.eclinm.2025.103663_bib42","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/S0895-4356(00)00314-0","article-title":"Adjusting for multiple testing\u2014when and how?","volume":"54","author":"Bender","year":"2001","journal-title":"J Clin Epidemiol"},{"key":"10.1016\/j.eclinm.2025.103663_bib43","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.81795","article-title":"The role of expectations, control and reward in the development of pain persistence based on a unified model","volume":"12","author":"B\u00fcchel","year":"2023","journal-title":"ELife"},{"issue":"5","key":"10.1016\/j.eclinm.2025.103663_bib44","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1053\/j.gastro.2024.05.010","article-title":"Effect of brain-gut behavioral treatments on abdominal pain in irritable bowel syndrome: systematic review and network meta-analysis","volume":"167","author":"Goodoory","year":"2024","journal-title":"Gastroenterology"},{"issue":"8","key":"10.1016\/j.eclinm.2025.103663_bib45","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1111\/jgh.16568","article-title":"Systematic review and meta-analysis: impact of depression on prognosis in inflammatory bowel disease","volume":"39","author":"Ji","year":"2024","journal-title":"J Gastroenterol Hepatol"},{"issue":"2","key":"10.1016\/j.eclinm.2025.103663_bib46","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1111\/apt.15325","article-title":"Systematic review with meta-analysis: the prevalence of anxiety and depression in patients with irritable bowel syndrome","volume":"50","author":"Zamani","year":"2019","journal-title":"Aliment Pharmacol Ther"},{"issue":"6","key":"10.1016\/j.eclinm.2025.103663_bib47","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1080\/16506073.2023.2225745","article-title":"Psychological treatments for irritable bowel syndrome: a comprehensive systematic review and meta-analysis","volume":"52","author":"Axelsson","year":"2023","journal-title":"Cogn Behav Ther"},{"issue":"12","key":"10.1016\/j.eclinm.2025.103663_bib48","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1016\/S2468-1253(24)00245-0","article-title":"Personalisation of therapy in irritable bowel syndrome: a hypothesis","volume":"9","author":"Black","year":"2024","journal-title":"Lancet Gastroenterol Hepatol"}],"container-title":["eClinicalMedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589537025005978?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589537025005978?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T21:38:13Z","timestamp":1794346693000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589537025005978"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":48,"alternative-id":["S2589537025005978"],"URL":"https:\/\/doi.org\/10.1016\/j.eclinm.2025.103663","relation":{},"ISSN":["2589-5370"],"issn-type":[{"value":"2589-5370","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Efficacy of a mechanism-based psychological intervention for persistent gastrointestinal symptoms in ulcerative colitis and irritable bowel syndrome: results of a three-arm randomised controlled trial (SOMA.GUT-RCT)","name":"articletitle","label":"Article Title"},{"value":"eClinicalMedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.eclinm.2025.103663","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"103663"}}