{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T06:29:25Z","timestamp":1793946565683,"version":"4.8.0"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T00:00:00Z","timestamp":1779753600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["eClinicalMedicine"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.eclinm.2026.104010","type":"journal-article","created":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T05:16:12Z","timestamp":1783919772000},"page":"104010","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Mesoglycan for long-term secondary prevention in patients with superficial vein thrombosis (METRO): a multicentre randomised clinical trial in Italy"],"prefix":"10.1016","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0881-5429","authenticated-orcid":false,"given":"Giuseppe","family":"Camporese","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Bernardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristiano","family":"Bortoluzzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franco","family":"Noventa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ambra","family":"Sammarco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Tonello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beniamino","family":"Zalunardo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corrado","family":"Amato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8343-4888","authenticated-orcid":false,"given":"Cecilia","family":"Becattini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ornella","family":"Barbato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo","family":"Santoliquido","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nello","family":"Zanatta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico","family":"Angiletta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Dentali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Mastroiacovo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter","family":"Dorigo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oriana","family":"Zingaretti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Amitrano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Catalini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella","family":"Tufano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8484-4598","authenticated-orcid":false,"given":"Pierpaolo","family":"Di Micco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios","family":"Kontothanassis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Simioni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Prandoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Campello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaele","family":"Pesavento","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Spiezia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Simion","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Scarinzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ngoc Vo","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michela","family":"Nardin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Maggiolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Vison\u00e0","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Bigolin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana Scanduzzi","family":"Piovesan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ida Maria","family":"Muratori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Contorno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Sartore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Franco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mara","family":"Graziani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Santoro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Zac\u00e0","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Di Stefano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia","family":"Abenante","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedetta","family":"Volpe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Frasca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro","family":"Pinelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Giantomassi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenza","family":"Pedone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Dimitri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaele","family":"Pulli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Paperetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Saturni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Mangiacapra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Cannavacciuolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Di Minno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.eclinm.2026.104010_bib1","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/S0741-5214(98)70233-2","article-title":"Saphenous vein thrombophlebitis (SVT): a deceptively benign disease","volume":"27","author":"Hanson","year":"1998","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.eclinm.2026.104010_bib2","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1111\/jth.12575","article-title":"Annual diagnosis rate of superficial-vein thrombosis of the lower limbs: the STEPH community-based study","volume":"12","author":"Frapp\u00e8","year":"2014","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.eclinm.2026.104010_bib3","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1182\/blood-2013-04-498014","article-title":"Clinical relevance of symptomatic superficial-vein thrombosis extension: lessons from the CALISTO study","volume":"122","author":"Leizorovicz","year":"2013","journal-title":"Blood"},{"issue":"6","key":"10.1016\/j.eclinm.2026.104010_bib4","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1016\/S0741-5214(99)70051-0","article-title":"An unexpectedly high rate of pulmonary embolism in patients with superficial thrombophlebitis of the thigh","volume":"30","author":"Verlato","year":"1999","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.eclinm.2026.104010_bib5","doi-asserted-by":"crossref","first-page":"218","DOI":"10.7326\/0003-4819-152-4-201002160-00006","article-title":"Superficial venous thrombosis and venous thromboembolism: a large prospective epidemiologic study","volume":"152","author":"Decousus","year":"2010","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.eclinm.2026.104010_bib6","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1160\/TH10-06-0406","article-title":"Predictive factors for concurrent deep vein thrombosis and symptomatic venous thromboembolic recurrence in case of superficial venous thrombosis. OPTIMEV study","volume":"105","author":"Galanaud","year":"2011","journal-title":"Thromb Haemost"},{"issue":"13","key":"10.1016\/j.eclinm.2026.104010_bib7","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1056\/NEJMoa0912072","article-title":"Fondaparinux for the treatment of superficial-vein thrombosis in the legs","volume":"363","author":"Decousus","year":"2010","journal-title":"NEJM"},{"issue":"6","key":"10.1016\/j.eclinm.2026.104010_bib8","doi-asserted-by":"crossref","first-page":"e545","DOI":"10.1016\/j.chest.2021.07.055","article-title":"Antithrombotic therapy for VTE disease: Second update of the CHEST Guideline and expert panel report","volume":"160","author":"Stevens","year":"2021","journal-title":"Chest"},{"key":"10.1016\/j.eclinm.2026.104010_bib9","article-title":"Treatment for superficial thrombophlebitis of the leg","volume":"4","author":"Di Nisio","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"issue":"2","key":"10.1016\/j.eclinm.2026.104010_bib10","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/j.jtha.2023.10.017","article-title":"Incidence of venous thromboembolism, recurrence, and bleeding after isolated superficial vein thrombosis: findings from the venous thrombosis registry in \u00d8stfold Hospital","volume":"22","author":"J\u00f8rgensen","year":"2024","journal-title":"J Thromb Haemost"},{"issue":"11","key":"10.1016\/j.eclinm.2026.104010_bib11","doi-asserted-by":"crossref","first-page":"2176","DOI":"10.1111\/jth.13840","article-title":"Clinical course of patients with symptomatic isolated superficial vein thrombosis: the ICARO follow-up study","volume":"15","author":"Barco","year":"2017","journal-title":"J Thromb Haemost"},{"issue":"2","key":"10.1016\/j.eclinm.2026.104010_bib12","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.ejvs.2021.04.015","article-title":"Management and outcomes of patients with isolated superficial vein thrombosis under real life conditions (INSIGHTS-SVT)","volume":"62","author":"Bauersachs","year":"2021","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"10.1016\/j.eclinm.2026.104010_bib13","doi-asserted-by":"crossref","first-page":"569","DOI":"10.2147\/VHRM.S15562","article-title":"Superficial venous thrombosis: disease progression and evolving treatment approaches","volume":"7","author":"Litzendorf","year":"2011","journal-title":"Vasc Health Risk Manag"},{"key":"10.1016\/j.eclinm.2026.104010_bib14","first-page":"70","article-title":"Superficial thrombophlebitis of lower limbs","volume":"91","author":"Husni","year":"1982","journal-title":"Surgery"},{"key":"10.1016\/j.eclinm.2026.104010_bib15","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/S0741-5214(95)70049-8","article-title":"Preliminary results of a nonoperative approach to saphenofemoral junction thrombophlebitis","volume":"22","author":"Ascher","year":"1995","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.eclinm.2026.104010_bib16","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1067\/mva.2003.157","article-title":"Superficial thrombophlebitis and risk for recurrent venous thromboembolism","volume":"37","author":"Schonauer","year":"2003","journal-title":"J Vasc Surg"},{"issue":"2","key":"10.1016\/j.eclinm.2026.104010_bib17","article-title":"Mesoglycan attenuates VSMC proliferation through activation of AMP-activated protein kinase and mTOR","volume":"22","author":"Lee","year":"2016","journal-title":"Clin Hypertens"},{"issue":"5","key":"10.1016\/j.eclinm.2026.104010_bib18","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1177\/0268355515587194","article-title":"Pharmacological adjuncts for chronic venous ulcer healing: a systematic review","volume":"31","author":"Varatharajan","year":"2016","journal-title":"Phlebology"},{"key":"10.1016\/j.eclinm.2026.104010_bib19","article-title":"Mesoglycan: clinical evidences for use in vascular diseases","volume":"2010","author":"Tufano","year":"2010","journal-title":"Int J Vasc Med"},{"key":"10.1016\/j.eclinm.2026.104010_bib20","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1182\/blood.V64.3.742.742","article-title":"Heparan sulfate and dermatan sulfate inhibit the generation of thrombin activity in plasma by complementary pathways","volume":"64","author":"Ofosu","year":"1984","journal-title":"Blood"},{"key":"10.1016\/j.eclinm.2026.104010_bib21","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.atherosclerosis.2015.10.007","article-title":"Mesoglycan improves vascular reactivity and insulin sensitivity in patients with metabolic syndrome","volume":"243","author":"Valvano","year":"2015","journal-title":"Atherosclerosis"},{"issue":"2","key":"10.1016\/j.eclinm.2026.104010_bib22","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1007\/s13304-024-01776-9","article-title":"Clinical evidence and rationale of mesoglycan to treat chronic venous disease and haemorrhoidal disease: a narrative review","volume":"76","author":"Gallo","year":"2014","journal-title":"Updates Surgery"},{"issue":"10","key":"10.1016\/j.eclinm.2026.104010_bib23","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0186116","article-title":"Regeneration of glycocalyx by heparan sulfate and sphingosine 1-phosphate restores inter-endothelial communication","volume":"12","author":"Mensah","year":"2017","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.eclinm.2026.104010_bib24","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1007\/s11239-023-02896-6","article-title":"Mesoglycan for the secondary prevention of superficial vein thrombosis: a randomized, controlled, double-blind study (METRO Study) \u2014rationale and protocol","volume":"57","author":"Camporese","year":"2023","journal-title":"J Thromb Thrombolysis"},{"key":"10.1016\/j.eclinm.2026.104010_bib25","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1067\/mva.2003.152","article-title":"Evaluating outcomes in chronic venous disorders of the leg: development of a scientifically rigorous patient-reported measure of symptoms and quality of life","volume":"37","author":"Lamping","year":"2003","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.eclinm.2026.104010_bib26","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/S0741-5214(03)00323-9","article-title":"Validation of the new venous severity scoring system in varicose vein surgery","volume":"38","author":"Kakkos","year":"2003","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.eclinm.2026.104010_bib27","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1016\/j.jvs.2010.06.161","article-title":"Revision of the venous clinical severity score: venous outcomes consensus statement: special communication of the American Venous Forum Ad Hoc Outcomes Working Group","volume":"52","author":"Vasquez","year":"2010","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.eclinm.2026.104010_bib28","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1016\/j.jclinepi.2005.10.016","article-title":"VEINES-QOL\/Sym questionnaire was a reliable and valid disease-specific quality of life measure for deep venous thrombosis","volume":"59","author":"Kahn","year":"2006","journal-title":"J Clin Epidemiol"},{"key":"10.1016\/j.eclinm.2026.104010_bib29","doi-asserted-by":"crossref","first-page":"73","DOI":"10.7326\/0003-4819-149-2-200807150-00003","article-title":"Low-molecular-weight heparin versus graduated compression stockings for prevention of venous thromboembolism after knee arthroscopy. A randomised trial","volume":"149","author":"Camporese","year":"2008","journal-title":"Ann Intern Med"},{"issue":"4","key":"10.1016\/j.eclinm.2026.104010_bib30","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1111\/j.1538-7836.2005.01204.x","volume":"3","author":"Schulman","year":"2005","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.eclinm.2026.104010_bib31","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.1111\/jth.13140","article-title":"Definition of clinically relevant non-major bleeding in studies of anticoagulants in atrial fibrillation and venous thromboembolic disease in non-surgical patients: communication from the SSC of the ISTH","volume":"13","author":"Kaatz","year":"2015","journal-title":"J Thromb Haemost"},{"issue":"3","key":"10.1016\/j.eclinm.2026.104010_bib32","doi-asserted-by":"crossref","first-page":"e105","DOI":"10.1016\/S2352-3026(17)30014-5","article-title":"SURPRISE investigators. Prevention of thromboembolic complications in patients with superficial-vein thrombosis given rivaroxaban or fondaparinux: the open-label, randomised, non-inferiority SURPRISE phase 3b trial","volume":"4","author":"Beyer-Westendorf","year":"2017","journal-title":"Lancet Haematol"},{"issue":"6","key":"10.1016\/j.eclinm.2026.104010_bib33","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1111\/j.1538-7836.2012.04727.x","article-title":"A randomized double-blind study of low-molecular-weight heparin (parnaparin) for superficial vein thrombosis: STEFLUX (Superficial ThromboEmbolism and Fluxum)","volume":"10","author":"Cosmi","year":"2012","journal-title":"J Thromb Haemost"},{"issue":"9","key":"10.1016\/j.eclinm.2026.104010_bib34","doi-asserted-by":"crossref","first-page":"4046","DOI":"10.3390\/ijms26094046","article-title":"Local and systemic endothelial damage in patients with CEAP C2 chronic venous insufficiency: role of mesoglycan","volume":"26","author":"Santoliquido","year":"2025","journal-title":"Int J Molec Sci"},{"key":"10.1016\/j.eclinm.2026.104010_bib35","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.bcp.2009.04.029","article-title":"Inflammatory cytokines in vascular dysfunction and vascular disease","volume":"78","author":"Sprague","year":"2009","journal-title":"Biochem Pharmacol"},{"issue":"2","key":"10.1016\/j.eclinm.2026.104010_bib36","doi-asserted-by":"crossref","first-page":"393","DOI":"10.5114\/aoms.2019.83292","article-title":"In patients with superficial vein thrombosis the inflammatory response is increased and related to the recanalization rate","volume":"15","author":"Poredos","year":"2019","journal-title":"Arch Med Sci"},{"issue":"4","key":"10.1016\/j.eclinm.2026.104010_bib37","first-page":"423","article-title":"The clinical course of deep-vein thrombosis. Prospective long-term follow-up of 528 symptomatic patients","volume":"82","author":"Prandoni","year":"1997","journal-title":"Haematologica"},{"key":"10.1016\/j.eclinm.2026.104010_bib38","series-title":"Evidence-based medicine: how to practice and teach EBM","author":"Sackett","year":"1997"}],"container-title":["eClinicalMedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589537026002592?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589537026002592?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T05:50:38Z","timestamp":1793944238000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589537026002592"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":38,"alternative-id":["S2589537026002592"],"URL":"https:\/\/doi.org\/10.1016\/j.eclinm.2026.104010","relation":{},"ISSN":["2589-5370"],"issn-type":[{"value":"2589-5370","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mesoglycan for long-term secondary prevention in patients with superficial vein thrombosis (METRO): a multicentre randomised clinical trial in Italy","name":"articletitle","label":"Article Title"},{"value":"eClinicalMedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.eclinm.2026.104010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"104010"}}