{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T10:30:00Z","timestamp":1793788200182,"version":"4.6.1"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100014630","name":"Minist\u00e8re des Solidarit\u00e9s et de la Sant\u00e9","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014630","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005978","name":"Ministere de la Sante et des Solidarites","doi-asserted-by":"publisher","award":["PHRC-15-15-0201"],"award-info":[{"award-number":["PHRC-15-15-0201"]}],"id":[{"id":"10.13039\/501100005978","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["eClinicalMedicine"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.eclinm.2026.104262","type":"journal-article","created":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T12:09:36Z","timestamp":1791806976000},"page":"104262","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Efficacy and safety of temporary selective portal vein embolization before major hepatectomy (EMBORES): a phase 2 trial"],"prefix":"10.1016","volume":"101","author":[{"given":"Hadrien","family":"Tranchart","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Maitre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edouard","family":"Girard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Ghelfi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximiliano","family":"Gelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lambros","family":"Tselikas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0360-0875","authenticated-orcid":false,"given":"Maxime","family":"Barat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Fuks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Sarran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Benoist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Meyrignac","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ailton","family":"Sepulveda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7464-3939","authenticated-orcid":false,"given":"Maxime","family":"Ronot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5826-6045","authenticated-orcid":false,"given":"Maryne","family":"Pou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mircea","family":"Chirica","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim","family":"Dagher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Sengel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Brouquet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brice","family":"Gayet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Vilgrain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Cauchy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Soubrane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonor","family":"Benhaim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitri","family":"Tzanis:","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves","family":"Menu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien","family":"Gaujoux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Rocher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georges","family":"Rafek:","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Chague","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"De Baere","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane","family":"Goere","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micka\u00ebl","family":"Lesurtel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panagiotis","family":"Lainas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Gaillard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Derienne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Dioguardi Burgio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annie","family":"Sibert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Abdo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teodor","family":"Vasile","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Severine","family":"Foucher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Chalopin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thibault","family":"Chouquet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Camps","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve","family":"Suzzoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierrick","family":"Bedouch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marylise","family":"Adechian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e8ne","family":"Agostini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lamiae","family":"Grimaldi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kawther","family":"Nheri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatah","family":"Tidadini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Soubrane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Baptiste","family":"Debry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.eclinm.2026.104262_bib1","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1002\/hep.510240612","article-title":"Preoperative portal vein embolization for extension of hepatectomy indications","volume":"24","author":"de Baere","year":"1996","journal-title":"Hepatology"},{"issue":"6","key":"10.1016\/j.eclinm.2026.104262_bib2","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1097\/01.RVI.0000159543.28222.73","article-title":"Portal vein embolization in preparation for major hepatic resection: evolution of a new standard of care","volume":"16","author":"Madoff","year":"2005","journal-title":"J Vasc Interv Radiol"},{"issue":"11","key":"10.1016\/j.eclinm.2026.104262_bib3","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.4254\/wjh.v13.i11.1629","article-title":"Current strategies to induce liver remnant hypertrophy before major liver resection","volume":"13","author":"Del Basso","year":"2021","journal-title":"World J Hepatol"},{"issue":"1","key":"10.1016\/j.eclinm.2026.104262_bib4","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s00270-012-0440-y","article-title":"Portal vein embolization before liver resection: a systematic review","volume":"36","author":"van Lienden","year":"2013","journal-title":"Cardiovasc Interv Radiol"},{"issue":"1","key":"10.1016\/j.eclinm.2026.104262_bib5","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1007\/s00423-024-03250-x","article-title":"Management of potential portal vein thrombus during laparoscopic right hemihepatectomy following portal vein embolization","volume":"409","author":"Kitano","year":"2024","journal-title":"Langenbecks Arch Surg"},{"issue":"3","key":"10.1016\/j.eclinm.2026.104262_bib6","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.jhep.2008.01.034","article-title":"Liver regeneration and recanalization time course following reversible portal vein embolization","volume":"49","author":"Lainas","year":"2008","journal-title":"J Hepatol"},{"issue":"3","key":"10.1016\/j.eclinm.2026.104262_bib7","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1002\/hep.22739","article-title":"Efficient hepatocyte engraftment and long-term transgene expression after reversible portal embolization in nonhuman primates","volume":"49","author":"Dagher","year":"2009","journal-title":"Hepatology"},{"issue":"4","key":"10.1016\/j.eclinm.2026.104262_bib8","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.jvir.2014.11.033","article-title":"Efficient liver regeneration following temporary portal vein embolization with absorbable gelatin sponge powder in humans","volume":"26","author":"Tranchart","year":"2015","journal-title":"J Vasc Interv Radiol"},{"key":"10.1016\/j.eclinm.2026.104262_bib9","first-page":"1009","article-title":"[Pathophysiology and classification of adhesions]","author":"Zuhlke","year":"1990","journal-title":"Langenbecks Arch Chir Suppl II Verh Dtsch Ges Chir"},{"issue":"2","key":"10.1016\/j.eclinm.2026.104262_bib10","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1097\/01.sla.0000133083.54934.ae","article-title":"Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey","volume":"240","author":"Dindo","year":"2004","journal-title":"Ann Surg"},{"issue":"3","key":"10.1016\/j.eclinm.2026.104262_bib11","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1067\/msy.2002.120234","article-title":"Preoperative selective portal vein embolization before hepatectomy for liver metastases: long-term results and impact on survival","volume":"131","author":"Elias","year":"2002","journal-title":"Surgery"},{"issue":"9","key":"10.1016\/j.eclinm.2026.104262_bib12","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1002\/bjs.10153","article-title":"Liver regeneration following repeated reversible portal vein embolization in an experimental model","volume":"103","author":"Tranchart","year":"2016","journal-title":"Br J Surg"},{"issue":"2\u20133","key":"10.1016\/j.eclinm.2026.104262_bib13","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1159\/000509713","article-title":"Liver regeneration and recanalization time course following repeated reversible portal vein embolization in swine","volume":"61","author":"Gaillard","year":"2020","journal-title":"Eur Surg Res"},{"issue":"1","key":"10.1016\/j.eclinm.2026.104262_bib14","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1002\/lt.25364","article-title":"Improving hepatocyte engraftment following hepatocyte transplantation using repeated reversible portal vein embolization in rats","volume":"25","author":"Gaillard","year":"2019","journal-title":"Liver Transpl"},{"issue":"2","key":"10.1016\/j.eclinm.2026.104262_bib15","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1055\/s-0032-1312568","article-title":"Portal vein embolization: rationale, technique, and current application","volume":"29","author":"May","year":"2012","journal-title":"Semin Interv Radiol"},{"issue":"1","key":"10.1016\/j.eclinm.2026.104262_bib16","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1097\/SLA.0b013e31815f6e5b","article-title":"Preoperative portal vein embolization for major liver resection: a meta-analysis","volume":"247","author":"Abulkhir","year":"2008","journal-title":"Ann Surg"},{"issue":"4","key":"10.1016\/j.eclinm.2026.104262_bib17","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1002\/ags3.70214","article-title":"Impact of recanalization on liver hypertrophy after portal vein embolization and the role of Re-Embolization","volume":"10","author":"Uemura","year":"2026","journal-title":"Ann Gastroenterol Surg"},{"key":"10.1016\/j.eclinm.2026.104262_bib18","article-title":"Effectiveness of balloon occlusion in percutaneous transhepatic portal vein embolization with gelatin sponge: a single-institutional retrospective study","volume":"10","author":"Kubo","year":"2025","journal-title":"Interv Radiol (Higashimatsuyama)"},{"issue":"3","key":"10.1016\/j.eclinm.2026.104262_bib19","doi-asserted-by":"crossref","first-page":"408","DOI":"10.3748\/wjg.v12.i3.408","article-title":"Portal vein embolization induces compensatory hypertrophy of remnant liver","volume":"12","author":"Huang","year":"2006","journal-title":"World J Gastroenterol"},{"issue":"9","key":"10.1016\/j.eclinm.2026.104262_bib20","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1002\/bjs.5341","article-title":"Sequential arterial and portal vein embolizations before right hepatectomy in patients with cirrhosis and hepatocellular carcinoma","volume":"93","author":"Ogata","year":"2006","journal-title":"Br J Surg"},{"issue":"28","key":"10.1016\/j.eclinm.2026.104262_bib21","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.4254\/wjh.v8.i28.1200","article-title":"Impaired liver function attenuates liver regeneration and hypertrophy after portal vein embolization","volume":"8","author":"Kageyama","year":"2016","journal-title":"World J Hepatol"},{"issue":"4","key":"10.1016\/j.eclinm.2026.104262_bib22","doi-asserted-by":"crossref","first-page":"HEP42","DOI":"10.2217\/hep-2021-0006","article-title":"Portal vein embolization: rationale, techniques, outcomes and novel strategies","volume":"8","author":"Chansangrat","year":"2021","journal-title":"Hepat Oncol"},{"issue":"8","key":"10.1016\/j.eclinm.2026.104262_bib23","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1007\/s00270-024-03743-8","article-title":"CIRSE standards of practice on portal vein embolization and double vein embolization\/liver venous deprivation","volume":"47","author":"Bilhim","year":"2024","journal-title":"Cardiovasc Interv Radiol"},{"issue":"11","key":"10.1016\/j.eclinm.2026.104262_bib24","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/s11912-021-01075-1","article-title":"Systematic reviews and meta-analyses of portal vein embolization, associated liver partition and portal vein ligation, and radiation lobectomy outcomes in hepatocellular carcinoma patients","volume":"23","author":"Charalel","year":"2021","journal-title":"Curr Oncol Rep"},{"issue":"11","key":"10.1016\/j.eclinm.2026.104262_bib25","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1002\/bjs.5836","article-title":"Portal vein embolization before major hepatectomy and its effects on regeneration, resectability and outcome","volume":"94","author":"Ribero","year":"2007","journal-title":"Br J Surg"},{"issue":"5","key":"10.1016\/j.eclinm.2026.104262_bib26","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1148\/radiographics.22.5.g02se161063","article-title":"Transhepatic portal vein embolization: anatomy, indications, and technical considerations","volume":"22","author":"Madoff","year":"2002","journal-title":"Radiographics"},{"issue":"13","key":"10.1016\/j.eclinm.2026.104262_bib27","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1002\/bjs.9317","article-title":"Portal vein embolization improves rate of resection of extensive colorectal liver metastases without worsening survival","volume":"100","author":"Shindoh","year":"2013","journal-title":"Br J Surg"},{"issue":"3","key":"10.1016\/j.eclinm.2026.104262_bib28","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.jhep.2008.06.004","article-title":"Temporary portal vein embolization as a starter of liver regeneration","volume":"49","author":"Lesurtel","year":"2008","journal-title":"J Hepatol"}],"container-title":["eClinicalMedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589537026005158?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589537026005158?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T10:09:46Z","timestamp":1793786986000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589537026005158"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":28,"alternative-id":["S2589537026005158"],"URL":"https:\/\/doi.org\/10.1016\/j.eclinm.2026.104262","relation":{},"ISSN":["2589-5370"],"issn-type":[{"value":"2589-5370","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Efficacy and safety of temporary selective portal vein embolization before major hepatectomy (EMBORES): a phase 2 trial","name":"articletitle","label":"Article Title"},{"value":"eClinicalMedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.eclinm.2026.104262","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"104262"}}