{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T09:09:10Z","timestamp":1791796150622,"version":"4.3.4"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T00:00:00Z","timestamp":1774569600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["FWO1S93026N"],"award-info":[{"award-number":["FWO1S93026N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002996","name":"Netherlands Heart Foundation","doi-asserted-by":"publisher","award":["03-003-2024-0118"],"award-info":[{"award-number":["03-003-2024-0118"]}],"id":[{"id":"10.13039\/501100002996","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002996","name":"Netherlands Heart Foundation","doi-asserted-by":"publisher","award":["02-001-2023-0141 2023 DHF-BHF- DZHK"],"award-info":[{"award-number":["02-001-2023-0141 2023 DHF-BHF- DZHK"]}],"id":[{"id":"10.13039\/501100002996","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["eClinicalMedicine"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.eclinm.2026.103894","type":"journal-article","created":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T16:07:38Z","timestamp":1776182858000},"page":"103894","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Resynchronising care: addressing sex differences in cardiac resynchronisation therapy"],"prefix":"10.1016","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-7748-7687","authenticated-orcid":false,"given":"Laura","family":"van Pelt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas","family":"Erzeel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominic A.","family":"Theuns","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilfried","family":"Mullens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4775-9140","authenticated-orcid":false,"given":"Rudolf A.","family":"de Boer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pieter","family":"Martens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chahinda","family":"Ghossein-Doha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.eclinm.2026.103894_bib1","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1093\/eurheartj\/ehv598","article-title":"Gender in cardiovascular diseases: impact on clinical manifestations, management, and outcomes","volume":"37","author":"Group","year":"2016","journal-title":"Eur Heart J"},{"issue":"1","key":"10.1016\/j.eclinm.2026.103894_bib2","doi-asserted-by":"crossref","first-page":"9","DOI":"10.15420\/aer.2011.3.1.9","article-title":"Current evidence and recommendations for cardiac resynchronisation therapy","volume":"3","author":"Dewhurst","year":"2014","journal-title":"Arrhythm Electrophysiol Rev"},{"issue":"8","key":"10.1016\/j.eclinm.2026.103894_bib3","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1093\/europace\/euaa411","article-title":"Optimized implementation of cardiac resynchronization therapy: a call for action for referral and optimization of care","volume":"23","author":"Mullens","year":"2021","journal-title":"Europace"},{"issue":"7","key":"10.1016\/j.eclinm.2026.103894_bib4","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/j.jacc.2010.06.061","article-title":"Cardiac resynchronization therapy is more effective in women than in men: the MADIT-CRT (Multicenter Automatic Defibrillator Implantation Trial with Cardiac Resynchronization Therapy) trial","volume":"57","author":"Arshad","year":"2011","journal-title":"J Am Coll Cardiol"},{"issue":"25","key":"10.1016\/j.eclinm.2026.103894_bib5","doi-asserted-by":"crossref","first-page":"2385","DOI":"10.1056\/NEJMoa1009540","article-title":"Cardiac-resynchronization therapy for mild-to-moderate heart failure","volume":"363","author":"Tang","year":"2010","journal-title":"N Engl J Med"},{"issue":"35","key":"10.1016\/j.eclinm.2026.103894_bib6","doi-asserted-by":"crossref","first-page":"3427","DOI":"10.1093\/eurheartj\/ehab364","volume":"42","author":"Glikson","year":"2021","journal-title":"Eur Heart J"},{"issue":"18","key":"10.1016\/j.eclinm.2026.103894_bib7","first-page":"e895","article-title":"2022 AHA\/ACC\/HFSA guideline for the management of heart failure: a report of the American College of Cardiology\/American Heart Association Joint Committee on clinical practice Guidelines","volume":"145","author":"Heidenreich","year":"2022","journal-title":"Circulation"},{"issue":"9","key":"10.1016\/j.eclinm.2026.103894_bib8","doi-asserted-by":"crossref","first-page":"e17","DOI":"10.1016\/j.hrthm.2023.03.1538","article-title":"2023 HRS\/APHRS\/LAHRS guideline on cardiac physiologic pacing for the avoidance and mitigation of heart failure","volume":"20","author":"Chung","year":"2023","journal-title":"Heart Rhythm"},{"issue":"14","key":"10.1016\/j.eclinm.2026.103894_bib9","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1056\/NEJMoa0906431","article-title":"Cardiac-resynchronization therapy for the prevention of heart-failure events","volume":"361","author":"Moss","year":"2009","journal-title":"N Engl J Med"},{"key":"10.1016\/j.eclinm.2026.103894_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijcard.2025.133526","article-title":"Sex-specific response to cardiac resynchronization therapy: the BIO|WOMEN trial","volume":"438","author":"Zamorano","year":"2025","journal-title":"Int J Cardiol"},{"issue":"10408","key":"10.1016\/j.eclinm.2026.103894_bib11","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1016\/S0140-6736(23)00912-1","article-title":"Adaptive versus conventional cardiac resynchronisation therapy in patients with heart failure (AdaptResponse): a global, prospective, randomised controlled trial","volume":"402","author":"Wilkoff","year":"2023","journal-title":"Lancet"},{"issue":"11","key":"10.1016\/j.eclinm.2026.103894_bib12","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1002\/clc.22203","article-title":"Gender-related safety and efficacy of cardiac resynchronization therapy","volume":"36","author":"Schuchert","year":"2013","journal-title":"Clin Cardiol"},{"issue":"2","key":"10.1016\/j.eclinm.2026.103894_bib13","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/s10840-005-6545-3","article-title":"Ventricular reverse remodeling and 6-month outcomes in patients receiving cardiac resynchronization therapy: analysis of the MIRACLE study","volume":"12","author":"Woo","year":"2005","journal-title":"J Interv Card Electrophysiol"},{"issue":"9","key":"10.1016\/j.eclinm.2026.103894_bib14","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1016\/j.jacep.2019.06.007","article-title":"Cardiac resynchronization in women: a substudy of the resynchronization-defibrillation for ambulatory heart failure trial","volume":"5","author":"de Waard","year":"2019","journal-title":"JACC Clin Electrophysiol"},{"issue":"6","key":"10.1016\/j.eclinm.2026.103894_bib15","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/j.hrthm.2024.01.058","article-title":"Relationship between sex, body size, and cardiac resynchronization therapy benefit: a patient-level meta-analysis of randomized controlled trials","volume":"21","author":"Friedman","year":"2024","journal-title":"Heart Rhythm"},{"issue":"5","key":"10.1016\/j.eclinm.2026.103894_bib16","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.3390\/jcm11051279","article-title":"QRS narrowing following CRT implantation: predictors, dynamics, and Association with improved long-term outcome","volume":"11","author":"Lapidot","year":"2022","journal-title":"J Clin Med"},{"issue":"5","key":"10.1016\/j.eclinm.2026.103894_bib17","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/j.hrthm.2011.12.013","article-title":"Potential mechanisms underlying the effect of gender on response to cardiac resynchronization therapy: insights from the SMART-AV multicenter trial","volume":"9","author":"Cheng","year":"2012","journal-title":"Heart Rhythm"},{"issue":"1","key":"10.1016\/j.eclinm.2026.103894_bib18","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCEP.120.008452","article-title":"Heart size corrected electrical dyssynchrony and its impact on sex-specific response to cardiac resynchronization therapy","volume":"14","author":"Salden","year":"2021","journal-title":"Circ Arrhythm Electrophysiol"},{"issue":"6","key":"10.1016\/j.eclinm.2026.103894_bib19","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1016\/j.jelectrocard.2014.07.022","article-title":"Normal values of the electrocardiogram for ages 16-90 years","volume":"47","author":"Rijnbeek","year":"2014","journal-title":"J Electrocardiol"},{"issue":"6","key":"10.1016\/j.eclinm.2026.103894_bib20","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1016\/S0735-1097(02)01712-6","article-title":"Gender differences and normal left ventricular anatomy in an adult population free of hypertension. A cardiovascular magnetic resonance study of the Framingham Heart Study Offspring cohort","volume":"39","author":"Salton","year":"2002","journal-title":"J Am Coll Cardiol"},{"issue":"6","key":"10.1016\/j.eclinm.2026.103894_bib21","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1536\/ihj.46.1105","article-title":"Gender disparities in cardiac cellular electrophysiology and arrhythmia susceptibility in human failing ventricular myocytes","volume":"46","author":"Verkerk","year":"2005","journal-title":"Int Heart J"},{"issue":"6","key":"10.1016\/j.eclinm.2026.103894_bib22","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1002\/ejhf.2524","article-title":"The effect of cardiac resynchronization without a defibrillator on morbidity and mortality: an individual patient data meta-analysis of COMPANION and CARE-HF","volume":"24","author":"Cleland","year":"2022","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.eclinm.2026.103894_bib23","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.ijcard.2017.10.055","article-title":"Gender differences in electro-mechanical characteristics of left bundle branch block: potential implications for selection and response of cardiac resynchronization therapy","volume":"257","author":"De Pooter","year":"2018","journal-title":"Int J Cardiol"},{"issue":"12","key":"10.1016\/j.eclinm.2026.103894_bib24","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.123.035279","article-title":"Heart size difference drives sex-specific response to cardiac resynchronization therapy: a post hoc analysis of the MORE-MPP CRT trial","volume":"13","author":"Wijesuriya","year":"2024","journal-title":"J Am Heart Assoc"},{"issue":"12","key":"10.1016\/j.eclinm.2026.103894_bib25","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1016\/j.bpj.2019.08.025","article-title":"Sex-Dependent QRS Guidelines for cardiac resynchronization therapy using computer model predictions","volume":"117","author":"Lee","year":"2019","journal-title":"Biophys J"},{"issue":"4","key":"10.1016\/j.eclinm.2026.103894_bib26","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.ihj.2019.09.007","article-title":"Incidence and predictors of super-response to cardiac resynchronization therapy","volume":"71","author":"Rohit","year":"2019","journal-title":"Indian Heart J"},{"issue":"5","key":"10.1016\/j.eclinm.2026.103894_bib27","first-page":"1362","article-title":"Cardiac resynchronization therapy in non-ischemic cardiomyopathy","volume":"8","author":"Shanks","year":"2016","journal-title":"J Atr Fibrillation"},{"issue":"5","key":"10.1016\/j.eclinm.2026.103894_bib28","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.hrthm.2013.01.003","article-title":"Cardiac MRI scar patterns differ by sex in an implantable cardioverter-defibrillator and cardiac resynchronization therapy cohort","volume":"10","author":"Loring","year":"2013","journal-title":"Heart Rhythm"},{"issue":"11","key":"10.1016\/j.eclinm.2026.103894_bib29","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1016\/j.jchf.2024.08.010","article-title":"Cardiac resynchronization therapy in ischemic versus nonischemic cardiomyopathy: patient-level meta-analysis of 7 randomized clinical trials","volume":"12","author":"Sudesh","year":"2024","journal-title":"JACC Heart Fail"},{"issue":"18","key":"10.1016\/j.eclinm.2026.103894_bib30","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1136\/heartjnl-2015-309212","article-title":"Ethnic differences in the association of QRS duration with ejection fraction and outcome in heart failure","volume":"102","author":"Gijsberts","year":"2016","journal-title":"Heart"}],"container-title":["eClinicalMedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589537026001422?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589537026001422?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T04:08:55Z","timestamp":1778904535000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589537026001422"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":30,"alternative-id":["S2589537026001422"],"URL":"https:\/\/doi.org\/10.1016\/j.eclinm.2026.103894","relation":{},"ISSN":["2589-5370"],"issn-type":[{"value":"2589-5370","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Resynchronising care: addressing sex differences in cardiac resynchronisation therapy","name":"articletitle","label":"Article Title"},{"value":"eClinicalMedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.eclinm.2026.103894","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"103894"}}