{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T17:56:23Z","timestamp":1778694983304,"version":"3.51.4"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2012,5,1]],"date-time":"2012-05-01T00:00:00Z","timestamp":1335830400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,5,1]],"date-time":"2012-05-01T00:00:00Z","timestamp":1335830400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004360","name":"Sveriges Lantbruksuniversitet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004360","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2012,5]]},"DOI":"10.1016\/j.ecoenv.2011.12.012","type":"journal-article","created":{"date-parts":[[2012,1,14]],"date-time":"2012-01-14T17:59:51Z","timestamp":1326563991000},"page":"148-152","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Verapamil does not modify catalytic activity of CYP450 in rainbow trout after long-term exposure"],"prefix":"10.1016","volume":"79","author":[{"given":"V.","family":"Burkina","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Zamaratskaia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Randak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z.H.","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Fedorova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Pickova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Zlabek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecoenv.2011.12.012_bib1","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0166-445X(00)00184-3","article-title":"7-Ethoxyresorufin O-deethylase induction in rainbow trout gill epithelium cultured on permeable supports: asymmetrical distribution of substrate metabolites","volume":"54","author":"Carlsson","year":"2001","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.ecoenv.2011.12.012_bib2","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/0141-1136(95)00045-3","article-title":"CYP1A1-, CYP2B- and CYP3A-like proteins in rainbow trout (Oncorhynchus mykiss) liver: CYP1A1-specific down-regulation after prolonged exposure to PCB","volume":"42","author":"Celander","year":"1996","journal-title":"Mar. Environ. Res."},{"key":"10.1016\/j.ecoenv.2011.12.012_bib3","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1007\/s00216-009-3251-5","article-title":"Identification of a CYP3A form (CYP3A126) in fathead minnow (Pimephales promelas) and characterisation of putative CYP3A enzyme activity","volume":"396","author":"Christen","year":"2010","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.ecoenv.2011.12.012_bib4","doi-asserted-by":"crossref","first-page":"287","DOI":"10.3109\/10408440903373590","article-title":"Pharmaceuticals in the aquatic environment: a critical review of the evidence for health effects in fish","volume":"40","author":"Corcoran","year":"2010","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.ecoenv.2011.12.012_bib5","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.aquatox.2005.09.009","article-title":"Ecotoxicology of human pharmaceuticals","volume":"76","author":"Fent","year":"2006","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.ecoenv.2011.12.012_bib6","first-page":"353","article-title":"P-Nitrophenol and glutathione response in medaka (Oryzias latipes) exposed to MX, a drinking water carcinogen","volume":"134","author":"Geter","year":"2003","journal-title":"Comp. Biochem. Physiol. C: Toxicol. Pharmacol."},{"key":"10.1016\/j.ecoenv.2011.12.012_bib7","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.pcad.2004.04.006","article-title":"Calcium antagonists","volume":"47","author":"Grossman","year":"2004","journal-title":"Prog. Cardiovasc. Dis."},{"key":"10.1016\/j.ecoenv.2011.12.012_bib8","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.chroma.2005.11.120","article-title":"Chiral capillary electrophoretic analysis of verapamil metabolism by cytochrome P450 3A4","volume":"1120","author":"Ha","year":"2006","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.ecoenv.2011.12.012_bib9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0098-2997(99)00005-9","article-title":"Human cytochromes P450","volume":"20","author":"Hasler","year":"1999","journal-title":"Mol. Aspects Med."},{"key":"10.1016\/j.ecoenv.2011.12.012_bib10","doi-asserted-by":"crossref","first-page":"2599","DOI":"10.3390\/s7112599","article-title":"Biochemical markers for assessing aquatic contamination","volume":"7","author":"Havelkov\u00e1","year":"2007","journal-title":"Sensors"},{"key":"10.1016\/j.ecoenv.2011.12.012_bib11","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/S0378-4274(02)00041-3","article-title":"Occurrence, fate, and removal of pharmaceutical residues in the aquatic environment: a review of recent research data","volume":"131","author":"Herberer","year":"2002","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.ecoenv.2011.12.012_bib12","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1006\/taap.1994.1254","article-title":"Immunohistochemical localization of CYP1A and CYP3A-like isozymes in hepatic and extrahepatic tissues of Atlantic cod (Gadus morhua L.), a marine fish","volume":"129","author":"Husoy","year":"1994","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.ecoenv.2011.12.012_bib13","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1111\/j.1432-1033.1988.tb13777.x","article-title":"Purification and characterization of a liver microsomal cytochrome P-450 isoenzyme with a high affinity and metabolic capacity for coumarin from pyrazole-treated D2 mice","volume":"171","author":"Juvonen","year":"1988","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.ecoenv.2011.12.012_bib14","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/0742-8413(85)90008-8","article-title":"Catalytic and immunological comparison of coumarin 7-hydroxylation in different species","volume":"81","author":"Kaipainen","year":"1985","journal-title":"Comp. Biochem. Phys. C"},{"key":"10.1016\/j.ecoenv.2011.12.012_bib15","unstructured":"Khan, S., 2002. Occurrence, behaviors and fate of pharmaceutical residues in sewage treatment. Ph.D. Thesis, School of Civil and Environmental Engineering, The University of New South Wales, Sydney, Australia."},{"key":"10.1016\/j.ecoenv.2011.12.012_bib16","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1007\/BF00169164","article-title":"Identification of P450 enzymes involved in metabolism of verapamil in humans","volume":"348","author":"Kroemer","year":"1993","journal-title":"N.-S. Arch. Pharmacol."},{"key":"10.1016\/j.ecoenv.2011.12.012_bib17","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0950-3501(95)80060-3","article-title":"Calcium channel blockers","volume":"9","author":"Leslie","year":"1995","journal-title":"Bailliere. Clin. Anaesth."},{"key":"10.1016\/j.ecoenv.2011.12.012_bib18","first-page":"385","article-title":"Ecotoxocological effects of short-term exposure to a human pharmaceutical Verapamil in juvenile rainbow trout (Oncorhynchus mykiss)","volume":"152","author":"Li","year":"2010","journal-title":"Comp. Biochem. Physiol. C: Toxicol. Pharmacol."},{"key":"10.1016\/j.ecoenv.2011.12.012_bib19","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1016\/j.jhazmat.2010.09.102","article-title":"Chronic toxicity of verapamil on juvenile rainbow trout (Oncorhynchus mykiss): effects on morphological indices, hematological parameters and antioxidant responses","volume":"185","author":"Li","year":"2011","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.ecoenv.2011.12.012_bib20","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.ecoenv.2010.09.008","article-title":"Acute toxicity of carbamazepine to juvenile rainbow trout (Oncorhynchus mykiss): effects on antioxidant responses, hematological parameters and hepatic EROD","volume":"74","author":"Li","year":"2011","journal-title":"Ecotox. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2011.12.012_bib21","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/0003-9861(85)90138-9","article-title":"Dealkylation of pentoxyresorufin: a rapid and sensitive assay for measuring induction of cytochrome(s) P450 by phenobarbital and other xenobiotics in rat","volume":"238","author":"Lubet","year":"1995","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.ecoenv.2011.12.012_bib22","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.tiv.2006.10.012","article-title":"Primary culture of rat hepatocytes in 96-well plates: effects of extracellular matrix configuration on cytochrome P450 enzyme activity and inducibility, and its application in in vitro cytotoxicity screening","volume":"21","author":"Mingoia","year":"2007","journal-title":"Toxicol. in Vitro"},{"key":"10.1016\/j.ecoenv.2011.12.012_bib24","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1016\/j.chemosphere.2003.09.027","article-title":"Induced alkoxyresorufin-O-dealkylases in tilapias (Oreochromis niloticus) from Guandu river, Rio de Janeiro, Brazil","volume":"54","author":"Parente","year":"2004","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2011.12.012_bib25","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/S0022-3565(24)39245-6","article-title":"Characterization of the major metabolites of Verapamil as substrates and Inhibitors of P-glycoprotein","volume":"293","author":"Pauli-Magnus","year":"2000","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ecoenv.2011.12.012_bib26","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/S0048-9697(99)00500-8","article-title":"Cytochrome P4501A (CYP1A) in teleostean fishes. A review of immunohistochemical studies","volume":"247","author":"Sarasquetea","year":"2000","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2011.12.012_bib27","doi-asserted-by":"crossref","first-page":"123","DOI":"10.2754\/avb200473010123","article-title":"Biochemical markers of aquatic environment contamination-cytochrome P450 in fish. A review","volume":"73","author":"\u0160iroka","year":"2004","journal-title":"Acta Vet. Brno"},{"key":"10.1016\/j.ecoenv.2011.12.012_bib28","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/0003-2697(85)90442-7","article-title":"Measurement of protein using bicinchoninic acid","volume":"150","author":"Smith","year":"1985","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.ecoenv.2011.12.012_bib29","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1016\/S0090-9556(24)13672-0","article-title":"Substrate-dependent modulation of CYP3A4 catalytic activity: analysis of 27 test compounds with four fluorometric substrates","volume":"28","author":"Stresser","year":"2000","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.ecoenv.2011.12.012_bib30","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.chemosphere.2008.02.022","article-title":"Aerobic biodegradability of the calcium channel antagonist verapamil and identification of a microbial dead-end transformation product studied by LC\u2013MS\/MS","volume":"72","author":"Trautwein","year":"2008","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2011.12.012_bib31","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S1382-6689(02)00126-6","article-title":"Fish bioaccumulation and biomarkers in environmental risk assessment: a review","volume":"13","author":"van der Oost","year":"2003","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.ecoenv.2011.12.012_bib32","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1006\/taap.1998.8449","article-title":"Chlorzoxazone metabolism by winter flounder liver microsomes: evidence for existence of a CYP2E1-like isoform in teleosts","volume":"151","author":"Wall","year":"1998","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.ecoenv.2011.12.012_bib33","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1124\/dmd.32.2.259","article-title":"Prediction of cytochrome P450 3A inhibition by verapamil enantiomers and their metabolites","volume":"32","author":"Wang","year":"2004","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.ecoenv.2011.12.012_bib34","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1383\/medc.31.10.37.27821","article-title":"Calcium Channel Blockers","volume":"31","author":"Whyte","year":"2003","journal-title":"Medicine"},{"key":"10.1016\/j.ecoenv.2011.12.012_bib35","doi-asserted-by":"crossref","first-page":"2134","DOI":"10.3390\/s90302134","article-title":"EROD and MROD as markers of cytochrome P450 1A activities in hepatic microsomes from entire and castrated male pigs","volume":"9","author":"Zamaratskaia","year":"2009","journal-title":"Sensors"},{"key":"10.1016\/j.ecoenv.2011.12.012_bib36","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1007\/s10695-011-9494-z","article-title":"Para-nitrophenol hydroxylation by fish liver microsomes: kinetics and effect of selective cytochrome P450 inhibitors","volume":"37","author":"Zamaratskaia","year":"2011","journal-title":"Fish Physiol. Biochem."},{"key":"10.1016\/j.ecoenv.2011.12.012_bib37","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1017\/S1751731109004510","article-title":"Modulation of porcine cytochrome P450 enzyme activities by surgical castration and immunocastration","volume":"3","author":"Zamaratskaia","year":"2009","journal-title":"Animal"},{"key":"10.1016\/j.ecoenv.2011.12.012_bib38","doi-asserted-by":"crossref","unstructured":"Zlabek, V., Zamaratskaia, G. Comparison of three fluorescent CYP3A substrates in two vertebrate models: pig and Atlantic salmon. Animal 1-8, doi:10.1017\/S1751731111002096, in press","DOI":"10.1017\/S1751731111002096"}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651311004696?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651311004696?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T04:37:17Z","timestamp":1758947837000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651311004696"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5]]},"references-count":37,"alternative-id":["S0147651311004696"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2011.12.012","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2012,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Verapamil does not modify catalytic activity of CYP450 in rainbow trout after long-term exposure","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2011.12.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}