{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T07:30:30Z","timestamp":1781854230198,"version":"3.54.5"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T00:00:00Z","timestamp":1772668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Institutes of Health National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["eClinicalMedicine"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.eclinm.2026.103841","type":"journal-article","created":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T14:49:24Z","timestamp":1774968564000},"page":"103841","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Impact of cisplatin dose, renal function, and other factors on audiometrically-assessed ototoxicity in more than 1400 adult-onset cancer survivors from The Platinum Study: a multicentre cohort study"],"prefix":"10.1016","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5033-6643","authenticated-orcid":false,"given":"Victoria A.","family":"Sanchez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0235-8519","authenticated-orcid":false,"suffix":"Jr.","given":"Paul C.","family":"Dinh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick O.","family":"Monahan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunkit","family":"Fung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Althouse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9593-3011","authenticated-orcid":false,"given":"Tim","family":"Stump","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennessa","family":"Rooker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Eileen","family":"Dolan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darren R.","family":"Feldman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"Hamilton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0766-9981","authenticated-orcid":false,"given":"Phillip M.","family":"Pierorazio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil E.","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Huddart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Kollmannsberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7332-6165","authenticated-orcid":false,"given":"James","family":"Root","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard D.","family":"Sesso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mandy","family":"Weinzierl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence H.","family":"Einhorn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert D.","family":"Frisina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lois B.","family":"Travis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.eclinm.2026.103841_bib1","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1080\/0284186X.2020.1724328","article-title":"Longitudinal kidney function outcome in aging testicular cancer survivors","volume":"59","author":"Nome","year":"2020","journal-title":"Acta Oncol"},{"issue":"7","key":"10.1016\/j.eclinm.2026.103841_bib2","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1001\/jamaoncol.2024.1233","article-title":"Comprehensive audiologic analyses after cisplatin-based chemotherapy","volume":"10","author":"Sanchez","year":"2024","journal-title":"JAMA Oncol"},{"issue":"23","key":"10.1016\/j.eclinm.2026.103841_bib3","doi-asserted-by":"crossref","first-page":"2712","DOI":"10.1200\/JCO.2016.66.8822","article-title":"Comprehensive audiometric analysis of hearing impairment and tinnitus after cisplatin-based chemotherapy in survivors of adult-onset cancer","volume":"34","author":"Frisina","year":"2016","journal-title":"J Clin Oncol"},{"issue":"12","key":"10.1016\/j.eclinm.2026.103841_bib4","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.1200\/JCO.22.01456","article-title":"Patient-reported functional impairment due to hearing loss and tinnitus after cisplatin-based chemotherapy","volume":"41","author":"Sanchez","year":"2023","journal-title":"J Clin Oncol"},{"issue":"5","key":"10.1016\/j.eclinm.2026.103841_bib5","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/s41581-024-00808-2","article-title":"The multifaceted links between hearing loss and chronic kidney disease","volume":"20","author":"Greenberg","year":"2024","journal-title":"Nat Rev Nephrol"},{"issue":"1","key":"10.1016\/j.eclinm.2026.103841_bib6","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1186\/s12882-020-01810-z","article-title":"The association between reduced kidney function and hearing loss: a cross-sectional study","volume":"21","author":"Liu","year":"2020","journal-title":"BMC Nephrol"},{"key":"10.1016\/j.eclinm.2026.103841_bib7","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/bs.acr.2021.03.008","article-title":"Cisplatin chemotherapy and renal function","volume":"152","author":"Zhang","year":"2021","journal-title":"Adv Cancer Res"},{"issue":"1","key":"10.1016\/j.eclinm.2026.103841_bib8","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-017-01837-1","article-title":"Cisplatin is retained in the cochlea indefinitely following chemotherapy","volume":"8","author":"Breglio","year":"2017","journal-title":"Nat Commun"},{"issue":"4S","key":"10.1016\/j.eclinm.2026.103841_bib9","first-page":"S117","article-title":"KDIGO 2024 clinical practice guideline for the evaluation and management of chronic kidney disease","volume":"105","year":"2024","journal-title":"Kidney Int"},{"issue":"12","key":"10.1016\/j.eclinm.2026.103841_bib10","doi-asserted-by":"crossref","first-page":"2994","DOI":"10.1681\/ASN.2021070988","article-title":"A unifying approach for GFR estimation: recommendations of the NKF-ASN task force on reassessing the inclusion of race in diagnosing kidney disease","volume":"32","author":"Delgado","year":"2021","journal-title":"J Am Soc Nephrol : JASN (J Am Soc Nephrol)"},{"issue":"6","key":"10.1016\/j.eclinm.2026.103841_bib11","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1097\/CCM.0000000000006237","article-title":"Toward equitable kidney function estimation in critical care practice: guidance from the society of critical care medicine's diversity, equity, and inclusion in renal clinical practice task force","volume":"52","author":"Miano","year":"2024","journal-title":"Crit Care Med"},{"issue":"3","key":"10.1016\/j.eclinm.2026.103841_bib12","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1124\/jpet.124.002287","article-title":"Understanding cisplatin pharmacokinetics and toxicodynamics to predict and prevent kidney injury","volume":"391","author":"Thompson","year":"2024","journal-title":"J Pharmacol Exp Therapeut"},{"key":"10.1016\/j.eclinm.2026.103841_bib13","series-title":"Using Multivariate Statistics. Seventh Edition","author":"Tabachnick","year":"2019"},{"issue":"21","key":"10.1016\/j.eclinm.2026.103841_bib14","doi-asserted-by":"crossref","first-page":"2433","DOI":"10.1200\/JCO-24-02534","article-title":"Nephrotoxicity surveillance for childhood and young adult survivors of cancer: recommendations from the international late effects of childhood cancer guideline harmonization group","volume":"43","author":"Kooijmans","year":"2025","journal-title":"J Clin Oncol"},{"issue":"3","key":"10.1016\/j.eclinm.2026.103841_bib15","doi-asserted-by":"crossref","DOI":"10.1002\/pbc.31479","article-title":"Otoprotective effects of sodium thiosulfate by demographic and clinical characteristics: a report from children's oncology group study ACCL0431","volume":"72","author":"Ohlsen","year":"2025","journal-title":"Pediatr Blood Cancer"},{"issue":"6","key":"10.1016\/j.eclinm.2026.103841_bib16","doi-asserted-by":"crossref","DOI":"10.3390\/cancers15061759","article-title":"Association of clinical aspects and genetic variants with the severity of cisplatin-induced ototoxicity in head and neck squamous cell carcinoma: a prospective cohort study","volume":"15","author":"Macedo","year":"2023","journal-title":"Cancers (Basel)"},{"issue":"6","key":"10.1016\/j.eclinm.2026.103841_bib17","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1002\/ohn.222","article-title":"Systematic review and meta-analysis of the influence of genetic variation on ototoxicity in platinum-based chemotherapy","volume":"168","author":"Hong","year":"2023","journal-title":"Otolaryngol Head Neck Surg :"},{"issue":"10","key":"10.1016\/j.eclinm.2026.103841_bib18","doi-asserted-by":"crossref","first-page":"3485","DOI":"10.1002\/lary.32237","article-title":"Physical activity, physical fitness for hearing loss in adults: a systematic review","volume":"135","author":"Li","year":"2025","journal-title":"Laryngoscope"},{"issue":"2","key":"10.1016\/j.eclinm.2026.103841_bib19","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1097\/AUD.0000000000000486","article-title":"Characteristics of real-world signal to noise ratios and speech listening situations of older adults with mild to moderate hearing loss","volume":"39","author":"Wu","year":"2018","journal-title":"Ear Hear"},{"issue":"3","key":"10.1016\/j.eclinm.2026.103841_bib20","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1002\/alz.12416","article-title":"Speech-in-noise hearing impairment is associated with an increased risk of incident dementia in 82,039 UK Biobank participants","volume":"18","author":"Stevenson","year":"2022","journal-title":"Alzheimer's Dement"},{"key":"10.1016\/j.eclinm.2026.103841_bib21","series-title":"Measuring Meaningful Outcomes for Adult Hearing Health Interventions","first-page":"266","year":"2025"},{"issue":"10","key":"10.1016\/j.eclinm.2026.103841_bib22","doi-asserted-by":"crossref","first-page":"2838","DOI":"10.1681\/ASN.2017040421","article-title":"Structural and functional changes in human kidneys with healthy aging","volume":"28","author":"Hommos","year":"2017","journal-title":"J Am Soc Nephrol"},{"issue":"1","key":"10.1016\/j.eclinm.2026.103841_bib23","doi-asserted-by":"crossref","DOI":"10.1172\/JCI142616","article-title":"Atorvastatin is associated with reduced cisplatin-induced hearing loss","volume":"131","author":"Fernandez","year":"2021","journal-title":"J Clin Investig"},{"key":"10.1016\/j.eclinm.2026.103841_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.heares.2022.108453","article-title":"Statins and hearing","volume":"425","author":"Whitlon","year":"2022","journal-title":"Hear Res"},{"issue":"25","key":"10.1016\/j.eclinm.2026.103841_bib25","doi-asserted-by":"crossref","first-page":"2376","DOI":"10.1056\/NEJMoa1801109","article-title":"Sodium thiosulfate for protection from cisplatin-induced hearing loss","volume":"378","author":"Brock","year":"2018","journal-title":"N Engl J Med"},{"issue":"25","key":"10.1016\/j.eclinm.2026.103841_bib26","doi-asserted-by":"crossref","first-page":"2465","DOI":"10.1056\/NEJMra1616601","article-title":"Hearing loss in adults","volume":"377","author":"Cunningham","year":"2017","journal-title":"N Engl J Med"},{"key":"10.1016\/j.eclinm.2026.103841_bib27","series-title":"World Report on Hearing","year":"2021"},{"issue":"10452","key":"10.1016\/j.eclinm.2026.103841_bib28","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/S0140-6736(24)01296-0","article-title":"Dementia prevention, intervention, and care: 2024 report of the Lancet standing Commission","volume":"404","author":"Livingston","year":"2024","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.eclinm.2026.103841_bib29","doi-asserted-by":"crossref","first-page":"e66","DOI":"10.1016\/S2666-7568(23)00232-5","article-title":"Association between hearing aid use and mortality in adults with hearing loss in the USA: a mortality follow-up study of a cross-sectional cohort","volume":"5","author":"Choi","year":"2024","journal-title":"Lancet Healthy Longev"},{"key":"10.1016\/j.eclinm.2026.103841_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.canep.2022.102203","article-title":"Global burden of ototoxic hearing loss associated with platinum-based cancer treatment: a systematic review and meta-analysis","volume":"79","author":"Dillard","year":"2022","journal-title":"Cancer Epidemiol"},{"issue":"5","key":"10.1016\/j.eclinm.2026.103841_bib31","doi-asserted-by":"crossref","DOI":"10.1002\/alz.70156","article-title":"Cognitive benefits of hearing intervention vary by risk of cognitive decline: a secondary analysis of the ACHIEVE trial","volume":"21","author":"Pike","year":"2025","journal-title":"Alzheimer's Dement"},{"issue":"12","key":"10.1016\/j.eclinm.2026.103841_bib32","doi-asserted-by":"crossref","first-page":"3784","DOI":"10.1111\/jgs.19185","article-title":"Effect of hearing intervention on communicative function: a secondary analysis of the ACHIEVE randomized controlled trial","volume":"72","author":"Sanchez","year":"2024","journal-title":"J Am Geriatr Soc"},{"issue":"10404","key":"10.1016\/j.eclinm.2026.103841_bib33","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1016\/S0140-6736(23)01406-X","article-title":"Hearing intervention versus health education control to reduce cognitive decline in older adults with hearing loss in the USA (ACHIEVE): a multicentre, randomised controlled trial","volume":"402","author":"Lin","year":"2023","journal-title":"Lancet"},{"issue":"4","key":"10.1016\/j.eclinm.2026.103841_bib34","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0283639","article-title":"Cisplatin-associated ototoxicity amongst cervical cancer patients: a prospective cohort study in South Africa","volume":"18","author":"Paken","year":"2023","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.eclinm.2026.103841_bib35","doi-asserted-by":"crossref","first-page":"22","DOI":"10.3390\/audiolres15020022","article-title":"Strategies to mitigate cisplatin-induced ototoxicity: a literature review of protective agents, mechanisms, and clinical gaps","volume":"15","author":"Orasan","year":"2025","journal-title":"Audiology Res"}],"container-title":["eClinicalMedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S258953702600088X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S258953702600088X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T04:08:59Z","timestamp":1778904539000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S258953702600088X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":35,"alternative-id":["S258953702600088X"],"URL":"https:\/\/doi.org\/10.1016\/j.eclinm.2026.103841","relation":{},"ISSN":["2589-5370"],"issn-type":[{"value":"2589-5370","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impact of cisplatin dose, renal function, and other factors on audiometrically-assessed ototoxicity in more than 1400 adult-onset cancer survivors from The Platinum Study: a multicentre cohort study","name":"articletitle","label":"Article Title"},{"value":"eClinicalMedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.eclinm.2026.103841","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"103841"}}