{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T01:10:12Z","timestamp":1780103412782,"version":"3.54.0"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31660352"],"award-info":[{"award-number":["31660352"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Natural Science Foundation","award":["2015GXNSFAA139079"],"award-info":[{"award-number":["2015GXNSFAA139079"]}]},{"DOI":"10.13039\/501100003009","name":"Science & Technology Development Fund","doi-asserted-by":"crossref","award":["Guinongke2017JZ11"],"award-info":[{"award-number":["Guinongke2017JZ11"]}],"id":[{"id":"10.13039\/501100003009","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003009","name":"Science & Technology Development Fund","doi-asserted-by":"crossref","award":["Guinongke2017JZ21"],"award-info":[{"award-number":["Guinongke2017JZ21"]}],"id":[{"id":"10.13039\/501100003009","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1016\/j.ecoenv.2018.03.060","type":"journal-article","created":{"date-parts":[[2018,4,21]],"date-time":"2018-04-21T11:28:37Z","timestamp":1524310117000},"page":"403-408","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":94,"special_numbering":"C","title":["The central role of hydrogen sulfide in plant responses to toxic metal stress"],"prefix":"10.1016","volume":"157","author":[{"given":"Huyi","family":"He","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingqiu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long-Fei","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecoenv.2018.03.060_bib1","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.ecoenv.2014.08.027","article-title":"Hydrogen sulfide alleviates cadmium-induced morpho-physiological and ultrastructural changes in Brassica napus","volume":"110","author":"Ali","year":"2014","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2018.03.060_bib2","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/s10725-014-9917-9","article-title":"Improvement of element uptake and antioxidative defense in Brassica napus under lead stress by application of hydrogen sulfide","volume":"74","author":"Ali","year":"2014","journal-title":"Plant Growth Regul."},{"key":"10.1016\/j.ecoenv.2018.03.060_bib3","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.ecoenv.2014.01.013","article-title":"Hydrogen sulfide alleviates lead-induced photosynthetic and ultrastructural changes in oil seed rape","volume":"102","author":"Ali","year":"2014","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2018.03.060_bib4","doi-asserted-by":"crossref","first-page":"3068","DOI":"10.1007\/s11356-014-3551-y","article-title":"Hydrogen sulfide alleviates the aluminum-induced changes in Brassica napus as revealed by physiochemical and ultrastructural study of plant","volume":"22","author":"Ali","year":"2015","journal-title":"Environ. Sci. Pollut. Res."},{"issue":"1","key":"10.1016\/j.ecoenv.2018.03.060_bib5","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1104\/pp.15.00009","article-title":"S-sulfhydration: a cysteine posttranslational modification in plant systems","volume":"168","author":"Aroca","year":"2015","journal-title":"Plant Physiol."},{"issue":"1\u20132","key":"10.1016\/j.ecoenv.2018.03.060_bib6","first-page":"301","article-title":"Hydrogen sulfide alleviates aluminum toxicity in barley seedlings","volume":"362","author":"Chen","year":"2013","journal-title":"Plant Soil"},{"issue":"10","key":"10.1016\/j.ecoenv.2018.03.060_bib7","doi-asserted-by":"crossref","first-page":"e109669","DOI":"10.1371\/journal.pone.0109669","article-title":"Cadmium-induced hydrogen sulfide synthesis is involved in cadmium tolerance in Medicago sativa by reestablishment of reduced (homo) glutathione and reactive oxygen species homeostases","volume":"9","author":"Cui","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.ecoenv.2018.03.060_bib8","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.jhazmat.2011.12.076","article-title":"Alleviation of aluminum oxicity by hydrogen sulfide is related to elevated ATPase, and uppressed aluminum uptake and oxidative stress in barley","volume":"209\u2013210","author":"Dawood","year":"2012","journal-title":"J. Hazard. Mater."},{"issue":"6","key":"10.1016\/j.ecoenv.2018.03.060_bib9","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.ceca.2014.10.004","article-title":"Hydrogen sulfide interacts with calcium signaling to enhance the chromium tolerance in Setaria italica","volume":"56","author":"Fang","year":"2014","journal-title":"Cell Calcium"},{"issue":"6","key":"10.1016\/j.ecoenv.2018.03.060_bib10","first-page":"758","article-title":"Ca2+ participates in H2S induced Cr6+ tolerance in Setaria italica. Chin","volume":"36","author":"Fang","year":"2014","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.ecoenv.2018.03.060_bib11","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1016\/j.envpol.2016.03.035","article-title":"An emphasis of hydrogen sulfide-cysteine cycle on enhancing the tolerance to chromium stress in Arabidopsis","volume":"213","author":"Fang","year":"2016","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2018.03.060_bib12","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/j.bbrc.2004.04.094","article-title":"Endogenous hydrogen sulfide regulation of myocardial injury induced by isoprotenol","volume":"318","author":"Geng","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"15","key":"10.1016\/j.ecoenv.2018.03.060_bib13","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1089\/ars.2012.5041","article-title":"Polysulfides link H2S to protein thiol oxidation","volume":"19","author":"Greiner","year":"2013","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.ecoenv.2018.03.060_bib14","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.plaphy.2014.02.012","article-title":"Hydrogen sulfide and cell signaling: team player or referee?","volume":"78","author":"Honcock","year":"2014","journal-title":"Plant Physiol. Biochem."},{"key":"10.1016\/j.ecoenv.2018.03.060_bib15","series-title":"Trace Elements in Soils","first-page":"229","article-title":"Assessing Bioavailability of Soil Trace Elements","author":"Hooda","year":"2010"},{"key":"10.1016\/j.ecoenv.2018.03.060_bib16","doi-asserted-by":"crossref","first-page":"397502","DOI":"10.1155\/2015\/397502","article-title":"Physiological implications of hydrogen sulfide in plants: pleasant exploration behind its unpleasant odour","volume":"2015","author":"Jin","year":"2015","journal-title":"Oxid. Med. Cell Longev."},{"key":"10.1016\/j.ecoenv.2018.03.060_bib17","doi-asserted-by":"crossref","first-page":"21903","DOI":"10.1074\/jbc.R110.128363","article-title":"Redox biochemistry of hydrogen sulfide","volume":"285","author":"Kabil","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ecoenv.2018.03.060_bib18","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1146\/annurev.arplant.55.031903.141655","article-title":"How do crop plants tolerate acid soils? Mechanisms of aluminum tolerance and phosphorous efficiency","volume":"55","author":"Kochian","year":"2004","journal-title":"Annu. Rev. Plant Biol."},{"issue":"3","key":"10.1016\/j.ecoenv.2018.03.060_bib19","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1007\/s10534-012-9551-9","article-title":"Roles of hydrogen sulfide and nitric oxide in the alleviation of cadmium-induced oxidative damage in alfalfa seedling roots","volume":"25","author":"Li","year":"2012","journal-title":"BioMetals"},{"key":"10.1016\/j.ecoenv.2018.03.060_bib20","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.3389\/fpls.2016.01621","article-title":"Hydrogen sulfide: a signal molecule in plant cross-adaptation","volume":"7","author":"Li","year":"2016","journal-title":"Front. Plant Sci."},{"issue":"12","key":"10.1016\/j.ecoenv.2018.03.060_bib21","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/j.plaphy.2010.09.016","article-title":"A novel hydrogen sulfide donor causes stomatal opening and reduces nitric oxide accumulation","volume":"48","author":"Lisjak","year":"2010","journal-title":"Plant Physiol. Biochem."},{"key":"10.1016\/j.ecoenv.2018.03.060_bib22","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/s11104-015-2719-7","article-title":"Hydrogen sulfide alleviates zinc toxicity by reducing zinc uptake and regulating genes expression of antioxidative enzymes and metallothioneins in roots of the cadmium\/zinc hyperaccumulator Solanum nigrum L","volume":"400","author":"Liu","year":"2016","journal-title":"Plant Soil"},{"issue":"11","key":"10.1016\/j.ecoenv.2018.03.060_bib23","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1007\/s11434-015-0787-y","article-title":"WRKY transcription factors down-regulate the expression of H2S generating genes, LCD and DES in Arabidopsis thaliana","volume":"60","author":"Liu","year":"2015","journal-title":"Sci. Bull."},{"issue":"10","key":"10.1016\/j.ecoenv.2018.03.060_bib24","first-page":"1085","article-title":"H2S Regulates foxtail millet responsing to stress by protein S-sulfhydration","volume":"31","author":"Liu","year":"2015","journal-title":"Chin. J. Biochem. Mol. Biol."},{"key":"10.1016\/j.ecoenv.2018.03.060_bib25","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1097\/01.shk.0000183393.83272.de","article-title":"Oxidative stress-dependent conversion of hydrogen sulfide to sulfite by activated neurophils","volume":"24","author":"Mitsuhashi","year":"2006","journal-title":"Shock"},{"key":"10.1016\/j.ecoenv.2018.03.060_bib26","doi-asserted-by":"crossref","first-page":"e14078","DOI":"10.1038\/srep14078","article-title":"Hydrogen sulfide modulates cadmium-induced physiological and biochemical responses to alleviate cadmium toxicity in rice","volume":"5","author":"Mostofa","year":"2015","journal-title":"Sci. Rep."},{"issue":"96","key":"10.1016\/j.ecoenv.2018.03.060_bib27","doi-asserted-by":"crossref","first-page":"ra72","DOI":"10.1126\/scisignal.2000464","article-title":"H2S signals through protein S-sulfhydration","volume":"2","author":"Mustafa","year":"2009","journal-title":"Sci. Signal."},{"issue":"5","key":"10.1016\/j.ecoenv.2018.03.060_bib28","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1055\/s-2007-965424","article-title":"Characterization of cysteine-degrading and H2S-releasing enzymes of higher plants - from the field to the test tube and back","volume":"9","author":"Papenbrock","year":"2007","journal-title":"Plant Biol."},{"issue":"8","key":"10.1016\/j.ecoenv.2018.03.060_bib29","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/nrm3391","article-title":"H2S signalling through protein sulfhydration and beyond","volume":"13","author":"Paul","year":"2012","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"1\u20132","key":"10.1016\/j.ecoenv.2018.03.060_bib30","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/s11104-015-2475-8","article-title":"H2S acting as a downstream signaling molecule of SA regulates Cd tolerance in Arabidopsis","volume":"393","author":"Qiao","year":"2015","journal-title":"Plant Soil"},{"issue":"1","key":"10.1016\/j.ecoenv.2018.03.060_bib31","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s11104-015-2643-x","article-title":"CDPKs enhance Cd tolerance through intensifying H2S signal in Arabidopsis thaliana","volume":"398","author":"Qiao","year":"2016","journal-title":"Plant Soil"},{"key":"10.1016\/j.ecoenv.2018.03.060_bib32","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.tplants.2005.08.006","article-title":"Sulfur metabolism: a versatile platform for launching defence operations","volume":"10","author":"Rausch","year":"2005","journal-title":"Trends Plant Sci."},{"key":"10.1016\/j.ecoenv.2018.03.060_bib33","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1111\/plb.12019","article-title":"Copper toxicity in Chinese cabbage is not influenced by plant sulphur status, but affects sulphur metabolism-related gene expression and the suggested regulatory metabolistes","volume":"16","author":"Shahbaz","year":"2014","journal-title":"Plant Biol."},{"issue":"2","key":"10.1016\/j.ecoenv.2018.03.060_bib34","first-page":"248","article-title":"Hydrogen sulfide protects wheat seedlings against copper stress by regulating the ascorbate and glutathione metabolism in leaves","volume":"6","author":"Shan","year":"2012","journal-title":"Aust. J. Crop Sci."},{"issue":"10","key":"10.1016\/j.ecoenv.2018.03.060_bib35","doi-asserted-by":"crossref","first-page":"e77047","DOI":"10.1371\/journal.pone.0077047","article-title":"Hydrogen sulfide improves drought tolerance in Arabidopsis thaliana by microRNA expressions","volume":"8","author":"Shen","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.ecoenv.2018.03.060_bib36","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.plaphy.2013.11.001","article-title":"Nitric oxide-activated hydrogen sulfide is essential for cadmium stress response in bermudagrass (Cynodon dactylon (L). Pers.)","volume":"74","author":"Shi","year":"2014","journal-title":"Plant Physiol. Biochem."},{"issue":"7","key":"10.1016\/j.ecoenv.2018.03.060_bib37","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1111\/jipb.12302","article-title":"Hydrogen sulfide regulates abiotic stress tolerance and biotic stress resistance in Arabidopsis","volume":"57","author":"Shi","year":"2015","journal-title":"J. Integr. Plant Biol."},{"key":"10.1016\/j.ecoenv.2018.03.060_bib38","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.jplph.2015.03.015","article-title":"Hydrogen sulfide alleviates toxic effects of arsenate in pea seedlings through up-regulation of the ascorbate-glutathione cycle: possible involvement of nitric oxide","volume":"181","author":"Singh","year":"2015","journal-title":"J. Plant Physiol."},{"key":"10.1016\/j.ecoenv.2018.03.060_bib39","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.plaphy.2013.01.003","article-title":"Hydrogen sulfide alleviates cadmium toxicity through regulations of cadmium transport across the plasma and vacuolar membranes in Populus euphratica cells","volume":"65","author":"Sun","year":"2013","journal-title":"Plant Physiol. Biochem."},{"issue":"4","key":"10.1016\/j.ecoenv.2018.03.060_bib40","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.tplants.2012.01.010","article-title":"Functions of microRNAs in plant stress responses","volume":"17","author":"Sunkar","year":"2012","journal-title":"Trends Plant Sci."},{"key":"10.1016\/j.ecoenv.2018.03.060_bib41","doi-asserted-by":"crossref","first-page":"530","DOI":"10.2741\/4500","article-title":"Role of hydrogen sulfide in the methyl jasmonate response to cadmium stress in foxtail millet","volume":"22","author":"Tian","year":"2017","journal-title":"Front. Biosci."},{"key":"10.1016\/j.ecoenv.2018.03.060_bib42","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1152\/physrev.00017.2011","article-title":"Physiological implications of hydrogen sulfide: a whiff exploration that blossomed","volume":"92","author":"Wang","year":"2012","journal-title":"Physiol. Rev."},{"issue":"2","key":"10.1016\/j.ecoenv.2018.03.060_bib43","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1104\/pp.61.2.184","article-title":"Light-dependent emission of hydrogen sulfide from plants","volume":"61","author":"Wilson","year":"1978","journal-title":"Plant Physiol."},{"key":"10.1016\/j.ecoenv.2018.03.060_bib44","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1111\/j.1471-4159.2004.02617.x","article-title":"The novel neuromodulater hydrogen sulfide: an endogenous peroxynitrite 'scavenger'?","volume":"90","author":"Whiteman","year":"2004","journal-title":"J. Neurochem."},{"key":"10.1016\/j.ecoenv.2018.03.060_bib45","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1039\/c3mt00022b","article-title":"A potential role of microRNAs in plant response to metal toxicity","volume":"5","author":"Yang","year":"2013","journal-title":"Metallomics"},{"key":"10.1016\/j.ecoenv.2018.03.060_bib46","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1111\/j.1744-7909.2008.00769.x","article-title":"Hydrogen sulfide promotes wheat seed germination and alleviates oxidative damage against copper stress","volume":"50","author":"Zhang","year":"2008","journal-title":"J. Integr. Plant Biol."},{"key":"10.1016\/j.ecoenv.2018.03.060_bib47","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1111\/j.1744-7909.2010.00946.x","article-title":"Hydrogen sulfide alleviates aluminum toxicity in germinating wheat seedlings","volume":"52","author":"Zhang","year":"2010","journal-title":"J. Integr. Plant Biol."},{"key":"10.1016\/j.ecoenv.2018.03.060_bib48","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1007\/s10535-010-0133-9","article-title":"Hydrogen sulfide alleviated chromium toxicity in wheat","volume":"54","author":"Zhang","year":"2010","journal-title":"Biol. Plant."},{"key":"10.1016\/j.ecoenv.2018.03.060_bib49","doi-asserted-by":"crossref","first-page":"804603","DOI":"10.1155\/2015\/804603","article-title":"Hydrogen sulfide alleviates cadmium-induced cell death through restraining ROS accumulation in roots of Brassica rapa L. ssp. pekinensis","volume":"2015","author":"Zhang","year":"2015","journal-title":"Oxid. Med. Cell Longev."}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651318302495?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651318302495?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T04:50:42Z","timestamp":1758948642000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651318302495"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8]]},"references-count":49,"alternative-id":["S0147651318302495"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2018.03.060","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2018,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The central role of hydrogen sulfide in plant responses to toxic metal stress","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2018.03.060","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}