{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:37:12Z","timestamp":1791268632319,"version":"4.1.0"},"reference-count":51,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2011,7,1]],"date-time":"2011-07-01T00:00:00Z","timestamp":1309478400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2011,7]]},"DOI":"10.1016\/j.ecoenv.2011.04.024","type":"journal-article","created":{"date-parts":[[2011,5,9]],"date-time":"2011-05-09T10:09:28Z","timestamp":1304935768000},"page":"1370-1380","source":"Crossref","is-referenced-by-count":80,"title":["Reduced body condition and enzymatic alterations in frogs inhabiting intensive crop production areas"],"prefix":"10.1016","volume":"74","author":[{"given":"Julie C.","family":"Brodeur","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romina P.","family":"Suarez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillermo S.","family":"Natale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia E.","family":"Ronco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Elena Zaccagnini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecoenv.2011.04.024_bib1","first-page":"RA141","article-title":"Pesticides and oxidative stress: A review","volume":"10","author":"Abdollahi","year":"2004","journal-title":"Med. Sci. Monit."},{"key":"10.1016\/j.ecoenv.2011.04.024_bib2","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1046\/j.1365-2435.1999.00323.x","article-title":"Relationships between body composition, body size and alternative reproductive tactics in a lekking sandpiper, the ruff (Philomachus pugnax)","volume":"13","author":"Bachman","year":"1999","journal-title":"Funct. Ecol"},{"key":"10.1016\/j.ecoenv.2011.04.024_bib3","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1890\/1540-9295(2003)001[0087:TCODA]2.0.CO;2","article-title":"The complexity of deformed amphibians","volume":"1","author":"Blaustein","year":"2003","journal-title":"Front. Ecol. Environ"},{"key":"10.1016\/j.ecoenv.2011.04.024_bib4","first-page":"109","article-title":"Plasma retinoid profile in bullfrogs, Rana catesbeiana, in relation to agricultural intensity of sub-watersheds in the Yamaska River drainage basin, Quebec, Canada. Aquat","volume":"71","author":"B\u00e9rub\u00e9","year":"2005","journal-title":"Toxicol"},{"key":"10.1016\/j.ecoenv.2011.04.024_bib5","unstructured":"Bindraban P.S., Franke A.C., Ferrar D.O., Ghersa C.M., Lotz L.A.P., Nepomuceno A., Smulders M.J.M., van de Wiel C.C.M.. 2009. GM-related sustainability: Agro-ecological impacts, risks and opportunities of soy production in Argentina and Brazil. Plant Research International B.V., Wageningen, The Netherlands."},{"key":"10.1016\/j.ecoenv.2011.04.024_bib6","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1023\/A:1005988611661","article-title":"Anuran development, density and diversity in relation to agricultural activity in the Holland River watershed, Ontario, Canada (1990\u20131992). Environ","volume":"57","author":"Bishop","year":"1999","journal-title":"Monit. Assess"},{"key":"10.1016\/j.ecoenv.2011.04.024_bib7","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.aquatox.2008.11.006","article-title":"Retinoid metabolism (LRAT, REH) in the liver and plasma retinoids of bullfrog, Rana catesbeiana, in relation to agricultural contamination","volume":"91","author":"Boily","year":"2009","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.ecoenv.2011.04.024_bib8","first-page":"609","article-title":"Amphibians of Argentina. Monitore. zool. ital","volume":"2","author":"Cei","year":"1980","journal-title":"Monographs"},{"key":"10.1016\/j.ecoenv.2011.04.024_bib9","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1046\/j.1523-1739.2002.01030.x","article-title":"Spatial tests of pesticides drifts, habitats destruction, UV\u2013B and climate change hypotheses for California amphibian declines","volume":"16","author":"Davidson","year":"2002","journal-title":"Conserv. Biol"},{"key":"10.1016\/j.ecoenv.2011.04.024_bib10","doi-asserted-by":"crossref","first-page":"1892","DOI":"10.1890\/03-5224","article-title":"Declining downwind: Amphibian population declines in California and historical pesticide use","volume":"14","author":"Davidson","year":"2004","journal-title":"Ecological Applications"},{"key":"10.1016\/j.ecoenv.2011.04.024_bib11","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1086\/285405","article-title":"Body mass, structural size, and life history patterns of the Columbian ground squirrel","volume":"140","author":"Dobson","year":"1992","journal-title":"Am. Natur"},{"key":"10.1016\/j.ecoenv.2011.04.024_bib12","doi-asserted-by":"crossref","first-page":"851","DOI":"10.2307\/1939350","article-title":"Maternal traits and reproduction in Richardson\u2019s ground squirrels","volume":"76","author":"Dobson","year":"1995","journal-title":"Ecology"},{"key":"10.1016\/j.ecoenv.2011.04.024_bib13","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/0006-2952(61)90145-9","article-title":"A new and rapid colorimetric determination of acetylcholinesterase activity","volume":"7","author":"Ellman","year":"1961","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.ecoenv.2011.04.024_bib14","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/S0269-7491(02)00137-9","article-title":"The measurement of cholinesterase activities as a biomarker in chub (Leuciscus cephalus): The fish length should not be ignored","volume":"120","author":"Flammarion","year":"2002","journal-title":"Environ. Pollut"},{"key":"10.1016\/j.ecoenv.2011.04.024_bib15","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.chemosphere.2007.09.048","article-title":"Cholinesterase activities as potential biomarkers: Characterization in two freshwater snails, Potamopyrgus antipodarum (Mollusca, Hydrobiidae, Smith 1889) and Valvata piscinalis (Mollusca, Valvatidae, Muller 1774)","volume":"71","author":"Gagnaire","year":"2008","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2011.04.024_bib16","unstructured":"Gallardo J.M. 1974. Anfibios de los alrededores de Buenos Aires. Editorial Universitaria de Buenos Aires (EUDEBA), Buenos Aires, Argentina."},{"key":"10.1016\/j.ecoenv.2011.04.024_bib17","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1007\/s00442-003-1210-y","article-title":"Exposure of leopard frogs to a pesticide mixture affects life history characteristics of the lungworm Rhabdias ranae","volume":"135","author":"Gendron","year":"2003","journal-title":"Oecologia"},{"key":"10.1016\/j.ecoenv.2011.04.024_bib18","unstructured":"GM Soy Debate. 2009. Agro-ecological impacts of genetically modified soy production in Argentina and Brazil. An analysis of twelve claims about GM soy. \u3008http:\/\/gmsoydebate.global-connections.nl\u3009"},{"key":"10.1016\/j.ecoenv.2011.04.024_bib19","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/0003-2697(66)90025-X","article-title":"The true oxidized glutathione content of red blood cells obtained by new enzymatic and paper chromatographic methods","volume":"15","author":"Guntherberg","year":"1966","journal-title":"Anal. Biochem"},{"key":"10.1016\/j.ecoenv.2011.04.024_bib20","doi-asserted-by":"crossref","first-page":"445","DOI":"10.3109\/10409239509083491","article-title":"The glutathione S-transferase supergene family: Regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance","volume":"30","author":"Hayes","year":"1995","journal-title":"Crit. Rev. Biochem. Mol. Biol"},{"key":"10.1016\/j.ecoenv.2011.04.024_bib21","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1289\/ehp.5932","article-title":"Atrazine induced hermaphroditism at 0.1 ppb in American leopard frogs (Rana pipiens): Laboratory and field evidence","volume":"111","author":"Hayes","year":"2003","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.ecoenv.2011.04.024_bib22","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1139\/f03-095","article-title":"The effects of adjacent land use on wetland amphibian species richness and community composition","volume":"60","author":"Houlahan","year":"2003","journal-title":"Can. J. Fish. Aquat. Sci."},{"key":"10.1016\/j.ecoenv.2011.04.024_bib23","series-title":"In Amphibian Declines: The Conservation Status of United States Species","first-page":"124","article-title":"Parasite infection and limb malformations: A growing problem in amphibian conservation","author":"Johnson","year":"2005"},{"key":"10.1016\/j.ecoenv.2011.04.024_bib24","doi-asserted-by":"crossref","first-page":"9900","DOI":"10.1073\/pnas.152098899","article-title":"Synergism between trematode infection and pesticide exposure: A link to amphibian limb deformities in nature?","volume":"99","author":"Kiesecker","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ecoenv.2011.04.024_bib25","doi-asserted-by":"crossref","unstructured":"LeNoir, J.S., McConnell, L.L., Fellers, G.M., Cahill, T.M., Seiber, J.N., 1999. Summertimetransport of current-use pesticides from California\u2019s Central Valley to the Sierra Nevada mountain range, USA. Environ. Toxicol. Chem. 18, 2715\u20132722.","DOI":"10.1002\/etc.5620181210"},{"key":"10.1016\/j.ecoenv.2011.04.024_bib26","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ecoenv.2011.04.024_bib27","unstructured":"MAP&G 2010. Ministerio de Agricultura, Pesca y Ganaderia. \u3008http:\/\/www.minagri.gob.ar\u3009."},{"key":"10.1016\/j.ecoenv.2011.04.024_bib28","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.aquatox.2008.10.001","article-title":"Combined effects of agricultural activity and parasites on biomarkers in the bullfrog, Rana catasbeiana","volume":"91","author":"Marcogliese","year":"2009","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.ecoenv.2011.04.024_bib29","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s11160-005-7846-4","article-title":"Antioxidant defenses in fish: Biotic and abiotic factors","volume":"15","author":"Mart\u00ednez-\u00c1lvarez","year":"2005","journal-title":"Rev. Fish Biol. Fish"},{"key":"10.1016\/j.ecoenv.2011.04.024_bib30","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1289\/ehp.11536","article-title":"Agriculture alters gonadal form and function in the toad Bufo marinus","volume":"116","author":"McCoy","year":"2008","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.ecoenv.2011.04.024_bib31","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.aquatox.2008.05.002","article-title":"Potential endocrine disruption of sexual development in free ranging male northern leopard frogs (Rana pipiens) and green frogs (Rana clamitans) from areas of intensive row crop agriculture","volume":"88","author":"McDaniel","year":"2008","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.ecoenv.2011.04.024_bib32","unstructured":"Meteyer C.U. 2000. Field guide to malformations of frogs and toads with radiographic interpretations. Biological Science Report USGS\/BRD\/BSR\u20132000\u20130005."},{"key":"10.1016\/j.ecoenv.2011.04.024_bib33","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.aquatox.2005.11.007","article-title":"Plasma steroid hormone concentrations, aromatase activities and GSI in ranid frogs collected from agricultural and non-agricultural sites in Michigan (USA)","volume":"77","author":"Murphy","year":"2006","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.ecoenv.2011.04.024_bib34","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.biocon.2007.05.007","article-title":"A documented amphibian decline over 40 years: Possible causes and implications for species recovery","volume":"138","author":"Nystrom","year":"2007","journal-title":"Biol. Conserv"},{"key":"10.1016\/j.ecoenv.2011.04.024_bib35","unstructured":"P\u00e9rez Leiva F., Anastasio M.D. 2003. Consumo de fitosanitarios en el contexto de expansi\u00f3n agr\u00edcola. Facultad de Agronom\u00eda, Universidad de Buenos Aires, Buenos Aires, Argentina. \u3008www.agro.uba.ar\/apuntes\/no_5\/agroquimicos.htm\u3009."},{"key":"10.1016\/j.ecoenv.2011.04.024_bib36","series-title":"Relevamiento del uso de pesticidas agr\u00edcolas en la alta cuenca del r\u00edo Salado (Provincia de Buenos Aires)","author":"Rennella","year":"2000"},{"key":"10.1016\/j.ecoenv.2011.04.024_bib37","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1038\/nature07281","article-title":"Agrochemicals increase trematode infections in a declining amphibian species","volume":"455","author":"Rohr","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.ecoenv.2011.04.024_bib38","doi-asserted-by":"crossref","first-page":"2879","DOI":"10.1897\/04-555R3.1","article-title":"Effects of chlorpyrifos on the catalytic efficiency and expression level of aceylcholinesterases in the bivalve mollusk Scapharca inaequilvis. Environ","volume":"24","author":"Romani","year":"2005","journal-title":"Toxicol. Chem"},{"key":"10.1016\/j.ecoenv.2011.04.024_bib39","series-title":"Environmental Pollution: New Research","first-page":"1","article-title":"Ecotoxicological perspectives of B-esterases in the assessment of pesticide contamination","author":"Sanchez-Hernandez","year":"2007"},{"key":"10.1016\/j.ecoenv.2011.04.024_bib40","first-page":"24","article-title":"Cambios tecnol\u00f3gicos en la agricultura argentina actual","volume":"15","author":"Satorre","year":"2005","journal-title":"Ciencia Hoy"},{"key":"10.1016\/j.ecoenv.2011.04.024_bib41","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1890\/04-0232","article-title":"Restitution of mass-size residuals: Validating body condition indices","volume":"86","author":"Schulte-Hostedde","year":"2005","journal-title":"Ecology"},{"key":"10.1016\/j.ecoenv.2011.04.024_bib42","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1002\/etc.5620200725","article-title":"Pesticides and amphibian population declines in California, USA","volume":"20","author":"Sparling","year":"2001","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.ecoenv.2011.04.024_bib43","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.aquatox.2008.09.011","article-title":"Study design, water quality, morphometrics and age of the bullfrog, Rana catesbeiana, in sub-watersheds of the Yamaska River drainage basin, Quebec, Canada","volume":"91","author":"Spear","year":"2009","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.ecoenv.2011.04.024_bib44","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/0003-2697(69)90064-5","article-title":"Enzymatic method for the quantitative determination of nanogram amounts of total and oxidized glutathione: Applications to mammalian blood and other tissues","volume":"27","author":"Tietze","year":"1969","journal-title":"Anal. Biochem"},{"key":"10.1016\/j.ecoenv.2011.04.024_bib45","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1023\/A:1008934505370","article-title":"Esterases as markers of exposure to organophosphates and carbamates","volume":"8","author":"Thompson","year":"1999","journal-title":"Ecotoxicology"},{"key":"10.1016\/j.ecoenv.2011.04.024_bib46","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1126\/science.1057544","article-title":"Forecasting agriculturally driven global environmental change","volume":"292","author":"Tilman","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.ecoenv.2011.04.024_bib47","doi-asserted-by":"crossref","first-page":"3890","DOI":"10.1016\/j.enpol.2009.05.031","article-title":"Argentinean soy-based biodiesel: An introduction to production and impacts","volume":"37","author":"Tomei","year":"2009","journal-title":"Energy Policy"},{"key":"10.1016\/j.ecoenv.2011.04.024_bib48","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S1382-6689(02)00126-6","article-title":"Fish bioaccumulation and biomarkers in environmental risk assessment: A review","volume":"13","author":"Van der Oost","year":"2003","journal-title":"Environ. Toxicol. Pharmacol"},{"key":"10.1016\/j.ecoenv.2011.04.024_bib49","unstructured":"Von Braun J. 2007. The world food situation: New driving forces and required actions. Food Policy Report. Washington, DC: International Food Policy Research Institute (IFPRI)."},{"key":"10.1016\/j.ecoenv.2011.04.024_bib50","doi-asserted-by":"crossref","first-page":"402","DOI":"10.2307\/3546126","article-title":"Lifetime reproductive success and its correlates in female eurasian red squirrels","volume":"72","author":"Wauters","year":"1995","journal-title":"Oikos"},{"key":"10.1016\/j.ecoenv.2011.04.024_bib51","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.aquatox.2009.05.006","article-title":"Acetylcholinesterase activity in Gammarus fossarum (Crustacea amphipoda) Intrinsic variability, reference levels, and a reliable tool for field surveys","volume":"93","author":"Xuereb","year":"2009","journal-title":"Aquat. Toxicol"}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651311001084?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651311001084?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,11,22]],"date-time":"2021-11-22T18:37:51Z","timestamp":1637606271000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651311001084"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,7]]},"references-count":51,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2011,7]]}},"alternative-id":["S0147651311001084"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2011.04.024","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2011,7]]}}}