{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T16:13:33Z","timestamp":1788884013636,"version":"build-2803163510"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2012,12]]},"DOI":"10.1016\/j.ecoenv.2012.08.030","type":"journal-article","created":{"date-parts":[[2012,10,22]],"date-time":"2012-10-22T22:33:14Z","timestamp":1350945194000},"page":"93-100","source":"Crossref","is-referenced-by-count":44,"special_numbering":"C","title":["Toxicity on the luminescent bacterium Vibrio fischeri (Beijerinck). II: Response to complex mixtures of heterogeneous chemicals at low levels of individual components"],"prefix":"10.1016","volume":"86","author":[{"given":"Sara","family":"Villa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Migliorati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianna Serafina","family":"Monti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Vighi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecoenv.2012.08.030_bib1","doi-asserted-by":"crossref","first-page":"2348","DOI":"10.1897\/1551-5028(2000)019<2348:POTTOA>2.3.CO;2","article-title":"Predictability of the toxicity of a multiple mixture of dissimilarly acting chemicals to Vibrio fischeri","volume":"19","author":"Backhaus","year":"2000","journal-title":"Environ. Toxicol. Chem."},{"issue":"2","key":"10.1016\/j.ecoenv.2012.08.030_bib2","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1897\/02-497","article-title":"Joint algal toxicity of phenylurea herbicides is equally predictable by concentration addition and independent action","volume":"23","author":"Backhaus","year":"2004","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.ecoenv.2012.08.030_bib3","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S0022-5193(85)80176-4","article-title":"The expected effect of a combination of agents: the general solution","volume":"114","author":"Berenbaum","year":"1985","journal-title":"J. Theor. Biol."},{"key":"10.1016\/j.ecoenv.2012.08.030_bib4","first-page":"585","volume":"26","author":"Bliss","year":"1939","journal-title":"The toxicity of poisons applied jointly"},{"key":"10.1016\/j.ecoenv.2012.08.030_bib5","series-title":"Text in Statistical Science","article-title":"Modelling binary data","author":"Collett","year":"2003"},{"key":"10.1016\/j.ecoenv.2012.08.030_bib6","doi-asserted-by":"crossref","first-page":"716","DOI":"10.2307\/2532957","article-title":"Assessment of the combined effects of substances: the relationship between concentration addition and independent action","volume":"51","author":"Drescher","year":"1995","journal-title":"Biometrics"},{"key":"10.1016\/j.ecoenv.2012.08.030_bib7","unstructured":"EC (European Commission), 2012. SCHER, SCCS, SCENIHR. Opinion on the Toxicity and Assessment of Chemical Mixtures. DG SANCO, Bruxelles."},{"key":"10.1016\/j.ecoenv.2012.08.030_bib8","series-title":"Kombinationseffekt von Schadstoffen auf aquatische Organismen: Pru\u00a8fung der Vorhersagbarkeit am Beispiel einzelliger Gr\u00fcnalgen","author":"Faust","year":"1999"},{"key":"10.1016\/j.ecoenv.2012.08.030_bib9","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0166-445X(01)00187-4","article-title":"Predicting the joint algal toxicity of multi-component s-triazine mixtures at low-effect concentrations of individual toxicants","volume":"56","author":"Faust","year":"2001","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.ecoenv.2012.08.030_bib10","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0166-445X(02)00133-9","article-title":"Joint algal toxicity of 16 dissimilarly acting chemicals is predictable by the concept of independent action","volume":"63","author":"Faust","year":"2003","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.ecoenv.2012.08.030_bib11","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.envres.2008.07.008","article-title":"The joint effect of polycyclic aromatic hydrocarbons on fish behavior","volume":"108","author":"Gon\u00e7alves","year":"2008","journal-title":"Environ. Res."},{"key":"10.1016\/j.ecoenv.2012.08.030_bib12","unstructured":"Junghans, M., 2004. Studies on Combination Effects of Environmentally Relevant Toxicants. Ph.D. Thesis. University of Bremen, Germany."},{"key":"10.1016\/j.ecoenv.2012.08.030_bib13","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1897\/08-135R.1","article-title":"Effects of photosystem II inhibitors and their mixture on freshwater phytoplankton succession in outdoor mesocosms","volume":"28","author":"Knauert","year":"2009","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.ecoenv.2012.08.030_bib14","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.envpol.2009.07.023","article-title":"Phytotoxicity of atrazine, isoproturon, and diuron to submersed macrophytes in outdoor mesocosms","volume":"158","author":"Knauert","year":"2010","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2012.08.030_bib15","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1007\/BF01952257","article-title":"\u00dcber Kombinationswirkungen. 1. Mitteilung: Hilfsmittel der Fragestellung. Naunyn Schmiedebergs","volume":"114","author":"Loewe","year":"1926","journal-title":"Arch. Exp. Pathol. Pharmakol."},{"key":"10.1016\/j.ecoenv.2012.08.030_bib16","volume":"vol. IV","author":"Mackay","year":"1995"},{"key":"10.1016\/j.ecoenv.2012.08.030_bib17","unstructured":"Microbics Corporation, 1982. How to Run Toxicity Tests Using the Microtox\u00ae Model 500. Manual 555880-R1. Carlsbad, CA."},{"key":"10.1016\/j.ecoenv.2012.08.030_bib18","series-title":"R: A Language and Environment for Statistical Computing","author":"R Development Core Team","year":"2011"},{"issue":"2","key":"10.1016\/j.ecoenv.2012.08.030_bib19","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1897\/1551-5028(2001)020<0448:AGBFMF>2.0.CO;2","article-title":"A general best fit method for concentration\u2013response curves and the estimation method of low effect concentrations","volume":"20","author":"Scholze","year":"2001","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.ecoenv.2012.08.030_bib20","first-page":"357","article-title":"Quantitative structure\u2013activity relationships for weak acid respiratory uncouplers to Vibrio fisheri","volume":"16","author":"Schultz","year":"1997","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.ecoenv.2012.08.030_bib21","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/0043-1354(70)90018-7","article-title":"Measurement of pollutant toxicity to fish. II. Utilizing and applying bioassay results","volume":"4","author":"Sprague","year":"1970","journal-title":"Water Res."},{"key":"10.1016\/j.ecoenv.2012.08.030_bib22","volume":"vol. 2A","author":"Stuart","year":"1999"},{"key":"10.1016\/j.ecoenv.2012.08.030_bib23","series-title":"British Crop Protection Council, Surrey","year":"2003"},{"key":"10.1016\/j.ecoenv.2012.08.030_bib24","unstructured":"U.S. EPA, 2012. EPISuite v. 4.0. \u3008http:\/\/www.epa.gov\/oppt\/exposure\/pubs\/EPISuitedl.htm\u3009."},{"key":"10.1016\/j.ecoenv.2012.08.030_bib25","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/0045-6535(92)90280-5","article-title":"Classifying environmental pollutants structure\u2013activity relationships for prediction of aquatic toxicity","volume":"25","author":"Verhaar","year":"1992","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2012.08.030_bib26","series-title":"Handbook of Environmental Data on Organic Chemicals","author":"Verschueren","year":"1996"},{"issue":"1","key":"10.1016\/j.ecoenv.2012.08.030_bib27","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.ecoenv.2008.05.008","article-title":"Toxicity on the luminescent bacterium Vibrio fischeri (Beijerinck). I: QSAR equation for narcotics and polar narcotics","volume":"72","author":"Vighi","year":"2009","journal-title":"Ecotoxicol. Environ. Saf."}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651312003338?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651312003338?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,11,19]],"date-time":"2018-11-19T20:22:51Z","timestamp":1542658971000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651312003338"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12]]},"references-count":27,"alternative-id":["S0147651312003338"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2012.08.030","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2012,12]]}}}