{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T22:32:11Z","timestamp":1793140331630,"version":"4.5.0"},"reference-count":61,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["RG\/F\/23\/110103"],"award-info":[{"award-number":["RG\/F\/23\/110103"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1101320"],"award-info":[{"award-number":["1101320"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["2009965"],"award-info":[{"award-number":["2009965"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001030","name":"National Heart Foundation of Australia","doi-asserted-by":"publisher","award":["105511"],"award-info":[{"award-number":["105511"]}],"id":[{"id":"10.13039\/501100001030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018956","name":"NIHR Cambridge Biomedical Research Centre","doi-asserted-by":"publisher","award":["NIHR203312"],"award-info":[{"award-number":["NIHR203312"]}],"id":[{"id":"10.13039\/501100018956","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["eClinicalMedicine"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.eclinm.2026.104159","type":"journal-article","created":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T12:49:07Z","timestamp":1787575747000},"page":"104159","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Integration of lipidomic and polygenic risk scores within contemporary clinical cardiovascular risk assessment pathways: a multi-cohort development and validation study"],"prefix":"10.1016","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-1110-454X","authenticated-orcid":false,"given":"Aleksandar","family":"Dakic","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2052-3875","authenticated-orcid":false,"given":"Jingqin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas G.","family":"Meikle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Huynh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changyu","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Habtamu B.","family":"Beyene","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agus","family":"Salim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Cinel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nat","family":"Mellett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thy","family":"Duong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra N.","family":"Faulkner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matilda","family":"van Buuren-Milne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anjali","family":"Bhagwat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan E.","family":"Shaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dianna J.","family":"Magliano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald F.","family":"Watts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Hung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennie","family":"Hui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John P.","family":"Beilby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Blangero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric K.","family":"Moses","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa C.","family":"Southey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger L.","family":"Milne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison M.","family":"Hodge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1049-5129","authenticated-orcid":false,"given":"John J.","family":"McNeil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Lacaze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenglong","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rory","family":"Wolfe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean YH.","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart M.","family":"Grieve","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4693-0038","authenticated-orcid":false,"given":"Clara K.","family":"Chow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen T.","family":"Vernon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1154-3011","authenticated-orcid":false,"given":"Michael P.","family":"Gray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gemma A.","family":"Figtree","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jedidiah I.","family":"Morton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5931-642X","authenticated-orcid":false,"given":"Paul","family":"Scuffham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9800-5296","authenticated-orcid":false,"given":"Mark","family":"Woodward","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Kalman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellie","family":"Paige","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melinda J.","family":"Carrington","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Inouye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6050-1259","authenticated-orcid":false,"given":"Corey","family":"Giles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2593-4665","authenticated-orcid":false,"given":"Peter J.","family":"Meikle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.eclinm.2026.104159_bib2","series-title":"Heart, stroke and vascular disease: australian facts, Summary","year":"2024"},{"key":"10.1016\/j.eclinm.2026.104159_bib3","first-page":"e596","article-title":"2019 ACC\/AHA Guideline on the primary prevention of cardiovascular disease: a report of the American college of Cardiology\/American Heart Association task force on clinical practice Guidelines","volume":"140","author":"Arnett","year":"2019","journal-title":"Circulation"},{"key":"10.1016\/j.eclinm.2026.104159_bib4","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1161\/CIRCULATIONAHA.123.067626","article-title":"Development and validation of the American Heart Association\u2019s PREVENT equations","volume":"149","author":"Khan","year":"2024","journal-title":"Circulation"},{"key":"10.1016\/j.eclinm.2026.104159_bib5","doi-asserted-by":"crossref","first-page":"2439","DOI":"10.1093\/eurheartj\/ehab309","article-title":"SCORE2 risk prediction algorithms: new models to estimate 10-year risk of cardiovascular disease in Europe","volume":"42","year":"2021","journal-title":"Eur Heart J"},{"key":"10.1016\/j.eclinm.2026.104159_bib6","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1038\/s41591-024-02905-y","article-title":"Development and validation of a new algorithm for improved cardiovascular risk prediction","volume":"30","author":"Hippisley-Cox","year":"2024","journal-title":"Nat Med"},{"key":"10.1016\/j.eclinm.2026.104159_bib7","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1016\/S0140-6736(18)30664-0","article-title":"Cardiovascular disease risk prediction equations in 400\u2008000 primary care patients in New Zealand: a derivation and validation study","volume":"391","author":"Pylypchuk","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.eclinm.2026.104159_bib8","doi-asserted-by":"crossref","first-page":"482","DOI":"10.5694\/mja2.52280","article-title":"2023 Australian guideline for assessing and managing cardiovascular disease risk","volume":"220","author":"Nelson","year":"2024","journal-title":"Med J Aust"},{"key":"10.1016\/j.eclinm.2026.104159_bib9","doi-asserted-by":"crossref","first-page":"197","DOI":"10.5694\/mja2.52718","article-title":"Development and calibration of the 2023 Australian cardiovascular disease risk prediction equations: a model updating study","volume":"223","author":"Paige","year":"2025","journal-title":"Med J Aust"},{"key":"10.1016\/j.eclinm.2026.104159_bib10","doi-asserted-by":"crossref","first-page":"e1406","DOI":"10.1016\/S2214-109X(25)00155-X","article-title":"The burden of cardiovascular events according to cardiovascular risk profile in adults from high-income, middle-income, and low-income countries (PURE): a cohort study","volume":"13","author":"Leong","year":"2025","journal-title":"Lancet Global Health"},{"key":"10.1016\/j.eclinm.2026.104159_bib11","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.jacc.2022.05.015","article-title":"New cardiovascular risk assessment techniques for primary prevention: JACC review topic of the week","volume":"80","author":"Verma","year":"2022","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.eclinm.2026.104159_bib12","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.chembiol.2018.10.008","article-title":"High-throughput plasma lipidomics: detailed mapping of the associations with cardiometabolic risk factors","volume":"26","author":"Huynh","year":"2019","journal-title":"Cell Chem Biol"},{"key":"10.1016\/j.eclinm.2026.104159_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.jlr.2021.100127","article-title":"Clinical lipidomics: realizing the potential of lipid profiling","volume":"62","author":"Meikle","year":"2021","journal-title":"J Lipid Res"},{"key":"10.1016\/j.eclinm.2026.104159_bib14","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1093\/ehjci\/jeu033","article-title":"Plasma lipidomic analysis predicts non-calcified coronary artery plaque in asymptomatic patients at intermediate risk of coronary artery disease","volume":"15","author":"Ellims","year":"2014","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"10.1016\/j.eclinm.2026.104159_bib15","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1093\/ehjci\/jeae058","article-title":"Plasma lipidomics and coronary plaque changes: a substudy of the SMARTool clinical trial","volume":"25","author":"Smit","year":"2024","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"10.1016\/j.eclinm.2026.104159_bib16","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.ahj.2022.05.012","article-title":"Associations of a polygenic risk score with coronary artery disease phenotypes in the prospective multicenter imaging study for evaluation of chest pain (PROMISE) trial","volume":"252","author":"Newman","year":"2022","journal-title":"Am Heart J"},{"key":"10.1016\/j.eclinm.2026.104159_bib17","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1016\/j.jcmg.2024.06.015","article-title":"Polygenic risk is associated with long-term coronary plaque progression and high-risk plaque","volume":"17","author":"Nurmohamed","year":"2024","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1016\/j.eclinm.2026.104159_bib18","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.jacc.2024.04.060","article-title":"Lipidomic risk score to enhance cardiovascular risk stratification for primary prevention","volume":"84","author":"Wu","year":"2024","journal-title":"JACC"},{"key":"10.1016\/j.eclinm.2026.104159_bib19","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1001\/jamacardio.2022.4466","article-title":"Predictive utility of a coronary artery disease polygenic risk score in primary prevention","volume":"8","author":"Marston","year":"2023","journal-title":"JAMA Cardiol"},{"key":"10.1016\/j.eclinm.2026.104159_bib20","doi-asserted-by":"crossref","first-page":"3152","DOI":"10.1093\/eurheartj\/ehae342","article-title":"Polygenic risk score adds to a clinical risk score in the prediction of cardiovascular disease in a clinical setting","volume":"45","author":"Samani","year":"2024","journal-title":"Eur Heart J"},{"key":"10.1016\/j.eclinm.2026.104159_bib21","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1093\/eurheartj\/ehae048","article-title":"Integration of a polygenic score into guideline-recommended prediction of cardiovascular disease","volume":"45","author":"Li","year":"2024","journal-title":"Eur Heart J"},{"key":"10.1016\/j.eclinm.2026.104159_bib22","first-page":"1861","article-title":"Combined clinical, metabolomic, and polygenic scores for cardiovascular risk prediction","volume":"47","author":"Ritchie","year":"2025","journal-title":"Eur Heart J"},{"key":"10.1016\/j.eclinm.2026.104159_bib23","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0168-8227(02)00025-6","article-title":"The Australian diabetes, obesity and lifestyle study (AusDiab)\u2013methods and response rates","volume":"57","author":"Dunstan","year":"2002","journal-title":"Diabetes Res Clin Pract"},{"key":"10.1016\/j.eclinm.2026.104159_bib24","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.2337\/diacare.26.6.1731","article-title":"The prevalence of and factors associated with diabetic retinopathy in the Australian population","volume":"26","author":"Tapp","year":"2003","journal-title":"Diabetes Care"},{"key":"10.1016\/j.eclinm.2026.104159_bib25","doi-asserted-by":"crossref","first-page":"650","DOI":"10.5694\/j.1326-5377.2008.tb02230.x","article-title":"On our selection: australian longitudinal research studies","volume":"189","author":"Gregory","year":"2008","journal-title":"Med J Aust"},{"key":"10.1016\/j.eclinm.2026.104159_bib26","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s00439-017-1856-x","article-title":"Pleiotropy of cardiometabolic syndrome with obesity-related anthropometric traits determined using empirically derived kinships from the Busselton Health Study","volume":"137","author":"Cadby","year":"2018","journal-title":"Hum Genet"},{"key":"10.1016\/j.eclinm.2026.104159_bib27","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1093\/ije\/dyx085","article-title":"Cohort Profile: The Melbourne Collaborative Cohort Study (Health 2020)","volume":"46","author":"Milne","year":"2017","journal-title":"Int J Epidemiol"},{"key":"10.1016\/j.eclinm.2026.104159_bib28","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1056\/NEJMoa1800722","article-title":"Effect of aspirin on disability-free survival in the healthy elderly","volume":"379","author":"McNeil","year":"2018","journal-title":"N Engl J Med"},{"key":"10.1016\/j.eclinm.2026.104159_bib29","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1056\/NEJMoa1805819","article-title":"Effect of aspirin on cardiovascular events and bleeding in the healthy elderly","volume":"379","author":"McNeil","year":"2018","journal-title":"N Engl J Med"},{"key":"10.1016\/j.eclinm.2026.104159_bib30","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2018-028649","article-title":"Biobanking for discovery of novel cardiovascular biomarkers using imaging-quantified disease burden: protocol for the longitudinal, prospective, BioHEART-CT cohort study","volume":"9","author":"Kott","year":"2019","journal-title":"BMJ Open"},{"key":"10.1016\/j.eclinm.2026.104159_bib31","doi-asserted-by":"crossref","first-page":"917","DOI":"10.3390\/biom13060917","article-title":"Lipidomics profiling and risk of coronary artery disease in the BioHEART-CT Discovery Cohort","volume":"13","author":"Zhu","year":"2023","journal-title":"Biomolecules"},{"key":"10.1016\/j.eclinm.2026.104159_bib32","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1161\/CIRCULATIONAHA.107.699579","article-title":"General cardiovascular risk profile for use in primary care","volume":"117","author":"D\u2019Agostino","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.eclinm.2026.104159_bib33","article-title":"High-coverage plasma lipidomics reveals novel sex-specific lipidomic fingerprints of age and BMI: Evidence from two large population cohort studies","volume":"18","author":"Beyene","year":"2020","journal-title":"PLoS Biol"},{"key":"10.1016\/j.eclinm.2026.104159_bib34","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1194\/jlr.RA119000594","article-title":"Heritability of 596 lipid species and genetic correlation with cardiovascular traits in the Busselton Family Heart Study [S]","volume":"61","author":"Cadby","year":"2020","journal-title":"J Lipid Res"},{"key":"10.1016\/j.eclinm.2026.104159_bib35","series-title":"Lipidomic analyses of large cohort studies define the role of lipid metabolism in bridging diet and metabolic health","author":"Meikle","year":"2025"},{"key":"10.1016\/j.eclinm.2026.104159_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2025.105826","article-title":"Trajectory of plasma lipidome associated with the risk of late-onset Alzheimer\u2019s disease: a longitudinal cohort study","volume":"118","author":"Wang","year":"2025","journal-title":"EBioMedicine"},{"key":"10.1016\/j.eclinm.2026.104159_bib37","doi-asserted-by":"crossref","first-page":"389","DOI":"10.3390\/metabo5020389","article-title":"An efficient single phase method for the extraction of plasma lipids","volume":"5","author":"Alshehry","year":"2015","journal-title":"Metabolites"},{"key":"10.1016\/j.eclinm.2026.104159_bib38","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1038\/s41467-024-45838-3","article-title":"Imputation of plasma lipid species to facilitate integration of lipidomic datasets","volume":"15","author":"Dakic","year":"2024","journal-title":"Nat Commun"},{"key":"10.1016\/j.eclinm.2026.104159_bib39","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1016\/j.jacc.2022.07.027","article-title":"Aspirin for primary prevention of cardiovascular events in relation to Lipoprotein(a) genotypes","volume":"80","author":"Lacaze","year":"2022","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.eclinm.2026.104159_bib40","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1038\/nprot.2010.116","article-title":"Data quality control in genetic case-control association studies","volume":"5","author":"Anderson","year":"2010","journal-title":"Nat Protoc"},{"key":"10.1016\/j.eclinm.2026.104159_bib41","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1038\/s41588-021-00783-5","article-title":"The Polygenic Score Catalog as an open database for reproducibility and systematic evaluation","volume":"53","author":"Lambert","year":"2021","journal-title":"Nat Genet"},{"key":"10.1016\/j.eclinm.2026.104159_bib42","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s13742-015-0047-8","article-title":"Second-generation PLINK: Rising to the challenge of larger and richer datasets","volume":"4","author":"Chang","year":"2015","journal-title":"GigaScience"},{"key":"10.1016\/j.eclinm.2026.104159_bib43","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v039.i05","article-title":"Regularization paths for Cox\u2019s proportional hazards model via coordinate descent","volume":"39","author":"Simon","year":"2011","journal-title":"J Stat Software"},{"key":"10.1016\/j.eclinm.2026.104159_bib44","doi-asserted-by":"crossref","first-page":"2109","DOI":"10.1002\/sim.1802","article-title":"Overall C as a measure of discrimination in survival analysis: model specific population value and confidence interval estimation","volume":"23","author":"Pencina","year":"2004","journal-title":"Stat Med"},{"key":"10.1016\/j.eclinm.2026.104159_bib45","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1177\/0962280213497434","article-title":"Assessing calibration of prognostic risk scores","volume":"25","author":"Crowson","year":"2016","journal-title":"Stat Methods Med Res"},{"key":"10.1016\/j.eclinm.2026.104159_bib46","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1002\/sim.4085","article-title":"Extensions of net reclassification improvement calculations to measure usefulness of new biomarkers","volume":"30","author":"Pencina","year":"2011","journal-title":"Stat Med"},{"key":"10.1016\/j.eclinm.2026.104159_bib47","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/1472-6947-8-53","article-title":"Extensions to decision curve analysis, a novel method for evaluating diagnostic tests, prediction models and molecular markers","volume":"8","author":"Vickers","year":"2008","journal-title":"BMC Med Inf Decis Making"},{"key":"10.1016\/j.eclinm.2026.104159_bib48","doi-asserted-by":"crossref","first-page":"i6","DOI":"10.1136\/bmj.i6","article-title":"Net benefit approaches to the evaluation of prediction models, molecular markers, and diagnostic tests","volume":"352","author":"Vickers","year":"2016","journal-title":"BMJ"},{"key":"10.1016\/j.eclinm.2026.104159_bib49","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1186\/1471-2288-13-113","article-title":"Derivation and assessment of risk prediction models using case-cohort data","volume":"13","author":"Sanderson","year":"2013","journal-title":"BMC Med Res Methodol"},{"key":"10.1016\/j.eclinm.2026.104159_bib50","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1093\/aje\/kwr374","article-title":"Risk prediction measures for case-cohort and nested case-control designs: an application to cardiovascular disease","volume":"175","author":"Ganna","year":"2012","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.eclinm.2026.104159_bib51","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.ajhg.2021.11.008","article-title":"Portability of 245 polygenic scores when derived from the UK Biobank and applied to 9 ancestry groups from the same cohort","volume":"109","author":"Priv\u00e9","year":"2022","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.eclinm.2026.104159_bib52","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1161\/CIRCULATIONAHA.114.013116","article-title":"Metabolite profiling and cardiovascular event risk","volume":"131","author":"W\u00fcrtz","year":"2015","journal-title":"Circulation"},{"key":"10.1016\/j.eclinm.2026.104159_bib53","doi-asserted-by":"crossref","DOI":"10.1093\/eurjpc\/zwaf254","article-title":"Metabolomics data improve 10-year cardiovascular risk prediction with the SCORE2 algorithm for the general population without cardiovascular disease or diabetes","author":"Xie","year":"2025","journal-title":"Eur J Prev Cardiol"},{"key":"10.1016\/j.eclinm.2026.104159_bib55","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1093\/eurjpc\/zwac176","article-title":"Including measures of chronic kidney disease to improve cardiovascular risk prediction by SCORE2 and SCORE2-OP","volume":"30","author":"Matsushita","year":"2023","journal-title":"Eur J Prev Cardiol"},{"key":"10.1016\/j.eclinm.2026.104159_bib56","doi-asserted-by":"crossref","first-page":"100552","DOI":"10.1016\/j.eclinm.2020.100552","article-title":"Incorporating kidney disease measures into cardiovascular risk prediction: development and validation in 9 million adults from 72 datasets","volume":"27","author":"Matsushita","year":"2020","journal-title":"eClinicalMedicine"},{"key":"10.1016\/j.eclinm.2026.104159_bib57","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.1253\/circj.CJ-19-0320","article-title":"Novel \u201cPredictor Patch\u201d method for adding predictors using estimates from outside datasets \u2015 A proof-of-concept study adding kidney measures to cardiovascular mortality prediction \u2015","volume":"83","author":"Matsushita","year":"2019","journal-title":"Circ J"},{"key":"10.1016\/j.eclinm.2026.104159_bib58","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3001561","article-title":"Lipidomic risk scores are independent of polygenic risk scores and can predict incidence of diabetes and cardiovascular disease in a large population cohort Locasale JW, editor","volume":"20","author":"Lauber","year":"2022","journal-title":"PLoS Biol"},{"key":"10.1016\/j.eclinm.2026.104159_bib59","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1373\/clinchem.2007.096529","article-title":"Statistical evaluation of prognostic versus diagnostic models: beyond the ROC curve","volume":"54","author":"Cook","year":"2008","journal-title":"Clin Chem"},{"key":"10.1016\/j.eclinm.2026.104159_bib60","doi-asserted-by":"crossref","first-page":"2385","DOI":"10.1016\/S0140-6736(21)00684-X","article-title":"The Lancet women and cardiovascular disease commission: reducing the global burden by 2030","volume":"397","author":"Vogel","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.eclinm.2026.104159_bib61","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1016\/S0140-6736(25)00055-8","article-title":"The Lancet Commission on rethinking coronary artery disease: moving from ischaemia to atheroma","volume":"405","author":"Zaman","year":"2025","journal-title":"Lancet"},{"key":"10.1016\/j.eclinm.2026.104159_bib62","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1093\/eurheartj\/ehae190","article-title":"Atherosclerosis evaluation and cardiovascular risk estimation using coronary computed tomography angiography","volume":"45","author":"Nurmohamed","year":"2024","journal-title":"Eur Heart J"},{"key":"10.1016\/j.eclinm.2026.104159_bib63","doi-asserted-by":"crossref","first-page":"9564","DOI":"10.1021\/acs.analchem.5c04984","article-title":"A clinical lipidomics platform: development and validation of a high-throughput LC-MS assay for cardiovascular disease risk assessment","volume":"98","author":"Meikle","year":"2026","journal-title":"Anal Chem"}],"container-title":["eClinicalMedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589537026004128?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589537026004128?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T21:35:00Z","timestamp":1793136900000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589537026004128"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":61,"alternative-id":["S2589537026004128"],"URL":"https:\/\/doi.org\/10.1016\/j.eclinm.2026.104159","relation":{},"ISSN":["2589-5370"],"issn-type":[{"value":"2589-5370","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Integration of lipidomic and polygenic risk scores within contemporary clinical cardiovascular risk assessment pathways: a multi-cohort development and validation study","name":"articletitle","label":"Article Title"},{"value":"eClinicalMedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.eclinm.2026.104159","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"104159"}}