{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T06:26:10Z","timestamp":1789194370309,"version":"build-2803163510"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,9,1]],"date-time":"2014-09-01T00:00:00Z","timestamp":1409529600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["51178321"],"award-info":[{"award-number":["51178321"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["51108327"],"award-info":[{"award-number":["51108327"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Major Project of Science & Technology Ministry of China","award":["2012ZX07403-001"],"award-info":[{"award-number":["2012ZX07403-001"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2014,9]]},"DOI":"10.1016\/j.ecoenv.2014.05.008","type":"journal-article","created":{"date-parts":[[2014,6,3]],"date-time":"2014-06-03T21:02:04Z","timestamp":1401829324000},"page":"30-35","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":43,"special_numbering":"C","title":["Chlorination and chloramination of tetracycline antibiotics: Disinfection by-products formation and influential factors"],"prefix":"10.1016","volume":"107","author":[{"given":"Shiqing","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yisheng","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naiyun","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shumin","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecoenv.2014.05.008_bib1","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1002\/jctb.1660","article-title":"Kinetics of reactions between chlorine or bromine and the herbicides diuron and isoproturon","volume":"82","author":"Acero","year":"2007","journal-title":"J. Chem. Technol. Biotechnol."},{"key":"10.1016\/j.ecoenv.2014.05.008_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/jac\/dkf801","article-title":"Global antibiotic resistance in Streptococcus pneumoniae","volume":"50","author":"Adam","year":"2002","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.ecoenv.2014.05.008_bib3","unstructured":"APHA (American Public Health Association), American Water Works Association, Water Environment Federation, 1998. Standard Methods for the Examination of Water and Wastewater. 20th ed. Washington, DC: American Public Health Association."},{"key":"10.1016\/j.ecoenv.2014.05.008_bib4","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.biortech.2005.10.041","article-title":"Composting rapidly reduces levels of extractable oxytetracycline in manure from therapeutically treated beef calves","volume":"98","author":"Arikan","year":"2007","journal-title":"Bioresour. Technol."},{"key":"10.1016\/j.ecoenv.2014.05.008_bib5","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1016\/j.wasman.2008.08.022","article-title":"Depletion of chlortetracycline during composting of aged and spiked manures","volume":"29","author":"Bao","year":"2009","journal-title":"Waste Manag."},{"key":"10.1016\/j.ecoenv.2014.05.008_bib6","doi-asserted-by":"crossref","first-page":"286a","DOI":"10.1021\/es032519b","article-title":"Are veterinary medicines causing environmental risks?","volume":"37","author":"Boxall","year":"2003","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2014.05.008_bib7","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1021\/es9406905","article-title":"Effect of bromide ion on haloacetic acid speciation resulting from chlorination and chloramination of aquatic humic substances","volume":"30","author":"Cowman","year":"1995","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2014.05.008_bib8","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0045-6535(03)00284-4","article-title":"Use of oxytetracycline and tylosin in intensive calf farming: evaluation of transfer to manure and soil","volume":"52","author":"De Liguoro","year":"2003","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2014.05.008_bib9","doi-asserted-by":"crossref","first-page":"5577","DOI":"10.1021\/es040006e","article-title":"Aqueous chlorination kinetics of some endocrine disruptors","volume":"38","author":"Deborde","year":"2004","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2014.05.008_bib10","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.watres.2006.10.029","article-title":"Aqueous chlorination of the antibacterial agent trimethoprim: reaction kinetics and pathways","volume":"41","author":"Dodd","year":"2007","journal-title":"Water Res."},{"key":"10.1016\/j.ecoenv.2014.05.008_bib11","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1002\/j.1551-8833.1982.tb04856.x","article-title":"Reactivity of halogens with aqueous micropollutants: a mechanism for the formation of trihalomethanes","volume":"74","author":"Dore","year":"1982","journal-title":"J. Am. Water Works Assoc."},{"key":"10.1016\/j.ecoenv.2014.05.008_bib12","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1111\/j.1749-6632.1948.tb27262.x","article-title":"Aureomycin: a product of the continuing search for new antibiotics","volume":"51","author":"Duggar","year":"1948","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"10.1016\/j.ecoenv.2014.05.008_bib13","doi-asserted-by":"crossref","first-page":"3418","DOI":"10.1016\/j.watres.2005.06.003","article-title":"Modeling monochloramine loss in the presence of natural organic matter","volume":"39","author":"Duirk","year":"2005","journal-title":"Water Res."},{"key":"10.1016\/j.ecoenv.2014.05.008_bib14","doi-asserted-by":"crossref","first-page":"6845","DOI":"10.1021\/es200983f","article-title":"Formation of toxic iodinated disinfection by-products from compounds used in medical imaging","volume":"45","author":"Duirk","year":"2011","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2014.05.008_bib15","doi-asserted-by":"crossref","first-page":"1934","DOI":"10.1016\/j.watres.2009.11.046","article-title":"Formation of carbonaceous and nitrogenous disinfection by-products from the chlorination of Microcystis aeruginosa","volume":"44","author":"Fang","year":"2010","journal-title":"Water Res."},{"key":"10.1016\/j.ecoenv.2014.05.008_bib16","doi-asserted-by":"crossref","first-page":"2757","DOI":"10.1021\/ic00340a010","article-title":"Non-metal redox kinetics: hypochlorite and hypochlorous acid reactions with cyanide","volume":"29","author":"Gerritsen","year":"1990","journal-title":"Inorg. Chem."},{"key":"10.1016\/j.ecoenv.2014.05.008_bib17","doi-asserted-by":"crossref","first-page":"3147","DOI":"10.1016\/j.watres.2010.02.004","article-title":"Innovative method for prioritizing emerging disinfection by-products (DBPs) in drinking water on the basis of their potential impact on public health","volume":"44","author":"Hebert","year":"2010","journal-title":"Water Res."},{"key":"10.1016\/j.ecoenv.2014.05.008_bib18","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.jhydrol.2012.10.040","article-title":"Properties of sediment NOM collected from a drinking water reservoir in South China, and its association with THMs and HAAs formation","volume":"476","author":"Hong","year":"2013","journal-title":"J. Hydrol."},{"key":"10.1016\/j.ecoenv.2014.05.008_bib19","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1111\/j.2042-7158.1968.tb09802.x","article-title":"Aspects of the epimerization of certain tetracycline derivatives","volume":"20","author":"Hussar","year":"1968","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.ecoenv.2014.05.008_bib20","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1021\/es011055j","article-title":"Pharmaceuticals, hormones, and other organic wastewater contaminants in US streams, 1999\u20132000: a national reconnaissance","volume":"36","author":"Kolpin","year":"2002","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2014.05.008_bib21","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.scitotenv.2004.01.015","article-title":"Urban contribution of pharmaceuticals and other organic wastewater contaminants to streams during differing flow conditions","volume":"328","author":"Kolpin","year":"2004","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2014.05.008_bib22","doi-asserted-by":"crossref","first-page":"2448","DOI":"10.1128\/AAC.41.11.2448","article-title":"Efficacy of enrofloxacin or doxycycline for treatment of Bartonella henselae or Bartonella clarridgeiae infection in cats","volume":"41","author":"Kordick","year":"1997","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ecoenv.2014.05.008_bib23","doi-asserted-by":"crossref","first-page":"7175","DOI":"10.1021\/es060353j","article-title":"Occurrence of a new generation of disinfection byproducts","volume":"40","author":"Krasner","year":"2006","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2014.05.008_bib24","doi-asserted-by":"crossref","first-page":"2082","DOI":"10.2134\/jeq2005.0026","article-title":"Antibiotic uptake by plants from soil fertilized with animal manure","volume":"34","author":"Kumar","year":"2005","journal-title":"J. Environ. Qual."},{"key":"10.1016\/j.ecoenv.2014.05.008_bib25","doi-asserted-by":"crossref","first-page":"3164","DOI":"10.1016\/j.watres.2011.03.035","article-title":"Chloramination of nitrogenous contaminants (pharmaceuticals and pesticides): NDMA and halogenated DBPs formation","volume":"45","author":"Le Roux","year":"2011","journal-title":"Water Res."},{"key":"10.1016\/j.ecoenv.2014.05.008_bib26","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1897\/07-080.1","article-title":"Determination and fate of oxytetracycline and related compounds in oxytetracycline production wastewater and the receiving river","volume":"27","author":"Li","year":"2008","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.ecoenv.2014.05.008_bib27","doi-asserted-by":"crossref","first-page":"3793","DOI":"10.1016\/j.scitotenv.2009.03.009","article-title":"Occurrence of pharmaceuticals in Taiwan\u05f3s surface waters: impact of waste streams from hospitals and pharmaceutical production facilities","volume":"407","author":"Lin","year":"2009","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2014.05.008_bib28","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.desal.2010.11.049","article-title":"Effects of UV\/H2O2 on NOM fractionation and corresponding DBPs formation","volume":"270","author":"Lin","year":"2011","journal-title":"Desalination"},{"key":"10.1016\/j.ecoenv.2014.05.008_bib29","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S0045-6535(00)00567-1","article-title":"Formation of volatile halogenated by-products during chlorination of isoproturon aqueous solutions","volume":"45","author":"Lopez","year":"2001","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2014.05.008_bib30","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.jhazmat.2008.05.058","article-title":"Evaluation of disinfection by-products formation during chlorination and chloramination of dissolved natural organic matter fractions isolated from a filtered river water","volume":"162","author":"Lu","year":"2009","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.ecoenv.2014.05.008_bib31","doi-asserted-by":"crossref","first-page":"3533","DOI":"10.1021\/es030653q","article-title":"Occurrence of antimicrobials in the final effluents of wastewater treatment plants in Canada","volume":"38","author":"Miao","year":"2004","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2014.05.008_bib32","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1021\/es010684q","article-title":"Formation of N-nitrosodimethylamine (NDMA) from dimethylamine during chlorination","volume":"36","author":"Mitch","year":"2002","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2014.05.008_bib33","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1021\/es00071a008","article-title":"Chlorination of cyanoethanoic acid in aqueous medium","volume":"24","author":"Peters","year":"1990","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2014.05.008_bib34","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1016\/0043-1354(95)00026-H","article-title":"Relationship between trihalomethanes and haloacetic acids with total organic halogen during chlorination","volume":"29","author":"Pourmoghaddas","year":"1995","journal-title":"Water Res."},{"key":"10.1016\/j.ecoenv.2014.05.008_bib35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2166\/aqua.2001.0001","article-title":"Formation and degradation of DCAN in drinking waters","volume":"50","author":"Reckhow","year":"2001","journal-title":"J. Water Supply Res. Technol.\u2014Aqua"},{"key":"10.1016\/j.ecoenv.2014.05.008_bib36","doi-asserted-by":"crossref","first-page":"4645","DOI":"10.1021\/ac9008012","article-title":"Water analysis: emerging contaminants and current issues","volume":"81","author":"Richardson","year":"2009","journal-title":"Anal. Chem."},{"key":"10.1016\/j.ecoenv.2014.05.008_bib37","doi-asserted-by":"crossref","first-page":"2048","DOI":"10.1016\/j.watres.2007.01.033","article-title":"Kinetics of the oxidation of cylindrospermopsin and anatoxin-a with chlorine, monochloramine and permanganate","volume":"41","author":"Rodr\u00edguez","year":"2007","journal-title":"Water Res."},{"key":"10.1016\/j.ecoenv.2014.05.008_bib38","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.scitotenv.2003.05.001","article-title":"Disinfection by-products (DBPs) in drinking water and predictive models for their occurrence: a review","volume":"321","author":"Sadiq","year":"2004","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2014.05.008_bib39","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.chemosphere.2006.03.026","article-title":"A global perspective on the use, sales, exposure pathways, occurrence, fate and effects of veterinary antibiotics (VAs) in the environment","volume":"65","author":"Sarmah","year":"2006","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2014.05.008_bib40","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1016\/j.watres.2010.09.036","article-title":"Demonstration of 20 pharmaceuticals and personal care products (PPCPs) as nitrosamine precursors during chloramine disinfection","volume":"45","author":"Shen","year":"2011","journal-title":"Water Res."},{"key":"10.1016\/j.ecoenv.2014.05.008_bib41","doi-asserted-by":"crossref","first-page":"5687","DOI":"10.1016\/j.watres.2011.08.034","article-title":"NDMA formation kinetics from three pharmaceuticals in four water matrices","volume":"45","author":"Shen","year":"2011","journal-title":"Water Res."},{"key":"10.1016\/j.ecoenv.2014.05.008_bib42","doi-asserted-by":"crossref","first-page":"6709","DOI":"10.1016\/j.watres.2011.10.004","article-title":"Reconnaissance of selected PPCP compounds in Costa Rican surface waters","volume":"45","author":"Spongberg","year":"2011","journal-title":"Water Res."},{"key":"10.1016\/j.ecoenv.2014.05.008_bib43","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.scitotenv.2007.01.095","article-title":"Efficiency of conventional drinking-water-treatment processes in removal of pharmaceuticals and other organic compounds","volume":"377","author":"Stackelberg","year":"2007","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2014.05.008_bib44","series-title":"Determination of Chlorination Disinfection by Products, Chlorinated Solvents, and Halogenated Pesticides\/Herbicides in Drinking Water by Liquid\u2013Liquid Extraction and Gas Chromatography with Electron-Capture Detection (Revision 1.0)","author":"U.S.EPA Method 551.1","year":"1995"},{"key":"10.1016\/j.ecoenv.2014.05.008_bib45","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1021\/es00171a012","article-title":"General acid catalysis of monochloramine disproportionation","volume":"22","author":"Valentine","year":"1988","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2014.05.008_bib46","doi-asserted-by":"crossref","first-page":"1766","DOI":"10.1016\/S0043-1354(00)00406-1","article-title":"Monochloramine decay in model and distribution system waters","volume":"35","author":"Vikesland","year":"2001","journal-title":"Water Res."},{"key":"10.1016\/j.ecoenv.2014.05.008_bib47","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1016\/j.chemosphere.2012.09.001","article-title":"Transformation of tetracycline during chloramination: kinetics, products and pathways","volume":"90","author":"Wan","year":"2013","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2014.05.008_bib48","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1016\/j.watres.2010.11.039","article-title":"Reactions of tetracycline antibiotics with chlorine dioxide and free chlorine","volume":"45","author":"Wang","year":"2011","journal-title":"Water Res."},{"key":"10.1016\/j.ecoenv.2014.05.008_bib49","unstructured":"Watts, C.D., Craythorne, M., Fielding, M., Steel, C. P., 1983. In: Proceedings of the Third European Symposium on Organic Micropollutants. September 19\u201321. Oslo, Norway, ."},{"key":"10.1016\/j.ecoenv.2014.05.008_bib50","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1016\/j.chemosphere.2010.11.067","article-title":"Occurrence of veterinary antibiotics in animal wastewater and surface water around farms in Jiangsu Province, China","volume":"82","author":"Wei","year":"2011","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2014.05.008_bib51","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1016\/j.watres.2006.12.004","article-title":"Factors affecting formation of haloacetonitriles, haloketones, chloropicrin and cyanogen halides during chloramination","volume":"41","author":"Yang","year":"2007","journal-title":"Water Res."}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651314002176?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651314002176?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,11]],"date-time":"2019-08-11T03:29:54Z","timestamp":1565494194000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651314002176"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9]]},"references-count":51,"alternative-id":["S0147651314002176"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2014.05.008","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2014,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chlorination and chloramination of tetracycline antibiotics: Disinfection by-products formation and influential factors","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2014.05.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}