{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T10:02:21Z","timestamp":1791280941851,"version":"4.1.0"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2017,2]]},"DOI":"10.1016\/j.ecoenv.2016.11.001","type":"journal-article","created":{"date-parts":[[2016,11,11]],"date-time":"2016-11-11T22:32:05Z","timestamp":1478903525000},"page":"126-134","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["The ascidian Styela plicata hemocytes as a potential biomarker of marine pollution: In vitro effects of seawater and organic mercury"],"prefix":"10.1016","volume":"136","author":[{"given":"D.","family":"Parrinello","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Bellante","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.G.","family":"Parisi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.A.","family":"Sanfratello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Indelicato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Piazzese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Cammarata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecoenv.2016.11.001_bib1","first-page":"58","article-title":"Inflammatory hemocytes in Ciona intestinalis innate immune response","volume":"6","author":"Arizza","year":"2009","journal-title":"Invertebr Survival J"},{"key":"10.1016\/j.ecoenv.2016.11.001_bib2","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1080\/11250003.2011.621072","article-title":"Stranded cetaceans as indicators of mercury pollution in the Mediterranean Sea","volume":"79","author":"Bellante","year":"2012","journal-title":"Ital. J. Zool."},{"key":"10.1016\/j.ecoenv.2016.11.001_bib3","doi-asserted-by":"crossref","DOI":"10.1002\/etc.3494","article-title":"Evaluation and comparison of trace metals accumulation indifferent tissues of potential bioindicator organisms: macrobenthic filter feeders Styela plicata, Sabella spallanzanii and Mytilus galloprovincialis","author":"Bellante","year":"2016","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.ecoenv.2016.11.001_bib4","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/S0955-0674(98)80040-9","article-title":"Extracellular matrix signaling: integration of form and function in normal and malignant cells","volume":"10","author":"Boudreau","year":"1998","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.ecoenv.2016.11.001_bib5","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0300-483X(99)00165-1","article-title":"Flow cytometry as a tool to demonstrate the disturbance of phagocytosis in the clam Mya arenaria following in vitro exposure to heavymetals","volume":"142","author":"Brousseau","year":"2000","journal-title":"Toxicology"},{"key":"10.1016\/j.ecoenv.2016.11.001_bib6","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1897\/07-396.1","article-title":"Morphometric alteration in Mytilus galloprovincialis: a new biomarker","volume":"27","author":"Calisi","year":"2008","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.ecoenv.2016.11.001_bib7","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1016\/j.ecoenv.2009.03.010","article-title":"Pollutant-induced alterations of granulocyte morphology in the earthworm Eisenia foetida","volume":"72","author":"Calisi","year":"2009","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2016.11.001_bib8","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1002\/aoc.1335","article-title":"In vitro effects of methylmercury on ascidian (Styela plicata) immunocyte responses","volume":"21","author":"Cammarata","year":"2007","journal-title":"Appl. Organomet. Chem."},{"key":"10.1016\/j.ecoenv.2016.11.001_bib9","first-page":"139","article-title":"Cytotoxic activity of Styela plicata hamocytes against mammalian cell targets: II. Properties of the in vitro reaction against human tumor cell lines","volume":"4","author":"Cammarata","year":"1995","journal-title":"Anim. Biol."},{"key":"10.1016\/j.ecoenv.2016.11.001_bib10","first-page":"302","article-title":"Phenoloxidase-dependent cytotoxic mechanism in ascidian Styela plicata hemocyte active against erythrocytes and K562 tumour cells","volume":"74","author":"Cammarata","year":"1997","journal-title":"Eur. J. Cell Biol."},{"key":"10.1016\/j.ecoenv.2016.11.001_bib11","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/S0166-445X(99)00064-8","article-title":"Tributyltin induces cytoskeletal alterations in the colonial ascidian Botryllus schlosseri phagocytes via interaction with calmodulin","volume":"48","author":"Cima","year":"2000","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.ecoenv.2016.11.001_bib12","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.marenvres.2004.03.083","article-title":"Effect of cadmium, copper, and mercury on antioxidant enzyme activities and lipid peroxidation in the gills of the hydrothermal vent mussel Bathymodiolus azoricus","volume":"58","author":"Company","year":"2004","journal-title":"Mar. Environ. Res."},{"key":"10.1016\/j.ecoenv.2016.11.001_bib13","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1016\/j.envint.2005.05.018","article-title":"Cellular alterations in Mytilus galloprovincialis (LMK) and Tapes philippinarum (Adams and Reeve, 1850) as biomarkers of environmental stress: field studies in the Lagoon of Venice (Italy)","volume":"31","author":"De Ros","year":"2005","journal-title":"Environ. Int."},{"key":"10.1016\/j.ecoenv.2016.11.001_bib14","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1080\/11250009209386669","article-title":"Ascidian hemocytes and their involvement in defense reactions","volume":"59","author":"De Leo","year":"1992","journal-title":"Boll. Zool."},{"key":"10.1016\/j.ecoenv.2016.11.001_bib15","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0166-445X(97)00095-7","article-title":"Modulations in the immune defences of mussels (Mytilus edulis) from contaminated sites in the UK","volume":"42","author":"Dyrynda","year":"1998","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.ecoenv.2016.11.001_bib16","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1590\/S1516-89132003000200021","article-title":"Ultrastructural and quantitative studies of hemocytes in the sugarcane borer, Diatraea saccharalis (Lepidoptera: Pyralidae)","volume":"46","author":"Falleiros","year":"2003","journal-title":"Braz. Arch. Biol. Technol."},{"key":"10.1016\/j.ecoenv.2016.11.001_bib17","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0300-483X(00)00387-5","article-title":"Effects of in vivo exposure of Mya arenaria to organic and inorganic mercury on phagocytic activity of hemocytes","volume":"161","author":"Fournier","year":"2001","journal-title":"Toxicology"},{"key":"10.1016\/j.ecoenv.2016.11.001_bib18","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1023\/A:1008939520263","article-title":"Immunotoxicity in invertebrates: measurements and ecotoxicological relevance","volume":"10","author":"Galloway","year":"2001","journal-title":"Ecotoxicology"},{"key":"10.1016\/j.ecoenv.2016.11.001_bib19","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/S0887-2333(03)00093-6","article-title":"Comparative effects of cadmium, copper, paraquat and benzo[a]pyrene on the actin cytoskeleton and production of reactive oxygen species (ROS) in mussel haemocytes","volume":"17","author":"G\u00f3mez-Mendikute","year":"2003","journal-title":"Toxicol. In Vitro"},{"key":"10.1016\/j.ecoenv.2016.11.001_bib20","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.tox.2004.11.020","article-title":"The immunosuppressive effect of methylmercury does not preclude development of autoimmunity in genetically susceptible mice","volume":"208","author":"Haggqvist","year":"2005","journal-title":"Toxicology"},{"key":"10.1016\/j.ecoenv.2016.11.001_bib21","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.scitotenv.2014.05.134","article-title":"Assessment of neurotoxic effects of mercury in beluga whales (Delphinapterus leucas), ringed seals (Pusa hispida) and polar bears (Ursus maritimus) from the Canadian Artic","volume":"510","author":"Krey","year":"2015","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2016.11.001_bib22","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1016\/S0965-1748(02)00092-9","article-title":"Insect hemocytes and their role in immunity","volume":"32","author":"Lavine","year":"2002","journal-title":"Insect Biochem. Mol. Biol."},{"key":"10.1016\/j.ecoenv.2016.11.001_bib23","first-page":"20","article-title":"Mercury induced alterations in the terrestrial snail Cantareus apertus as novel biomarker","volume":"183\u2013184","author":"Leomanni","year":"2016","journal-title":"Comp. Biochem. Physiol. C: Toxicol. Pharmacol."},{"key":"10.1016\/j.ecoenv.2016.11.001_bib24","doi-asserted-by":"crossref","first-page":"4731","DOI":"10.1046\/j.1432-1327.2000.01526.x","article-title":"Organization-dependent effects of toxic bivalent ions Microtubule assembly and glycolysis","volume":"267","author":"Liliom","year":"2000","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.ecoenv.2016.11.001_bib25","first-page":"131","article-title":"Citotoxic activity of Styela plicata hemocytes agaist mammalian cell targets: I. Properties of the in vitro reaction agaist erythrocytes","volume":"4","author":"Lipari","year":"1995","journal-title":"Anim. Biol."},{"key":"10.1016\/j.ecoenv.2016.11.001_bib26","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.jtemb.2015.06.008","article-title":"Toxicity of organic and inorganic mercury species in differentiated human neurons and human astrocytes","volume":"32","author":"Lohren","year":"2015","journal-title":"J. Trace Elem. Med. Biol."},{"key":"10.1016\/j.ecoenv.2016.11.001_bib27","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/BF02472006","article-title":"Incidence of adverse biological effects within ranges of chemical concentrations in marine and estuarine sediments","volume":"19","author":"Long","year":"1995","journal-title":"Environ. Manag."},{"issue":"4","key":"10.1016\/j.ecoenv.2016.11.001_bib28","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1002\/etc.5620170428","article-title":"Predicting toxicity in marine sediments with numerical sediment quality guidelines","volume":"17","author":"Long","year":"1998","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.ecoenv.2016.11.001_bib29","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/0166-445X(94)00045-X","article-title":"Contaminant induced lysosomal membrane damage in marine mussel digestive cell: an in vitro study","volume":"30","author":"Lowe","year":"1994","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.ecoenv.2016.11.001_bib30","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/BF00118995","article-title":"Development and evaluation of sediment quality guidelines for Florida coastal waters","volume":"5","author":"Macdonald","year":"1996","journal-title":"Ecotoxicology"},{"key":"10.1016\/j.ecoenv.2016.11.001_bib31","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.aquatox.2003.09.003","article-title":"Mercury- and copper-induced lysosomal membrane destabilization depends on [Ca2+] dependent phospholipase A2 activation","volume":"66","author":"Marchi","year":"2004","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.ecoenv.2016.11.001_bib32","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1016\/j.chemosphere.2004.09.093","article-title":"Biomonitoring of trace metals in a mine-polluted estuarine system (Spain)","volume":"58","author":"Morillo","year":"2005","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2016.11.001_bib33","first-page":"205","article-title":"Cellular state of copper and nickel accumulation in ascidians related to the naturally and sinthropic-enriched New Caledonian environment","volume":"70","author":"Monniot","year":"1994","journal-title":"Ann. Inst. Oceanogr. Paris"},{"key":"10.1016\/j.ecoenv.2016.11.001_bib34","first-page":"14","article-title":"Profiling the physiological and molecular response to sulfonamidic drug in Procambarus clarkii","volume":"166","author":"Nicosia","year":"2014","journal-title":"Comp. Biochem. Physiol. C"},{"key":"10.1016\/j.ecoenv.2016.11.001_bib35","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.aquatox.2005.12.013","article-title":"Cellular biomarkers for monitoring estuarine environments: transplanted versus native mussels","volume":"77","author":"Nigro","year":"2006","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.ecoenv.2016.11.001_bib36","series-title":"Lessons in immunity","first-page":"177","article-title":"Inflammatory response of the ascidian Ciona intestinalis","author":"Parrinello","year":"2016"},{"key":"10.1016\/j.ecoenv.2016.11.001_bib37","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1007\/s10661-010-1645-7","article-title":"Hemocytical responses to environmental stress in invertebrates: a review","volume":"177","author":"Perez","year":"2011","journal-title":"Environ. Monit. Assess."},{"key":"10.1016\/j.ecoenv.2016.11.001_bib38","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/0145-305X(92)90012-2","article-title":"Generation of reactive oxygen metabolites by the haemocytes of the mussel Mytilus edulis","volume":"16","author":"Pipe","year":"1992","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.ecoenv.2016.11.001_bib39","first-page":"343","article-title":"A hemocyte classification scheme for the tunicate Styela plicata (Lesueur, 1823)","volume":"79","author":"Radford","year":"1998","journal-title":"Acta Zool."},{"issue":"4","key":"10.1016\/j.ecoenv.2016.11.001_bib40","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1006\/jipa.2000.4979","article-title":"Effects of metal-based environmental pollutants on tunicate hemocytes","volume":"76","author":"Radford","year":"2000","journal-title":"J. Invertebr. Pathol."},{"key":"10.1016\/j.ecoenv.2016.11.001_bib41","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1007\/BF02624470","article-title":"In vitro culture of tissue from the tunicate Styela clava","volume":"26A","author":"Raftos","year":"1990","journal-title":"In Vitro Cell. Dev. Biol."},{"key":"10.1016\/j.ecoenv.2016.11.001_bib42","series-title":"Heavy Metals in the Marine Environment","first-page":"67","article-title":"Heavy metal levels in marine invertebrates","author":"Rainbow","year":"1990"},{"key":"10.1016\/j.ecoenv.2016.11.001_bib43","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/0025-326X(95)00116-5","article-title":"Biomonitoring of heavy metal availability in the marine environment","volume":"31","author":"Rainbow","year":"1995","journal-title":"Mar. Pollut. Bull."},{"key":"10.1016\/j.ecoenv.2016.11.001_bib44","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0269-7491(02)00238-5","article-title":"Trace metal concentrations in acquatic invertebrates: why and so what?","volume":"120","author":"Rainbow","year":"2002","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2016.11.001_bib45","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0166-445X(01)00232-6","article-title":"Phagocytic activity of marine and freshwater bivalves: in vitro exposure of haemocytes to metals (Ag, Cd, Hg and Zn)","volume":"58","author":"Sauve","year":"2002","journal-title":"Aquat. Toxicol."},{"issue":"4","key":"10.1016\/j.ecoenv.2016.11.001_bib46","doi-asserted-by":"crossref","first-page":"E65","DOI":"10.1038\/ncb0402-e65","article-title":"Networks and crosstalk: integrin signalling spreads","author":"Schwartz","year":"2002","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.ecoenv.2016.11.001_bib47","doi-asserted-by":"crossref","DOI":"10.1007\/s002540050123","article-title":"Heavy metals in freshly deposited sediments of Gomti river (a tributary of the Ganga river): effects of human activities","volume":"29","author":"Singh","year":"1997","journal-title":"Environ. Geol."},{"key":"10.1016\/j.ecoenv.2016.11.001_bib48","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.etap.2006.03.005","article-title":"Effects of polychlorinated biphenyls, hexachlorocyclohexanes and mercury on human neutrophil apoptosis, actin cytoskelton, and oxidative state","volume":"22","author":"Sweet","year":"2006","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.ecoenv.2016.11.001_bib49","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.taap.2009.09.022","article-title":"Methylmercury disrupts the balance between phosphorylated and non-phosphorylated cofilin in primary cultures of mice cerebellar granule cells: a proteomic study","volume":"242","author":"Vendrell","year":"2010","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.ecoenv.2016.11.001_bib50","first-page":"565","article-title":"Urochordate","volume":"2","author":"Wright","year":"1981"}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651316304547?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651316304547?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,6]],"date-time":"2018-09-06T15:51:05Z","timestamp":1536249065000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651316304547"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2]]},"references-count":50,"alternative-id":["S0147651316304547"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2016.11.001","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2017,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The ascidian Styela plicata hemocytes as a potential biomarker of marine pollution: In vitro effects of seawater and organic mercury","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2016.11.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}